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https://www.readbyqxmd.com/read/29767434/regenerative-surgical-therapy-for-peri-implantitis-using-deproteinized-bovine-bone-mineral-with-10-collagen-enamel-matrix-derivative-and-doxycycline-a-prospective-3-year-cohort-study
#1
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
OBJECTIVES: There is limited evidence regarding the long-term efficacy of regenerative treatment for peri-implantitis. The aim of this study was to evaluate a combination therapy of deproteinized bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and Doxycycline in the regeneration of bone defects associated with peri-implantitis. METHODS: Thirty patients diagnosed with peri-implantitis (BoP/suppuration, probing depth greater than 4 mm, minimum radiographic bone loss of 20%, at least 2 years in function) were enrolled in the study...
May 16, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29757468/treatment-of-class-iii-multiple-gingival-recessions-prognostic-factors-for-achieving-a-complete-root-coverage
#2
Sofia Aroca, Antoine Barbieri, Marco Clementini, Franck Renouard, Massimo de Sanctis
BACKGROUND: This report is intended to present a supplemental analysis of data from a prior report (Aroca 2010) to investigate factors associated with a complete root coverage at 1 year. The purpose of the prior report was to investigate at 1 year the adjunction effect of EMD for the treatment of Miller's class III recession defects using a coronally advanced modified tunnel/CTG technique with (test group) or without (control group). The purpose of this report is to investigate additional factors associated with root coverage in the same data set...
May 14, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29698944/mucosally-expressed-cytokines-are-associated-with-the-esophageal-motility-function
#3
Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, Tsutomu Iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa
BACKGROUND AND AIM: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. METHODS: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. RESULTS: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1)...
April 26, 2018: Digestion
https://www.readbyqxmd.com/read/29694406/impact-of-point-of-care-ultrasound-on-clinical-decision-making-at-an-urban-emergency-department-in-tanzania
#4
Teri Ann Reynolds, Stas Amato, Irene Kulola, Chuan-Jay Jeffrey Chen, Juma Mfinanga, Hendry Robert Sawe
BACKGROUND: Point of care ultrasound (PoCUS) is an efficient, inexpensive, safe, and portable imaging modality that can be particularly useful in resource-limited settings. However, its impact on clinical decision making in such settings has not been well studied. The objective of this study is to describe the utilization and impact of PoCUS on clinical decision making at an urban emergency department in Dar es Salaam, Tanzania. METHODS: This was a prospective descriptive cross-sectional study of patients receiving PoCUS at Muhimbili National Hospital's Emergency Medical Department (MNH EMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29692699/a-control-scheme-that-uses-dynamic-postural-synergies-to-coordinate-a-hybrid-walking-neuroprosthesis-theory-and-experiments
#5
Naji A Alibeji, Vahidreza Molazadeh, Brad E Dicianno, Nitin Sharma
A hybrid walking neuroprosthesis that combines functional electrical stimulation (FES) with a powered lower limb exoskeleton can be used to restore walking in persons with paraplegia. It provides therapeutic benefits of FES and torque reliability of the powered exoskeleton. Moreover, by harnessing metabolic power of muscles via FES, the hybrid combination has a potential to lower power consumption and reduce actuator size in the powered exoskeleton. Its control design, however, must overcome the challenges of actuator redundancy due to the combined use of FES and electric motor...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29678455/different-behavioral-and-pathological-changes-between-epilepsy-associated-depression-and-primary-depression-models
#6
Wei-Feng Peng, Fan Fan, Xin Li, Qian-Qian Zhang, Jing Ding, Xin Wang
PURPOSE: Comorbid depression is common in patients with epilepsy. However, the epilepsy-associated depression is generally atypical and has not been fully recognized by neurologists. This study aimed to compare the behavioral and pathological changes between the chronic lithium chloride-pilocarpine rat epilepsy model (Licl-pilocarpine model) and the Chronic Unpredictable Mild Stress rat depression model (CUMS model), to evaluate for differences between epilepsy-associated depression and primary depression...
