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https://www.readbyqxmd.com/read/28316639/feature-extraction-and-classification-of-ehg-between-pregnancy-and-labour-group-using-hilbert-huang-transform-and-extreme-learning-machine
#1
Lili Chen, Yaru Hao
Preterm birth (PTB) is the leading cause of perinatal mortality and long-term morbidity, which results in significant health and economic problems. The early detection of PTB has great significance for its prevention. The electrohysterogram (EHG) related to uterine contraction is a noninvasive, real-time, and automatic novel technology which can be used to detect, diagnose, or predict PTB. This paper presents a method for feature extraction and classification of EHG between pregnancy and labour group, based on Hilbert-Huang transform (HHT) and extreme learning machine (ELM)...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28314844/abituzumab-targeting-of-alphav-class-integrins-inhibits-prostate-cancer-progression
#2
Yuan Jiang, Jinlu Dai, Zhi Yao, Greg Shelley, Evan T Keller
Integrins that contain an integrin alpha V subunit contribute to multiple functions that promote cancer progression. The goal of this study was to determine if abituzumab (DI17E6, EMD 525797), a humanized monoclonal antibody (mAb) against integrin alpha V impacts, prostate cancer (PCa) progression. To evaluate this, PCa cells were treated with DI17E6 and its effects on proliferation, apoptosis, cell cycle, adhesion, detachment, migration, invasion and phosphorylation of downstream targets, including FAK, Akt and ERK were determined...
March 17, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28304211/furcation-therapy-with-enamel-matrix-derivative-effects-on-the-subgingival-microbiome
#3
Lucas A Queiroz, Renato C V Casarin, Shareef M Dabdoub, Dimitris N Tatakis, Enilson A Sallum, Purnima S Kumar
BACKGROUND: Although enamel matrix derivative (EMD) has been used to promote periodontal regeneration, little is known of its effect on the microbiome. Therefore, this investigation aimed to identify the changes in periodontal microbiome following treatment with EMD using a deep-sequencing approach. METHODS: Thirty-nine patients having mandibular class II buccal furcation defects were randomized to beta-tricalcium-phosphate/hydroxyapatite graft (BONE group), EMD+BONE or EMD alone...
March 17, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28303584/long-term-results-of-periodontal-regenerative-therapy-a-retrospective-practice-based-cohort-study
#4
Frank Bröseler, Christina Tietmann, Ann-Katrin Hinz, Søren Jepsen
AIM: Evaluation of the long-term effectiveness of regenerative treatment of intrabony defects in periodontal practice. MATERIAL AND METHODS: A total of 1008 intrabony defects in 176 patients were analyzed after using collagen-added deproteinized bovine bone mineral (DBBMc) with or without collagen membrane (CM) or enamel matrix derivative (EMD). Defects were classified as 1- and 2-wall and as shallow (≤ 6 mm), moderate (> 6 and < 11 mm) and deep (≥11 mm)...
March 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28290476/emerin-plays-a-crucial-role-in-nuclear-invagination-and-in-the-nuclear-calcium-transient
#5
Masaya Shimojima, Shinsuke Yuasa, Chikaaki Motoda, Gakuto Yozu, Toshihiro Nagai, Shogo Ito, Mark Lachmann, Shin Kashimura, Makoto Takei, Dai Kusumoto, Akira Kunitomi, Nozomi Hayashiji, Tomohisa Seki, Shugo Tohyama, Hisayuki Hashimoto, Masaki Kodaira, Toru Egashira, Kenshi Hayashi, Chiaki Nakanishi, Kenji Sakata, Masakazu Yamagishi, Keiichi Fukuda
Alteration of the nuclear Ca(2+) transient is an early event in cardiac remodeling. Regulation of the nuclear Ca(2+) transient is partly independent of the cytosolic Ca(2+) transient in cardiomyocytes. One nuclear membrane protein, emerin, is encoded by EMD, and an EMD mutation causes Emery-Dreifuss muscular dystrophy (EDMD). It remains unclear whether emerin is involved in nuclear Ca(2+) homeostasis. The aim of this study is to elucidate the role of emerin in rat cardiomyocytes by means of hypertrophic stimuli and in EDMD induced pluripotent stem (iPS) cell-derived cardiomyocytes in terms of nuclear structure and the Ca(2+) transient...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28282892/detection-of-the-vibration-signal-from-human-vocal-folds-using-a-94-ghz-millimeter-wave-radar
#6
Fuming Chen, Sheng Li, Yang Zhang, Jianqi Wang
The detection of the vibration signal from human vocal folds provides essential information for studying human phonation and diagnosing voice disorders. Doppler radar technology has enabled the noncontact measurement of the human-vocal-fold vibration. However, existing systems must be placed in close proximity to the human throat and detailed information may be lost because of the low operating frequency. In this paper, a long-distance detection method, involving the use of a 94-GHz millimeter-wave radar sensor, is proposed for detecting the vibration signals from human vocal folds...
