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https://www.readbyqxmd.com/read/29142420/exploring-the-cytotoxic-potential-of-triterpenoids-enriched-fraction-of-bacopa-monnieri-by-implementing-in-vitro-in-vivo-and-in-silico-approaches
#1
Md Nasar Mallick, Washim Khan, Rabea Parveen, Sayeed Ahmad, Sadaf, Mohammad Zeeshan Najm, Istaq Ahmad, Syed Akhtar Husain
Background: Bacopa monnieri (BM) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. We hypothesized that the extract of the whole plant might contain numerous molecules with having antitumor activities that could be very effective in killing of human cancer cells. Objectives: This work investigated anticancer activity of bioactive fraction of BM. Materials and Methods: The hydroalcoholic extract of BM was fractionated with different solvent, namely, hexane, dichloromethane (DCM), acetone, methanol, and water...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29134976/uptake-of-zinc-by-pteridium-aquilinum-bracken-fern-and-response-of-clarias-gariepinus-juveniles-during-chronic-and-sub-lethal-exposure
#2
F E Olaifa, A A Fabusoro
Zinc is an essential trace element but can be toxic to fish at elevated concentrations. This study was carried out to assess the uptake of zinc by Clarias gariepinus juveniles and Pteridium aquilinum during chronic exposure to sub lethal concentrations. Two experiments were undertaken simultaneously in static renewal bioassays for 28 days.Haematology, histology, zinc accumulation in tissues of C.gariepinus and P. aquilinum were recorded fortnightly. Packed Cell Volume, haemoglobin concentration, Red Blood Cells, White blood cells, Lymphocytes, Neutrophils, Mean Corpuscular Volume, Mean Corpuscular Haemoglobin Concentration and Mean Corpuscular Haemoglobin of C...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29121941/the-nutritional-status-affects-the-complete-blood-count-of-goats-experimentally-infected-with-haemonchus-contortus
#3
S Cériac, C Jayles, R Arquet, D Feuillet, Y Félicité, H Archimède, J-C Bambou
BACKGROUND: Gastrointestinal nematode (GIN) remains the most important pathogenic constraint of small ruminant production worldwide. The improvement of the host immune response against GIN though breeding for improved animal resistance, vaccination and nutritional supplementation appear as very promising methods. The objective of this study was to investigate the effect of four nutritional status differing in protein and energy levels (Hay: 5.1 MJ/Kg of dry matter (DM) and 7.6% of crude protein (CP), Ban: 8...
November 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29077952/eggshell-temperature-manipulations-during-incubation-and-in-ovo-injection-of-thyroxine-are-associated-with-a-decreased-incidence-of-cold-induced-ascites-in-broiler-chickens
#4
O Afsarian, M H Shahir, A Lourens, A Akhlaghi, H Lotfolahian, A Hoseini, N Mousavi
A hypothesis was tested that eggshell temperature manipulations during incubation and in ovo injection of thyroxine (T4) would help their progeny chicks to better survive the ascites-inducing condition during the growing period. In experiment 1, a total of 4,800 hatching eggs was randomly arranged in a 2 × 4 factorial design (8 replicates of 75 eggs per treatment), in which the eggs were incubated at a constant eggshell temperature (EST) of 37.8°C throughout the incubation period (CON) or were exposed to 15°C for one h on d 11, 13, 15, and 17 of incubation (EST manipulations; ESTM), and 4 treatment groups of 3 control groups (no injection; INJN, needle pricked; INJP, and sterilized distilled water injection; INJW) and one T4 treatment group (injected with sterilized distilled water containing 65 ng of T4; INJT4)...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29054515/blood-transfusion-management-and-transfusion-related-outcomes-in-daratumumab-treated-patients-with-relapsed-or-refractory-multiple-myeloma
#5
Ajai Chari, Suzanne Arinsburg, Sundar Jagannath, Toshihisa Satta, Ivey Treadwell, Donna Catamero, Gillian Morgan, Huaibao Feng, Clarissa Uhlar, Imran Khan, Parul Doshi, Saad Usmani
INTRODUCTION: Daratumumab, a human CD38 monoclonal antibody approved for multiple myeloma (MM) treatment, binds red blood cells (RBCs), resulting in panagglutination in compatibility tests. Published mitigation methods avoid additional testing, ensuring timely release of blood products. Blood transfusion management and transfusion-related outcomes of daratumumab-treated patients in the SIRIUS study are reported, with emphasis on 2 clinical sites. PATIENTS AND METHODS: Patients had MM treated with ≥ 3 prior lines of therapy, including a proteasome inhibitor and an immunomodulatory drug, or were refractory to a proteasome inhibitor and an immunomodulatory drug...
