keyword
MENU ▼
Read by QxMD icon Read
search

pathogenesis lupus

keyword
https://www.readbyqxmd.com/read/29650017/toll-like-receptors-in-lupus-nephritis
#1
REVIEW
Satish Kumar Devarapu, Hans-Joachim Anders
The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity. However, data accumulating over the last decade imply an important role also for numerous elements of innate immunity, namely the Toll-like receptors in the pathogenesis of SLE. Here we discuss their role in the most common organ complication of SLE, i.e. lupus nephritis. We summarize experimental and clinical data on the expression and functional contribution of the Toll-like receptors in immune complex glomerulonephritis, and intrarenal inflammation...
April 12, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29627289/mechanisms-of-neuropsychiatric-lupus-the-relative-roles-of-the-blood-cerebrospinal-fluid-barrier-versus-blood-brain-barrier
#2
Sivan Gelb, Ariel D Stock, Shira Anzi, Chaim Putterman, Ayal Ben-Zvi
The pathogenesis of neuropsychiatric lupus (NPSLE) is believed to include the entry of circulating neuropathic antibodies to the brain via a pathologically permeable blood-brain barrier (BBB). Nevertheless, direct evidence of BBB pathology or mechanisms underlying BBB dysfunction is missing. Here, we examined BBB integrity in an established NPSLE mouse model (MRL/faslpr/lpr ). Surprisingly, challenging the barrier with various exogenous tracers demonstrated insignificant changes in BBB permeability. Furthermore, electron microscopy showed no ultrastructure changes supporting hyper-permeability...
April 4, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29625966/identification-of-st3agl4-mfhas1-csnk2a2-and-cd226-as-loci-associated-with-systemic-lupus-erythematosus-sle-and-evaluation-of-sle-genetics-in-drug-repositioning
#3
Yong-Fei Wang, Yan Zhang, Zhengwei Zhu, Ting-You Wang, David L Morris, Jiangshan Jane Shen, Huoru Zhang, Hai-Feng Pan, Jing Yang, Sen Yang, Dong-Qing Ye, Timothy J Vyse, Yong Cui, Xuejun Zhang, Yujun Sheng, Yu Lung Lau, Wanling Yang
OBJECTIVES: Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic component in its pathogenesis. Through genome-wide association studies (GWAS), we recently identified 10 novel loci associated with SLE and uncovered a number of suggestive loci requiring further validation. This study aimed to validate those loci in independent cohorts and evaluate the role of SLE genetics in drug repositioning. METHODS: We conducted GWAS and replication studies involving 12 280 SLE cases and 18 828 controls, and performed fine-mapping analyses to identify likely causal variants within the newly identified loci...
April 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29623390/the-role-of-genetics-and-epigenetics-in-rheumatic-diseases-are-they-really-a-target-to-be-aimed-at
#4
REVIEW
Masaru Kato, Shinsuke Yasuda, Tatsuya Atsumi
To date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from these genetic and epigenetic findings. For example, tumor necrosis factor inhibitors are quite successful in the treatment of rheumatoid arthritis (RA), Behçet's disease (BD), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) but not in that of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SS) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV), conversely, RA shares genetic backgrounds more with SLE, SSc, SS and AAV than BD, AS and PsA...
April 5, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29619588/autoimmune-inflammatory-syndrome-induced-by-mineral-oil-a-health-problem
#5
Olga Vera-Lastra, Gabriela Medina, María Pilar Cruz-Domínguez, Gabriel Medrano Ramírez, Raymundo Benjamin Priego Blancas, Ana Lilia Peralta Amaro, Anabel Villanueva Martínez, Jesús Sepúlveda Delgado, Luis J Jara
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) includes the following conditions: siliconosis, Gulf War syndrome, macrophagic myofasciitis syndrome, and post-vaccination phenomena. Afterward, other syndromes have been recognized, such as in ASIA by mineral oil (ASIA-MO). These conditions are triggered by adjuvants and they are the result of the interplay of genetic and environmental factors. ASIA-MO is defined as the infiltration of oily type modeling substances for cosmetic purposes. It has been reported in many countries and used surreptitiously...
