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Autologous stem cell transplant

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https://www.readbyqxmd.com/read/29456529/challenges-and-opportunities-for-biomarkers-of-clinical-response-to-ahsct-in-autoimmunity
#1
Kristina M Harris, Tingting Lu, Noha Lim, Laurence A Turka
Autoimmunity represents a broad category of diseases that involve a variety of organ targets and distinct autoantigens. For patients with autoimmune diseases who fail to respond to approved disease-modifying treatments, autologous hematopoietic stem cell transplantation (AHSCT) after high-dose immunosuppressive therapy provides an alternative strategy. Although more than 100 studies have been published on AHSCT efficacy in autoimmunity, the mechanisms that confer long-term disease remission as opposed to continued deterioration or disease reactivation remain to be determined...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29455334/septicemia-from-lactobacillus-rhamnosus-gg-from-a-probiotic-enriched-yogurt-in-a-patient-with-autologous-stem-cell-transplantation
#2
Satoshi Koyama, Hiroyuki Fujita, Takeshi Shimosato, Aki Kamijo, Yasufumi Ishiyama, Eri Yamamoto, Yoshimi Ishii, Yukako Hattori, Maki Hagihara, Etsuko Yamazaki, Naoto Tomita, Hideaki Nakajima
Probiotic-rich foods are consumed without much restriction. We report here, a case of septic shock caused by yogurt derived Lactobacillus species in a 54-year-old male patient with acute promyelocytic leukemia, in second complete remission, and who was an autologous stem cell transplantation recipient. He received high dose chemotherapy and autologous peripheral blood stem cell transplantation. He ingested commercially available probiotic-enriched yogurt because of severe diarrhea. One week later, he developed septic shock, and the pathogen was determined by strain-specific PCR analysis as Lactobacillus rhamnosus GG (ATCC 53103), which was found to be identical with the strain in the yogurt he consumed...
February 17, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29455251/establishing-and-characterizing-lacrispheres-from-human-lacrimal-gland-for-potential-clinical-application
#3
Shubha Tiwari, Rohini M Nair, Praseeda Vamadevan, Mohammad Javed Ali, Milind N Naik, Santosh G Honavar, Geeta K Vemuganti
PURPOSE: Lacrimal gland (LG) dysfunction leading to dry eye syndrome (DES) is an important cause of ocular morbidity. One of the potential and promising long-term management therapies for restoration of LG function could be transplantation of autologous ex vivo expanded stem cells. The present study was aimed at exploring the 2D and 3D cultures of human LG, identifying inherent stem cells and evaluating their secretory potential. METHODS: Fresh human lacrimal gland (HuLG) (n = 5) from patients undergoing therapeutic exenteration was harvested after ethical approval and informed consent...
February 17, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29454547/long-term-results-of-autologous-bone-marrow-mesenchymal-stem-cell-transplantation-for-cartilage-defects-in-the-patella-two-case-reports-with-more-than-18-years-of-follow-up
#4
Akira Tsujii, Kunihiko Hiramatsu, Kazunori Shimomura, Masato Kobayashi, Hisashi Mera, Shigeyuki Wakitani, Norimasa Nakamura, Shuji Horibe, Tomoki Mitsuoka
No abstract text is available yet for this article.
February 14, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29453811/multimodal-treatment-including-tandem-high-dose-chemotherapy-and-autologous-stem-cell-transplantation-in-children-with-anaplastic-ependymomas
#5
Ji Won Lee, Do Hoon Lim, Ki Woong Sung, Hyeong Jin Lee, Eun Sang Yi, Keon Hee Yoo, Hong Hoe Koo, Yeon-Lim Suh, Hyung Jin Shin
In this study, we evaluated the results of multimodal treatment that included tandem HDCT/auto-SCT in children with anaplastic ependymomas. Fourteen patients with anaplastic ependymomas were enrolled from 2006 to 2014. Six cycles of induction chemotherapy were administered to all patients before they underwent tandem HDCT/auto-SCT. Patients who were older than 3 years of age were administered RT after two cycles of induction chemotherapy. In patients under 3 years of age, RT was either omitted or delayed until they reached 3 years of age, if the patients experienced CR after tandem HDCT/auto-SCT...
