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https://www.readbyqxmd.com/read/29775916/cortisol-trajectory-melancholia-and-response-to-electroconvulsive-therapy
#1
Brian J Mickey, Yarden Ginsburg, Adam F Sitzmann, Clara Grayhack, Srijan Sen, Clemens Kirschbaum, Daniel F Maixner, James L Abelson
While biomarkers have been used to define pathophysiological types and to optimize treatment in many areas of medicine, in psychiatry such biomarkers remain elusive. Based on previously described abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function in severe forms of depression, we hypothesized that the temporal trajectory of basal cortisol levels would vary among individuals with depression due to heterogeneity in pathophysiology, and that cortisol trajectories that reflect elevated or increasing HPA activity would predict better response to electroconvulsive therapy (ECT)...
May 15, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29728692/nationwide-analysis-of-the-relationships-between-mental-health-body-mass-index-and-tinnitus-in-premenopausal-female-adults-in-korea-2010-2012-knhanes
#2
Dong-Hee Lee, Young Soo Kim, Hiun Suk Chae, Kyungdo Han
Tinnitus is related to serious comorbidities such as suicidal ideation and attempts. Body mass index (BMI) is associated with auditory symptoms including hearing loss. The aim of this nationwide, population-based, cross-sectional study was to evaluate the relationship between mental health, body mass index and tinnitus in a Korean premenopausal female population. This study analyzed data from the Korea National Health and Nutrition Examination Surveys in 2010-2012. Data were collected from 4628 19 years or older, premenopausal women...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29707086/epigenetics-of-metabolic-syndrome-as-a-mood-disorder
#3
REVIEW
Sermin Kesebir
Mood disorders comprise major depressive disorder (MDD), bipolar disorder (BD) and the milder forms of these two disorders. Reccurring MDD is also known as unipolar disorder. The distinction between unipolar and bipolar disorders was first suggested in 1957 by Leonard and was made official after support by several studies in 1980. Indeed, in 150 AD, Aretaeus of Cappadocia wrote "It seems to me that melancholia is the beginning and a part of mania". Additionally, Kraepelin, who proposed the first medical disease model in psychiatry a century ago, considered recurrent unipolar depression cases under the category of bipolar disorder and conceptualized spectrum disorders...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29702301/a-quantitative-review-on-outcome-to-antidepressants-in-melancholic-unipolar-depression
#4
REVIEW
Marina P Valerio, Alejandro G Szmulewicz, Diego J Martino
The aim of this study was to explore outcome to antidepressants profile in melancholic unipolar depression. We conducted a systematic review of electronic databases and meta-analysis of randomized and nonrandomized trials comparing: 1) outcome to antidepressants and placebo between melancholic and non-melancholic depression; 2) outcome to different antidepressant classes in melancholic depression. Two outcomes were considered: clinical remission and response. Significant lower odds of remission to antidepressants in melancholic than in non-melancholic depressions were found...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29672517/white-matter-alterations-in-the-internal-capsule-and-psychomotor-impairment-in-melancholic-depression
#5
Matthew P Hyett, Alistair Perry, Michael Breakspear, Wei Wen, Gordon B Parker
Emerging evidence suggests that structural brain abnormalities may play a role in the pathophysiology of melancholic depression. We set out to test whether diffusion-derived estimates of white matter structure were disrupted in melancholia in regions underpinning psychomotor function. We hypothesized that those with melancholia (and evidencing impaired psychomotor function) would show disrupted white matter organization in internal capsule subdivisions. Diffusion magnetic resonance imaging (dMRI) data were acquired from 22 melancholic depressed, 23 non-melancholic depressed, and 29 healthy control participants...
2018: PloS One
https://www.readbyqxmd.com/read/29660788/melancholia-and-cancer-the-bladder-cancer-narrative
#6
EDITORIAL
Andres F Correa, Marc C Smaldone
No abstract text is available yet for this article.