April 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29618665/b-lymphocytes-confer-immune-tolerance-via-cell-surface-garp-tgf-%C3%AE-complex
#6
Caroline H Wallace, Bill X Wu, Mohammad Salem, Ephraim A Ansa-Addo, Alessandra Metelli, Shaoli Sun, Gary Gilkeson, Mark J Shlomchik, Bei Liu, Zihai Li
GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expressed by platelets and activated Tregs. While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown. Although B cells do not express GARP at baseline, we found that the GARP-TGF-β complex is induced on activated human and mouse B cells by ligands for multiple TLRs, including TLR4, TLR7, and TLR9. GARP overexpression on B cells inhibited their proliferation, induced IgA class-switching, and dampened T cell-independent antibody production...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29611821/galectin-9-inhibits-tlr7-mediated-autoimmunity-in-murine-lupus-models
#7
Santosh K Panda, Valeria Facchinetti, Elisaveta Voynova, Shino Hanabuchi, Jodi L Karnell, Richard N Hanna, Roland Kolbeck, Miguel A Sanjuan, Rachel Ettinger, Yong-Jun Liu
Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. The importance of galectin-9 (Gal-9) in regulating various autoimmune diseases, including lupus, has been demonstrated. However, the precise mechanism by which Gal-9 mediates this effect remains unclear. Here, using spontaneous murine models of lupus (i.e., BXSB/MpJ and NZB/W F1 mice), we demonstrate that administration of Gal-9 results in reduced TLR7-mediated autoimmune manifestations...
April 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29606700/low-expression-and-clinical-value-of-hsa_circ_0049224-and-has_circ_0049220-in-systemic-lupus-erythematous-patients
#8
Chengzhong Zhang, Jie Huang, Yue Chen, Weimin Shi
BACKGROUND The aim of this study was to discuss the possible roles and clinical value of 2 circRNAs (hsa_circ_0049224 and has_circ_0049220) in SLE patients. MATERIAL AND METHODS Reverse-transcription real-time polymerase chain reaction (RT-PCR) was conducted to detect the expressions of hsa_circ_0049224, has_circ_0049220, and DNMT1 in peripheral blood mononuclear cells (PBMCs) from 18 diagnosed SLE patients and 10 healthy controls. RESULTS We found that the expressions of hsa_circ_0049224 and has_circ_0049220 in healthy control groups were both much higher than those in inactive and active SLE patients...
April 2, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29605707/epigenome-wide-association-studies-for-systemic-autoimmune-diseases-the-road-behind-and-the-road-ahead
#9
Elena Carnero-Montoro, Marta E Alarcón-Riquelme
Epigenetics is known to be an important mechanism in the pathogenesis of autoimmune diseases. Epigenetic variations can act as integrators of environmental and genetic exposures and propagate activated states in immune cells. Studying epigenetic alterations by means of genome-wide approaches promises to unravel novel molecular mechanisms related to disease etiology, disease progression, clinical manifestations and treatment responses. This paper reviews what we have learned in the last five years from epigenome-wide studies for three systemic autoimmune diseases, namely systemic lupus erythematosus, primary Sjögren's syndrome, and rheumatoid arthritis...