April 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#7
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29658884/modal-analysis-of-the-thermal-conductivity-of-canowires-examining-unique-thermal-transport-features
#8
Nalaka Samaraweera, Jason Larkin, Kin Lung Chan, Kumar Mithraratne
In this study, unique thermal transport features of nanowires over bulk materials are investigated using a combined analysis based on lattice dynamics and equilibrium molecular dynamics (EMD). The evaluation of the thermal conductivity (TC) of Lenard-Jones nanowires becomes feasible due to the multi-steps normal mode decomposition (NMD) procedure implemented in the study. A convergence issue of the TC of nanowires is addressed by the NMD implementation for two case studies, which employ pristine and superlattice nanowires...
April 16, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29658656/comparison-between-endoscopic-and-laparoscopic-removal-of-gastric-submucosal-tumor
#9
REVIEW
Nobutsugu Abe, Hirohisa Takeuchi, Atsuko Ohki, Yoshikazu Hashimoto, Toshiyuki Mori, Masanori Sugiyama
BACKGROUND AND AIM: A retrospective study was conducted to compare two resection methods, namely, endoscopic resection (ER) procedures (endoscopic submucosal dissection [ESD], endoscopic muscularis dissection [EMD], and endoscopic full-thickness resection [EFTR]) and laparoscopic resections (LR) (laparoscopic endoscopic cooperative surgery [LECS] and laparoscopic wedge resection). METHODS: Seventy-three patients who underwent ER (N = 33: ESD, N = 4; EMD, N = 15; EFTR, N = 14) or LR (N = 39: LECS, N = 16; wedge resection, N = 23) for gastric submucosal tumor (G-SMT) smaller than 50 mm were included in this study...
April 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29651627/equivalence-testing-of-complex-particle-size-distribution-profiles-based-on-earth-mover-s-distance
#10
Meng Hu, Xiaohui Jiang, Mohammad Absar, Stephanie Choi, Darby Kozak, Meiyu Shen, Yu-Ting Weng, Liang Zhao, Robert Lionberger
Particle size distribution (PSD) is an important property of particulates in drug products. In the evaluation of generic drug products formulated as suspensions, emulsions, and liposomes, the PSD comparisons between a test product and the branded product can provide useful information regarding in vitro and in vivo performance. Historically, the FDA has recommended the population bioequivalence (PBE) statistical approach to compare the PSD descriptors D50 and SPAN from test and reference products to support product equivalence...
April 12, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29650313/a-novel-feature-extraction-technique-for-pulmonary-sound-analysis-based-on-emd
#11
Ashok Mondal, Poulami Banerjee, Hong Tang
BACKGROUND AND OBJECTIVE: The stethoscope based auscultation technique is a primary diagnostic tool for chest sound analysis. However, the performance of this method is limited due to its dependency on physicians experience, knowledge and also clarity of the signal. To overcome this problem we need an automated computer-aided diagnostic system that will be competent in noisy environment. In this paper, a novel feature extraction technique is introduced for discriminating various pulmonary dysfunctions in an automated way based on pattern recognition algorithms...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29643402/spatial-encoding-of-translational-optic-flow-in-planar-scenes-by-elementary-motion-detector-arrays
#12
Julien Lecoeur, Emily Baird, Dario Floreano
Elementary Motion Detectors (EMD) are well-established models of visual motion estimation in insects. The response of EMDs are tuned to specific temporal and spatial frequencies of the input stimuli, which matches the behavioural response of insects to wide-field image rotation, called the optomotor response. However, other behaviours, such as speed and position control, cannot be fully accounted for by EMDs because these behaviours are largely unaffected by image properties and appear to be controlled by the ratio between the flight speed and the distance to an object, defined here as relative nearness...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29605977/esophageal-motor-disorders-are-a-strong-and-independant-associated-factor-of-barrett-s-esophagus
#13
Camille Bazin, Alban Benezech, Marine Alessandrini, Jean-Charles Grimaud, Veronique Vitton
Background/Aims: Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett's esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. Methods: A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29596006/accuracy-of-prehospital-identification-of-stroke-in-a-large-stroke-belt-municipality
#14
Nee-Kofi Mould-Millman, