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VES-13

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https://www.readbyqxmd.com/read/29126383/predictive-performance-of-four-frailty-screening-tools-in-community-dwelling-elderly
#1
Bienvenu Bongue, Aurélie Buisson, Caroline Dupre, François Beland, Régis Gonthier, Émilie Crawford-Achour
BACKGROUND: This study compares the performance of four frailty screening tools in predicting relevant adverse outcome (disability, institutionalization and mortality) in community-dwelling elderly. METHODS: Our study involved a secondary analysis of data from the FréLE cohort study. We focused on the following four frailty screening tools: the abbreviated Comprehensive Geriatric Assessment (aCGA), the Groningen Frailty Indicator (GFI), the Vulnerable Elders Survey-13 (VES-13) and the Fried scale...
November 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28957686/the-linear-relationship-between-the-vulnerable-elders-survey-13-score-and-mortality-in-an-asian-population-of-community-dwelling-older-persons
#2
Jye Wang, Wender Lin, Ling-Hui Chang
BACKGROUND: The Vulnerable Elders Survey-13 (VES-13) has been used as a screening tool to identify vulnerable community-dwelling older persons for more in-depth assessment and targeted interventions. Although many studies supported its use in different populations, few have addressed Asian populations. The optimal scaling system for the VES-13 in predicting health outcomes also has not been adequately tested. This study (1) assesses the applicability of the VES-13 to predict the mortality of community-dwelling older persons in Taiwan, (2) identifies the best scaling system for the VES-13 in predicting mortality using generalized additive models (GAMs), and (3) determines whether including covariates, such as socio-demographic factors and common geriatric syndromes, improves model fitting...
September 18, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28905751/re-which-better-predicts-mortality-among-older-men-a-prostate-cancer-pca-diagnosis-or-vulnerability-on-the-vulnerable-elders-survey-ves-13-a-retrospective-cohort-study
#3
https://www.readbyqxmd.com/read/28814275/randomized-study-comparing-full-dose-monotherapy-s-1-followed-by-irinotecan-and-reduced-dose-combination-therapy-s-1-oxaliplatin-followed-by-s-1-irinotecan-as-initial-therapy-for-older-patients-with-metastatic-colorectal-cancer-nordic-9
#4
Stine Braendegaard Winther, Pia Österlund, Åke Berglund, Bengt Glimelius, Camilla Qvortrup, Halfdan Sorbye, Per Pfeiffer
BACKGROUND: Metastatic colorectal cancer (mCRC) is a disease of older age, but there is a relative lack of knowledge about effects of chemotherapy in older patients as they are under-represented in clinical trials. Little data can guide whether the strategy in older mCRC patients should be a sequential full-dose monotherapy chemotherapy approach or a dose-reduced combination chemotherapy approach. The oral 5FU prodrug S-1 seems to have less side effects than capecitabine and should be an optimal drug for older patients, but few data are available...
August 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28743505/short-physical-performance-battery-usual-gait-speed-grip-strength-and-vulnerable-elders-survey-each-predict-functional-decline-among-older-women-with-breast-cancer
#5
Cynthia Owusu, Seunghee Margevicius, Mark Schluchter, Siran M Koroukian, Nathan A Berger
OBJECTIVE: To determine the ability of three performance-based measures [Short Physical Performance Battery (SPPB), gait speed, and Grip Strength] and a self-report measure [Vulnerable Elders Survey (VES-13)] to predict functional decline among older women with breast cancer. PATIENTS AND METHODS: Longitudinal data from a study of women ≥65years, with newly diagnosed stages I-III breast cancer, recruited from ambulatory oncology clinics between July 2010 and April 2014, was used...
July 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28602709/factors-associated-with-the-use-of-potentially-inappropriate-medications-by-older-adults-with-cancer
#6
Cristiane Moreira Reis, Andrezza Gouvêa Dos Santos, Paula de Jesus Souza, Adriano Max Moreira Reis
OBJECTIVES: To determine the frequency and the factors associated with the use of potentially inappropriate medications (PIMs) by older adults with cancer at an onco-haematology ambulatory clinic of a teaching hospital in Brazil. MATERIAL AND METHODS: Patients aged 60years or older (n=160) subjected to parenteral antineoplastic chemotherapy from May to December 2015 and treated with one or more medications in the ambulatory clinic were interviewed. Data on medications, comorbidities, oncological diagnosis, and functional status were recorded...
July 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28592379/comprehensive-geriatric-assessment-in-men-aged-70-years-or-older-with-localised-prostate-cancer-undergoing-radical-radiotherapy
#7
G E C Osborne, S A Appleyard, D C Gilbert, C I Jones, C Lorimer, M Villanueva, E Peasgood, A Robinson, A Nikapota, A Ring
AIMS: Treatment decisions for men aged 70 years or over with localised prostate cancer need to take into account the risk of death from competing causes and fitness for the proposed treatment. Objective assessments such as those included in a comprehensive geriatric assessment (CGA) might help to inform the decision-making process. The aim of this study was to describe the CGA scores of a cohort of older men with prostate cancer, evaluate potential screening tools in this population and assess whether any CGA component predicts significant acute radiotherapy toxicity...
