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https://www.readbyqxmd.com/read/28637755/seasonal-h3n2-and-2009-pandemic-h1n1-influenza-a-viruses-reassort-efficiently-but-produce-attenuated-progeny
#1
Kara L Phipps, Nicolle Marshall, Hui Tao, Shamika Danzy, Nina Onuoha, John Steel, Anice C Lowen
Reassortment of gene segments between co-infecting influenza A viruses (IAV) facilitates viral diversification and has significant epidemiological impact on seasonal and pandemic influenza. Since 1977, human IAVs of H1N1 and H3N2 subtypes have co-circulated with relatively few documented cases of reassortment. We evaluated the potential for viruses of the 2009 pandemic H1N1 (pH1N1) and seasonal H3N2 lineages to reassort under experimental conditions. Results of heterologous co-infections with pH1N1 and H3N2 viruses were compared to those obtained following co-infection with homologous, genetically tagged, pH1N1 viruses as a control...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28617196/factors-associated-with-having-a-physician-nurse-practitioner-or-physician-assistant-as-primary-care-provider-for-veterans-with-diabetes-mellitus
#2
Perri Morgan, Christine M Everett, Valerie A Smith, Sandra Woolson, David Edelman, Cristina C Hendrix, Theodore S Z Berkowitz, Brandolyn White, George L Jackson
Expanded use of nurse practitioners (NPs) and physician assistants (PAs) is a potential solution to workforce issues, but little is known about how NPs and PAs can best be used. Our study examines whether medical and social complexity of patients is associated with whether their primary care provider (PCP) type is a physician, NP, or PA. In this national retrospective cohort study, we use 2012-2013 national Veterans Administration (VA) electronic health record data from 374 223 veterans to examine whether PCP type is associated with patient, clinic, and state-level factors representing medical and social complexity, adjusting for all variables simultaneously using a generalized logit model...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28602803/patient-preference-in-primary-care-provider-type
#3
Brandi Leach, Margaret Gradison, Perri Morgan, Christine Everett, Michael J Dill, Justine Strand de Oliveira
BACKGROUND: Given the growing roles of nurse practitioners (NPs) and physician assistants (PAs), patients are increasingly able to choose their primary care provider type. Studies examining patient preferences among provider types are limited and ours is the first to examine reasons for patients' provider type preferences. METHODS: Using data from the 2014 Association of American Medical Colleges' (AAMC) Consumer Survey of Health Care Access, we used qualitative analysis to identify themes in open text responses of reasons for respondents' provider type preference (N = 4220)...
June 9, 2017: Healthcare
https://www.readbyqxmd.com/read/28572910/a-supramolecular-tr%C3%A3-ger-s-base-derived-coordination-zinc-polymer-for-fluorescent-sensing-of-phenolic-nitroaromatic-explosives-in-water
#4
Sankarasekaran Shanmugaraju, Charlyne Dabadie, Kevin Byrne, Aramballi J Savyasachi, Deivasigamani Umadevi, Wolfgang Schmitt, Jonathan A Kitchen, Thorfinnur Gunnlaugsson
A V-Shaped 4-amino-1,8-napthalimide derived tetracarboxylic acid linker (L; bis-[N-(1,3-benzenedicarboxylic acid)]-9,18-methano-1,8-naphthalimide-[b,f][1,5]diazocine) comprising the Tröger's base (TB) structural motif was rationally designed and synthesised to access a nitrogen-rich fluorescent supramolecular coordination polymer. By adopting the straight forward precipitation method, a new luminescent nanoscale Zn(ii) coordination polymer (TB-Zn-CP) was synthesized in quantitative yield using Zn(OAc)2·2H2O and tetraacid linker L (1 : 0...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28558842/natriuretic-peptides-improve-the-developmental-competence-of-in-vitro-cultured-porcine-oocytes
#5
Yanhao Zhang, Huarong Wang, Wei Liu, Ye Yang, Xiao Wang, Zhiyuan Zhang, Qirui Guo, Chao Wang, Guoliang Xia
BACKGROUND: Natriuretic peptides (NPs), brain and C type NPs (BNP and CNP), were involved in the maintenance of porcine oocyte meiotic arrest. The present study investigated the effects of NPs on developmental competence of immature porcine oocytes with follicles of different sizes. METHODS: Follicular fluid NP levels were examined by radioimmunoassay. The developmental competence of porcine oocytes was evaluated by cleavage and blastocyst developmental rates after in vitro fertilization (IVF) or parthenogenetic activation (PA) of cumulus oocyte complexes (COCs), which were recovered from follicle with different sizes...
May 30, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28554207/provider-type-and-management-of-common-visits-in-primary-care
#6
Douglas W Roblin, Hangsheng Liu, Lee F Cromwell, Michael Robbins, Brandi E Robinson, David Auerbach, Ateev Mehrotra
OBJECTIVES: Debate continues on whether nurse practitioners (NPs) and physician assistants (PAs) are more likely to order ancillary services, or order more costly services among alternatives, than primary care physicians (PCPs). We compared prescription medication and diagnostic service orders associated with NP/PA versus PCP visits for management of neck or back (N/B) pain or acute respiratory infection (ARI). STUDY DESIGN: Retrospective, observational study of visits from January 2006 through March 2008 in the adult primary care practice of Kaiser Permanente in Atlanta, Georgia...
