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https://www.readbyqxmd.com/read/29732720/distribution-of-gene-segments-of-the-pandemic-a-h1n1-2009-virus-lineage-in-pig-populations
#1
K Okuya, A Matsuu, T Kawabata, F Koike, M Ito, T Furuya, A Taneno, S Akimoto, E Deguchi, M Ozawa
Swine influenza viruses (SIVs) are important not only for pig farming, but also for public health. In fact, pandemic A(H1N1) 2009 viruses [A(H1N1)pdm09] were derived from SIVs. Therefore, timely characterization of locally circulating SIVs is necessary for understanding the global status of SIVs. To genetically characterize SIVs circulating in Japanese pig populations, we isolated 24 SIVs of three subtypes (17 H1N1, four H1N2 and three H3N2 strains) from 14 pig farms in Japan from 2013 to 2016. Genetic analyses revealed that the haemagglutinin (HA) and neuraminidase (NA) genes of the 17 H1N1 and the HA gene of one H1N2, A/swine/Aichi/02/2016 (H1N2), SIVs belonged to the A(H1N1)pdm09 lineage...
May 6, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29707841/activatable-semiconducting-theranostics-simultaneous-generation-and-ratiometric-photoacoustic-imaging-of-reactive-oxygen-species-in-vivo
#2
Zhen Yang, Yunlu Dai, Chao Yin, Quli Fan, Wansu Zhang, Justin Song, Guocan Yu, Wei Tang, Wenpei Fan, Bryant C Yung, Jie Li, Xiang Li, Xiangchun Li, Yufu Tang, Wei Huang, Jibin Song, Xiaoyuan Chen
Enhancing the generation of reactive oxygen species (ROS) is an effective anticancer strategy. However, it is a great challenge to control the production and to image ROS in vivo, both of which are vital for improving the efficacy and accuracy of cancer therapy. Herein, an activatable semiconducting theranostic nanoparticle (NP) platform is developed that can simultaneously enhance ROS generation while self-monitoring its levels through ratiometric photoacoustic (PA) imaging. The NP platform can further guide in vivo therapeutic effect in tumors...
April 30, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29698370/emergency-physician-evaluation-of-pa-and-np-practice-patterns
#3
Andrew W Phillips, Kevin M Klauer, Chad S Kessler
The unprecedented surge in physician assistants (PAs) and NPs in the ED developed quickly in recent years, but scope of practice and practice patterns are not well described. METHODS: We conducted two cross-sectional electronic surveys of the American College of Emergency Physicians' council. Survey construction was informed by interviews and evaluated with validity and reliability studies. Univariate analyses to establish associations also were performed. RESULTS: Most councilors' departments employ PAs and NPs (72...
May 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29683691/veterans-with-recent-substance-use-and-aggression-ptsd-substance-use-and-social-network-behaviors
#4
Minden B Sexton, Alan K Davis, Katherine R Buchholz, Jamie J Winters, Sheila A M Rauch, Maegan Yzquibell, Erin E Bonar, Steven Friday, Stephen T Chermack
OBJECTIVE: Violence is a salient concern among veterans, yet relationships between psychiatric comorbidity, social networks, and aggression are poorly understood. We examined associations between biopsychosocial factors (substance use, posttraumatic stress disorder [PTSD], and social network behaviors) with aggression. METHOD: We recruited veterans endorsing past-year aggression and substance use (N = 180) from Department of Veterans Affairs outpatient treatment clinics...
April 23, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29667576/case-of-seasonal-reassortant-a-h1n2-influenza-virus-infection-the-netherlands-march-2018
#5
Adam Meijer, Corien M Swaan, Martin Voerknecht, Edin Jusic, Sharon van den Brink, Lisa A Wijsman, Bettie Cg Voordouw, Gé A Donker, Jacqueline Sleven, Wendelien W Dorigo-Zetsma, Sanela Svraka, Michiel van Boven, Manon R Haverkate, Aura Timen, Jaap T van Dissel, Marion Pg Koopmans, Theo M Bestebroer, Ron Am Fouchier
A seasonal reassortant A(H1N2) influenza virus harbouring genome segments from seasonal influenza viruses A(H1N1)pdm09 (HA and NS) and A(H3N2) (PB2, PB1, PA, NP, NA and M) was identified in March 2018 in a 19-months-old patient with influenza-like illness (ILI) who presented to a general practitioner participating in the routine sentinel surveillance of ILI in the Netherlands. The patient recovered fully. Further epidemiological and virological investigation did not reveal additional cases.
