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https://www.readbyqxmd.com/read/29251178/putamen-volume-differences-among-older-adults-depression-status-melancholia-and-age
#1
Natalie J Sachs-Ericsson, Greg Hajcak, Julia L Sheffler, Ian H Stanley, Edward A Selby, Guy G Potter, David C Steffens
BACKGROUND: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigated striatal volume differences in older adults and by depression subtypes. METHOD: We used baseline data from the Neurocognitive Outcomes of Depression in the Elderly study. We examined volumetric differences in the putamen and caudate nucleus among older adults (60 years and older), comparing healthy control participants (n = 134) to depressed participants (n = 226), and comparing nonmelancholic depressed participants (n = 93) to melancholic depressed participants (n = 133)...
January 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29247900/risk-factors-for-recurrence-in-depression-in-the-lundby-population-1947-1997
#2
Linnéa Nöbbelin, Mats Bogren, Cecilia Mattisson, Louise Brådvik
BACKGROUND: Depression is a common disorder in both men and women, and the recurrence rate is high. The aim of this study was to identify risk factors for recurrence in depression in the Lundby Study. METHODS: The Lundby Study is a community-based longitudinal study with focus on mental health. The study started in 1947 and three follow-ups have been carried out since, the last one in 1997. The population consists of 3563 subjects. Data from 508 subjects afflicted by depression was gathered...
November 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29218020/peripheral-immune-alterations-in-major-depression-the-role-of-subtypes-and-pathogenetic-characteristics
#3
Frank Euteneuer, Katharina Dannehl, Adriana Del Rey, Harald Engler, Manfred Schedlowski, Winfried Rief
Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseline data from the Outcome of Psychological Interventions in Depression trial, this exploratory study examines associations between depression subtypes and pathogenetic characteristics (i.e., melancholic vs non-melancholic depression, chronic vs non-chronic depression, age of onset, cognitive-affective and somatic symptom dimensions) with plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and numbers of leukocyte subpopulations in 98 patients with major depression (MD) and 30 age and sex-matched controls...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29197929/transdiagnostic-symptom-clusters-and-associations-with-brain-behavior-and-daily-function-in-mood-anxiety-and-trauma-disorders
#4
Katherine A Grisanzio, Andrea N Goldstein-Piekarski, Michelle Yuyun Wang, Abdullah P Rashed Ahmed, Zoe Samara, Leanne M Williams
Importance: The symptoms that define mood, anxiety, and trauma disorders are highly overlapping across disorders and heterogeneous within disorders. It is unknown whether coherent subtypes exist that span multiple diagnoses and are expressed functionally (in underlying cognition and brain function) and clinically (in daily function). The identification of cohesive subtypes would help disentangle the symptom overlap in our current diagnoses and serve as a tool for tailoring treatment choices...
December 3, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29184205/an-opening-for-humor-in-melancholy
#5
E David Leonardo, Alex Dranovsky
No abstract text is available yet for this article.
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29182201/-indian-humor-in-medical-knowledge-during-the-16th-and-17th-centuries
#6
Germán Morong R, Víctor Brangier P
During the first Modern Era (15th-17th c.), bodily health and expressions of physiognomy were explained under the doctrine of humors. This doctrine -based on Corpus Hipocraticum-established a close relation between humors (blood, yellow bile, phlegm, and black bile), qualities (dry, moist, warm, and cold) and the elements (water, air, earth, and fire). One of these humors -black bile-, commonly a hallmark of the melancholic temperament, was associated to the complexion and nature of American Indians. This accusation was legitimized by the empirical examination of the physiognomy of a subject that was melancholic, sad and pusillanimous...