April 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28553474/impact-and-oxidation-of-single-silver-nanoparticles-at-electrode-surfaces-one-shot-versus-multiple-events
#7
Jon Ustarroz, Minkyung Kang, Erin Bullions, Patrick R Unwin
Single nanoparticle (NP) electrochemical impacts is a rapidly expanding field of fundamental electrochemistry, with applications from electrocatalysis to electroanalysis. These studies, which involve monitoring the electrochemical (usually current-time, I-t) response when a NP from solution impacts with a collector electrode, have the scope to provide considerable information on the properties of individual NPs. Taking the widely studied oxidative dissolution of individual silver nanoparticles (Ag NPs) as an important example, we present measurements with unprecedented noise (< 5 pA) and time resolution (time constant 100 μs) that are highly revealing of Ag NP dissolution dynamics...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28538427/return-on-investment-of-advanced-practice-medical-degrees-nps-vs-pas
#8
Christopher K Craig, James H Holmes, Jeffery E Carter
As the United States faces a predicted physician shortage over the next 2 decades, physician assistants (PAs) and NPs are expected to fill the void. At the same time, because education is expensive, student loan and tuition increases have many potential applicants assessing differences in reimbursement and wondering about their return on investment (ROI). An analysis compared PA and NP salaries by incorporating national salary data, federal income tax, and student loans for a comparative analysis of each career pathway...
June 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28471805/np-or-pa-what-influences-student-choice
#9
Folusho Ogunfiditimi
No abstract text is available yet for this article.
June 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28471804/np-or-pa-pursue-your-passion
#10
Robert Estridge
No abstract text is available yet for this article.
June 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28456338/urgent-care-medicine-and-the-role-of-the-app-within-this-specialty
#11
Jessica Memmel, Marcy Spalsbury
The field of urgent care medicine offers an additional medical pathway for patients who have immediate, but non-life-threatening, medical concerns. Urgent care medicine offers a more varied set of resources and services than a physician office setting, with more flexible hours. This gives patients an opportunity to not have to go to the emergency department for non-emergent care. As a newer specialty within the medical field, certain roles of healthcare providers other than physicians are becoming established, including the advanced practice provider (APP)...
April 26, 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/28417068/photoacoustic-in-vitro-flow-cytometry-for-nanomaterial-research
#12
Dmitry A Nedosekin, Tariq Fahmi, Zeid A Nima, Jacqueline Nolan, Chengzhong Cai, Mustafa Sarimollaoglu, Enkeleda Dervishi, Alexei Basnakian, Alexandru S Biris, Vladimir P Zharov
Conventional flow cytometry is a versatile tool for drug research and cell characterization. However, it is poorly suited for quantification of non-fluorescent proteins and artificial nanomaterials without the use of additional labeling. The rapid growth of biomedical applications for small non-fluorescent nanoparticles (NPs) for drug delivery and contrast and therapy enhancement, as well as research focused on natural cell pigments and chromophores, demands high-throughput quantification methods for the non-fluorescent components...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28405632/evidence-of-intercontinental-spread-and-uncommon-variants-of-low-pathogenicity-avian-influenza-viruses-in-ducks-overwintering-in-guatemala
#13
Ana S Gonzalez-Reiche, Martha I Nelson, Mathew Angel, Maria L Müller, Lucia Ortiz, Jayeeta Dutta, Harm van Bakel, Celia Cordon-Rosales, Daniel R Perez
Over a hundred species of aquatic birds overwinter in Central America's wetlands, providing opportunities for the transmission of influenza A viruses (IAVs). To date, limited IAV surveillance in Central America hinders our understanding of the evolution and ecology of IAVs in migratory hosts within the Western Hemisphere. To address this gap, we sequenced the genomes of 68 virus isolates obtained from ducks overwintering along Guatemala's Pacific Coast during 2010 to 2013. High genetic diversity was observed, including 9 hemagglutinin (HA) subtypes, 7 neuraminidase (NA) subtypes, and multiple avian IAV lineages that have been detected at low levels (<1%) in North America...
