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https://www.readbyqxmd.com/read/28659013/-there-s-a-catch-22-the-complexities-of-pain-management-for-people-with-advanced-dementia-nearing-the-end-of-life-a-qualitative-exploration-of-physicians-perspectives
#1
Bannin De Witt Jansen, Kevin Brazil, Peter Passmore, Hilary Buchanan, Doreen Maxwell, Sonja J McIlfatrick, Sharon M Morgan, Max Watson, Carole Parsons
BACKGROUND: Pain management is a cornerstone of palliative care. The clinical issues encountered by physicians when managing pain in patients dying with advanced dementia, and how these may impact on prescribing and treatment, are unknown. AIM: To explore physicians' experiences of pain management for patients nearing the end of life, the impact of these on prescribing and treatment approaches, and the methods employed to overcome these challenges. DESIGN: Qualitative, semi-structured interview study exploring barriers to and facilitators of pain management, prescribing and treatment decisions, and training needs...
October 1, 2016: Palliative Medicine
https://www.readbyqxmd.com/read/28506440/the-wistar-audiogenic-rat-war-strain-and-its-contributions-to-epileptology-and-related-comorbidities-history-and-perspectives
#2
Norberto Garcia-Cairasco, Eduardo H L Umeoka, José A Cortes de Oliveira
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar Audiogenic Rat (WAR), first introduced to the neuroscience international community more than 25years ago. The WAR strain is a genetically selected reflex model susceptible to audiogenic seizures (AS), acutely mimicking brainstem-dependent tonic-clonic seizures and chronically (by audiogenic kindling), temporal lobe epilepsy (TLE). Seminal neuroethological, electrophysiological, cellular, and molecular protocols support the WAR strain as a suitable and reliable animal model to study the complexity and emergent functions typical of epileptogenic networks...
June 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28457834/a-network-perspective-on-antimicrobial-peptide-combination-therapies-the-potential-of-colistin-polymyxin-b-and-nisin
#3
REVIEW
Paula Jorge, Martín Pérez-Pérez, Gael Pérez Rodríguez, Maria Olívia Pereira, Anália Lourenço
Antimicrobial combinations involving antimicrobial peptides (AMPs) attract considerable attention within current antimicrobial and anti-resistance research. The objective of this study was to review the available scientific literature on the effects of antimicrobial combinations involving colistin (polymyxin E), polymyxin B and nisin, which are US Food and Drug Administration (FDA)-approved AMPs broadly tested against prominent multidrug-resistant pathogens. A bioinformatics approach based on literature mining and manual expert curation supported the reconstruction of experimental evidence on the potential of these AMP combinations, as described in the literature...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28453708/towards-a-global-cancer-knowledge-network-dissecting-the-current-international-cancer-genomic-sequencing-landscape
#4
D J Vis, J Lewin, R G Liao, M Mao, F Andre, R L Ward, F Calvo, B T Teh, A A Camargo, B M Knoppers, C L Sawyers, L F A Wessels, M Lawler, L L Siu, E Voest
Background: While next generation sequencing has enhanced our understanding of the biological basis of malignancy, current knowledge on global practices for sequencing cancer samples is limited. To address this deficiency, we developed a survey to provide a snapshot of current sequencing activities globally, identify barriers to data sharing and use this information to develop sustainable solutions for the cancer research community. Methods: A multi-item survey was conducted assessing demographics, clinical data collection, genomic platforms, privacy/ethics concerns, funding sources and data sharing barriers for sequencing initiatives globally...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28415007/religion-spirituality-and-mental-health-of-u-s-military-veterans-results-from-the-national-health-and-resilience-in-veterans-study
#5
Vanshdeep Sharma, Deborah B Marin, Harold K Koenig, Adriana Feder, Brian M Iacoviello, Steven M Southwick, Robert H Pietrzak
BACKGROUND: In the last three decades, there has been increased interest in studying the association between religion/spirituality (R/S), and mental health and functional outcomes. METHODS: Using data from a contemporary, nationally representative sample of 3151 U.S. military veterans maintained by GfK Knowledge Networks, Inc., we evaluated the relation between R/S and a broad range of mental health, and psychosocial variables. Veterans were grouped into three groups based on scores on the Duke University Religion Index: High R/S (weighted 11...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28410607/aprecisekure-an-approach-of-precision-medicine-in-a-rare-disease
#6
Ottavia Spiga, Vittoria Cicaloni, Andrea Bernini, Andrea Zatkova, Annalisa Santucci
BACKGROUND: Alkaptonuria (AKU; OMIM:203500) is a classic Mendelian genetic disorder described by Garrod already in 1902. It causes urine to turn black upon exposure to air and also leads to ochronosis as well as early osteoarthritis. Our objective is the implementation of a Precision Medicine (PM) approach to AKU. We present here a novel ApreciseKUre database facilitating the collection, integration and analysis of patient data in order to create an AKU-dedicated "PM Ecosystem" in which genetic, biochemical and clinical resources can be shared among registered researchers...