July 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29167049/does-the-presence-of-multiple-sclerosis-impact-on-symptom-profile-in-depressed-patients
#7
Rosa E Boeschoten, Roxanne Schaakxs, Joost Dekker, Bernard M J Uitdehaag, Aartjan T F Beekman, Johannes H Smit, Brenda W J H Penninx, Patricia van Oppen
OBJECTIVE: Major depressive disorder (MDD) is common in patients with multiple sclerosis (MS) but may remain unrecognized because of overlapping symptoms and different presentation due to its specific MS-related neurobiological aetiology. We aimed to investigate the clinical profile of MDD in MS. METHODS: In a sample of MDD patients with MS (n=83) and without MS (n=782), MDD characteristics, 30 depressive symptoms, and sum scores of cognitive, somatic, atypical and melancholic symptom clusters were compared using logistic regression analyses and analysis of co-variance...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29153629/elevated-fingernail-cortisol-levels-in-major-depressive-episodes
#8
Andres Herane-Vives, Susanne Fischer, Valeria de Angel, Toby Wise, Eric Cheung, Kia-Chong Chua, Danilo Arnone, Allan H Young, Anthony J Cleare
BACKGROUND: The extent to which cortisol levels are elevated in major depressive episodes (MDE), and hence could act as a biomarker of illness, remains unclear. Although patient characteristics may explain some of this variation - for example elevated cortisol being more often found in patients with severe, psychotic or melancholic depression - problems with the methods used to measure cortisol may also have contributed to the inconsistent findings. Fingernails are a novel sample that can be used to assess aggregate cortisol concentrations over a 15-day period, and may provide a more accurate reflection of longer term cortisol level changes in MDE and help clarify this issue...
November 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29150144/atypical-depression-and-non-atypical-depression-is-hpa-axis-function-a-biomarker-a-systematic-review
#9
REVIEW
Mario F Juruena, Mariia Bocharova, Bruno Agustini, Allan H Young
BACKGROUND: The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29135134/treating-the-incurables-cancer-asylums-in-18th-and-19th-century
#10
Marianna Karamanou, Theodora Psaltopoulou, Kostas Markatos, Georgios Karaoglanis, George Androutsos
For centuries several hypotheses were formulated on cancer's pathogenesis such as contagiousness, melancholy, heredity and sexuality. In the 18th and 19th century, despite the advent of medical thought and practice, cancer was considered an incurable and contagious disease. Hospitals were refusing to treat cancer patients while the social stigma which followed the disease made primordial the need for the establishment of special institutions. In our article we will present the cancer asylums which counterbalanced the prejudices of the time and contributed to the establishment of modern cancer hospitals...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29103192/lipid-peroxidation-and-immune-biomarkers-are-associated-with-major-depression-and-its-phenotypes-including-treatment-resistant-depression-and-melancholia
#11
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
To examine immune-inflammatory and oxidative (I&O) biomarkers in major depression (MDD) and its related phenotypes, we recruited 114 well-phenotyped depressed patients and 50 healthy controls and measured serum levels of interleukin (IL)-1α, soluble IL-1 receptor antagonist (sIL-1RA), soluble IL-2 receptor (sIL-2R), soluble IL-6 receptor (sIL-6R), soluble tumor necrosis factor receptor 60 and 80 kDa (sTNF-R1/R2), and thiobarbituric acid reactive substances (TBARS). Obtained results indicate that MDD is characterized by increased sIL-1RA, sTNF-R1, and TBARS concentrations...
November 4, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29079491/biological-research-on-burnout-depression-overlap-long-standing-limitations-and-on-going-reflections
#12
Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent
In this commentary, we discuss seldom-noticed methodological problems affecting biological research on burnout and depression and make recommendations to overcome the limitations of past studies conducted in this area. First, we suggest that identified subtypes of depression (e.g., depression with melancholic features and depression with atypical features) should be taken into account in future biological research on burnout and depression, given that different subtypes of depression have been associated with distinct autonomic and neuroendocrine profiles...
October 25, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29055250/clinical-characteristics-of-patients-with-diagnostic-uncertainty-of-major-depressive-disorder
#13
Taichi Mogi, Hiroyuki Toda, Aihide Yoshino
BACKGROUND: Physicians do not always confidently diagnose psychiatric disorders. The present study was conducted to identify the clinical characteristics of patients in whom a definitive diagnosis of major depressive disorder (MDD) could not be established. METHODS: The participants were 199 consecutive outpatients with MDD, who were comprehensively diagnosed using the Mini International Neuropsychiatric Interview (MINI). The physician in charge of each patient quantified his/her sense of self-confidence in diagnosing the patient with MDD using the self-rating questionnaire in which the score ranged from 1 (not at all confident) to 5 (definitely MDD)...