September 19, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29051431/haematological-biochemical-and-antioxidant-changes-in-wistar-rats-exposed-to-dichlorvos-based-insecticide-formulation-used-in-southeast-nigeria
#6
Kingsley C Kanu, Solomon N Ijioma, Odudu Atiata
The indiscriminate use of pesticide is a treat to non-target organisms. This study evaluates the haematological and biochemical changes induced by inhalation of local Nigerian dichlorvos insecticide on rats. The rats were randomly assigned to a control group which received only food and water and a test group which, in addition to food and water, was exposed to the pesticide for a period of 4 h daily for 28 days, after which exposure was discontinued for seven days. Five animals were sacrificed from each group on days 1, 7, 14, 21, 28 and 35, and blood was collected by cardiac puncture for haematological, biochemical and antioxidant analysis...
November 29, 2016: Toxics
https://www.readbyqxmd.com/read/29036803/extracellular-atp-activates-enos-and-increases-intracellular-no-generation-in-red-blood-cells
#7
Pinar Ulker, Nur Özen, Günel Abdullayeva, Sadi Köksoy, Nazmi Yaraş, Filiz Basrali
BACKGROUND: It has been well documented that ATP activates NOS enzymes and causes increased NO production in several cell types. Although RBC known to possesses eNOS enzyme activity, it has not been investigated whether RBC eNOS could be induced by extracellular ATP. OBJECTIVE: The aim of the present study is to evaluate extracellular ATP mediated eNOS activation and NO production in RBC. METHODS: RBC packed were isolated from healthy volunteers and re-suspended in Hepes solution at a hematocrit of 0...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28969893/does-a-balanced-transfusion-ratio-of-plasma-to-packed-red-blood-cells-improve-outcomes-in-both-trauma-and-surgical-patients-a-meta-analysis-of-randomized-controlled-trials-and-observational-studies
#8
REVIEW
Mohamed Rahouma, Mohamed Kamel, Diana Jodeh, Thomas Kelley, Lucas B Ohmes, Andreas R de Biasi, Ahmed A Abouarab, Umberto Benedetto, T Sloane Guy, Christopher Lau, Paul C Lee, Leonard N Girardi, Mario Gaudino
BACKGROUND: The effect of high transfusion ratios of fresh frozen plasma (FFP): packed red blood cell (RBC) on mortality is still controversial. Observational evidence contradicts a recent randomized controlled trial regarding mortality benefit. This is an updated meta-analysis, including a non-trauma cohort. METHODS: Patients were grouped into high vs. low based on FFP:RBC ratio. Primary outcomes were 24-h and 30-day/in-hospital mortality. Secondary outcomes were acute respiratory distress syndrome and acute lung injury rates...
September 23, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28965917/phospholipid-composition-of-packed-red-blood-cells-and-that-of-extracellular-vesicles-show-a-high-resemblance-and-stability-during-storage
#9
Eva Laurén, Feven Tigistu-Sahle, Sami Valkonen, Melissa Westberg, Anne Valkeajärvi, Juha Eronen, Pia Siljander, Ville Pettilä, Reijo Käkelä, Saara Laitinen, Erja Kerkelä
Red blood cells (RBCs) are stored up to 35-42days at 2-6°C in blood banks. During storage, the RBC membrane is challenged by energy depletion, decreasing pH, altered cation homeostasis, and oxidative stress, leading to several biochemical and morphological changes in RBCs and to shedding of extracellular vesicles (EVs) into the storage medium. These changes are collectively known as RBC storage lesions. EVs accumulate in stored RBC concentrates and are, thus, transfused into patients. The potency of EVs as bioactive effectors is largely acknowledged, and EVs in RBC concentrates are suspected to mediate some adverse effects of transfusion...
