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https://www.readbyqxmd.com/read/27899173/procoagulant-role-of-microparticles-in-routine-storage-of-packed-red-blood-cells-potential-risk-for-prothrombotic-post-transfusion-complications
#1
Htet Htet Aung, John-Paul Tung, Melinda M Dean, Robert L Flower, Natalie M Pecheniuk
During routine storage, packed red blood cells (PRBC) undergo biochemical and morphological changes including loss of red blood cell (RBC) membrane asymmetry and release of microparticles (MPs) bearing phosphatidylserine (PS), a procoagulant phospholipid. This study investigated the association between PRBC storage duration, MP profile and procoagulant activity. Leukodepleted PRBC-supernatant (PRBC-SN; n=13) was prepared at weekly intervals throughout storage. Phospholipid-dependent procoagulant activity, assessed using a factor X-activated clotting time (XACT) assay, decreased throughout storage (p<0...
November 26, 2016: Pathology
https://www.readbyqxmd.com/read/27893645/preperitoneal-pelvic-packing-reduces-mortality-in-patients-with-life-threatening-hemorrhage-due-to-unstable-pelvic-fractures
#2
Clay Cothren Burlew, Ernest E Moore, Philip F Stahel, Andrea E Geddes, Amy E Wagenaar, Fredric M Pieracci, Charles J Fox, Eric M Campion, Jeffrey L Johnson, Cyril Mauffrey
BACKGROUND: A 2015 AAST trial reported a 32% mortality for pelvic fracture patients in shock. Angioembolization (AE) is the most common intervention; the Maryland group revealed time to AE averaged 5 hours. The goal of this study was to evaluate the time to intervention and outcomes of an alternative approach for pelvic hemorrhage. We hypothesized preperitoneal pelvic packing (PPP) results in a shorter time to intervention and lower mortality. METHODS: In 2004 we initiated a PPP protocol for pelvic fracture hemorrhage...
November 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27877032/pulmonary-complications-after-abdominal-surgery-in-patients-with-mild-to-moderate-chronic-obstructive-pulmonary-disease
#3
Tae Hoon Kim, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh
Postoperative pulmonary complications (PPCs) are one of the most important causes of postoperative morbidity and mortality after abdominal surgery. Although chronic obstructive pulmonary disease (COPD) has been considered a risk factor for PPCs, it remains unclear whether mild-to-moderate COPD is a risk factor. This retrospective cohort study included 387 subjects who underwent abdominal surgery with general anesthesia in a tertiary referral hospital. PPCs included pneumonia, pulmonary edema, pulmonary thromboembolism, atelectasis, and acute exacerbation of COPD...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27867278/effect-of-methanolic-leaf-extract-of-talinum-triangulare-jacq-willd-on-biochemical-parameters-in-diet-induced-dyslipidemia-wistar-rats
#4
Olubukola Sinbad Olorunnisola, Adewale Adetutu, Anthony Jide Afolayan, Abiodun Olusoji Owoade
OBJECTIVE: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status, and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. MATERIAL AND METHODS: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27823688/the-effect-of-fresh-versus-standard-blood-transfusion-on-microvascular-endothelial-function
#5
Yasir Parviz, Cyrus Hsia, Mistre Alemayehu, Sabrina Wall, Rodrigo Bagur, Nour AbuRomeh, Ian Chin-Yee, Shahar Lavi
BACKGROUND: The duration of red blood cell (RBC) storage may have a negative impact on endothelial nitric oxide bioavailability. We tested the hypothesis that transfused fresh blood will have a more favorable effect on microvascular endothelial function as compared to older standard issue blood. METHODS: Participants requiring chronic RBC transfusions were enrolled in a crossover design study to receive fresh (<7 days of storage) or standard (up to 42 days of storage) blood on 2 separate visits...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27822238/efficacy-of-repeated-doses-of-diminazene-aceturate-dinazene-%C3%A2-in-the-treatment-of-experimental-trypanosoma-brucei-infection-of-albino-rats
#6
I O Ezeh, E N Ugwu, O V Enemuo, C F Obi, C N Iheagwam, R C Ezeokonkwo, D N Onah
The efficacy of repeated doses of Dinazene(®) in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 10(6) trypanosomes in 400 µL of PBS diluted blood while groups E (uninfected treated) and F (uninfected untreated) served as controls. The rats in the groups A-D as well as those in group E were treated with 7...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27805246/bovine-neonatal-pancytopenia-correlation-between-clinical-symptoms-hematological-parameters-and-lifespan
#7
Marek Gehrke, Vivian Junge, Jędrzej M Jaśkowski, Mirosław P Polak, Krzysztof Urbaniak, Aleksandra Żuraw
OBJECTIVE: To compare the hematological parameters and clinical symptoms between Bovine Neonatal Pancytopenia (BNP) diseased calves dying before and after 14 days of life. MATERIAL AND METHODS: Clinical observations included 47 calves from dams which underwent a 3-year vaccination program with the inactivated PregSure(®) BVD vaccine. In 25 of these 47 BNP affected calves blood examinations were performed and in 22 dead calves diagnosis was mainly based on post-mortem findings...