March 29, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29600248/cd11b-activity-modulates-pathogenesis-of-lupus-nephritis
#10
REVIEW
Samia Q Khan, Imran Khan, Vineet Gupta
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) with unclear etiology and limited treatment options. Immune cell infiltration into the kidneys, a hallmark of LN, triggers tissue damage and proteinuria. CD11b, the α-chain of integrin receptor CD11b/CD18 (also known as αMβ2 , Mac-1, and CR3), is highly expressed on the surface of innate immune cells, including macrophages and neutrophils. Genetic variants in the human ITGAM gene, which encodes for CD11b, are strongly associated with susceptibility to SLE, LN, and other complications of SLE...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29595356/chorea-revealing-systemic-lupus-erythematosus-in-a-13-year-old-boy-a-case-report-and-short-review-of-the-literature
#11
E Athanasopoulos, I Kalaitzidou, G Vlachaki, S Stefanaki, A Tzagkaraki, G Niotakis, I Tritou, F Ladomenou
Among the neurological manifestations of systemic lupus erythematosus (SLE), chorea is rare, presenting in less than 7% of the pediatric SLE patients. It can appear early in the onset of SLE, be the first or even the sole clinical feature of the illness and has strongly been associated with the presence of antiphospholipid antibodies. We report on the case of a 13-year old boy, admitted with acute onset chorea and finally diagnosed with SLE. Subsequently, we present a short review of the literature on the epidemiology, suggested pathogenesis, clinical presentation and treatment of this rare presentation of SLE...
March 29, 2018: International Reviews of Immunology
https://www.readbyqxmd.com/read/29593732/a-distinct-t-follicular-helper-cell-subset-infiltrates-the-brain-in-murine-neuropsychiatric-lupus
#12
Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman
Neuropsychiatric symptoms in systemic lupus erythematosus (SLE) are not uncommon, yet the mechanisms underlying disease initiation and progression in the brain are incompletely understood. Although the role of T cells in other lupus target organs such as the kidney is well defined, which T cells contribute to the pathogenesis of neuropsychiatric SLE is not known. The present study was aimed at characterizing the CD4 T cell populations that are present in the choroid plexus (CP) of MRL/MpJ-fas lpr mice, the primary site of brain infiltration in this classic lupus mouse model which exhibits a prominent neurobehavioral phenotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29593681/intestinal-microbiota-influences-non-intestinal-related-autoimmune-diseases
#13
REVIEW
Maria C Opazo, Elizabeth M Ortega-Rocha, Irenice Coronado-Arrázola, Laura C Bonifaz, Helene Boudin, Michel Neunlist, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel
The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29578533/microrna-663-induces-immune-dysregulation-by-inhibiting-tgf-%C3%AE-1-production-in-bone-marrow-derived-mesenchymal-stem-cells-in-patients-with-systemic-lupus-erythematosus
#14
Linyu Geng, Xiaojun Tang, Kangxing Zhou, Dandan Wang, Shiying Wang, Genhong Yao, Weiwei Chen, Xiang Gao, Wanjun Chen, Songtao Shi, Nan Shen, Xuebing Feng, Lingyun Sun
Mesenchymal stem cells (MSCs) are critical for immune regulation. Although several microRNAs (miRNAs) have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function, the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear. Here, we show that patients with systemic lupus erythematosus (SLE) display a unique miRNA signature in bone marrow-derived MSCs (BMSCs) compared with normal controls, among which miR-663 is closely associated with SLE disease activity...
March 26, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29576632/maternal-thrombophilia-and-recurrent-miscarriage-is-there-evidence-that-heparin-is-indicated-as-prophylaxis-against-recurrence
#15
Ana-Luisa Stefanski, Christoph Specker, Rebecca Fischer-Betz, Wolfgang Henrich, Ekkehard Schleussner, Thomas Dörner
Background: Recurrent miscarriage, also referred to as recurrent spontaneous abortion (RSA), affects 1 - 5% of couples and has a multifactorial genesis. Acquired and congenital thrombophilia have been discussed as hemostatic risk factors in the pathogenesis of RSA. Method: This review article was based on a selective search of the literature in PubMed. There was a special focus on the current body of evidence studying the association between RSA and antiphospholipid syndrome and hereditary thrombophilia disorders...
