Read by QxMD icon Read


Jacob Chen, Xiaowu Wu, Jeffrey Keesee, Bin Liu, Daniel N Darlington, Andrew P Cap
INTRODUCTION: We have recently shown that human whole blood stored at 4°C maintains hemostatic and platelet function. In this study, we compared restoration of hemodynamic, metabolic and hemostatic function after limited resuscitation with rat fresh whole blood, rat stored whole blood, or Lactated Ringers in traumatized rats. METHODS: Rat whole blood was stored for 10 days at 4°C for evaluation of hemostatic function. Polytrauma was performed on isoflurane-anesthetized Sprague-Dawley rats (350-450 g) by damage to the intestines, liver, right leg skeletal muscle and right femur fracture, followed by 40% hemorrhage...
September 19, 2016: Shock
Xiaowu Wu, Michael A Dubick, Martin G Schwacha, Andrew P Cap, Daniel N Darlington
INTRODUCTION: Severe trauma, hemorrhage and resuscitation can lead to a trauma related acute lung injury that involves rapid infiltration of immune cells and platelets. This infiltration involves exymatic degradation of matrix proteins, including plasmin, and causes loss of barrier function. Since tranexamic acid (TXA) inhibits plasminogen/ plasmin binding to target substrates, it may attenuate loss of barrier function after severe trauma, hemorrhage and resuscitation. METHODS: Sprague-Dawley rats were subjected to polytrauma (laparotomy, and trauma to intestines, liver, right leg skeletal muscle and right femur fracture), then bled 40% of their blood volume...
September 19, 2016: Shock
Aaron K Bassett, Jonathan D Auten, Tara J Zieber, Nicole L Lunceford
Balanced component therapy (BCT) remains the mainstay in trauma resuscitation of the critically battle injured. In austere medical environments, access to packed red blood cells, apheresis platelets, and fresh frozen plasma is often limited. Transfusion of warm, fresh whole blood (FWB) has been used to augment limited access to full BCT in these settings. The main limitation of FWB is that it is not readily available for transfusion on casualty arrival. This small case series evaluates the impact early, mechanism-of-injury (MOI)-based, preactivation of the walking blood bank has on time to transfusion...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Robert T Gerhardt, Elon Glassberg, John B Holcomb, Robert L Mabry, Martin B Schreiber, Philip C Spinella
BACKGROUND: Uncontrolled major hemorrhage and delayed evacuation remain substantial contributors to potentially survivable combat death, along with mission, environment, terrain, logistics, and hostile action. Life-saving interventions and the onset of acute traumatic coagulopathy (ATC) may also contribute. OBJECTIVE: Analyze US casualty records from the DoD Trauma Registry, using International Normalized Ratio (INR) of 1.5 for onset of ATC. METHODS: Retrospective cohort study from September 2007 to June 2011, inclusive...
September 2016: Shock
Peter L Jernigan, Richard S Hoehn, Daniel Cox, Judy Heyl, Warren C Dorlac, Timothy A Pritts
INTRODUCTION: Hypertonic crystalloid solutions, colloids, and fresh whole blood (FWB) have all been proposed for prehospital resuscitation after hemorrhage. However, there are no direct comparisons of the efficacy of these different fluids. We compared Hextend, 3% hypertonic saline (HS), and FWB in a porcine model of hemorrhagic shock. MATERIALS AND METHODS: Female swine (n = 5/group) underwent splenectomy and pressure-controlled hemorrhage followed by resuscitation with Hextend, 3% HS, or FWB...
September 2016: Shock
Shariq S Khwaja, Amit Roy, Stephanie Markovina, Todd A Dewees, Steven Hunt, Benjamin Tan, Robert J Myerson, Jeffrey R Olsen, Parag J Parikh
PURPOSE: A prospective phase 2 trial of short-course (SC) radiation therapy (RT) with 25 Gy over 5 fractions, followed by 4 cycles of 5-fluorouracil, oxaliplatin, and leucovorin (mFOLFOX6) before surgery was recently completed at our institution. We present here the patient-reported quality of life (QOL) outcomes from this trial. METHODS AND MATERIALS: Eighty patients with cT3/T4, any N, any M rectal adenocarcinoma planned for resection were enrolled between 2009 and 2012...
August 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Pınar Kendigelen, Zeynep Kamalak, Deniz Abat
Early management of rapid massive hemorrhage requires early administration of blood products and rapid surgical control of bleeding. Professionals in peripheral hospitals with limited resources often work under conditions similar to those in the military. Described in the present report are 3 cases in which warm fresh whole blood (WFWB) was used in patients with massive bleeding who presented to a peripheral hospital that had no blood products suitable for emergency conditions. Described first is the case of a 16-year-old female patient who underwent emergency cesarean section...