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29667375/core-curriculum-to-facilitate-the-expansion-of-a-rheumatology-practice-to-include-nurse-practitioners-and-physician-assistants
#6
Benjamin J Smith, Marcy B Bolster, Barbara Slusher, Christine Stamatos, Jeanne R Scott, Heather Benham, Salahuddin Kazi, Elizabeth A Schlenk, Daniel E Schaffer, Vikas Majithia, Calvin R Brown, Joan M von Feldt, Joseph Flood, David M Haag, Karen L Smarr
OBJECTIVE: Due to an aging population, increasing prevalence of rheumatic disease, and a growing supply and demand gap of rheumatology providers, innovative solutions are needed to meet the needs of persons with rheumatic conditions. Nurse practitioners (NPs) and physician assistants (PAs) have been identified as a group of health professionals who could help address the workforce shortage. The Executive Committee of the Association of Rheumatology Health Professionals (ARHP), a division of the American College of Rheumatology (ACR), charged a task force to facilitate the preparation of NPs/PAs to work in a rheumatology practice setting...
April 17, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29666412/extensive-t-cell-cross-reactivity-between-diverse-seasonal-influenza-strains-in-the-ferret-model
#7
Adrian J Reber, Nedzad Music, Jin Hyang Kim, Shane Gansebom, Jufu Chen, Ian York
Influenza virus causes widespread, yearly epidemics by accumulating surface protein mutations to escape neutralizing antibodies established from prior exposure. In contrast to antibody epitopes, T cell mediated immunity targets influenza epitopes that are more highly conserved and have potential for cross-protection. The extent of T cell cross-reactivity between a diverse array of contemporary and historical influenza strains was investigated in ferrets challenged with 2009 pandemic H1N1 influenza or the seasonal H3N2 strain, A/Perth/16/2009...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29556085/radionuclide-uptake-by-colloidal-and-particulate-humic-acids-obtained-from-14-soils-collected-worldwide
#8
Peng Lin, Chen Xu, Wei Xing, Luni Sun, Daniel I Kaplan, Nobuhide Fujitake, Chris M Yeager, Kathleen A Schwehr, Peter H Santschi
Uptake of six particle-reactive and/or redox-sensitive radionuclides (210 Pb,234 Th,7 Be,59 Fe,237 Np and233 Pa) by 14 humic acids (HAs) was investigated in artificial groundwater under mildly acidic conditions (pH~5.5). In HA-groundwater slurry, Pb, Be, Fe and Pa bound strongly to particulate HA (>0.45 µm), supporting their application as tracers of soil erosion. Th bound strongly to the colloidal HA (3 kDa-0.45 µm) and as such, would not be a good candidate as a tracer for monitoring soil erosion...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29502417/quantifying-vascular-distribution-and-adhesion-of-nanoparticles-with-protein-corona-in-microflow
#9
Yan Teck Ho, Sharon Wei Ling Lee, Nurul 'Ain Azman, Fion Wen Yee Loh, Nhan Phan Thien, James Chen Yong Kah
The protein corona has emerged as an important determinant of biological response in nanoparticle (NP) drug delivery. However, there is presently no reported study on how the protein corona affects the behavior of NPs in microflow and its subsequent interactions with the vascular endothelium, which could affect their delivery to the target tumor site regardless of its targeting mechanism. Furthermore, a consensus on the role of physical and surface characteristics of NPs in affecting the margination of NPs is lacking due to different methods of quantifying margination...
March 27, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29482454/np-and-pa-privileging-in-acute-care-settings-do-scope-of-practice-laws-matter
#10
Patricia Pittman, Brandi Leach, Chris Everett, Xinxin Han, Debra McElroy
As hospitals' interest in nurse practitioners (NPs) and physician assistants (PAs) grows, their leadership is eager to know how their medical staffing privileging policies for these professionals compare to peer hospitals. This study assesses the extent of variation of these policies in four clinical areas and examines whether the differences are associated with state scope of practice laws for NPs and PAs. We also examine the relationship of NP and PA privileging policies to each other. Our analysis finds no evidence that hospital privileging is associated with state scope of practice, and indeed within-state variation is more significant than cross-state variation...