April 14, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28398145/visualization-maps-for-the-evolution-of-research-hotspots-in-the-field-of-regional-health-information-networks
#7
Yanjun Wang, Jianzhong Zheng, Ailian Zhang, Wei Zhou, Haiyuan Dong
OBJECTIVES: The aim of this study was to reveal research hotspots in the field of regional health information networks (RHINs) and use visualization techniques to explore their evolution over time and differences between countries. METHODS: We conducted a literature review for a 50-year period and compared the prevalence of certain index terms during the periods 1963-1993 and 1994-2014 and in six countries. We applied keyword frequency analysis, keyword co-occurrence analysis, multidimensional scaling analysis, and network visualization technology...
April 11, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28391811/a-study-of-emr-based-medical-knowledge-network-and-its-applications
#8
Chao Zhao, Jingchi Jiang, Zhiming Xu, Yi Guan
BACKGROUND AND OBJECTIVE: Electronic medical records (EMRs) contain an amount of medical knowledge which can be used for clinical decision support. We attempt to integrate this medical knowledge into a complex network, and then implement a diagnosis model based on this network. METHODS: The dataset of our study contains 992 records which are uniformly sampled from different departments of the hospital. In order to integrate the knowledge of these records, an EMR-based medical knowledge network (EMKN) is constructed...
May 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28347217/the-evolution-of-publication-hotspots-in-the-field-of-telemedicine-from-1962-to-2015-and-differences-among-six-countries
#9
Yanjun Wang, Ye Zhao, Jianzhong Zheng, Ailian Zhang, Haiyuan Dong
Introduction Telemedicine has been implemented in many countries and has captured the attention of many researchers. Herein, we aim to quantify publication hotspots in the field of telemedicine, analyse their evolution, compare them in different countries, and provide visual representations. Methods We used software tools to process PubMed entries for a 54-year period and identified publication hotspots using keyword frequency analysis. We employed a keyword co-occurrence analysis, principal component analysis, multidimensional scaling analysis, and network visualization technology...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28327897/towards-a-global-cancer-knowledge-network-dissecting-the-current-international-cancer-genomic-sequencing-landscape
#10
D J Vis, J Lewin, R G Liao, M Mao, F Andre, R L Ward, F Calvo, B T Teh, A A Camargo, B M Knoppers, C Sawyers, L F A Wessels, M Lawler, L L Siu, E Voest
Background: While next generation sequencing has enhanced our understanding of the biological basis of malignancy, current knowledge on global practices for sequencing cancer samples is limited. To address this deficiency, we developed a survey to provide a snapshot of current sequencing activities globally, identify barriers to data sharing and use this information to develop sustainable solutions for the cancer research community. Methods: A multi-item survey was conducted assessing demographics, clinical data collection, genomic platforms, privacy/ethics concerns, funding sources and data sharing barriers for sequencing initiatives globally...
February 3, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28236762/relational-vs-attributive-interpretation-of-nominal-compounds-differentially-engages-angular-gyrus-and-anterior-temporal-lobe
#11
Christine Boylan, John C Trueswell, Sharon L Thompson-Schill
The angular gyrus (AG) and anterior temporal lobe (ATL) have been found to respond to a number of tasks involving combinatorial processing. In this study, we investigate the conceptual combination of nominal compounds, and ask whether ATL/AG activity is modulated by the type of combinatorial operation applied to a nominal compound. We compare relational and attributive interpretations of nominal compounds and find that ATL and AG both discriminate these two types, but in distinct ways. While right AG demonstrated greater positive task-responsive activity for relational compounds, there was a greater negative deflection in the BOLD response in left AG for relational compounds...
February 22, 2017: Brain and Language
https://www.readbyqxmd.com/read/28166226/social-network-analysis-of-multi-stakeholder-platforms-in-agricultural-research-for-development-opportunities-and-constraints-for-innovation-and-scaling
#12
Frans Hermans, Murat Sartas, Boudy van Schagen, Piet van Asten, Marc Schut
Multi-stakeholder platforms (MSPs) are seen as a promising vehicle to achieve agricultural development impacts. By increasing collaboration, exchange of knowledge and influence mediation among farmers, researchers and other stakeholders, MSPs supposedly enhance their 'capacity to innovate' and contribute to the 'scaling of innovations'. The objective of this paper is to explore the capacity to innovate and scaling potential of three MSPs in Burundi, Rwanda and the South Kivu province located in the eastern part of Democratic Republic of Congo (DRC)...
2017: PloS One
https://www.readbyqxmd.com/read/28125703/text-authorship-identified-using-the-dynamics-of-word-co-occurrence-networks
#13
Camilo Akimushkin, Diego Raphael Amancio, Osvaldo Novais Oliveira
Automatic identification of authorship in disputed documents has benefited from complex network theory as this approach does not require human expertise or detailed semantic knowledge. Networks modeling entire books can be used to discriminate texts from different sources and understand network growth mechanisms, but only a few studies have probed the suitability of networks in modeling small chunks of text to grasp stylistic features. In this study, we introduce a methodology based on the dynamics of word co-occurrence networks representing written texts to classify a corpus of 80 texts by 8 authors...