October 16, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29042881/clinical-validation-of-the-psychotic-depression-assessment-scale-hamilton-depression-rating-scale-6-and-brief-psychiatric-rating-scale-5-results-from-the-clinical-research-center-for-depression-study
#14
Seon-Cheol Park, Eun Young Jang, Jae-Min Kim, Tae-Youn Jun, Min-Soo Lee, Jung-Bum Kim, Hyeon-Woo Yim, Yong Chon Park
OBJECTIVE: The aim of this study was to validate the psychotic depression assessment scale (PDAS), which includes the six-item melancholia subscale from the Hamilton depression rating scale (HAMD-6) and the five-item psychosis subscale from the brief psychiatric rating scale (BPRS-5). Data from the Clinical Research Center for Depression (CRESCEND) study, which is a 52-week naturalistic trial, were analyzed. METHODS: Fifty-two patients with psychotic depression from the CRESCEND study met our inclusion criteria...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29033570/atypical-depression-current-perspectives
#15
REVIEW
Dorota Łojko, Janusz K Rybakowski
The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with atypical feature is present for both diagnostic groups, that is, depressive disorders and bipolar and related disorders. This specifier includes mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29022850/the-devolution-of-melancholia-into-psychosis-the-case-of-a-child-whose-mother-was-unable-to-grieve
#16
Yaakov Roitman
The author explores the intersubjective aspect of the devolution of melancholia into psychosis, particularly as it involves the unconscious intersubjective role of the mother. The author considers the possibility that maternal inability to mourn contributes significantly to the foreclosure of the child's "tertiary processes" (the processes involved in the child's development of a differentiated autonomous self and symbolization). In the clinical case presented in detail in this paper, the child's undifferentiated experience with his mother (who was unable to grieve) left no room for the father as the necessary third element in the child's maturational processes...
October 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/29022214/two-new-species-of-trouessartia-canestrini-1899-astigmata-trouessartiidae-from-passeriform-birds-in-brazil
#17
Fabio A Hernandes
Two new feather mite species of the genus Trouessartia Canestrini, 1899 (Analgoidea: Trouessartiidae) are described from passerines (Aves: Passeriformes) in Brazil: T. calcealgiana n. sp. from Philydor atricapillus (Wied) (Furnariidae), and T. gigaphallus n. sp. from Tyrannus melancholicus Vieillot (Tyrannidae). Both species have unique features, such as the large hook-like seta sR on trochanters III in T. calcealgiana, and the large male genitalia in T. gigaphallus, which are at least twice as long as normally found in most species of Trouessartia...
November 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28990833/prevalence-of-restless-legs-symptoms-according-to-depressive-symptoms-and-depression-type-a-cross-sectional-study
#18
Piritta Auvinen, Pekka Mäntyselkä, Hannu Koponen, Hannu Kautiainen, Katariina Korniloff, Tiina Ahonen, Mauno Vanhala
BACKGROUND: Restless legs syndrome is a sensorimotor disorder and it is associated with several other diseases especially mental illnesses. AIMS: To analyze the relationship between the symptoms of restless legs syndrome and the severity of depressive symptoms and the prevalence of restless legs symptoms in depression subtypes. METHODS: A cross-sectional study of primary care patients in the Central Finland Hospital District. The prevalence of restless legs symptoms was studied in 706 patients with increased depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire...
October 9, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28987022/debate-on-defining-melancholia-a-core-mood-disorder
#19
Lucas Primo de Carvalho Alves, Neusa Sica da Rocha
OBJECTIVES: Recently, a debate article by Parker et al. was published regarding the biological type of depression, melancholia, in which they discussed its clinical presentation, particularly that involving psychomotor disturbances. However, there is one feature of melancholia that is frequently forgotten, to which this article aims to devote special attention: ruminative thoughts of guilt. METHODS: A critical review of the literature. RESULTS: The symptom of ruminative thoughts of guilt has been described historically in melancholia, and some recent data, such as neurobiological abnormalities and poor prognosis, support it as an important feature of depression...
October 7, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28980139/evidence-of-depression-associated-circadian-rhythm-disruption-and-regret-in-prostate-cancer-patients-after-surgery
#20
Joanne Christie, Christopher F Sharpley, Vicki Bitsika, David Christie
PURPOSE: The purpose of this study is to investigate the association between prostate cancer (PCa) patients' regret that their surgery harmed them, and their scores on the two key symptoms of major depressive disorder (depressed mood, anhedonia) and a symptom of melancholic depression (disruption to circadian rhythm). METHODS: Forty PCa patients who had received surgery for their PCa completed a postal survey including background information, regret about surgery that 'did them a lot of harm' and three items drawn from the Zung Self-Rating Depression Scale measuring depressed mood, anhedonia and circadian rhythm disruption...
December 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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