February 1, 2018: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29410395/two-reassortant-types-of-highly-pathogenic-h5n8-avian-influenza-virus-from-wild-birds-in-central-china-in-2016
#11
Liping Ma, Tao Jin, Hanzhong Wang, Haizhou Liu, Runkun Wang, Yong Li, Guoxiang Yang, Yanping Xiong, Jing Chen, Jun Zhang, Guang Chen, Wei Li, Di Liu, Peng Lin, Yueying Huang, George F Gao, Quanjiao Chen
Since 2016, the highly pathogenic avian influenza H5N8 virus has emerged in the Central Asian flyway and Europe, causing massive deaths in poultry and wild birds. In this study, we isolated and identified three H5N8 viruses from swan goose and black swans in Hubei province during the 2016/2017 winter season. Whole-genome sequencing and phylogenetic analysis revealed that the three viruses clustered into a group of H5N8 viruses from Qinghai Lake and Europe. A novel reassortment virus from swan goose was distinguished from that of black swans, in that its PA and NP genes were distinct from those of Qinghai Lake viruses...
February 7, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29392495/spatial-transmission-of-h5n6-highly-pathogenic-avian-influenza-viruses-among-wild-birds-in-ibaraki-prefecture-japan-2016-2017
#12
Ryota Tsunekuni, Yuji Yaguchi, Yuki Kashima, Kaoru Yamashita, Nobuhiro Takemae, Junki Mine, Taichiro Tanikawa, Yuko Uchida, Takehiko Saito
From 29 November 2016 to 24 January 2017, sixty-three cases of H5N6 highly pathogenic avian influenza virus (HPAIV) infections were detected in wild birds in Ibaraki Prefecture, Japan. Here, we analyzed the genetic, temporal, and geographic correlations of these 63 HPAIVs to elucidate their dissemination throughout the prefecture. Full-genome sequence analysis of the Ibaraki isolates showed that 7 segments (PB2, PB1, PA, HA, NP, NA, NS) were derived from G1.1.9 strains while the M segment was from G1.1 strains; both groups of strains circulated in south China...
May 2018: Archives of Virology
https://www.readbyqxmd.com/read/29324680/phylogenetic-analysis-and-characterization-of-a-sporadic-isolate-of-equine-influenza-a-h3n8-from-an-unvaccinated-horse-in-2015
#13
Chithra C Sreenivasan, Sunayana S Jandhyala, Sisi Luo, Ben M Hause, Milton Thomas, David E B Knudsen, Pamela Leslie-Steen, Travis Clement, Stephanie E Reedy, Thomas M Chambers, Jane Christopher-Hennings, Eric Nelson, Dan Wang, Radhey S Kaushik, Feng Li
Equine influenza, caused by the H3N8 subtype, is a highly contagious respiratory disease affecting equid populations worldwide and has led to serious epidemics and transboundary pandemics. This study describes the phylogenetic characterization and replication kinetics of recently-isolated H3N8 virus from a nasal swab obtained from a sporadic case of natural infection in an unvaccinated horse from Montana, USA. The nasal swab tested positive for equine influenza by Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR)...
January 11, 2018: Viruses
https://www.readbyqxmd.com/read/29297852/predominance-of-influenza-a-h3n2-viruses-during-the-2016-2017-season-in-bulgaria
#14
Neli Korsun, Svetla Angelova, Ivelina Trifonova, Iren Tzotcheva, Sirma Mileva, Silvia Voleva, Irina Georgieva, Penka Perenovska
PURPOSE: Influenza viruses are characterised by high variability, which makes them able to cause annual epidemics. The aim of this study is to determine the antigenic and genetic characteristics of influenza viruses circulating in Bulgaria during the 2016/2017 season. METHODOLOGY: The detection and typing/subtyping of influenza viruses were performed using real time RT-PCR. Results of antigenic characterisation, phylogenetic and amino acid sequence analyses of representative influenza strains are presented herein...
February 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29248796/multiple-introductions-of-reassorted-highly-pathogenic-avian-influenza-viruses-h5n8-clade-2-3-4-4b-causing-outbreaks-in-wild-birds-and-poultry-in-egypt
#15
Nahed Yehia, Mahmoud M Naguib, Ruiyun Li, Naglaa Hagag, Mohamed El-Husseiny, Zainab Mosaad, Ahmed Nour, Neveen Rabea, Wafaa M Hasan, Mohamed K Hassan, Timm Harder, Abdel-Satar A Arafa
Recently, an increased incidence of outbreaks of highly pathogenic avian influenza (HPAI) H5N8 in poultry linked to infected migratory birds has been reported from different European, Asian and African countries. In Egypt, incursion of HPAI H5N8 virus of clade 2.3.4.4b has been recently registered. Full genomic characterization of 3 virus isolates from wild birds and poultry (backyard and commercial farm sectors) showed high nucleotide similarity among the HA, NA, M, and NS gene segments of the three Egyptian HPAI H5N8 viruses, indicating that they are descendants of a common ancestral virus...
