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Ricardo Abdalla

Jefferson Comin Jonco Aquino-Junior, BreAnne MacKenzie, Ana Roberta Almeida-Oliveira, Ana Carolina Martins, Manoel Carneiro Oliveira-Junior, Auriléa Aparecida Britto, Fernanda Magalhaes Arantes-Costa, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Ligeiro de Oliveira, Dioze Guadagnini, Luiz Osorio Leiria, Djalma Rabelo Ricardo, Mario Jose Abdalla Saad, Rodolfo Paula Vieira
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15)...
April 2018: Cytokine
Fausto Feres, Ricardo A Costa, Dimytri Siqueira, J Ribamar Costa, Daniel Chamié, Rodolfo Staico, Áurea J Chaves, Alexandre Abizaid, José Antônio Marin-Neto, Anis Rassi, Roberto Botelho, Cláudia Maria Rodrigues Alves, Jamil Abdalla Saad, José A Mangione, Pedro A Lemos, Alexandre S Quadros, Marcelo A Cartaxo Queiroga, Marcelo J C Cantarelli, Hélio Roque Figueira
No abstract text is available yet for this article.
June 2017: Arquivos Brasileiros de Cardiologia
Marcio C Ferreira, Carlos Eduardo S Franciozi, Marcelo S Kubota, Ricardo D Priore, Sheila J M Ingham, Rene J Abdalla
BACKGROUND: To analyze 2 methods of manual spreader gap assessment accuracy, visual vs blinded, compared with a controlled tensioner in total knee arthroplasty. METHODS: Twenty-two fresh frozen cadaver knees were used to perform total knee arthroplasty by 22 surgeons. Extension and flexion gaps were measured with empirical manual force application with spreaders in 2 different manners: (1) surgeons were blinded to gap geometry formation-blind method group (BM) and (2) surgeons viewed them-viewing method group (VM)...
July 2017: Journal of Arthroplasty
Victor Ricardo Manuel Muñoz Lora, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Cristina Gomes Macedo, Giancarlo de la Torre Canales, Celia Marisa Rizzatti Barbosa
OBJECTIVE: This study aimed to investigate the antinociceptive effects of Botulinum toxin type A (BoNT-A) on persistent inflammatory hypernociception induced by arthritis in the temporomandibular joint (TMJ) of rats. MATERIAL AND METHODS: Wistar rats were induced to persistent inflammatory hypernociception in the left TMJ. Then, animals were treated with intra-TMJ injections of BoNT-A, using doses of 3.5, 7 and 14 U/kg. Saline was used as control group. Behavioral tests were applied to evaluated the effect of BoNT-A in the inflammatory hypernociception...
April 2017: Toxicon: Official Journal of the International Society on Toxinology
Nathalie Ferreira Silva de Melo, Cristina Gomes de Macedo, Ricardo Bonfante, Henrique Ballassini Abdalla, Camila Morais Gonçalves da Silva, Tatiane Pasquoto, Renata de Lima, Leonardo Fernandes Fraceto, Juliana Trindade Clemente-Napimoga, Marcelo Henrique Napimoga
15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has physiological properties including pronounced anti-inflammatory activity, though it binds strongly to serum albumin. The use of solid lipid nanoparticles (SLN) can improve therapeutic properties increasing drug efficiency and availability. 15d-PGJ2-SLN was therefore developed and investigated in terms of its immunomodulatory potential. 15d-PGJ2-SLN and unloaded SLN were physicochemically characterized and experiments in vivo were performed...
2016: PloS One
Rosemeire A Silva, Ricardo J Giordano, Paulo S Gutierrez, Viviane Z Rocha, Martina Rudnicki, Patrick Kee, Dulcinéia S P Abdalla, Pedro Puech-Leão, Bruno Caramelli, Wadih Arap, Renata Pasqualini, José C Meneghetti, Fabio L N Marques, Menka Khoobchandani, Kattesh V Katti, Ademar B Lugão, Jorge Kalil
The purpose of our work was to select phages displaying peptides capable of binding to vascular markers present in human atheroma, and validate their capacity to target the vascular markers in vitro and in low-density lipoprotein receptor knockout (LDLr(-/-)) mouse model of atherosclerosis. By peptide fingerprinting on human atherosclerotic tissues, we selected and isolated four different peptides sequences, which bind to atherosclerotic lesions and share significant similarity to known human proteins with prominent roles in atherosclerosis...
August 24, 2016: International Journal of Molecular Sciences
Moises Cohen, Joicemar Tarouco Amaro, Ricardo de Souza Campos Fernandes, Gustavo Gonçalves Arliani, Diego da Costa Astur, Camila Cohen Kaleka, Abdalla Skaf
OBJECTIVE: The primary aim of this study was to assess the clinical and functional evolution of patients with total-thickness symptomatic cartilaginous injury of the patellar joint surface, treated by means of osteochondral autologous transplantation. METHODS: This prospective study was conducted from June 2008 to March 2011 and involved 17 patients. The specific questionnaires of Lysholm, Kujala and Fulkerson were completed preoperatively and one year postoperatively in order to assess the affected knee, and SF-36 was used to assess these patients' general quality of life...
