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https://www.readbyqxmd.com/read/28236682/spectroscopic-and-theoretical-studies-of-charge-transfer-interaction-of-1-2-pyridylazo-2-napthol-with-nitroaromatics
#1
Animesh Karmakar, Bula Singh
1-(2-Pyridylazo)-2-napthol (hereafter 1Q) is widely used as a chelating ligand applied in chelatometric, spectrophotometric analysis of metal ions. It appeared from the literature survey that no inclusion complex of 1Q was reported with nitroaromatics. The formation of charge-transfer complex gives an opportunity to improve the physico-chemical properties of different donors. So the complex of 1Q with 4-nitrophenol (4-NP), 2,4-dinitrophenol (2,4-DNP), picric acid (PA), and 3,5-dinitrosalicylic acid (3,5-DNSA) was described in this work in methanol medium...
January 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28192964/collisions-of-ir-oxide-nanoparticles-with-carbon-nanopipettes-experiments-with-one-nanoparticle
#2
Min Zhou, Yun Yu, Keke Hu, Huolin L Xin, Michael V Mirkin
Investigating the collisions of individual metal nanoparticles (NPs) with electrodes can provide new insights into their electrocatalytic behavior, mass transport, and interactions with surfaces. Here we report a new experimental setup for studying NP collisions based on the use of carbon nanopipettes to enable monitoring multiple collision events involving the same NP captured inside the pipet cavity. A patch clamp amplifier capable of measuring pA-range currents on the microsecond time scale with a very low noise and stable background was used to record the collision transients...
February 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28181421/complete-genome-sequence-of-a-novel-influenza-a-h1n2-virus-circulating-in-swine-from-central-bajio-region-mexico
#3
J I Sánchez-Betancourt, J B Cervantes-Torres, M Saavedra-Montañez, R A Segura-Velázquez
The aim of this study was to perform the complete genome sequence of a swine influenza A H1N2 virus strain isolated from a pig in Guanajuato, México (A/swine/Mexico/GtoDMZC01/2014) and to report its seroprevalence in 86 counties at the Central Bajio zone. To understand the evolutionary dynamics of the isolate, we undertook a phylogenetic analysis of the eight gene segments. These data revealed that the isolated virus is a reassortant H1N2 subtype, as its genes are derived from human (HA, NP, PA) and swine (M, NA, PB1, PB2 and NS) influenza viruses...
February 8, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28173766/factors-influencing-decision-of-general-practitioners-and-managers-to-train-and-employ-a-nurse-practitioner-or-physician-assistant-in-primary-care-a-qualitative-study
#4
Mieke van der Biezen, Emmy Derckx, Michel Wensing, Miranda Laurant
BACKGROUND: Due to the increasing demand on primary care, it is not only debated whether there are enough general practitioners (GPs) to comply with these demands but also whether specific tasks can be performed by other care providers. Although changing the workforce skill mix care by employing Physician Assistants (PAs) and Nurse Practitioners (NPs) has proven to be both effective and safe, the implementation of those professionals differs widely between and within countries. To support policy making regarding PAs/NPs in primary care, the aim of this study is to provide insight into factors influencing the decision of GPs and managers to train and employ a PA/NP within their organisation...
February 7, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28155798/promoting-physical-activity-among-children-the-%C3%A2-great-live-and-move-challenge%C3%A2
#5
Marion Mourgues, Mathieu Gourlan, Olivier Coste, Bruno Fregeac, Lucile Mora, Florence Cousson-Gélie
Objective: The “Great Live and Move Challenge” (GLMC) is an intervention designed to promote physical activity (PA) in schools and the community among 6- to 11-year-old schoolchildren and their families.Method: This project, implemented in the Montpellier and Pays Coeur d’Hérault regions since 2013, encourages children to quantify their daily PA level by illustrating each 15 minutes of exercise by an “energy cube”. Based on collaboration between pilots, teachers and policymakers, this project is implemented over a 6-week period in schools, municipalities and recreation centres...
8, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28155795/-physical-activity-of-students-prevalence-and-profiles-of-associated-risk-behaviours
#6
Joël Ladner, Alessandro Porrovecchio, Philippe Masson, Gauthier Zunquin, Rémy Hurdiel, Thierry Pezé, Denis Theunynck, Marie-Pierre Tavolacci
More than 40% of students do not practice any PA. These results highlight the need for a better understanding to develop intervention strategies for students, based on new public health approaches. The contribution of social and physical environmental factors to changes in PA needs to be further explored.<np pagenum="066"/> </ce:para>.