November 2, 2016: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/27798697/long-term-stored-hemoglobin-vesicles-a-cellular-type-of-hemoglobin-based-oxygen-carrier-has-resuscitative-effects-comparable-to-that-for-fresh-red-blood-cells-in-a-rat-model-with-massive-hemorrhage-without-post-transfusion-lung-injury
#8
Masahiro Tokuno, Kazuaki Taguchi, Keishi Yamasaki, Hiromi Sakai, Masaki Otagiri
Hemoglobin-vesicles (HbV), encapsulating highly concentrated human hemoglobin in liposomes, were developed as a substitute for red blood cells (RBC) and their safety and efficacy in transfusion therapy has been confirmed in previous studies. Although HbV suspensions are structurally and physicochemically stabile for least 1-year at room temperature, based on in vitro experiments, the issue of whether the use of long-term stored HbV after a massive hemorrhage can be effective in resuscitations without adverse, post-transfusion effects remains to be clarified...
2016: PloS One
https://www.readbyqxmd.com/read/27662564/hematocrit-levels-blood-testing-and-blood-transfusion-in-infants-after-heart-surgery
#9
Claudia Delgado-Corcoran, Katherine H Wolpert, Kathryn Lucas, Stephanie Bodily, Angela P Presson, Susan L Bratton
OBJECTIVE: To determine whether judicious blood testing impacts timing or amount of packed RBC transfusions in infants after heart surgery. DESIGN: A retrospective study comparing before and after initiation of a quality improvement process. SETTING: A university-affiliated cardiac ICU at a tertiary care children's hospital. PATIENTS: Infants less than 1 year old with Risk Adjustment for Congenital Heart Surgery category 4, 5, 6, or d-transposition of great arteries (Risk Adjustment for Congenital Heart Surgery 3) consecutively treated during 2010 through 2013...
November 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27619554/plasma-vitamin-c-levels-in-esrd-patients-and-occurrence-of-hypochromic-erythrocytes
#10
Eric Seibert, Anja Richter, Martin K Kuhlmann, Suxin Wang, Nathan W Levin, Peter Kotanko, Garry J Handelman
Introduction The achievement of erythropoiesis in hemodialysis (HD) patients is typically managed with erythropoiesis-stimulating-agents (ESA's) and intravenous iron (IV-iron). Using this treatment strategy, HD patients frequently show an elevated fraction of red blood cells (RBC) with hemoglobin (Hb) content per cell that is below the normal range, called hypochromic RBC. The low Hb content per RBC is the result of the clinical challenge of providing sufficient iron content to the bone marrow during erythropoiesis...