May 2012: Revista Brasileira de Ortopedia
André Nathan Costa, Rafael Medeiros Carraro, Ellen Caroline Toledo Nascimento, Jose Eduardo Afonso Junior, Silvia Vidal Campos, Priscila Cilene León Bueno de Camargo, Ricardo Henrique de Oliveira Braga Teixeira, Marcos Naoyuki Samano, Lucas Matos Fernandes, Luis Gustavo Abdalla, Marisa Dolhnikoff
No abstract text is available yet for this article.
March 2016: Transplantation
Priscila Cilene León Bueno de Camargo, Ricardo Henrique de Oliveira Braga Teixeira, Rafael Medeiros Carraro, Silvia Vidal Campos, José Eduardo Afonso Junior, André Nathan Costa, Lucas Matos Fernandes, Luis Gustavo Abdalla, Marcos Naoyuki Samano, Paulo Manuel Pêgo-Fernandes
Lung transplantation is a well-established treatment for patients with advanced lung disease. The evaluation of a candidate for transplantation is a complex task and involves a multidisciplinary team that follows the patient beyond the postoperative period. Currently, the mean time on the waiting list for lung transplantation in the state of São Paulo, Brazil, is approximately 18 months. For Brazil as a whole, data from the Brazilian Organ Transplant Association show that, in 2014, there were 67 lung transplants and 204 patients on the waiting list for lung transplantation...
November 2015: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Erik Schadde, Dimitri Aristotle Raptis, Andreas A Schnitzbauer, Victoria Ardiles, Christoph Tschuor, Mickaël Lesurtel, Eddie K Abdalla, Roberto Hernandez-Alejandro, Elio Jovine, Marcel Machado, Massimo Malago, Ricardo Robles-Campos, Henrik Petrowsky, Eduardo De Santibanes, Pierre-Alain Clavien
OBJECTIVES: The aim of this study was to identify predictors of 90-day mortality after Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), available after stage-1, either to omit or delay stage-2. BACKGROUND DATA: ALPPS is a two-stage hepatectomy for patients with extensive liver tumors with predicted small liver remnants, which has been criticized for its high mortality rate. Risk factors for mortality are unknown. METHODS: Patients in the International Registry undergoing ALPPS from April 2011 to July 2014 were analyzed...
November 2015: Annals of Surgery
Patrick H Pun, Safa Abdalla, Geoffrey A Block, Glenn M Chertow, Ricardo Correa-Rotter, Bastian Dehmel, Tilman B Drüeke, Jürgen Floege, William G Goodman, Charles A Herzog, Gerard M London, Kenneth W Mahaffey, Sharon M Moe, Patrick S Parfrey, David C Wheeler, John P Middleton
Among patients receiving hemodialysis, abnormalities in calcium regulation have been linked to an increased risk of cardiovascular events. Cinacalcet lowers serum calcium concentrations through its effect on parathyroid hormone secretion and has been hypothesized to reduce the risk of cardiovascular events. In observational cohort studies, prescriptions of low dialysate calcium concentration and larger observed serum-dialysate calcium gradients have been associated with higher risks of in-dialysis facility or peri-dialytic sudden cardiac arrest...
July 2016: Hemodialysis International
José Eduardo Afonso Júnior, Eduardo de Campos Werebe, Rafael Medeiros Carraro, Ricardo Henrique de Oliveira Braga Teixeira, Lucas Matos Fernandes, Luis Gustavo Abdalla, Marcos Naoyuki Samano, Paulo Manuel Pêgo-Fernandes
Lung transplantation is a globally accepted treatment for some advanced lung diseases, giving the recipients longer survival and better quality of life. Since the first transplant successfully performed in 1983, more than 40 thousand transplants have been performed worldwide. Of these, about seven hundred were in Brazil. However, survival of the transplant is less than desired, with a high mortality rate related to primary graft dysfunction, infection, and chronic graft dysfunction, particularly in the form of bronchiolitis obliterans syndrome...
April 2015: Einstein
Sharon M Moe, Safa Abdalla, Glenn M Chertow, Patrick S Parfrey, Geoffrey A Block, Ricardo Correa-Rotter, Jürgen Floege, Charles A Herzog, Gerard M London, Kenneth W Mahaffey, David C Wheeler, Bastian Dehmel, William G Goodman, Tilman B Drüeke
Fractures are frequent in patients receiving hemodialysis. We tested the hypothesis that cinacalcet would reduce the rate of clinical fractures in patients receiving hemodialysis using data from the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events trial, a placebo-controlled trial that randomized 3883 hemodialysis patients with secondary hyperparathyroidism to receive cinacalcet or placebo for ≤64 months. This study was a prespecified secondary analysis of the trial whose primary end point was all-cause mortality and non-fatal cardiovascular events, and one of the secondary end points was first clinical fracture event...