March 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29181006/protective-effect-of-panax-notoginseng-root-water-extract-against-influenza-a-virus-infection-by-enhancing-antiviral-interferon-mediated-immune-responses-and-natural-killer-cell-activity
#16
Jang-Gi Choi, Young-Hee Jin, Heeeun Lee, Tae Woo Oh, Nam-Hui Yim, Won-Kyung Cho, Jin Yeul Ma
Influenza is an acute respiratory illness caused by the influenza A virus, which causes economic losses and social disruption mainly by increasing hospitalization and mortality rates among the elderly and people with chronic diseases. Influenza vaccines are the most effective means of preventing seasonal influenza, but can be completely ineffective if there is an antigenic mismatch between the seasonal vaccine virus and the virus circulating in the community. In addition, influenza viruses resistant to antiviral drugs are emerging worldwide...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29174083/addition-of-an-egfp-tag-to-the-n-terminal-of-influenza-virus-m1-protein-impairs-its-ability-to-accumulate-in-nd10
#17
Toshikatsu Shibata, Kuniaki Nerome, Mitsuhiko Moriyama, Satoshi Hayakawa, Kazumichi Kuroda
A previous report demonstrated that influenza virus infection induces accumulation of EGFP-tagged M1 protein (EGFP-M1) in the sub-nuclear domain ND10. Here, we show that the transfection of four viral protein (NP, PB2, PB1, PA) expression vectors and eight RNA segment expression vectors induced the formation of nuclear dots of EGFP-M1 as seen in virus infections. Omission of the segment 7 RNA expression vector, however, abolished the nuclear dots of EGFP-M1. This result suggests an essential role for authentic M1 protein and/or M2 protein, both of which are encoded in segment 7, in the formation of nuclear dots of EGFP-M1...
February 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29155988/opioid-prescribing-patterns-and-patient-outcomes-by-prescriber-type-in-the-oregon-prescription-drug-monitoring-program
#18
Patrick B Fink, Richard A Deyo, Sara E Hallvik, Christi Hildebran
Objective: Prescription drug monitoring programs (PDMPs) were created to facilitate responsible use of controlled substances. In Oregon, physicians, physician's assistants (MDs/DOs/PAs), dentists, nurse practitioners (NPs), and naturopathic physicians (NDs) may prescribe opioids, but differences in prescribing practices, patient mix, and patient outcomes among prescriber types have not been characterized. Methods: De-identified Oregon PDMP data from October 2011 through October 2014 were linked with vital records and a statewide hospital discharge registry...
November 16, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29148351/opioid-prescribing-by-nurse-practitioners-in-medicare-part-d-impact-of-state-scope-of-practice-legislation
#19
Elissa Ladd, Casey Fryer Sweeney, Anthony Guarino, Alex Hoyt
Many state legislatures restrict nurse practitioner (NP) scope of practice as a way of addressing patient safety concerns. The purpose of this study was to investigate the influence of state NP scope of practice laws on the prescription of oxycodone and hydrocodone containing medications by NP and MD/DO/PA prescribers to Medicare Part D beneficiaries. Using the Medicare Part D public use file, we analyzed oxycodone and hydrocodone containing prescriptions per Medicare Part D beneficiary by prescriber type, NP state scope of practice, and geographic variables...
August 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29118172/multicenter-evaluation-of-the-modified-carbapenem-inactivation-method-and-the-carba-np-for-detection-of-carbapenemase-producing-pseudomonas-aeruginosa-and-acinetobacter-baumannii
#20
Patricia J Simner, J Kristie Johnson, William B Brasso, Karen Anderson, David R Lonsway, Virginia M Pierce, April M Bobenchik, Zabrina C Lockett, Angella Charnot-Katsikas, Lars F Westblade, Brian B Yoo, Stephen G Jenkins, Brandi M Limbago, Sanchita Das, Darcie E Roe-Carpenter
The purpose of this study was to develop the modified carbapenem inactivation method (mCIM) for the detection of carbapenemase-producing Pseudomonas aeruginosa (CP-PA) and carbapenemase-producing Acinetobacter baumannii (CP-AB) and perform a multicenter evaluation of the mCIM and Carba NP tests for these nonfermenters. Thirty P. aeruginosa and 30 A. baumannii isolates previously characterized by whole-genome sequencing from the CDC-FDA Antibiotic Resistance Isolate Bank were evaluated, including CP isolates (Ambler class A, B, and D), non-carbapenemase-producing (non-CP) carbapenem-resistant isolates, and carbapenem-susceptible isolates...
January 2018: Journal of Clinical Microbiology
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