September 12, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27608699/gastric-mucormycosis-with-hemolytic-uremic-syndrome
#11
K Sunil Raviraj, P Miglani, A Garg, P K Agarwal
Mucormycosis, is an emerging fungal infection in immunocompromised and diabetic individuals, usually affects rhino-orbito-cerebral, cutaneous and pulmonary regions. But mucormycosis in immunocompetent environment is rare and occurrence of gastric mucormycosis is unusual. We report a case of 19 year old female, with no pre-existing co-morbidities, presented with fever, dysentery, vomiting, and melena for 4 days. On evaluation she was found to have pancytopenia, acute kidney injury, hemolytic anemia, coagulopathy and hepatic derangement and treated with hemodialysis, plasmapheresis along with antibiotics and packed cell RBC transfusion...
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27604182/measurement-of-the-hematocrit-using-paper-based-microfluidic-devices
#12
Samuel B Berry, Syrena C Fernandes, Anjali Rajaratnam, Nicholas S DeChiara, Charles R Mace
The quantification of blood cells provides critical information about a patient's health status. Sophisticated analytical equipment, such as hematology analyzers, have been developed to perform these measurements, but limited-resource settings often lack the infrastructure required to purchase, operate, and maintain instrumentation. To address these practical challenges, paper-based microfluidic devices have emerged as a platform to develop diagnostic assays specifically for use at the point-of-care. To date, paper-based microfluidic devices have been used broadly in diagnostic assays that apply immunoassay, clinical chemistry, and electrochemistry techniques...
October 7, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27602911/angiographic-embolization-for-hemorrhage-following-pelvic-fracture-is-it-time-for-a-paradigm-shift
#13
Ronald Tesoriero, Brandon Bruns, Mayur Narayan, Joseph Dubose, Sundeep Guliani, Megan Brenner, Sharon Boswell, Deborah M Stein, Thomas Scalea
INTRODUCTION: Major pelvic disruption with hemorrhage has a high rate of lethality. Angiographic embolization remains the mainstay of treatment. Delays to angiography have been shown to worsen outcomes, in part because time spent awaiting mobilization of resources needed to perform angiography allows ongoing hemorrhage. Alternative techniques like pelvic pre-peritoneal packing (PPP) and aortic balloon occlusion (REBOA) now exist. We hypothesized that time to angiographic embolization at our level 1 trauma center would be longer than 90 minutes...
September 16, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27581231/a-population-study-using-the-human-erythrocyte-pig-a-assay
#14
Yiyi Cao, Li Yang, Nannan Feng, Oumin Shi, Jing Xi, Xinyue You, Chunrong Yin, Huan Yang, Katsuyoshi Horibata, Masamitsu Honma, Biyun Qian, Wei Weng, Yang Luan
Erythrocyte-based PIG-A assay is sensitive and reliable in detecting exposure to mutagenetic agents in animal studies, but there are few data from human populations. In this study, we employed a method for detecting CD59 phenotypic variants, resulting from mutation in the PIG-A gene, in human red blood cells (RBCs), and determined the CD59-deficient RBC (RBC(CD59-) ) frequencies in 217 subjects from general population. The majority of subjects had a relatively low mutant frequencies (MFs) (average, 5.25 ± 3...
October 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27554084/biomarkers-defining-the-metabolic-age-of-red-blood-cells-during-cold-storage
#15
Giuseppe Paglia, Angelo D'Alessandro, Óttar Rolfsson, Ólafur E Sigurjónsson, Aarash Bordbar, Sirus Palsson, Travis Nemkov, Kirk C Hansen, Sveinn Gudmundsson, Bernhard O Palsson
Metabolomic investigations of packed red blood cells (RBCs) stored under refrigerated conditions in saline adenine glucose mannitol (SAGM) additives have revealed the presence of 3 distinct metabolic phases, occurring on days 0-10, 10-18, and after day 18 of storage. Here we used receiving operating characteristics curve analysis to identify biomarkers that can differentiate between the 3 metabolic states. We first recruited 24 donors and analyzed 308 samples coming from RBC concentrates stored in SAGM and additive solution 3...