March 8, 2017: Sensors
https://www.readbyqxmd.com/read/28281367/a-review-of-the-literature-antibiotic-usage-and-its-relevance-to-the-infection-in-periodontal-flaps
#7
Yiying Liu, Dingyu Duan, Yuejiao Xin, Lin Bai, Tianyu Li, Chuwen Li, Yi Xu
OBJECTIVE: This study aimed to investigate the systemic antibiotic usage in the perioperative period of periodontal flaps and its relevance to the infection after surgeries through reviewing the papers of the last decade. MATERIALS AND METHODS: A search was conducted for the studies of randomized clinical trials between 2005 and 2014 that reported periodontal flaps in chronic periodontitis patients. Data were extracted and the rate of the systemic antibiotic use, the infection rate after surgeries and the number needed to treat (NNT) to prevent one infected case were calculated...
March 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28278363/comparisons-of-periodontal-regenerative-therapies-a-meta-analysis-on-the-long-term-efficacy
#8
REVIEW
Yun-Chun Wu, Liang-Ko Lin, Cheng-Jie Song, Yu-Xuan Su, Yu-Kang Tu
AIM: We conducted a meta-analysis for the long-term differences in treatment outcomes between periodontal regeneration therapies and flap operation. METHODS: A systematic literature search was conducted using the EMBASE, PubMed, and Cochrane databases up to June 2016. Treatment outcomes were changes in probing pocket depth and clinical attachment level. We extracted data reported at different time points after periodontal surgery and incorporated all data into the same model...
March 9, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28271324/5-ht6-receptor-agonist-and-antagonist-against-%C3%AE-amyloid-peptide-induced-neurotoxicity-in-pc-12-cells
#9
Anand M Bokare, A K Praveenkumar, Mandar Bhonde, Yogendra Nayak, Ravindra Pal, Rajan Goel
Beta-amyloid peptide (Aβ) induced neurotoxicity is considered as a hallmark of the pathogenesis of Alzheimer's disease (AD). The present study demonstrated the neuroprotective role of 5-HT6 receptors against Aβ-induced neurotoxicity in PC-12 cells. The 5-HT6 receptor agonist EMD-386088 and antagonist SB-399885 were used as pharmacological tools. The NMDA receptor antagonist, memantine, was used as reference standard. The Aβ25-35 (50 µM) induced apoptosis, increased reactive oxygen species (ROS) generation and impaired neurite outgrowth in PC-12 cells...
March 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28269082/the-role-of-electromechanical-delay-in-modelling-the-emg-force-relationship-during-quasi-dynamic-contractions-of-the-upper-limb
#10
Gregg Johns, Evelyn Morin, Keyvan Hashtrudi-Zaad
There is a discontinuity in published electromechanical delays (EMD) in upper-limb muscles and the state-of-the-art in modelling end-point force from electromyographic signals collected from one or more muscles. Published values are typically in the range of 10 to 30ms, depending on the nature of the contraction. In published literature where the EMG-force relationship is modelled, generally a delay of 100ms or more is induced during linear enveloping to match the EMD. The implications of EMD on end-point force prediction were considered using inter-session end-point force modelling with a support-vector-regression model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269077/fluorescence-background-removal-method-for-biological-raman-spectroscopy-based-on-empirical-mode-decomposition
#11
Maritza Leon-Bejarano, Guadalupe Dorantes-Mendez, Miguel Ramirez-Elias, Martin O Mendez, Alfonso Alba, Ildefonso Rodriguez-Leyva, M Jimenez
Raman spectroscopy of biological tissue presents fluorescence background, an undesirable effect that generates false Raman intensities. This paper proposes the application of the Empirical Mode Decomposition (EMD) method to baseline correction. EMD is a suitable approach since it is an adaptive signal processing method for nonlinear and non-stationary signal analysis that does not require parameters selection such as polynomial methods. EMD performance was assessed through synthetic Raman spectra with different signal to noise ratio (SNR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268661/validation-of-empirical-mode-decomposition-combined-with-notch-filtering-to-extract-electrical-stimulation-artifact-from-surface-electromyograms-during-functional-electrical-stimulation
#12
Rakesh Pilkar, Arvind Ramanujam, Erica Garbarini, Gail Forrest