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29652947/-predictors-of-remission-from-major-depressive-disorder-in-secondary-care
#7
Lilian Salvo, Sandra Saldivia, Carlos Parra, Manuel Cifuentes, Claudio Bustos, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
Background The knowledge of predictive factors in depression should help to deal with the disease. Aim To assess potential predictors of remission of major depressive disorders (MDD) in secondary care and to propose a predictive model. Material and Methods A 12 month follow-up study was conducted in a sample of 112 outpatients at three psychiatric care centers of Chile, with baseline and quarterly assessments. Demographic, psychosocial, clinical and treatment factors as potential predictors, were assessed. A clinical interview with the checklist of DSM-IV diagnostic criteria, the Hamilton Depression Scale and the List of Threatening Experiences and Multidimensional Scale of Perceived Social Support were applied...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29652306/-assessment-of-clinical-manifestations-and-treatment-of-post-stroke-depression-in-young-patients-with-ischemic-stroke
#8
M L Chukhlovina, A A Chukhlovin
AIM: To consider clinical manifestations and treatment of post-stroke depression in young patients with carotid ischemic stroke. MATERIAL AND METHODS: Forty patients, 24 women and 16 men, aged from 18 to 45 years old, diagnosed with ICD-10 post-stroke depression were examined. All patients underwent neurological examination, brain MRI and MR-angiography of cerebral vessels. The following psychometric tests were used: MMSE, Hamilton depression scale, CES-D depression scale, a questionnaire on nocturnal sleep assessment, and Epworth Sleepiness Scale...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29619634/add-on-treatment-with-n-acetylcysteine-for-bipolar-depression-a-24-week-randomized-double-blind-parallel-group-placebo-controlled-multicentre-trial-nacos-study-protocol
#9
Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi, Connie Thuroee Nielsen
BACKGROUND: Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depressive episodes, especially compared with the efficacy of treatment for acute mania. N-Acetylcysteine (NAC) has been explored for psychiatric disorders for some time given its antioxidant and anti-inflammatory properties. The current trial aims at testing the clinical effects of adjunctive NAC treatment (compared to placebo) for bipolar depression...
April 5, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29613946/clinical-predictors-of-response-to-magnetic-seizure-therapy-in-depression-a-preliminary-report
#10
Sarah Kayser, Bettina H Bewernick, Stefanie Wagner, Thomas E Schlaepfer
OBJECTIVES: Magnetic seizure therapy (MST) is a novel convulsive brain stimulation method in clinical testing, which is used as an alternative for electroconvulsive therapy in patients with treatment-resistant depression (TRD). Preliminary studies have suggested that MST leads to fewer cognitive adverse effects than electroconvulsive therapy but has similar efficacy. However, the clinical predictors of response to MST have not been evaluated yet. This study aimed to investigate whether these predictors can be identified in patients with TRD...
April 2, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29604382/the-role-of-depressive-subtypes-within-the-neuroinflammation-hypothesis-of-major-depressive-disorder
#11
Marie Woelfer, Vanessa Kasties, Sascha Kahlfuss, Martin Walter
Major depressive disorder (MDD) is a very common disease that affects more than 350 million people worldwide, representing an enormous socioeconomic burden. From a clinical perspective, MDD can be divided into different subtypes, such as melancholic or atypical MDD. Interestingly, increasing evidence points towards an involvement of the immune system in MDD pathogenesis. However, inflammation does not seem to have the same impact on every MDD type. Here, we describe how inflammation can affect monoaminergic and glutamatergic neurotransmission, which provides a possible mechanism for MDD onset...
March 28, 2018: Neuroscience
https://www.readbyqxmd.com/read/29554991/historical-precedents-for-the-dsm-iii-bereavement-exclusion-criteria-for-major-depression
#12
Kenneth S Kendler
BACKGROUND: I review the historical antecedents of the two key features of the bereavement exclusion (BE) for major depression (MD) criteria initially proposed in DSM-III: (i) a context-dependent approach to the evaluation of MD which required that the diagnosis be given only when course, symptoms and signs are 'out of proportion' to experienced adversities, and (ii) bereavement is the sole adversity for which this context-dependent approach should be utilized. METHODS: A review of 49 textbook and review articles on depression or melancholia published 1880-1960...
March 20, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29548306/psychopathological-and-sociodemographic-features-in-treatment-resistant-unipolar-depression-versus-bipolar-depression-a-comparative-study
#13
Nicolas A Nuñez, Stefano Comai, Eduard Dumitrescu, Maykel F Ghabrash, John Tabaka, Marie Saint-Laurent, Stephen Vida, Theodore Kolivakis, Allan Fielding, Nancy Low, Pablo Cervantes, Linda Booij, Gabriella Gobbi
BACKGROUND: Some authors have hypothesized that Treatment-Resistant Unipolar Depression (TRD-UP) should be considered within the bipolar spectrum disorders and that hidden bipolarity may be a risk factor for TRD-UP. However, there are neither studies comparing clinical and sociodemographic data of patients with TRD-UP versus Bipolar (BP) disorders nor are there any examining differences versus Bipolar type I (BP-I) and Bipolar type II (BP-II). METHODS: Charts analysis was conducted on 194 patients followed at the Mood Disorders Clinic of the McGill University Health Center...
March 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29529482/depression-the-search-for-separable-behaviors-and-circuits
#14
REVIEW
Ryan J Post, Melissa R Warden
Major depressive disorder can manifest as different combinations of symptoms, ranging from a profound and incapacitating sadness, to a loss of interest in daily life, to an inability to engage in effortful, goal-directed behavior. Recent research has focused on defining the neural circuits that mediate separable features of depression in patients and preclinical animal models, and connections between frontal cortex and brainstem neuromodulators have emerged as candidate targets. The development of methods permitting recording and manipulation of neural circuits defined by connectivity has enabled the investigation of prefrontal-neuromodulatory circuit dynamics in animal models of depression with exquisite precision, a systems-level approach that has brought new insights by integrating these fields of depression research...