March 2017: MSphere
https://www.readbyqxmd.com/read/28401023/biopolymer-based-nanosystem-for-doxorubicin-targeted-delivery
#14
Zsuzsanna Csikós, Krisztina Kerekes, Erika Fazekas, Sándor Kun, János Borbély
This study describes formation of an actively and passively targeted, water-soluble drug delivery system (DDS) which contains doxorubicin (DOX). The system comprises two biocompatible and biodegradable polymers: poly-γ-glutamic acid (PGA) and chitosan (CH). Self-assembly of these biopolymers in aqueous medium results stable nanoparticles (NPs) with a hydrodynamic size of 80-150 nm and slightly negative surface charge. Folic acid (FA) was used as targeting agent bonded to the polyanion (PA) and also to the surface of the NPs...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28400751/ethanolic-extract-of-melia-fructus-has-anti-influenza-a-virus-activity-by-affecting-viral-entry-and-viral-rna-polymerase
#15
Young-Hee Jin, Jang-Gi Choi, Won-Kyung Cho, Jin Yeul Ma
Meliae Fructus (MF) is the dried ripe fruit of Melia toosendan Siebold et Zuccarini, Meliaceae family. MF is widely used in traditional medicine to treat inflammation and helminthic infection and has anti-bacterial, anti-oxidant, anti-cancer, anti-inflammatory, and analgesic activities. However, potential anti-influenza properties of MF have yet to be investigated. We determined whether an ethanolic extract of MF (EMF) has anti-viral activity via an EMF pre-, co-, and post-treatment assay, using the Influenza A/PR/8/34 and H3N2 virus on Madin-Darby canine kidney (MDCK) cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28386784/genetic-analysis-of-a-novel-reassortant-h11n9-isolated-from-waterfowl-in-south-korea-in-2016
#16
Tran Bac Le, In Hong Lee, Hyun Soo Kim, Seung Kyoo Oh, Sang Heui Seo
Aquatic birds are known to harbor all the known influenza A viruses. In the winter of January 2016, we surveyed influenza A virus in the feces of migratory birds in South Korea. The novel re-assorted H11N9 avian influenza virus, which contains genes from avian influenza viruses of poultry and wild birds, was isolated. The polymerase basic 2 (PB2), polymerase basic 1 (PB1), hemagglutinin (HA), and nucleoprotein (NP) genes were most closely related to those of domestic duck-origin avian influenza viruses, while the non-structural (NS) gene was closely related to that of domestic goose-origin avian influenza virus...
April 6, 2017: Virus Genes
https://www.readbyqxmd.com/read/28345873/impact-of-semiconducting-perylene-diimide-nanoparticle-size-on-lymph-node-mapping-and-cancer-imaging
#17
Zhen Yang, Rui Tian, Jinjun Wu, Quli Fan, Bryant C Yung, Gang Niu, Orit Jacobson, Zhantong Wang, Gang Liu, Guocan Yu, Wei Huang, Jibin Song, Xiaoyuan Chen
Semiconducting molecules of perylene diimide (PDI) with strong light absorption properties in the near-infrared region and good biocompatibility have received increasing attention in the field of theranostics, especially as photoacoustic (PA) imaging agents. Herein, we report a series of [(64)Cu]-labeled PDI nanoparticles (NPs) of different sizes (30, 60, 100, and 200 nm) as dual positron emission tomography (PET) and PA imaging probes and photothermal therapy agents. The precise size control of the PDI NPs can be achieved by adjusting the initial concentration of PDI molecules in the self-assembly process, and the photophysical property of different sized PDI NPs was studied in detail...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28291308/what-can-a-pa-or-np-do-for-your-practice
#18
Victoria S Kaprielian, Joel Kase
No abstract text is available yet for this article.
March 2017: Family Practice Management
https://www.readbyqxmd.com/read/28240881/organic-semiconducting-nanoparticles-as-efficient-photoacoustic-agents-for-lightening-early-thrombus-and-monitoring-thrombolysis-in-living-mice
#19
Cao Cui, Zhen Yang, Xiang Hu, Jinjun Wu, Kangquan Shou, Hengheng Ma, Chao Jian, Yong Zhao, Baiwen Qi, Xiaoming Hu, Aixi Yu, Quli Fan
Acute venous thrombosis is prevalent and potentially fatal. Accurate diagnosis of early thrombus is needed for patients in timely clinical intervention to prevent life-threatening conditions. Photoacoustic imaging (PAI) with excellent spatial resolution and high optical contrast shows more promise for this purpose. However, its application is dramatically limited by its signal-off effect on thrombus because of the ischemia in thrombus which lacks the endogenous photoacoustic (PA) signal of hemoglobin. To address this dilemma, we herein report the feasibility of using organic semiconducting nanoparticles (NPs) for contrast-enhanced PAI of thrombus in living mice...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28236682/spectroscopic-and-theoretical-studies-of-charge-transfer-interaction-of-1-2-pyridylazo-2-napthol-with-nitroaromatics
#20
Animesh Karmakar, Bula Singh
1-(2-Pyridylazo)-2-napthol (hereafter 1Q) is widely used as a chelating ligand applied in chelatometric, spectrophotometric analysis of metal ions. It appeared from the literature survey that no inclusion complex of 1Q was reported with nitroaromatics. The formation of charge-transfer complex gives an opportunity to improve the physico-chemical properties of different donors. So the complex of 1Q with 4-nitrophenol (4-NP), 2,4-dinitrophenol (2,4-DNP), picric acid (PA), and 3,5-dinitrosalicylic acid (3,5-DNSA) was described in this work in methanol medium...
January 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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