This paper presents the validity of Empirical Mode Decomposition (EMD) combined with Notch filtering to remove the electrical stimulation (ES) artifact from surface electromyogram (EMG) data for interpretation of muscle responses during Functional Electrical Stimulation (FES) experiments. We hypothesized that the EMD algorithm provides a suitable platform for decomposing the EMG signal into physically meaningful intrinsic mode functions (IMFs) which can be further used to isolate electrical stimulation (ES) artifact...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268370/example-based-super-resolution-for-enhancing-spatial-resolution-of-medical-images
#13
Dai-Viet Tran, Sebastien Li-Thiao-Te, Marie Luong, Thuong Le-Tien, Francoise Dibos, Jean-Marie Rocchisani
This paper proposes an effective exampled-based super-resolution (SR) method to improve the spatial resolution of medical image heavily corrupted by noise. Based on the sparsity of patches, the reconstruction of a high-resolution (HR) patch from each low-resolution (LR) input patch can be performed with the help of a database, by solving a non-negative sparse optimization problem. The challenge is to effectively solve this problem in case of a large size database. To cope with this issue, we propose a metric to measure the similarity between image patches based on the Earth Mover's Distance (EMD) in order to select only the most similar candidates that will be used in the optimization problem...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262554/target-expression-generation-preclinical-activity-and-pharmacokinetics-of-the-bcma-t-cell-bispecific-antibody-em801-for-multiple-myeloma-treatment
#14
Anja Seckinger, Jose Antonio Delgado, Samuel Moser, Laura Moreno, Brigitte Neuber, Anna Grab, Susanne Lipp, Juana Merino, Felipe Prosper, Martina Emde, Camille Delon, Melanie Latzko, Reto Gianotti, Remo Lüoend, Ramona Murr, Ralf J Hosse, Lydia Jasmin Harnisch, Marina Bacac, Tanja Fauti, Christian Klein, Aintzane Zabaleta, Jens Hillengass, Elisabetta Ada Cavalcanti-Adam, Anthony D Ho, Michael Hundemer, Jesus F San Miguel, Klaus Strein, Pablo Umaña, Dirk Hose, Bruno Paiva, Minh Diem Vu
We identified B cell maturation antigen (BCMA) as a potential therapeutic target in 778 newly diagnosed and relapsed myeloma patients. We constructed an IgG-based BCMA-T cell bispecific antibody (EM801) and showed that it increased CD3(+) T cell/myeloma cell crosslinking, followed by CD4(+)/CD8(+) T cell activation, and secretion of interferon-γ, granzyme B, and perforin. This effect is CD4 and CD8 T cell mediated. EM801 induced, at nanomolar concentrations, myeloma cell death by autologous T cells in 34 of 43 bone marrow aspirates, including those from high-risk patients and patients after multiple lines of treatment, tumor regression in six of nine mice in a myeloma xenograft model, and depletion of BCMA(+) cells in cynomolgus monkeys...
February 27, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28257127/electrosensory-capture-during-multisensory-discrimination-of-nearby-objects-in-the-weakly-electric-fish-gnathonemus-petersii
#15
Sarah Schumacher, Theresa Burt de Perera, Gerhard von der Emde
Animal multisensory systems are able to cope with discrepancies in information provided by individual senses by integrating information using a weighted average of the sensory inputs. Such sensory weighting often leads to a dominance of a certain sense during particular tasks and conditions, also called sensory capture. Here we investigated the interaction of vision and active electrolocation during object discrimination in the weakly electric fish Gnathonemus petersii. Fish were trained to discriminate between two objects using both senses and were subsequently tested using either only vision or only the active electric sense...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254079/bidimensional-unconstrained-optimization-approach-to-emd-an-algorithm-revealing-skin-perfusion-alterations-in-pseudoxanthoma-elasticum-patients
#16
Anne Humeau-Heurtier, Marcelo A Colominas, Gastón Schlotthauer, Maxime Etienne, Ludovic Martin, Pierre Abraham
BACKGROUND AND OBJECTIVE: Pseudoxanthoma elasticum (PXE) is an inherited and systemic metabolic disorder that affects the skin, leading among other things to a peau d'orange appearance. Unfortunately, PXE is still poorly understood and there is no existing therapy to treat the disease. Because the skin is the first organ to be affected in PXE, we propose herein a study of skin microvascular perfusion. By means of this analysis, our goal is to increase knowledge of PXE. METHODS: For this purpose, microvascular data from patients suffering from PXE and from healthy control subjects were recorded using the laser speckle contrast imaging (LSCI) modality...
