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Caring wisely

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https://www.readbyqxmd.com/read/28818800/the-step-wise-framework-to-design-a-chromatography-based-hydrophobicity-assay-for-viral-particles
#1
Sarah A Johnson, Alison Walsh, Matthew R Brown, Scott C Lute, David J Roush, Michael S Burnham, Kurt A Brorson
A high-salt, hydrophobic interaction chromatography (HIC) method was developed to measure the relative hydrophobicity of a diverse set of solutes. Through the careful control of buffer pH and salt concentration, this assay was then used to ascertain for the first time the relative hydrophobicity values of three different bacteriophage, four mammalian viruses, and a range of biotech medicinal proteins as benchmarked to protein standards previously characterized for hydrophobicity.
August 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28800760/perceptions-of-patients-and-providers-on-myocardial-perfusion-imaging-for-asymptomatic-patients-choosing-wisely-and-professional-liability
#2
Kristopher P Kline, Leslee Shaw, Rebecca J Beyth, Jared Plumb, Linda Nguyen, Tianyao Huo, David E Winchester
BACKGROUND: Despite efforts by professional societies to reduce low value care, many reports indicate that unnecessary tests, such as nuclear myocardial perfusion imaging (MPI), are commonly used in contemporary practice. The degree to which lack of awareness and professional liability concerns drive these behaviors warrants further study. We sought to investigate patient and provider perceptions about MPI in asymptomatic patients, the Choosing Wisely (CW) campaign, and professional liability concerns...
August 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28798721/the-parkinson-care-advocate-integrating-care-delivery
#3
Leonard L Sokol, Debbie Shapiro, Michael J Young, Adina H Wise, Uri P Hadelsberg, Yakir Kaufman, Alberto J Espay, Aristide Merola
No abstract text is available yet for this article.
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28796163/hypertension-caused-by-lenvatinib-and-everolimus-in-the-treatment-of-metastatic-renal-cell-carcinoma
#4
REVIEW
Mathias Alrø Fichtner Bendtsen, Daniela Grimm, Johann Bauer, Markus Wehland, Petra Wise, Nils E Magnusson, Manfred Infanger, Marcus Krüger
Multikinase inhibitors (MKI) and mammalian target of rapamycin (mTOR) inhibitors prolong progression-free (PFS) and overall survival (OS) in the treatment of metastatic renal cell carcinoma (mRCC) by reducing angiogenesis and tumor growth. In this regard, the MKI lenvatinib and the mTOR inhibitor everolimus proved effective when applied alone, but more effective when they were administered combined. Recently, both drugs were included in clinical trials, resulting in international clinical guidelines for the treatment of mRCC...
August 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28783425/choosing-wisely-in-oncology-are-we-ready-for-value-based-care
#5
Gabrielle Rocque, Douglas W Blayney, Mohammad Jahanzeb, August Knape, Merry Jennifer Markham, Trang Pham, Jeremy Shelton, Preeti Sudheendra, Tracey Evans
INTRODUCTION: In 2012, ASCO created the Top Five Choosing Wisely (CW) list of low-value tests and procedures for which there is little evidence of benefit. ASCO's Quality Oncology Practice Initiative, an oncologist-led practice-based quality assessment program, includes measures on the basis of these recommendations. METHODS: CW test measures from spring and fall 2013, spring 2014, and spring 2015 were evaluated for concordance rates, change in the concordance over time, and variability by practice characteristics...
August 7, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28774936/prospective-study-of-glaucoma-referrals-across-europe-are-we-using-resources-wisely
#6
Panayiota Founti, Fotis Topouzis, Gábor Holló, Barbara Cvenkel, Michele Iester, Anna-Bettina Haidich, Péter Kóthy, Anneta Kiana, Despoina Kolokotroni, Ananth C Viswanathan
BACKGROUND: To investigate the outcomes of glaucoma referrals across different European countries. METHODS: 250 patients newly referred to tertiary referral glaucoma specialist practices in the UK, Hungary, Slovenia, Italy and Greece were prospectively enrolled (50 consecutive patients per centre). Referral accuracy and predictive value of referral criteria for an intervention or further monitoring (positive predictive value) were analysed. RESULTS: Same-day discharges occurred in 43% (95% CI 39% to 75%) (12/28) of optometrist-initiated referrals (UK only), 37% (95% CI 30% to 45%) (59/158) of ophthalmologist-initiated referrals (all centres) and 54% (95% CI 40% to 68%) (26/48) of self-referrals (Hungary, Italy and Greece)...
August 3, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28762342/assessment-of-malocclusion-severity-and-orthodontic-treatment-needs-in-12-15-year-old-school-children-of-namakkal-district-tamil-nadu-using-dental-aesthetic-index
#7
S Nagalakshmi, S James, C Rahila, K Balachandar, R Satish
OBJECTIVES: The present study was aimed to assess the severity of malocclusion and orthodontic treatment needs among 12-15-year-old schoolchildren in rural area of Namakkal district, Tamil Nadu, India, using the Dental Aesthetic Index (DAI). MATERIALS AND METHODS: A cross-sectional study was conducted among a sample of 1078 schoolchildren (12-15 years of age) who were selected by two-stage cluster sampling technique. Severity of malocclusion and orthodontic treatment needs were assessed according to the DAI using a specially designed survey pro forma with the aid of the WHO's Oral Health Survey: Basic Methods...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28745572/prevalence-of-thalassemia-traits-and-iron-deficiency-anemia-in-sindh-pakistan
#8
Abdul H Kandhro, Virapong Prachayasittikul, Chartchalerm Isarankura Na-Ayudhya, Pornlada Nuchnoi
Among microcytic hypochromic anemias, the most common disorders are iron deficiency anemia and co-pathological conditions such as α- or β-thalassemia (α- or β-thal) traits. The aim of the present study was to determine the frequency and prevalence of iron deficiency anemia and α- or β-thal traits based on clinical laboratory data across different ethnic groups in five districts of Sindh Province, Pakistan. The present retrospective study analyzed 3 years (2012-2015) of encoded and unlinked clinical laboratory data, and identified 3030 microcytic hypochromic anemia cases...
July 26, 2017: Hemoglobin
https://www.readbyqxmd.com/read/28745454/metal-based-antimicrobial-strategies
#9
Raymond J Turner
Metal based-antimicrobials have potential for profiling sustainability solutions to infection care and health; with biotechnological applications providing novel compounds. Yet they must be used wisely for sustainable use in human and agricultural health with thoughts towards bioremediation for recovery should be considered.
July 26, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28744243/the-odyssey-of-dental-anxiety-from-prehistory-to-the-present-a-narrative-review
#10
REVIEW
Enrico Facco, Gastone Zanette
Dental anxiety (DA) can be considered as a universal phenomenon with a high prevalence worldwide; DA and pain are also the main causes for medical emergencies in the dental office, so their prevention is an essential part of patient safety and overall quality of care. Being DA and its consequences closely related to the fight-or-flight reaction, it seems reasonable to argue that the odyssey of DA began way back in the distant past, and has since probably evolved in parallel with the development of fight-or-flight reactions, implicit memory and knowledge, and ultimately consciousness...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28739651/improving-asthma-care-by-building-statewide-quality-improvement-infrastructure
#11
Judith C Dolins, Jennifer Powell, Edward Wise, Kimberly Giuliano, Peggy Stemmler, Wes Stubblefield, P Cooper White, James Wiley, Dennis Z Kuo
BACKGROUND AND OBJECTIVES: Pediatric medical professionals have an increasing desire for quality improvement (QI) methods that produce sustainable changes in health care delivery. Previous reports have described QI in single settings or single coordinating entities that work with multiple sites. The objectives of this project are (1) to improve care for children with asthma across multiple practice settings and (2) to develop state-level expertise to support QI projects across entities in multiple states...
July 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28738984/transfusing-wisely-clinical-decision-support-improves-blood-transfusion-practices
#12
Ian Jenkins, Jay J Doucet, Brian Clay, Patricia Kopko, Donald Fipps, Eema Hemmen, Debra Paulson
BACKGROUND: The cost and risks of red blood cell (RBC) transfusions, along with evidence of overuse, suggest that improving transfusion practices is a key opportunity for health systems to improve both the quality and value of patient care. Previous work, which included a BestPractice Advisory (BPA), was adapted in a quality improvement project designed to reduce both exposure to unnecessary blood products and costs. METHODS: A prospective, pre-post study was conducted at an academic medical center with a diverse patient population...
August 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28737117/prevalence-and-correlates-of-traumatic-brain-injury-tbi-in-older-adults-results-from-the-well-being-of-the-singapore-elderly-wise-study
#13
Laxman Cetty, Edimansyah Abdin, Janhavi Ajit Vaingankar, Anitha Jeyagurunathan, Boon Yiang Chua, Louisa Picco, Martin Prince, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: Older adults are among the most susceptible to sustain traumatic brain injury (TBI). The study aimed to determine the (1) prevalence of TBI among older adults in Singapore, and (2) socio-demographic, lifestyle, and clinical correlates of TBI. METHODS: Data were extracted from the cross-sectional, Well-being of the Singapore Elderly (WiSE) study. The study included 2,565 participants aged 60 years and above (Mean = 72.75, SD = 9.54). Information on TBI, socio-demographic, and lifestyle factors were collected using participant self-report and verified with the informant report where necessary...
July 24, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28730751/tuberculosis-and-biologics-in-rheumatology-india-a-special-situation
#14
REVIEW
Rohini Handa, Sundeep Upadhyaya, Sanjiv Kapoor, Ramesh Jois, Bimlesh D Pandey, Anuj K Bhatnagar, Ashwani Khanna, Vishal Goyal, Kamal Kumar
India has a huge patient burden of rheumatic diseases (RDs) including rheumatoid arthritis. The use of biologics has transformed the treatment paradigm for RD; however, biologic treatment-related infections (especially tuberculosis [TB]) are an area of potential concern for TB-endemic nations like India. Anti-tumor necrosis factor (TNF) therapy impairs the physiological TNF-mediated signaling and may cause reactivation and dissemination of latent TB infection (LTBI). Careful screening is, thus, crucial in RD patients who are about to commence anti-TNF treatment...
July 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28729776/expenditure-of-hospital-care-on-cancer-in-china-from-2011-to-2015
#15
Yue Cai, Ming Xue, Wanqing Chen, Maogui Hu, Zhiwen Miao, Lan Lan, Rongshou Zheng, Qun Meng
OBJECTIVE: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention. However, studies on economic burden of cancers in China are scant and the results are inconsistent. METHODS: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28716794/incidence-of-live-attenuated-influenza-vaccine-administration-beyond-expiry-date-in-children-and-adolescents-aged-2-17-years-in-the-uk-a-population-based-cohort-study
#16
Herve Caspard, Robert P Wise, Amy Steffey, Robert S Brody
OBJECTIVES: To estimate the proportion of live-attenuated influenza vaccine (LAIV) doses administered beyond expiry date in children and adolescents during influenza seasons 2013-2014 and 2014-2015 in the UK. DESIGN: This was a retrospective cohort study. Two cohorts of children and adolescents who received LAIV from 1 September 2013 to 31 March 2014 and from 1 September 2014 to 31 March 2015 and aged 2-17 years at time of LAIV administration were identified from the Clinical Practice Research Datalink (CPRD)...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28707960/biofunctionalized-hybrid-magnetic-gold-nanoparticles-as-catalysts-for-photothermal-ablation-of-colorectal-liver-metastases
#17
Sarah B White, Dong-Hyun Kim, Yang Guo, Weiguo Li, Yihe Yang, Jeane Chen, Venkateswara R Gogineni, Andrew C Larson
Purpose To demonstrate that anti-MG1 conjugated hybrid magnetic gold nanoparticles (HNPs) act as a catalyst during photothermal ablation (PTA) of colorectal liver metastases, and thus increase ablation zones. Materials and Methods All experiments were performed with approval of the institutional animal care and use committee. Therapeutic and diagnostic multifunctional HNPs conjugated with anti-MG1 monoclonal antibodies were synthesized, and the coupling efficiency was determined. Livers of 19 Wistar rats were implanted with 5 × 10(6) rat colorectal liver metastasis cell line cells...
July 13, 2017: Radiology
https://www.readbyqxmd.com/read/28706550/effect-of-acupressure-on-early-complications-of-menopause-in-women-referring-to-selected-health-care-centers
#18
Maryam Armand, Gity Ozgoli, Reza Heshmat Giti, Hamid Alavi Majd
BACKGROUND: Menopausal period is accompanied by numerous disorders and complications. Nowadays, hormone therapy is the most effective existing method to treat these complications, but many women cannot undergo that due to the known potentiality of risk. So, the present study aimed to investigate the effect of acupressure on early complications of menopause. MATERIALS AND METHODS: This is a blind random clinical trial conducted on 70 menopaused women referring to selected health care centers in Tehran who were qualified to enter the study...
May 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28701226/the-application-of-geographic-information-systems-gis-in-identifying-the-priority-areas-for-maternal-care-and-services
#19
Fatemeh Salehi, Leila Ahmadian
BACKGROUND: Improving maternal health is globally introduced as an important health priority. The purpose of this study is to identify the high priority areas which require more maternal health services in Kerman, Iran. METHODS: This is a descriptive cross-sectional study, performed in 2015. The literatures were first explored in order to extract geographic indicators and sub indicators relevant to the maternal health. Data were collected by the use of a questionnaire designed on the basis of AHP (Analytic Hierarchy Process) method...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28699935/use-of-simulation-to-assess-incoming-interns-recognition-of-opportunities-to-choose-wisely
#20
Kathleen Wiest, Jeanne Farnan, Ellen Byrne, Lukas Matern, Melissa Cappaert, Kristen Hirsch, Vineet Arora
BACKGROUND: Despite increasing healthcare costs, training on cost-consciousness is lacking in graduate medical education (GME). Medical centers must consider how best to incorporate value-based training into their GME curricula. OBJECTIVE: To incorporate low-value principles into an existing GME simulation exercise and assess incoming interns' recognition of low-value care. METHODS: Choosing Wisely™ lists were reviewed to identify 4 low-value hazards to be embedded into a simulated hospital room in addition to the 8 patient safety hazards used previously...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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