March 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Sriram Yennurajalingam, Supakarn Tayjasanant, Dave Balachandran, Nikhil S Padhye, Janet L Williams, Diane D Liu, Susan Frisbee-Hume, Eduardo Bruera
BACKGROUND: There is limited research in advanced cancer patients (ACP) regarding association between objectively measured daytime activity and sleep (as measured by actigraphy), patient characteristics, and cancer symptoms (fatigue, sleep, anxiety, depression, cachexia, and symptom distress scores [SDSs]). OBJECTIVES: Our aim of the study was to determine the association between mean daytime activity (MDTA) and the following items: fatigue (FACIT-F), SDSs (Edmonton Symptom Assessment Scale [ESAS]), sleep quality (Pittsburg Sleep Quality Index [PSQI]), objective sleep variables (OSV) (sleep onset, sleep efficacy, wake after sleep onset, total sleep time), anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), body composition scores, and overall survival (OS)...
August 2016: Journal of Palliative Medicine
Qian Lu, Jin You, April Kavanagh, Krystal Warmoth, Zhiqiang Meng, Zhen Chen, Kavita D Chandwani, George H Perkins, Jennifer Leigh McQuade, Nelamangala V Raghuram, Raghuram Nagarathna, Zhongxing Liao, Hongasandra Ramarao Nagendra, Jiayi Chen, Xiaoma Guo, Luming Liu, Banu Arun, Lorenzo Cohen
OBJECTIVE: It has been speculated that cancer survivors in Asia may have lower quality of life (QOL) compared with their Western counterparts. However, no studies have made international comparisons in QOL using a comprehensive measure. This study aimed to compare Chinese breast cancer survivors' QOL with US counterparts and examine if demographic and medical factors were associated with QOL across groups. METHOD: The sample consisted of 159 breast cancer patients (97 Chinese and 62 American) who completed the Functional Assessment for Cancer Therapy Breast Cancer (FACT-B) scale before the start of radiotherapy in Shanghai, China and Houston, USA...
September 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Benjamin L Baker, Doug Powell, Jamie Riesberg, Sean Keenan
The Prolonged Field Care Working Group concurs that fresh whole blood (FWB) is the fluid of choice for patients in hemorrhagic shock, and the capability to transfuse FWB should be a basic skill set for Special Operations Forces (SOF) Medics. Prolonged field care (PFC) must also address resuscitative and maintenance fluid requirements in nonhemorrhagic conditions.
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Jesse Owen, Frank D Fincham, Geneva Polser
Friends with benefit relationships (FWB) combine elements of ongoing friendship and physical intimacy. Although many studies have examined predictors of who are likely to enter these relationships as well as their outcomes, we do not know what relational factors are associated with FWB relationship outcomes. This study examined the association between three commitment variables: couple identity, satisfaction with sacrifice, and alternative availability and FWB relationship adjustment and sexual satisfaction...
March 16, 2016: Archives of Sexual Behavior
C G Pinheiro, C M Machado, L P Amaral, D T Silva, C A A Almeida, S J Longhi, C A Mallmann, B M Heinzmann
This study was developed to evaluate the effect of seasonality on the yield and chemical composition of the essential oil (EO) of Hesperozygis ringens (Benth.) Epling, a native species from the Brazilian Pampa. Leaves were collected from four specimens of a single population in each of the four seasons for a year and were extracted in triplicate by hydro-distillation for 2 hours. The yield of EO (% w/w) was calculated on fresh weight basis (FWB), and the 16 oil samples were analyzed by gas chromatography coupled to mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (GC-FID)...
February 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
Ronald Chow, May Tsao, Natalie Pulenzas, Liying Zhang, Arjun Sahgal, David Cella, Hany Soliman, Cyril Danjoux, Carlo DeAngelis, Sherlyn Vuong, Edward Chow
BACKGROUND: The purpose was to examine the baseline characteristics, symptoms and quality of life (QOL) in patients who receive different treatments for brain metastases. METHODS: Eligible patients were divided and analysed based on their treatment: whole brain radiotherapy (WBRT) alone versus stereotactic radiosurgery (SRS) or neurosurgery with or without WBRT. The Functional Assessment of Cancer Therapy-Brain (FACT-Br) items were grouped according to different domains for summary scores...