February 16, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29453224/simple-limbal-epithelial-transplantation-slet-in-failed-cultivated-limbal-epithelial-transplantation-clet-for-unilateral-chronic-ocular-burns
#6
Sayan Basu, Sashwanthi Mohan, Swapnil Bhalekar, Vivek Singh, Virender Sangwan
AIMS: Cultivated limbal epithelial transplantation (CLET) fails in around 20%-30% of cases. This study aimed to report the clinical outcomes of autologous simple limbal epithelial transplantation (SLET) in eyes with recurrent unilateral limbal stem cell deficiency (LSCD) due to failure of CLET. METHODS: This was a prospective case series which included 30 eyes of 30 patients who underwent SLET between 2010 and 2016 after failure of one (n=24) or two (n=6) previous CLET procedures for chronic unilateral ocular burns...
February 16, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29452671/what-is-the-optimal-initial-management-of-the-younger-mantle-cell-lymphoma-patient
#7
REVIEW
Rory McCulloch, Simon Rule
The last 20 years has seen considerable advances made in the management of younger patients with mantle cell lymphoma. The use of high dose cytarabine and rituximab in induction therapy, usually followed by autologous stem cell transplant consolidation, has become established practice and the median overall survival now exceeds 10 years. However, this high intensity upfront approach is not necessarily appropriate for all newly diagnosed patients. A minority exhibit disease that behaves in an indolent fashion with no proven benefit from early intervention, and at the opposite end of the spectrum a high-risk group exists who do poorly with conventional treatment...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29452664/the-role-of-stem-cell-transplantation-in-follicular-lymphoma
#8
REVIEW
Georg Hess
With the introduction of novel treatments paradigms to if or when to use transplantation strategies for patients with follicular lymphoma have changed substantially. Autologous transplantation has been intensively evaluated as consolidation after first induction treatment with positive effects, however the introduction of Rituximab led to comparable improvements and HDT has been moved to relapse treatment. In this indication HDT was frequently use already at first relapse, but now is dominantly used in patients with a highrisk profile, e...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29448001/induced-pluripotent-stem-cells-ipsc-derived-retinal-cells-in-disease-modeling-and-regenerative-medicine
#9
REVIEW
Reena Rathod, Harshini Surendran, Rajani Battu, Jogin Desai, Rajarshi Pal
Retinal degenerative disorders are a leading cause of the inherited, irreversible and incurable vision loss. While various rodent model systems have provided crucial information in this direction.lack of disease-relevant tissue availability and species-specific differences have proven to be a major roadblock. Human induced pluripotent stem cells (iPSC) have opened up a whole new avenue of possibilities not just in understanding the disease mechanism but also potential therapeutic approaches towards a cure. In this review, we have summarized recent advances in the methods of deriving retinal cell types from iPSCs which can serve as a renewable source of disease-relevant cell population for basic as well as translational studies...