April 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29522944/inflammatory-markers-and-cortisol-parameters-across-depressive-subtypes-in-an-older-cohort
#15
REVIEW
E M Veltman, F Lamers, H C Comijs, M L Stek, R C van der Mast, D Rhebergen
BACKGROUND: There is growing evidence that inflammatory and cortisol dysregulation are underlying pathophysiological mechanisms in the aetiology of major depressive disorder, particularly in younger adults. However, findings of biological disturbances in late-life depression have been divergent, probably due to the even greater heterogeneity of depression in older adults with aging processes influencing biological factors. Using empirically derived subtypes may enable the identification of biological disturbances underlying depression in older adults...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29516593/lower-levels-of-brain-derived-neurotrophic-factor-are-associated-with-melancholic-psychomotor-retardation-among-depressed-inpatients
#16
Lucas Primo de Carvalho Alves, Neusa Sica da Rocha
OBJECTIVES: Melancholic depression is a type of depression which is closely related to biological variables than are other types of depression. Its clinical features can be assessed using six items on the Hamilton Depression Rating Scale (HAM-D6 ). Previous studies have shown, using item response theory, that the symptom depressed mood is the least severe melancholic feature; work and activities, somatic symptoms and psychic anxiety are of moderate severity; and feelings of guilt and psychomotor retardation are the most severe...
March 8, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29505804/outcome-of-a-three-phase-treatment-algorithm-for-inpatients-with-melancholic-depression
#17
Marlijn Vermeiden, Astrid M Kamperman, Witte J G Hoogendijk, Walter W van den Broek, Tom K Birkenhäger
BACKGROUND: In patients suffering from major depressive disorder, non-response to initial antidepressant monotherapy is relatively common. The use of treatment algorithms may optimize and enhance treatment outcome. METHODS: A single-center 3-phase treatment algorithm was evaluated for inpatients with major depressive disorder, i.e. phase I (n = 85): 7 weeks optimal antidepressant monotherapy (imipramine or venlafaxine); phase II (n = 39): 4 weeks subsequent plasma level-targeted dose lithium addition in case of insufficient improvement of antidepressant monotherapy; and phase III (n = 8): subsequent electroconvulsive therapy in case of insufficient improvement of antidepressant‑lithium treatment...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29502785/exploring-the-path-to-death-through-barnes-s-older-characters-between-irony-and-melancholic-meditation
#18
Maricel Oró-Piqueras
This article aims at analysing four of Julian Barnes's novels with protagonists either entering or in their old age in order to discern to what extent conceptions of ageing, old age and death are depicted in Barnes's fiction and develop throughout his writing career. Barnes's memoir Nothing to Be Frightened Of (2008) will also be central in the discussion, since, in it, the author reflects on conceptions of old age and death from different philosophers and authors intermingling them with his own personal experience and that of his family, specially his parents...
March 2018: Journal of Aging Studies
https://www.readbyqxmd.com/read/29498147/subtypes-of-depression-and-their-overlap-in-a-naturalistic-inpatient-sample-of-major-depressive-disorder
#19
Richard Musil, Florian Seemüller, Sebastian Meyer, Ilja Spellmann, Mazda Adli, Michael Bauer, Klaus-Thomas Kronmüller, Peter Brieger, Gerd Laux, Wolfram Bender, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Rebecca Schennach, Hans-Jürgen Möller, Michael Riedel
Subtyping depression is important in order to further delineate biological causes of depressive syndromes. The aim of this study was to evaluate clinical and outcome characteristics of distinct subtypes of depression and to assess proportion and features of patients fulfilling criteria for more than one subtype. Melancholic, atypical and anxious subtypes of depression were assessed in a naturalistic sample of 833 inpatients using DSM-IV specifiers based on operationalized criteria. Baseline characteristics and outcome criteria at discharge were compared between distinct subtypes and their overlap...
March 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29497189/psychiatric-morbidity-among-female-commercial-sex-workers
#20
Marboh Goretti Iaisuklang, Arif Ali
Context: Psychological distress is higher in women working in sex industry. The various psycho social issues are associated with female commercial sex workers (FCSWs). The host of psychosocial vulnerabilities including, childhood sexual abuse, exposure to childhood physical abuse, poverty, interpersonal violence in adulthood, sexually transmitted diseases, and substance use, forms a fertile ground for psychiatric morbidity. Aim: This study aims to assess the psychiatric morbidity among FCSWs in Shillong, India...
October 2017: Indian Journal of Psychiatry
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