2017: PloS One
https://www.readbyqxmd.com/read/28121162/quorum-sensing-inhibition-in-pseudomonas-aeruginosa-biofilms-new-insights-through-network-mining
#14
Martín Pérez-Pérez, Paula Jorge, Gael Pérez Rodríguez, Maria Olívia Pereira, Anália Lourenço
Quorum sensing plays a pivotal role in Pseudomonas aeruginosa's virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databases was used to create a knowledge network of potential anti-quorum sensing agents for P. aeruginosa...
January 25, 2017: Biofouling
https://www.readbyqxmd.com/read/28051138/prior-knowledge-is-essential-for-the-beneficial-effect-of-targeted-memory-reactivation-during-sleep
#15
Sabine Groch, Thomas Schreiner, Björn Rasch, Reto Huber, Ines Wilhelm
Prior knowledge speeds up system consolidation and accelerates integration of newly acquired memories into existing neocortical knowledge networks. By using targeted memory reactivations, we demonstrate that prior knowledge is also essential for successful reactivation and consolidation of memories during sleep, both on the behavioral and oscillatory level (i.e., theta and fast spindle activity). Thus, prior knowledge is a prerequisite for new memories to enter processes of system consolidation during sleep...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28018846/developing-integrated-crop-knowledge-networks-to-advance-candidate-gene-discovery
#16
Keywan Hassani-Pak, Martin Castellote, Maria Esch, Matthew Hindle, Artem Lysenko, Jan Taubert, Christopher Rawlings
The chances of raising crop productivity to enhance global food security would be greatly improved if we had a complete understanding of all the biological mechanisms that underpinned traits such as crop yield, disease resistance or nutrient and water use efficiency. With more crop genomes emerging all the time, we are nearer having the basic information, at the gene-level, to begin assembling crop gene catalogues and using data from other plant species to understand how the genes function and how their interactions govern crop development and physiology...
December 2016: Applied & Translational Genomics
https://www.readbyqxmd.com/read/27984404/determinants-of-knowledge-sharing-networks-in-primary-care
#17
Daniele Mascia, Francesca Pallotti, Roberto Dandi
BACKGROUND: Around the world, health reforms are increasingly fostering collaboration and integration among primary care physicians with the aim of facilitating knowledge sharing and evidence-informed decision-making. Although extant research on this topic is abundant, the evidence and results regarding social and organizational factors affecting the formation of knowledge-sharing networks in this setting are inconclusive. PURPOSE: The aim of this article is to explore multiple theoretical mechanisms explaining the formation of knowledge-sharing networks among primary care physicians across relevant clinical areas...
December 15, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27982362/role-of-paho-who-in-ehealth-capacity-building-in-the-americas-analysis-of-the-2011-2015-period
#18
David Novillo-Ortiz, Marcelo D'Agostino, Francisco Becerra-Posada
Political will and adoption of measures toward the use of eHealth have been steadily increasing, facilitating mobilization of resources necessary to adopt and implement digital services that will make it possible to improve access, expand coverage, and increase financial efficiency of health care systems. Adoption of the Strategy and Plan of Action on eHealth of the Pan American Health Organization (PAHO) in 2011 by all Member States in the Region of the Americas has led the Region to major progress in this regard, including the following: creation of knowledge networks and development of information sources, establishment of eHealth sustainability models, support for development of electronic health records, promotion of standards on health data and related technologies that ensure exchange of information, use of mobile devices to improve health, and improvement in quality of care through telemedicine...
August 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27913294/sleep-mediated-memory-consolidation-depends-on-the-level-of-integration-at-encoding
#19
Lea Himmer, Elias Müller, Steffen Gais, Monika Schönauer
There is robust evidence that sleep facilitates declarative memory consolidation. Integration of newly acquired memories into existing neocortical knowledge networks has been proposed to underlie this effect. Here, we test whether sleep affects memory retention for word-picture associations differently when it was learned explicitly or using a fast mapping strategy. Fast mapping is an incidental form of learning that references new information to existing knowledge and possibly allows neocortical integration already during encoding...
January 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27828677/innovation-development-and-financing-of-institutions-of-higher-education-in-health
#20
Mario Roberto Dal Poz, Maria Helena Costa Couto, Thais de Andrade Vidaurre Franco
The article analyzes the configuration and trends in institutions of Higher Education and their relationship as components of the Health Economic-Industrial Complex (HEIC). The expansion of higher education is part of the transition from elite to mass systems, with tensions between quantitative and qualitative aspects. Such changes reflect different cultures and are related to international phenomena such as globalization, economic transformations, the development of new information and communication technologies, and the emergence of an international knowledge network...
November 3, 2016: Cadernos de Saúde Pública
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