February 12, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29445583/deep-sustained-response-to-daratumumab-monotherapy-associated-with-t-cell-expansion-in-triple-refractory-myeloma
#10
Saad Z Usmani, Imran Khan, Christopher Chiu, David Foureau, Lawrence J Druhan, Katherine Rigby, Tineke Casneuf, A Kate Sasser
Background: Daratumumab, a human CD38 monoclonal antibody that has direct on-tumor and immunomodulatory mechanisms of action, demonstrated clinical benefit as monotherapy or in combination with established regimens in patients with multiple myeloma with one or more prior lines of therapy. Case presentation: A male patient, who was 70 years of age at the time of diagnosis of multiple myeloma in 2011, relapsed after five lines of therapy, including autologous stem cell transplantation...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29444919/tracheal-replacement
#11
REVIEW
Harry Etienne, Dominique Fabre, Abel Gomez Caro, Frederic Kolb, Sacha Mussot, Olaf Mercier, Delphine Mitilian, Francois Stephan, Elie Fadel, Philippe Dartevelle
Tracheal reconstruction is one of the greatest challenges in thoracic surgery when direct end-to-end anastomosis is impossible or after this procedure has failed. The main indications for tracheal reconstruction include malignant tumours (squamous cell carcinoma, adenoid cystic carcinoma), tracheoesophageal fistula, trauma, unsuccessful surgical results for benign diseases and congenital stenosis. Tracheal substitutes can be classified into five types: 1) synthetic prosthesis; 2) allografts; 3) tracheal transplantation; 4) tissue engineering; and 5) autologous tissue composite...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29443409/cellular-collection-by-apheresis
#12
REVIEW
Anand Padmanabhan
Cellular collection is an important and increasingly used apheresis procedure. These collections are performed by leukocytapheresis, a procedure involving the removal of a patient's or donor's white blood cells, and are used to collect hematopoietic progenitor cells, specific cell populations (such as T-lymphocytes), and granulocytes. Hematopoietic progenitor cell apheresis and T-lymphocyte collection are performed by procedures that enrich for mononuclear cells. Hematopoietic progenitor cells are used for autologous and allogeneic hematopoietic stem cell transplantation, whereas T-cell collection is being used increasingly in novel cellular therapy approaches and for donor lymphocyte infusions to induce graft-versus-leukemia effect...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29440738/advantages-of-non-cryopreserved-autologous-hematopoietic-stem-cell-transplantation-against-a-cryopreserved-strategy
#13
M Sarmiento, P Ramírez, R Parody, M Q Salas, N Beffermann, V Jara, P Bertín, I Pizarro, C Lorca, E Rivera, M Galleguillos, M Ocqueteau, I Sánchez-Ortega, B Patiño, A Sureda
Autologous stem cell transplantation (auto-HSCT) is an effective treatment strategy for hematological malignancies. The standard mode of handling hematopoietic progenitors for the autologous procedure (CRYO) consists on its collection and freezing with dimethyl sulfoxide (DMSO) and its subsequent thawing and re-infusion. This process is toxic and expensive. Non-cryopreserved (non-CRYO) is a less expensive mode of auto-HSCT. We designed a comparative study between both strategies performed in two different centers to analyze the short-term complications...
February 13, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29438465/does-stromal-vascular-fraction-ensure-a-higher-survival-in-autologous-fat-grafting-for-breast-augmentation-a-volumetric-study-using-3-dimensional-laser-scanning
#14
Cheng-Hung Chiu
Background: Cell-assisted lipotransfer (CAL) has been considered a promising technique for promoting adipogenesis and angiogenesis in fat grafts. Objectives: The author sought to objectively analyze the change of breast volume in patients who underwent stromal vascular fraction (SVF)-enriched fat grafting for breast augmentation and compared the clinical results with those who underwent conventional fat grafting without SVF by using 3D laser scanning. Methods: From April 2015 to March 2016, 105 patients who underwent traditional fat grafting without SVF enrichment for breast augmentation were assigned to group A and served as the control...
February 9, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29438096/fda-approval-summary-lenalidomide-as-maintenance-therapy-after-autologous-stem-cell-transplant-in-newly-diagnosed-multiple-myeloma
#15
Elizabeth Dianne Pulte, Andrew Dmytrijuk, Lei Nie, Kirsten B Goldberg, Amy E McKee, Ann T Farrell, Richard Pazdur
On February 22, 2017, the U.S. Food and Drug Administration (FDA) granted approval for the use of lenalidomide as maintenance therapy after autologous hematopoietic stem cell transplantation (auto-HSCT) for patients with multiple myeloma. The approval was based on evidence from two randomized, blinded trials of maintenance lenalidomide versus placebo in patients with myeloma who had undergone auto-HSCT along with a third trial of lenalidomide versus no therapy. Each of the trials demonstrated superior progression-free survival for the patients treated with lenalidomide...