March 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28241472/operational-modal-analysis-of-bridge-structures-with-data-from-gnss-accelerometer-measurements
#17
Chunbao Xiong, Huali Lu, Jinsong Zhu
Real-time dynamic displacement and acceleration responses of the main span section of the Tianjin Fumin Bridge in China under ambient excitation were tested using a Global Navigation Satellite System (GNSS) dynamic deformation monitoring system and an acceleration sensor vibration test system. Considering the close relationship between the GNSS multipath errors and measurement environment in combination with the noise reduction characteristics of different filtering algorithms, the researchers proposed an AFEC mixed filtering algorithm, which is an combination of autocorrelation function-based empirical mode decomposition (EMD) and Chebyshev mixed filtering to extract the real vibration displacement of the bridge structure after system error correction and filtering de-noising of signals collected by the GNSS...
February 23, 2017: Sensors
https://www.readbyqxmd.com/read/28228713/metabolic-and-cardiovascular-benefits-and-risks-of-emd386088-a-5-ht6-receptor-partial-agonist-and-dopamine-transporter-inhibitor
#18
Magdalena Kotańska, Joanna Śniecikowska, Magdalena Jastrzębska-Więsek, Marcin Kołaczkowski, Karolina Pytka
Since 5-HT6 receptors play role in controlling feeding and satiety and dopamine is essential for normal feeding behavior, we evaluated the ability of EMD 386088-5-HT6 receptor partial agonist and dopamine transporter inhibitor-to reduce body weight in obese rats, as well as its anorectic properties (calorie intake reduction) in rat model of excessive eating and the influence on metabolism (plasma glucose and glycerol levels). We also determined the effect of the studied compound on pica behavior in rats and its influence on blood pressure after single administration...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28227302/the-role-of-electromechanical-delay-in-modelling-the-emg-force-relationship-during-quasi-dynamic-contractions-of-the-upper-limb
#19
Gregg Johns, Evelyn Morin, Keyvan Hashtrudi-Zaad, Gregg Johns, Evelyn Morin, Keyvan Hashtrudi-Zaad, Keyvan Hashtrudi-Zaad, Gregg Johns, Evelyn Morin
There is a discontinuity in published electromechanical delays (EMD) in upper-limb muscles and the state-of-the-art in modelling end-point force from electromyographic signals collected from one or more muscles. Published values are typically in the range of 10 to 30ms, depending on the nature of the contraction. In published literature where the EMG-force relationship is modelled, generally a delay of 100ms or more is induced during linear enveloping to match the EMD. The implications of EMD on end-point force prediction were considered using inter-session end-point force modelling with a support-vector-regression model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227296/fluorescence-background-removal-method-for-biological-raman-spectroscopy-based-on-empirical-mode-decomposition
#20
Maritza Leon-Bejarano, Guadalupe Dorantes-Mendez, Miguel Ramirez-Elias, Martin O Mendez, Alfonso Alba, Ildefonso Rodriguez-Leyva, M Jimenez, Maritza Leon-Bejarano, Guadalupe Dorantes-Mendez, Miguel Ramirez-Elias, Martin O Mendez, Alfonso Alba, Ildefonso Rodriguez-Leyva, M Jimenez, Ildefonso Rodriguez-Leyva, Alfonso Alba, M Jimenez, Martin O Mendez, Miguel Ramirez-Elias, Maritza Leon-Bejarano, Guadalupe Dorantes-Mendez
Raman spectroscopy of biological tissue presents fluorescence background, an undesirable effect that generates false Raman intensities. This paper proposes the application of the Empirical Mode Decomposition (EMD) method to baseline correction. EMD is a suitable approach since it is an adaptive signal processing method for nonlinear and non-stationary signal analysis that does not require parameters selection such as polynomial methods. EMD performance was assessed through synthetic Raman spectra with different signal to noise ratio (SNR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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