September 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28471574/frailty-transitions-in-community-dwelling-older-people
#8
Netta Bentur, Shelley A Sternberg, Jennifer Shuldiner
BACKGROUND: Frailty is a dynamic process with transitions over time. OBJECTIVES: To examine frailty transitions and their relationship to utilization of health services. METHODS: Frailty status using the Vulnerable Elders Survey (VES-13) was determined for 608 community-dwelling older people interviewed in a 2008 national survey and for 281 re-interviewed in 2014. The effect of frailty on death 6 years later was assessed using Cox proportional hazards analysis...
August 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28400051/frailty-and-vulnerability-as-predictors-of-radiotoxicity-in-older-adults-a-longitudinal-study-in-peru
#9
Fernando M Runzer-Colmenares, Diego Urrunaga-Pastor, Luis G Aguirre, C Mahony Reategui-Rivera, José F Parodi, Alvaro Taype-Rondan
BACKGROUND AND OBJECTIVE: To assess the association between frailty/vulnerability and the development of radiotoxicity in older adults at a hospital in Peru. MATERIAL AND METHODS: Cohort study that included patients with cancer with medical recommendation of radiotherapy, who attended the outpatient department of geriatrics at Naval Medical Center (Lima, Peru) between 2013 and 2015. Before receiving radiation therapy sessions, we measured frailty using Fried phenotype, and vulnerability using VES-13 and G-8 scales...
October 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28369691/adapting-the-vulnerable-elders-survey-13-to-predict-mortality-using-responses-to-the-medicare-health-outcomes-survey
#10
Megan K Beckett, Marc N Elliott, Douglas Ritenour, Laura A Giordano, Susan C Grace, Rochelle Malinoff, Debra Saliba
OBJECTIVES: To use items from the Medicare Health Outcomes Survey (HOS) to adapt or validate a simple method for identifying community-dwelling older adults at greater risk of death and to extend the method to identify a very high-risk group. DESIGN: Analysis of longitudinal data. SETTING: National sample of beneficiaries from Medicare Advantage plans with 500 or more enrollees. PARTICIPANTS: Medicare beneficiaries aged 65 and older responding to 2009 baseline and 2011 follow-up HOS (N = 238,687)...
May 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28327973/modeling-individual-and-relative-accuracy-of-screening-tools-in-geriatric-oncology
#11
C A Bellera, F Artaud, M Rainfray, P L Soubeyran, S Mathoulin-Pélissier
Background: Classification probabilities reflect to what degree a screening test represents the true disease state and include true positive (TPF) and false positive fractions (FPF). With two tests, one can compare TPF and FPF using relative probabilities which offer advantages in terms of interpretation and statistical modeling. Our objective was to highlight how individual and relative TPF and FPF can be easily estimated and compared within a regression modeling framework. This allows the modeling of tests' accuracy while adjusting for multiple covariates, and thus provides valuable information in addition to the crude TPF and FPF...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28320329/external-validation-of-the-vulnerable-elder-s-survey-for-predicting-mortality-and-emergency-admission-in-older-community-dwelling-people-a-prospective-cohort-study
#12
Emma Wallace, Ronald McDowell, Kathleen Bennett, Tom Fahey, Susan M Smith
BACKGROUND: Prospective external validation of the Vulnerable Elder's Survey (VES-13) in primary care remains limited. The aim of this study is to externally validate the VES-13 in predicting mortality and emergency admission in older community-dwelling adults. METHODS: Design: Prospective cohort study with 2 years follow-up (2010-2012). SETTING: 15 General Practices (GPs) in the Republic of Ireland. PARTICIPANTS: n = 862, aged ≥70 years, community-dwellers Exposure: VES-13 calculated at baseline, where a score of ≥3 denoted high risk...
March 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/27756545/a-comparison-of-the-carg-tool-the-ves-13-and-oncologist-judgment-in-predicting-grade-3-toxicities-in-men-undergoing-chemotherapy-for-metastatic-prostate-cancer
#13
Shabbir M H Alibhai, Salman Aziz, Tharsika Manokumar, Narhari Timilshina, Henriette Breunis
OBJECTIVE: Since the benefits of chemotherapy in treating older men with metastatic castration-resistant prostate cancer (mCRPC) are modest, validated tools that predict the risk of treatment toxicity may aid clinical decision-making. Whether these tools are better than oncologist judgment remains unclear. We compared the Cancer and Aging Research Group (CARG) tool, the Vulnerable Elders Survey-13 (VES-13), and oncologist judgment in predicting toxicity in men with mCRPC undergoing chemotherapy...