February 7, 2018: Oncologist
https://www.readbyqxmd.com/read/29436059/outcomes-of-penetrating-keratoplasty-following-autologous-cultivated-limbal-epithelial-stem-cell-transplantation
#16
Gustavo S Figueiredo, Borja Salvador-Culla, Oliver J Baylis, Hardeep S Mudhar, Majlinda Lako, Francisco C Figueiredo
PURPOSE: To investigate the outcomes of penetrating keratoplasty (PKP) following autologous cultivated limbal epithelial stem cell transplantation (CLET). METHODS: A prospective, single centre, interventional cohort study investigating patients with unilateral total limbal stem cell deficiency (LSCD) treated with CLET who underwent PKP. Patients with confirmed corneal re-epithelialization > 6 months post-CLET, and with best-corrected visual acuity (BCVA) <0...
February 13, 2018: Stem Cells
https://www.readbyqxmd.com/read/29434288/stem-cell-transplantation-for-t-cell-lymphomas-in-taiwan
#17
Ya-Ting Hsu, Hui-Jen Tsai, Jeffrey S Chang, Sin-Syue Li, Jih-Luh Tang, Su-Peng Yeh, Wen-Li Hwang, Jin-Hwang Liu, Tran-Der Tan, Po-Nan Wang, Hui-Hua Hsiao, Tsai-Yun Chen
T-cell lymphomas are generally aggressive malignancies with poor prognosis. There are no standard treatment guidelines for T-cell lymphomas, and the timing of stem cell transplantation (SCT) is not well known. In this study, we investigated the outcomes of Taiwanese patients with T-cell lymphomas after SCT. We retrospectively analyzed 131 patients with T-cell lymphomas receiving SCT (autologous: 90, allogeneic: 41) from 2009 to 2014. More autologous SCT recipients were ALCL or in complete remission, and more allogeneic recipients had advanced disease...
February 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29431006/cell-density-dependent-cytological-stage-profile-and-its-application-for-a-screen-of-cytostatic-agents-active-towards-leukemic-stem-cells
#18
Jan Jakub Lica, Grzegorz Jan Grabe, Mateusz Heldt, Majus Misiak, Patrycja Bloch, Marcin Serocki, Marta Switalska, Joanna Wietrzyk, Maciej Baginski, Andrzej Hellmann, Edward Borowski, Andrzej Skladanowski
Proliferation and expansion of leukemia is driven by Leukemic Stem Cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in Acute Myeloid Leukemia (AML) treatment. Here we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells which include LSCs determining the overall stage profile. This change manifested in: morphology, expression of both cell surface markers and redox-state proteins as well as mitochondrial potential...
February 12, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29428902/recent-advance-on-genome-editing-for-therapy-of-%C3%AE-hemoglobinopathies
#19
Jia-Wei Liu, Tao Hong, Xin Qin, Ying-Min Liang, Ping Zhang
β-hemoglobinopathies are one of six groups of common illnesses affecting human health. Although the genetic mechanisms have been elucidated for several decades, curable treatment options, other than allogeneic bone marrow transplantation, are still lacking. In recent years, rapid development in genome editing technologies and their clinical applications have opened up new directions for treatment of β-hemoglobinopathies. Genome editing technologies, as applied in autologous CD34 + hematopoietic stem and progenitor cells, represents a promising remedial means for the β-globin disorders...
February 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29427192/community-acquired-respiratory-infections-are-common-in-patients-with-non-hodgkin-lymphoma-and-multiple-myeloma
#20
Noa Lavi, Irit Avivi, Zipora Kra-Oz, Ilana Oren, Emilia Hardak
PURPOSE: Available data suggest that respiratory infections are associated with increased morbidity and mortality in patients hospitalized due to acute leukemia and allogeneic stem cell transplantation (allo-SCT). However, the precise incidence, risk factors, and severity of respiratory infection, mainly community-acquired, in patients with lymphoma and multiple myeloma (MM) are not fully determined. The current study aimed to investigate risk factors for respiratory infections and their clinical significance in patients with B cell non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) in the first year of diagnosis...
February 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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