June 8, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28155793/-modes-of-public-care-in-the-prevention-of-ageing-by-local-physical-activities
#7
Cécile Collinet, Pierre-Olaf Schut
This study also highlights the fact that prevention by PA remains a fragmented and diversified field, in which the sports movement is still struggling to find its place.<np pagenum="042"/> </ce:para>.
June 8, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28154333/structural-and-biochemical-analyses-on-the-rna-dependent-rna-polymerase-of-influenza-virus-for-development-of-novel-anti-influenza-agents
#8
Dai Hatakeyama
 The PA, PB1, and PB2 subunits, components of the RNA-dependent RNA polymerase of influenza A virus, and the nucleoprotein (NP) interact with the genomic RNA of influenza viruses and form ribonucleoproteins. Especially, the PB2 subunit binds to the host RNA cap [7-methylguanosine triphosphate (m(7)GTP)] and supports the endonuclease activity of PA to "snatch" the cap from host pre-mRNAs. In this study, we describe a novel Val/Arg/Gly (VRG) site in the PB2 cap-binding domain, which is necessary for interaction with acetyl-CoA found in eukaryotic histone acetyltransferases (HATs)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28153255/conjugated-microporous-polymers-based-fluorescein-for-fluorescence-detection-of-2-4-6-trinitrophenol
#9
Tong-Mou Geng, Sai-Nan Ye, Yu Wang, Hai Zhu, Xie Wang, Xue Liu
2,4,6-Trinitrophenol (TNP, also called picric acid, PA) pose a large threat to environmental health, public safety and military security. Conjugated microporous polymers are emerging new fluorescence sensing materials for TNP. In this paper, we report the synthesis of two fluorescein containing conjugated microporous polymers (DTF and TTF) through the palladium catalyzed Sonogashira-Hagihara polycondensation reactions of tetraiodofluorescein sodium salt (TIFA) with 1,4-diethynylbenzene (DEB) or 1,3,5-triethynylbenzene (TEB)...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28129386/whole-genome-phylogenetic-analysis-of-influenza-b-phuket-3073-2013-like-viruses-and-unique-reassortants-detected-in-malaysia-between-2012-and-2014
#10
Xiang Yong Oong, Kim Tien Ng, Joon Ling Tan, Kok Gan Chan, Adeeba Kamarulzaman, Yoke Fun Chan, I-Ching Sam, Kok Keng Tee
Reassortment of genetic segments between and within influenza B lineages (Victoria and Yamagata) has been shown to generate novel reassortants with unique genetic characteristics. Based on hemagglutinin (HA) and neuraminidase (NA) genes, recent surveillance study has identified reassortment properties in B/Phuket/3073/2013-like virus, which is currently used in the WHO-recommended influenza vaccine. To understand the potential reassortment patterns for all gene segments, four B/Phuket/3073/2013-like viruses and two unique reassortants (one each from Yamagata and Victoria) detected in Malaysia from 2012-2014 were subjected to whole-genome sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#11
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
: Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27993133/synthesis-and-functionalization-of-protease-activated-nanoparticles-with-tissue-plasminogen-activator-peptides-as-targeting-moiety-and-diagnostic-tool-for-pancreatic-cancer
#12
Sophie Dobiasch, Szilard Szanyi, Aleko Kjaev, Jens Werner, Albert Strauss, Christian Weis, Lars Grenacher, Katya Kapilov-Buchman, Liron-Limor Israel, Jean-Paul Lellouche, Erica Locatelli, Mauro Comes Franchini, Jennifer Vandooren, Ghislain Opdenakker, Klaus Felix
BACKGROUND: Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed delivery with a suitable target-biomarker to detect early pancreatic ductal adenocarcinoma (PDAC). Promising targets are galectins (Gal), due to their strong expression in and on PDAC-cells and occurrence at early stages in cancer precursor lesions, but not in adjacent normal tissues...
December 19, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27936462/sinu-virus-a-novel-and-divergent-orthomyxovirus-related-to-members-of-the-genus-thogotovirus-isolated-from-mosquitoes-in-colombia
#13
María Angélica Contreras-Gutiérrez, Marcio R T Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F Cardoso, Vsevolod L Popov, Steven G Widen, Thomas G Wood, Nikos Vasilakis, Robert B Tesh
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6)...