January 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27492449/a-profile-of-four-patterns-of-vulnerability-to-functional-decline-in-older-general-medicine-patients-in-victoria-australia-a-cross-sectional-survey
#14
Lenore Beddoes-Ley, Damien Khaw, Maxine Duke, Mari Botti
BACKGROUND: There are limited published data reporting Australian hospitalized elders' vulnerability to functional decline to guide best practice interventions. The objectives of this study were to describe the prevalence of vulnerability to functional decline and explore profiles of vulnerability related to the performance of physical activity in a representative group of elders in a single centre in Victoria, Australia. METHODS: A cross-sectional survey of patients aged ≥ 70 years (Mean age 82...
August 5, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27480793/which-better-predicts-mortality-among-older-men-a-prostate-cancer-pca-diagnosis-or-vulnerability-on-the-vulnerable-elders-survey-ves-13-a-retrospective-cohort-study
#15
Lisa M Lowenstein, Supriya G Mohile, Heather Hopkins Gil, Chintan Pandya, Joshua Hemmerich, Miriam Rodin, William Dale
OBJECTIVES: Older men with a prostate cancer (PCa) diagnosis face competing mortality risks. Little is known about the prevalence of vulnerability and predictors of mortality in this population compared to men without a PCa diagnosis. We examined the predictive utility of the Vulnerable Elders Survey (VES-13) for mortality in older men with a PCa diagnosis as compared to controls. MATERIALS AND METHODS: Men aged ≥65years from an urban geriatrics clinic completed the VES-13 between 2003 and 2008...
November 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27348765/vulnerable-elders-survey-and-socioeconomic-status-predict-functional-decline-and-death-among-older-women-with-newly-diagnosed-nonmetastatic-breast-cancer
#16
Cynthia Owusu, Seunghee Margevicius, Mark Schluchter, Siran M Koroukian, Kathryn H Schmitz, Nathan A Berger
BACKGROUND: The purpose of this study was to determine the ability of the Vulnerable Elders Survey (VES-13) to predict the composite outcome of functional decline and death within 12 months of breast cancer treatment among women 65 years old or older with newly diagnosed stage I to III breast cancer. METHODS: Two hundred and six participants were recruited from ambulatory oncology clinics at an academic center between April 2008 and April 2013. Participants competed the VES-13 at baseline just before neoadjuvant/adjuvant treatment...
August 15, 2016: Cancer
https://www.readbyqxmd.com/read/27160741/a-questionnaire-study-to-assess-the-value-of-the-vulnerable-elders-survey-g8-and-predictors-of-toxicity-as-screening-tools-for-frailty-and-toxicity-in-geriatric-cancer-patients
#17
Leopold Hentschel, Anke Rentsch, Felicitas Lenz, Beate Hornemann, Jochen Schmitt, Michael Baumann, Gerhard Ehninger, Markus Schuler
BACKGROUND: The aim of this study was to identify an appropriate screening instrument for the identification of frail elderly patients in a tertiary cancer center. In order to improve cancer care for older patients, the use of a geriatric assessment (GA) has been proposed to identify frail patients or those who are at a higher risk for chemotherapy-related toxicities. In busy clinical routine, an appropriate screening instrument could be used to spare time- and resource-consuming application of GA...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/26853769/a-prospective-study-examining-elder-relevant-outcomes-in-older-adults-with-prostate-cancer-undergoing-treatment-with-chemotherapy-or-abiraterone
#18
Tharsika Manokumar, Salman Aziz, Henriette Breunis, S Faraz Rizvi, Anthony M Joshua, Ian F Tannock, Shabbir M H Alibhai
BACKGROUND: Treatment of metastatic castration-resistant prostate cancer (mCRPC) with chemotherapy improves disease control and survival in fit older men (age 65+) but its impact on function is not clear. We hypothesized that chemotherapy would impair daily function in older men with mCRPC. METHODS: Men aged 65+ with mCRPC starting chemotherapy or abiraterone were enrolled in this prospective observational pilot study. Daily function was evaluated with the OARS Instrumental Activities of Daily Living (IADL) scale...
March 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/26779367/how-to-select-elderly-colorectal-cancer-patients-for-surgery-a-pilot-study-in-an-italian-academic-medical-center
#19
Giampaolo Ugolini, Francesco Pasini, Federico Ghignone, Davide Zattoni, Maria Letizia Bacchi Reggiani, Daniele Parlanti, Isacco Montroni
OBJECTIVE: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer (CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or under-treatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC...
December 2015: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/26700296/attitudes-of-older-adults-with-serious-competing-health-risks-toward-their-implantable-cardioverter-defibrillators-a-pilot-study
#20
Ariel R Green, Cynthia M Boyd, John Rickard, Robert Gomon, Bruce Leff
BACKGROUND: In elderly heart failure patients, the survival benefit of implantable cardioverter-defibrillators (ICDs) may be attenuated due to competing health risks, and the risk of adverse outcomes magnified. Our objective was to examine older adults' attitudes towards ICD implantation in the context of competing health risks, exploring the determinants of ICD decision-making among a group of patients who had faced the decision in the past. METHODS: Telephone survey with a qualitative component...
2015: BMC Geriatrics
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