September 29, 2016: Blood
https://www.readbyqxmd.com/read/27540574/discharge-hemoglobin-and-outcome-in-patients-with-acute-nonvariceal-upper-gastrointestinal-bleeding
#16
Jae Min Lee, Eun Sun Kim, Hoon Jai Chun, Young-Jae Hwang, Jae Hyung Lee, Seung Hun Kang, In Kyung Yoo, Seung Han Kim, Hyuk Soon Choi, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Chang Duck Kim
BACKGROUND AND STUDY AIMS: Many patients with acute gastrointestinal bleeding present with anemia and frequently require red blood cell (RBC) transfusion. A restrictive transfusion strategy and a low hemoglobin (Hb) threshold for transfusion had been shown to produce acceptable outcomes in patients with acute upper gastrointestinal bleeding. However, most patients are discharged with mild anemia owing to the restricted volume of packed RBCs (pRBCs). We investigated whether discharge Hb influences the outcome in patients with acute nonvariceal upper gastrointestinal bleeding...
August 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27536033/effect-of-feeding-cottonseed-meal-on-some-hematological-and-serum-biochemical-parameters-in-broiler-birds
#17
G Thirumalaisamy, M R Purushothaman, P Vasantha Kumar, P Selvaraj
AIM: The study was undertaken to find out the effect of feeding cottonseed meal (CSM) on performance of hematological and serum biochemical parameters in broiler birds. MATERIALS AND METHODS: A 6-week biological trial was carried out with 432-day-old Cobb 400 broiler chicks distributed to nine experimental diets with six replicates, each containing eight chicks. The experimental diets were formulated based on total amino acids (BTAA) or based on digestible amino acids (BDAA) with or without iron supplementation with two levels of CSM (2% and 4%) and control diet based on maize - soybean...
July 2016: Veterinary World
https://www.readbyqxmd.com/read/27520363/establishment-of-reference-values-of-%C3%AE-tocopherol-in-plasma-red-blood-cells-and-adipose-tissue-in-healthy-children-to-improve-the-management-of-chylomicron-retention-disease-a-rare-genetic-hypocholesterolemia
#18
Charlotte Cuerq, Lioara Restier, Jocelyne Drai, Emilie Blond, Adeline Roux, Sybil Charriere, Marie-Caroline Michalski, Mathilde Di Filippo, Emile Levy, Alain Lachaux, Noël Peretti
BACKGROUND: Chylomicron retention disease (CMRD), a rare genetic hypocholesterolemia, results in neuro-ophtalmologic damages, which can be prevented by high doses of vitamin E during infancy. In these patients, plasma vitamin E concentration is significantly reduced due to defects of chylomicron secretion. Vitamin E in adipose tissue (AT) and red blood cells (RBC) have been proposed as potential relevant biomarkers of vitamin E status but no reference values in children are available...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27508880/effect-of-visible-laser-light-on-atp-level-of-anaemic-red-blood-cell
#19
Nursakinah Suardi, Bashiru Kayode Sodipo, Mohd Zulkifli Mustafa, Zalila Ali
In this work we present influence of visible laser light on ATP level and viability of anaemic red blood cell (RBC). The visible laser lights used in this work are 460nm and 532nm. The responses of ATP level in anaemic and normal RBC before and after laser irradiation at different exposure time (30, 40, 50 and 60s) were observed. Three aliquots were prepared from the ethylenediaminetetraacetic acid (EDTA) blood sample. One served as a control (untreated) and another two were irradiated with 460nm and 560nm lasers...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27488090/aged-human-stored-red-blood-cell-supernatant-inhibits-macrophage-phagocytosis-in-an-hmgb1-dependent-manner-after-trauma-in-a-murine-model
#20
Kent R Zettel, Mitchell Dyer, Jay S Raval, Xubo Wu, John R Klune, Andres Gutierrez, Darrell J Triulzi, Timothy R Billiar, Matthew D Neal
Red blood cell transfusions in the setting of trauma is a double edged sword, as it is a necessary component for life-sustaining treatment in massive hemorrhagic shock, but also associated with increased risk for nosocomial infections and immune suppression. The mechanisms surrounding this immune suppression are unclear. Using supernatant from human packed red blood cell (RBC), we demonstrate that clearance of E. coli by macrophages is inhibited both in vitro and in vivo using a murine model of trauma and hemorrhagic shock...
August 2, 2016: Shock
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