January 2016: Annals of Palliative Medicine
Sung-Moon Hong, Eui-Chun Chung, Cheol-Hyun Kim
High-protein fermented whey beverage (FWB) was manufactured using whey protein concentrate (WPC) and Lactobacillus plantarum DK211 isolated from kimchi. This study was designed to evaluate the anti-obesity activity of FWB in male rats fed a high-fat diet. Male Sprague-Dawley rats were randomly assigned to three groups (n=8 per group). The three groups differed in their diet; one group received a normal diet (ND), another, a high-fat diet (HD), and the third, a HD plus fermented whey beverage (HDFWB), for 4 wk...
2015: Korean J Food Sci Anim Resour
Young-Hee Cho, Il-Seung Shin, Sung-Moon Hong, Cheol-Hyun Kim
The aim of this study was to manufacture functional high protein fermented beverage, using whey protein concentrate (WPC) and Lactobacillus plantarum DK211 isolated from kimchi, and to evaluate the physicochemical, functional, and sensory properties of the resulting product. The fermented whey beverage (FWB) was formulated with whey protein concentrate 80 (WPC 80), skim milk powder, and sucrose; and fermented with Lactobacillus plantarum DK211 as single, or mixed with Lactococcus lactis R704, a commercial starter culture...
2015: Korean Journal for Food Science of Animal Resources
Marcelo Filonzi dos Santos, Adrian Yamada, Saskia Carolina Seulin, Vilma Leyton, Carlos Augusto Gonçalves Pasqualucci, Daniel Romero Muñoz, Mauricio Yonamine
In forensic bioanalytical methods, there is a general agreement that calibrators should be prepared by fortifying analytes in matrix-based blank samples (matrix-based). However, in the case of vitreous humor (VH), the collection of blank samples for the validation and for routine analysis would require the availability of many cadavers. Besides the difficulty of obtaining enough blank VH, this procedure could also represent an ethical issue. Here, a study of matrix effect was performed taking into consideration human and bovine vitreous and saline solution (SS) (NaCl 0...
April 2016: Journal of Analytical Toxicology
Jerard Seghatchian, Jeffrey S Putter
The primary resuscitation of severely injured patients, acute haemorrhage and shock-trauma has been well reported in the literature. Resuscitation protocols include the use of diverse agents such as fresh whole blood [FWB], packed red blood cells [PRBCs], reconstituted blood products, fresh frozen plasma [FFP] and its derivative concentrates or recombinant products, volume expanders and tranexamic acid [TXA]. The reasonably prudent use of these agents and products is necessary to reverse risk factors of haemorrhagic shock such as haemodilution, hypothermia, acidosis and coagulopathy...
December 2015: Transfusion and Apheresis Science
Benjamin Movsas, Chen Hu, Jeffrey Sloan, Jeffrey Bradley, Ritsuko Komaki, Gregory Masters, Vivek Kavadi, Samir Narayan, Jeff Michalski, Douglas W Johnson, Christopher Koprowski, Walter J Curran, Yolanda I Garces, Rakesh Gaur, Raymond B Wynn, John Schallenkamp, Daphna Y Gelblum, Robert M MacRae, Rebecca Paulus, Hak Choy
IMPORTANCE: A recent randomized radiation dose-escalation trial in unresectable stage III non-small-cell lung cancer (NSCLC) (Radiation Therapy Oncology Group [RTOG] 0617) showed a lower survival rate in the high-dose radiation therapy (RT) arm (74 Gy) than in the low-dose arm (60 Gy) with concurrent chemotherapy. OBJECTIVE: The primary QOL hypothesis predicted a clinically meaningful decline in quality of life (QOL) via the Functional Assessment of Cancer Therapy (FACT)-Lung Cancer Subscale (LCS) in the high-dose RT arm at 3 months...
March 2016: JAMA Oncology
Irina Kinchin, Susan Jacups, Komla Tsey, Katrina Lines
BACKGROUND: Empowerment programs have been shown to contribute to increased empowerment of individuals and build capacity within the community or workplace. To-date, the impact of empowerment programs has yet to be quantified in the published literature in this field. This study assessed the Indigenous-developed Family Wellbeing (FWB) program as an empowerment intervention for a child safety workforce in remote Indigenous communities by measuring effect sizes. The study also assessed the value of measurement tools for future impact evaluations...
2015: BMC Psychology
N Gutteck, D Wohlrab, A Zeh, F Radetzki, K-S Delank, S Lebek
BACKGROUND: The arthrodesis of the first tarsometatarsal joint has a high correction potential in the treatment of hallux valgus deformity. Compared to distal correction procedures, a pseudarthrosis rate of 12-20% is quoted, however. In a prospective study the results of two different treatment procedures after correction arthrodesis were compared. METHODS: In 17 cases the patients were mobilised with a short arthrodeses shoe with floor contact (NWB group) and in 17 cases in a short arthrodeses shoe with immediate fullweightbearing (FWB group)...
September 2015: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"