March 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29574040/epigenetics-as-biomarkers-in-autoimmune-diseases
#16
Haijing Wu, Jieyue Liao, Qianwen Li, Ming Yang, Ming Zhao, Qianjin Lu
Autoimmune diseases are immune system disorders in which immune cells cannot distinguish self-antigens from foreign ones. The current criteria for autoimmune disease diagnosis are based on clinical manifestations and laboratory tests. However, none of these markers shows both high sensitivity and specificity. In addition, some autoimmune diseases, for example, systemic lupus erythematosus (SLE), are highly heterogeneous and often exhibit various manifestations. On the other hand, certain autoimmune diseases, such as Sjogren's syndrome versus SLE, share similar symptoms and autoantibodies, which also causes difficulties in diagnosis...
March 21, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29571080/increased-serum-il-36%C3%AE-and-il-36%C3%AE-levels-in-patients-with-systemic-lupus-erythematosus-association-with-disease-activity-and-arthritis
#17
Shao-Zhen Mai, Chi-Jun Li, Xiao-Ying Xie, Hui Xiong, Min Xu, Fan-Qin Zeng, Qing Guo, Yan-Fang Han
IL-36 cytokines (IL-36Ra, IL-36α, IL-36β and IL-36γ) belong to the IL-1 family and have been linked to several autoimmune diseases. However, little is known about the relationships between systemic lupus erythematosus (SLE) and IL-36 cytokines. In this study, serum IL-36 cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA), and their associations with SLE-related parameters were analyzed in 72 SLE patients and 63 healthy controls. Additionally, IL-36 cytokine mRNA levels were assessed in 30 of 72 SLE patients and 20 of 63 healthy controls using real-time quantitative reverse transcription polymerase chain reaction (RT-PCR)...
March 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29568300/tailoring-immune-responses-toward-autoimmunity-transcriptional-regulators-that-drive-the-creation-and-collusion-of-autoreactive-lymphocytes
#18
REVIEW
Kim L Good-Jacobson, Joanna R Groom
T-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby culminating in the formation of germinal centers (GCs) and eventual differentiation into memory cells and long-lived plasma cells (PCs). CD4 T cell-derived signals drive the formation of a tailored B cell response. Downstream of these signals are transcriptional regulators that are the critical enactors of immune cell programs. In particular, a core group of transcription factors regulate both B and T cell differentiation, identity, and function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29563616/type-i-interferons-promote-the-survival-and-proinflammatory-properties-of-transitional-b-cells-in-systemic-lupus-erythematosus-patients
#19
Mei Liu, Qiang Guo, Chunmei Wu, Delphine Sterlin, Shyamal Goswami, Ying Zhang, Teng Li, Chunde Bao, Nan Shen, Qiong Fu, Xiaoming Zhang
A hallmark of systemic lupus erythematosus (SLE) is the breaking of B-cell tolerance with the generation of high-affinity autoantibodies; however, the antibody-independent features of the B-cell compartment in SLE are less understood. In this study, we performed an extensive examination of B-cell subsets and their proinflammatory properties in a Chinese cohort of new-onset SLE patients. We observed that SLE patients exhibited an increased frequency of transitional B cells compared with healthy donors and rheumatoid arthritis patients...
March 21, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29563177/relative-contributions-of-b-cells-and-dendritic-cells-from-lupus-prone-mice-to-cd4-t-cell-polarization
#20
Seung-Chul Choi, Zhiwei Xu, Wei Li, Hong Yang, Derry C Roopenian, Herbert C Morse, Laurence Morel
Mouse models of lupus have shown that multiple immune cell types contribute to autoimmune disease. This study sought to investigate the involvement of B cells and dendritic cells in supporting the expansion of inflammatory and regulatory CD4+ T cells that are critical for lupus pathogenesis. We used lupus-prone B6.NZM2410.Sle1.Sle2.Sle3 (TC) and congenic C57BL/6J (B6) control mice to investigate how the genetic predisposition of these two cell types controls the activity of normal B6 T cells. Using an allogeneic in vitro assay, we showed that TC B1-a and conventional B cells expanded Th17 cells significantly more than their B6 counterparts...
March 21, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
keyword
keyword
113322
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"