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metfomin uses

Raquel Díez, Juan José García, María José Diez, Matilde Sierra, Ana M Sahagun, Nélida Fernández
BACKGROUND: Metformin is an oral hypoglycemic agent frequently used in patients with type 2 diabetes. In this study, we have investigated the influence of the dietary fiber Plantago ovata husk on the pharmacokinetics of this drug when included in the diet, as well as when administered at the same time as metformin. METHODS: Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with fiber (3.5 mg/kg/day)...
June 7, 2017: BMC Complementary and Alternative Medicine
Jian-Cai Tang, Rui An, Yi-Qing Jiang, Jian Yang
PURPOSE: The purpose of this study was to observe the effects of metformin on human esophageal cancer cell and to investigate its possible mechanisms. MATERIALS AND METHODS: Cell viability was detected by using a Cell Counting Kit-8, while cell cycle and apoptosis were assessed by flow cytometry and western blot was used to measure the expression of the related proteins. RNAi was used to knockout pyruvate kinase muscle isozyme 2 (PKM2). An Eca109 tumor model was established to evaluate the antitumor effect in vivo...
July 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Yueyang Wu, Wei Zhao, Youyi Zhang, Xinheng Feng, Zhaoping Li, Wei Gao
OBJECTIVE: To explore the effects of metformin on left ventricular remodeling in patients with primary hypertension and type 2 diabetes mellitus, and to investigate the effects of hypertension duration and duration of drug administration on metformin's cardiac action. METHODS: The clinical and echocardiographic data of 176 patients with primary hypertension and type 2 diabetes mellitus who were admitted to department of cardiology from January to December 2012 were retrospectively analyzed...
November 24, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Christian Omar Ramos-Peñafiel, Carlos Martínez-Murillo, Adrián Santoyo-Sánchez, Fiacro Jiménez-Ponce, Etta Rozen-Fuller, Juan Collazo-Jaloma, Irma Olarte-Carrillo, Adolfo Martínez-Tovar
BACKGROUND: Recently it has been reported a benefit effect with the use of metformin in patients with malignant disease. Our objective was to evaluate the effect of adding metformin to chemotherapy regimen over the percentage of early relapse in acute lymphoblastic leukemia. METHODS: A prospective, longitudinal and experimental study was performed in patients with de novo acute lymphoblastic leukemia enrolled in the Hospital General de México. They were divided in two groups: first group received chemotherapy + metformin (850 mg three times a day); second group only received standard chemotherapy...
May 2014: Revista Médica del Instituto Mexicano del Seguro Social
Amir Ziaee, Sonia Oveisi, Atefeh Abedini, Sima Hashemipour, Toktam Karimzadeh, Azam Ghorbani
AIM: to compare the effectiveness of metformin and pioglitazone in ameliorating insulin resistance and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). METHODS: this study was a randomized clinical trial to compare treatment with metformin and pioglitozone. Fifty two women with PCOS aged 20-45 years were randomly allocated to one of the two treatment groups. All patients underwent clinical and biochemical evaluation and analyses involving these measures which consisted of repeated measures MANOVA using the pre- and post-intervention fasting blood sugar (FBS), lipid profiles, body mass index (BMI), serum insulin in two groups...
January 2012: Acta Medica Indonesiana
Jianfang Fu, Jufang Fu, Jun Yuan, Nanyan Zhang, Bin Gao, Guoqiang Fu, Yanyang Tu, Yongsheng Zhang
Combination therapy had become very popular currently for the diabetes mellitus and its complications, because of long term unreasonable drug use and adverse reaction to human body. In this study, a polysaccharide (ASP) from the roots of Acanthopanax senticosus was evaluated as an adjuvant with metformin for antidiabetic therapy in alloxan-induced diabetic rats. The result identified ASP plus metformin had a more beneficial promotion for relieving the symptoms of diabetes and reversing liver and kidney damage to normal level than only metfomin administration to diabetic rats...
April 1, 2012: International Journal of Biological Macromolecules
Carlos G Galindo García, Maria de Jesús Vega Arias, Imelda Hernández Marín, Aquiles R Ayala
Polycystic ovarian disease (PCOD) is the most important endocrine abnormality that affects women in reproductive age. It is characterized by chronic anovulation and hyperandrogenemia probably secondary to insulin resistance. Hence insulin sensitizers agents had been used in PCOD. Metformin is a biguanide used in the treatment of PCOD via decrease of hepatic gluconeogenesis and insulinemia; improvement peripheral glucose utilization, oxidative glucose metabolism, nonoxidative glucose metabolism and intracellular glucose transport...
March 2007: Ginecología y Obstetricia de México
Stefano Palomba, Angela Falbo, Francesco Orio, Francesco Manguso, Tiziana Russo, Achille Tolino, Colao Annamaria, Brian Dale, Fulvio Zullo
BACKGROUND: There are few data in the literature regarding the utility of metfomin before and during gonadotrophin administration in women with polycystic ovary syndrome (PCOS). The aim of the present study was to assess the effect of the pre-treatment and co-administration of metformin in infertile PCOS women treated with controlled ovarian stimulation (COS) followed by timed intercourse (TI) or intrauterine insemination (IUI). METHODS: Seventy insulin-resistant primary infertile women with PCOS were randomized to receive metformin cloridrate (850 mg twice daily; group A) or placebo tablets (two tablets daily; group B) for 3 months...
October 2005: Human Reproduction
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