January 15, 2017: Virology
https://www.readbyqxmd.com/read/27918408/full-practice-authority-for-nurse-practitioners
#14
Deborah Dillon, Faye Gary
Implementation of the Affordable Care Act (2010) enabled more than 30 million people to have new access to primary care services. On the basis of current utilization patterns, demand for primary care providers is expected to grow more rapidly than physician supply. This imbalance is expected to worsen, as the aging population requires more health care resources. In addition, more patients are requiring critical care services and physician numbers are not keeping with this growing need. Restrictions on resident physician practice hours have impacted inpatient care as well...
January 2017: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/27867373/two-genetically-similar-h9n2-influenza-a-viruses-show-different-pathogenicity-in-mice
#15
Qingtao Liu, Yuzhuo Liu, Jing Yang, Xinmei Huang, Kaikai Han, Dongmin Zhao, Keran Bi, Yin Li
H9N2 Avian influenza virus has repeatedly infected humans and other mammals, which highlights the need to determine the pathogenicity and the corresponding mechanism of this virus for mammals. In this study, we found two H9N2 viruses with similar genetic background but with different pathogenicity in mice. The A/duck/Nanjing/06/2003 (NJ06) virus was highly pathogenic for mice, with a 50% mouse lethal dose (MLD50) of 10(2.83) 50% egg infectious dose (EID50), whereas the A/duck/Nanjing/01/1999 (NJ01) virus was low pathogenic for mice, with a MLD50 of >10(6...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27862064/cytotoxicity-oxidative-stress-and-inflammation-induced-by-zno-nanoparticles-in-endothelial-cells-interaction-with-palmitate-or-lipopolysaccharide
#16
Yu Gong, Yuejia Ji, Fang Liu, Juan Li, Yi Cao
Recent studies showed that ZnO nanoparticles (NPs) might induce the toxicity to human endothelial cells. However, little is known about the interaction between ZnO NPs and circulatory components, which is likely to occur when NPs enter the blood. In this study, we evaluated ZnO NP-induced cytotoxicity, oxidative stress and inflammation in human umbilical vein endothelial cells (HUVECs), with the emphasis on the interaction with palmitate (PA) or lipopolysaccharide (LPS), because PA and LPS are normal components in human blood that increase in metabolic diseases...
November 15, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27859043/monocyte-derived-dendritic-cells-enhance-protection-against-secondary-influenza-challenge-by-controlling-the-switch-in-cd8-t-cell-immunodominance
#17
Jazmina L G Cruz, José V Pérez-Girón, Anja Lüdtke, Sergio Gómez-Medina, Paula Ruibal, Juliana Idoyaga, César Muñoz-Fontela
Influenza virus infection triggers an increase in the number of monocyte-derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8(+) T cells and trigger the switch in immunodominance of the CD8(+) T-cell response from acidic polymerase specificity to nucleoprotein specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge...
November 18, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27849754/110-comparison-of-np-pa-residency-trained-graduates-and-on-the-job-training-on-time-to-max-productivity
#18
Kejun Xu, Sara Gregg, David Carpenter, Rob Grabenkort, Heather Meissen
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27799877/genetic-characteristics-and-immunogenicity-of-pandemic-h1n1-influenza-virus-isolate-from-pig-in-korea
#19
Hyoung Joon Moon, Jin Sik Oh, Woonsung Na, Minjoo Yeom, Sang Yoon Han, Sung Jae Kim, Bong Kyun Park, Dae Sub Song, Bo Kyu Kang
A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27782815/the-complexity-of-human-infected-aiv-h5n6-isolated-from-china
#20
Zhijie Zhang, Rui Li, Lufang Jiang, Chenglong Xiong, Yue Chen, Genming Zhao, Qingwu Jiang
BACKGROUND: Novel avian influenza viruses (AIVs) of H7N9, H10N8, and H5N6 are currently circulating in China's poultry flocks, occasionally infecting human and other mammals. Human infected AIV H5N6 in China during 2014-2015 is believed to be a triple reassortant originated from H6N6 and two clades of H5 viruses. The current report suggests that its reassortment history is more complicated. METHODS: Genomes of human infected isolates of AIV H5N6 were searched from the NCBI Influenza Virus Sequence Database and the Global Initiative on Sharing Avian Influenza Data...
October 25, 2016: BMC Infectious Diseases
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