Manuel Adrían Velazquez-Cervantes, Orestes López-Ortega, Victor Javier Cruz-Holguín, Luis Herrera Moro-Huitron, Arturo Flores-Pliego, Ignacio Lara-Hernandez, Mauricio Comas-García, Oscar Villavicencio-Carrisoza, Addy Cecilia Helguera-Reppeto, Haruki Arévalo-Romero, Edgar Ricardo Vázquez-Martínez, Moises León-Juárez
Zika virus (ZIKV) infections have been associated with severe clinical outcomes, which may include neurological manifestations, especially in newborns with intrauterine infection. However, licensed vaccines and specific antiviral agents are not yet available. Therefore, a safe and low-cost therapy is required, especially for pregnant women. In this regard, metformin, an FDA-approved drug used to treat gestational diabetes, has previously exhibited an anti-ZIKA effect in vitro in HUVEC cells by activating AMPK...
April 9, 2024: Current Microbiology