September 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28899777/jerusalem-artichoke-enriched-diet-on-growth-performance-immuno-hematological-changes-and-disease-resistance-against-aeromonas-hydrophila-in-asian-seabass-lates-calcarifer
#10
Sajjad Syed Raffic Ali, Kondusamy Ambasankar, Mohamed Saiyad Musthafa, Ramasamy Harikrishnan
A 45 days feeding trial was conducted to study the effect of Jerusalem artichoke (JA) on growth performance, body composition, biochemical, immuno-hematological parameters and disease resistance in Asian seabass (Lates calcarifer) fingerlings against Aeromonas hydrophila. JA was supplemented at three different levels viz., control 0, 5, 10, and 20 g kg(-1) in the commercial diet (403 g kg(-1)protein and 89 g kg (-1)lipid) in L. calcarifer. The results showed that there were no significant (P > 0...
September 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28880900/phase-separation-of-the-plasma-membrane-in-human-red-blood-cells-as-a-potential-tool-for-diagnosis-and-progression-monitoring-of-type-1-diabetes-mellitus
#11
Giuseppe Maulucci, Ermanno Cordelli, Alessandro Rizzi, Francesca De Leva, Massimiliano Papi, Gabriele Ciasca, Daniela Samengo, Giovambattista Pani, Dario Pitocco, Paolo Soda, Giovanni Ghirlanda, Giulio Iannello, Marco De Spirito
Glycosylation, oxidation and other post-translational modifications of membrane and transmembrane proteins can alter lipid density, packing and interactions, and are considered an important factor that affects fluidity variation in membranes. Red blood cells (RBC) membrane physical state, showing pronounced alterations in Type 1 diabetes mellitus (T1DM), could be the ideal candidate for monitoring the disease progression and the effects of therapies. On these grounds, the measurement of RBC membrane fluidity alterations can furnish a more sensitive index in T1DM diagnosis and disease progression than Glycosylated hemoglobin (HbA1c), which reflects only the information related to glycosylation processes...
2017: PloS One
https://www.readbyqxmd.com/read/28858373/electrolyte-acid-base-and-hemoglobin-oxygen-affinity-alterations-following-irradiation-and-storage-of-canine-packed-red-blood-cells
#12
Saya A Press, Edward S Cooper, Jason W Stull
BACKGROUND: Irradiation of RBC before transfusion is required to prevent transfusion-associated graft-versus-host disease for human patients undergoing hematopoietic stem cell transplantation. Additional applications for irradiated blood may exist in oncologic surgery. The effect of irradiation on canine packed RBC (pRBC) is unknown. OBJECTIVES: The aim of this study was to explore and characterize the in vitro electrolyte, acid-base, and oxygen-carrying capacity changes to pRBC immediately following irradiation and during storage...
August 31, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28834579/topical-flurbiprofen-toxicosis-in-a-cat
#13
Elizabeth M Yi, Elizabeth Leech
OBJECTIVE: To describe the clinical presentation and treatment of a cat with flurbiprofen toxicosis due to topical cream exposure. CASE SUMMARY: A 3-year-old castrated male domestic shorthair cat presented to an emergency and referral center for acute lethargy, hematemesis, and anemia. Severe azotemia was observed on serum biochemistry panel. The patient's anemia was treated with packed RBC transfusion, and treatment with crystalloid fluids, famotidine, pantoprazole, ampicillin, and sucralfate were begun on presentation...
August 23, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28795619/hematological-and-molecular-characterization-of-a-novel-hb-a2-variant-with-homozygous-%C3%AE-thalassemia-2-in-a-southern-thai-individual
#14
Manit Nuinoon, Nutjaree Jeenduang, Aumpika Kesornsit, Dararat Horpet, Thunyaluk Plyduang
We report here the hematological and molecular features of a novel δ-globin chain variant found in a Southern Thai woman. Her complete blood count was as follows: red blood cell (RBC) count 5.90 × 10(12)/L, hemoglobin concentration (Hb) 12.6 g/dL, packed cell volume (PCV) 0.41 L/L, mean corpuscular volume (MCV) 69.5 fL, mean corpuscular Hb (MCH) 21.4 pg, mean corpuscular Hb concentration (MCHC) 30.7 g/dL and RBC distribution width (RDW) 13.1%. The blood smear demonstrated microcytic hypochromic RBCs suggestive of thalassemia trait...
August 10, 2017: Hemoglobin
https://www.readbyqxmd.com/read/28782124/supernatant-reduction-of-stored-gamma-irradiated-red-blood-cells-minimizes-potentially-harmful-substances-present-in-transfusion-aliquots-for-neonates
#15
Katherine Serrano, Chantale Pambrun, Elena Levin, Dana V Devine
BACKGROUND: In neonate transfusion, the use of a dedicated red blood cell (RBC) unit decreases donor exposure. A separate safety measure involves gamma irradiation of the RBCs to abrogate the possibility of transfusion-associated graft-versus-host disease. However, in combination, storage of gamma-irradiated RBCs leads to accumulation of potentially harmful substances in the supernatant. STUDY DESIGN AND METHODS: For this study, RBCs were pooled and split into three study arms...