June 2015: Journal of the American Society of Nephrology: JASN
David C Wheeler, Gerard M London, Patrick S Parfrey, Geoffrey A Block, Ricardo Correa-Rotter, Bastian Dehmel, Tilman B Drüeke, Jürgen Floege, Yumi Kubo, Kenneth W Mahaffey, William G Goodman, Sharon M Moe, Marie-Louise Trotman, Safa Abdalla, Glenn M Chertow, Charles A Herzog
BACKGROUND: Premature cardiovascular disease limits the duration and quality of life on long-term hemodialysis. The objective of this study was to define the frequency of fatal and nonfatal cardiovascular events attributable to atherosclerotic and nonatherosclerotic mechanisms, risk factors for these events, and the effects of cinacalcet, using adjudicated data collected during the EValuation of Cinacalcet HCl Therapy to Lower CardioVascular Events (EVOLVE) Trial. METHODS AND RESULTS: EVOLVE was a randomized, double-blind, placebo-controlled clinical trial that randomized 3883 hemodialysis patients with moderate to severe secondary hyperparathyroidism to cinacalcet or matched placebo for up to 64 months...
November 17, 2014: Journal of the American Heart Association
Mariana Silva Quinteiro, Marcelo Henrique Napimoga, Cristina Gomes Macedo, Fabiana Furtado Freitas, Henrique Balassini Abdalla, Ricardo Bonfante, Juliana Trindade Clemente-Napimoga
The aim of this study was to evaluate the peripheral effect of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) in albumin-induced arthritis in temporomandibular joint (TMJ) of rats. Antigen-induced arthritis (AIA) was generated in rats with methylated bovine serum albumin (mBSA) diluted in complete Freund׳s adjuvant. Pretreatment with an intra-articular injection of 15d-PGJ2 (100 ng/TMJ) before mBSA intra-articular injection (10 µg/TMJ) (challenge) in immunized rats significantly reduced the albumin-induced arthritis inflammation...
October 5, 2014: European Journal of Pharmacology
Ricardo Zugaib Abdalla, Rodrigo Biscuola Garcia, Danniel Frade Said, Beatrice Martinez Zugaib Abdalla
BACKGROUND: The laparoscopic ventral hernia repair technique made possible surgeries with smaller skin incisions and smaller dissection of the soft tissue around the hernia, therefore with a better wound, a quicker postoperative recovery and a lower complication rate. AIM: To evaluate the applicability of a quality of life survey based on the molds of the American Hernia Society, European Hernia Society and Carolinas Equation for Quality of Life, through telephone in patients submitted to laparoscopic hernioplasty by IPOM technique...
January 2014: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Ricardo Zugaib Abdalla, Rodrigo Biscuola Garcia, Rafael Izar Domingues da Costa, Beatrice Martinez Zugaib Abdalla
INTRODUCTION: Minimally invasive videosurgery has modified anatomy dissection of diseases that are treated operatively. However, the benefit of this method has been delayed due to the lack of development of technologies and articulated movements for the abdominal wall, demanding the need for investments and time for solidification. This approach to repair the abdominal wall is based on the Rives-Stoppa principles. TECHNIQUE: With the patient in supine position, a small supra pubic incision is done and the pre-peritoneal space is achieved and inflated...
November 2013: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Ricardo Zugaib Abdalla, Marcelo Averbach, Ulysses Ribeiro-Junior, Marcel Autran Cerqueira Machado, Cláudio Renato Penteado de Luca-Filho
BACKGROUND: Robotic brought to laparoscopy the enrichment of movements, the easy to perform maneuvers and procedures, visualization in three dimensions, and ergonomics for the surgeon. AIM: To describe Brazilian experience with robotically-assisted abdominal surgery. METHODS: From July 2008 to April 2010, patients were admitted for abdominal surgery and agreed to being operated with the help of the robot by a trained medical staff. All patients were operated by the same surgical robotic approach...
July 2013: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Márcia Pereira Bueno, Frances Lilian Lanhellas Gonçalves, Dioze Guadagnini, Ricardo Barini, Mario José Abdalla Saad, Rodrigo Melo Gallindo, Augusto Frederico Schmidt, Lourenço Sbragia
PURPOSE: To evaluate the intrauterine growth restriction (IUGR) by the expression of IR-β, IRS-1, IRS-2, IGF-IRβ and Ikappaβ in experimental model of gastroschisis. METHODS: Pregnant rats at 18.5 days of gestation were submitted to surgery to create experimental fetal gastroschisis (term = 22 days) were divided in three groups: gastroschisis (G), control (C) and sham (S). Fetuses were evaluated for body weight (BW), intestinal (IW), liver (LW) and their relations IW/BW and LW/BW...
2013: Acta Cirúrgica Brasileira
Ricardo Zugaib Abdalla, Rodrigo Biscuola Garcia, Rafael Izar Domingues da Costa, Claudio Renato Penteado de Luca, Beatrice Martinez Zugaib Abdalla
BACKGROUND: The weakness of the linea alba can be caused by congenital and aquired factors. The conventional procedure to correct these imperfections generally involve large incisions with big detachments of the skin and subcutaneous tissue. The use of videosurgery for the repair of these weaknesses is still controversy. AIM: To describe a new procedure using robotics in the repair of the linea alba, associating minimally invasive tecniques by Rives/Stoppa and component separation tecniques...
April 2012: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
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