August 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28712138/hematologic-reference-intervals-and-age-effect-in-european-strigiformes
#16
Susana Agusti Montolio, Rafael Molina López, Carolyn Cray, Santiago Lavín González, Olga Nicolás Francisco, Ignasi Marco Sánchez, Encarna Casas-Díaz, Rafaela Cuenca Valera
BACKGROUND: The clinical importance of hematologic testing in avian veterinary medicine is reflected in the increasing number of studies for the establishment of hematologic RIs of Strigiformes and other species. Age is an important physiologic factor in birds and the effect on hematology variable should be understood. OBJECTIVES: The objective of this study was to determine baseline data of hematologic variables in 5 species of Iberian Strigiformes in different age classes...
July 16, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28703962/haematological-and-biochemical-studies-on-justicia-carnea-leaves-extract-in-phenylhydrazine-induced-anemia-in-albino-rats
#17
Chimaraoke Onyeabo, Ngozi K Achi, Chima A Ekeleme-Egedigwe, Chidinma U Ebere, Chidinma K Okoro
BACKGROUND: Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Aim. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. METHODS: The experimental animals were randomly grouped into five groups of six rats each – group 1 (non-anemic control), group 2 (anemic control), group 3 (500 mg/kg of JC extract), group 4 (1000 mg/kg of JC extract) and group 5 (DMSO control)...
April 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28685240/in-vivo-evaluation-of-the-toxic-effect-of-ethyl-acetate-extracts-of-marine-antibiotic-resistance-pseudomonas-species-derived-from-the-red-sea
#18
Mervat Morsy Abbas Ahmed El-Gendy, Hind A A Al-Zahrani, Najlaa Y Abozinadah, Ahmed Mohamed Ahmed El-Bondkly
Eighty-nine cultured Pseudomonas species isolated from the sediment and water samples collected from five industrial Red Sea regions that have been affected by petroleum and industry. Genotypic (exoT, exoS, exoU, exoY, lasA, lasB, rhlA, rhlB, Pf1, PAGI-1, -2, and -3) and phenotypic (DNase, elastase, lipase, protease, siderophore, antibiotic resistance patterns) characteristics were determined. Out of these isolates, nine Pseudomonas isolates were selected as the hyperactive virulence factors producers along with highly resistant pattern against all antibiotics of different classes included in this study...
July 6, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28648253/statistical-validation-of-1-h-nmr-protocol-vs-standard-biochemical-assay-in-quality-control-of-rbc-packed-units
#19
Thelma A Pertinhez, Emanuela Casali, Laura Zambianchi, Alberto Spisni, Roberto Baricchi
BACKGROUND: Time dependent quantification of endogenous metabolites in biological samples (blood, urine, biological tissues extracts) in normal and pathological conditions as well as following therapeutic protocols is well established. In the clinical practice, such a dynamic flux of information allows the physician to identify and appreciate alterations associated to biochemical pathways of specific organs. In the years, many biochemical assays have been developed to detect, selectively, this vast array of molecules...
June 15, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28641501/hematological-characterizations-and-molecular-diagnostic-aspects-of-hb-wiangpapao-%C3%AE-44-ce2-pro%C3%A2-ser-%C3%AE-1-ccg-tcg-hba1-c-133c-t-a-new-%C3%AE-globin-variant-found-in-a-pregnant-thai-woman
#20
Sitthichai Panyasai, Sakorn Pornprasert
We report the hematological parameters and provide a rapid molecular analysis method for detection of Hb Wiangpapao [α44(CE2)Pro→Ser, CCG>TCG; HBA1: c.133C>T], a new α-globin variant found in a pregnant Thai woman. Her red cell indices were measured by an automated blood counter. The results were: red blood cell (RBC) count 4.03 × 10(12)/L, Hb 13.1 (g/dL), packed cell volume (PCV) 0.39 L/L, mean corpuscular volume (MCV) 97.0 fL, mean corpuscular hemoglobin (Hb) (MCH) 32.5 pg, mean corpuscular Hb concentration (MCHC) 33...
March 2017: Hemoglobin
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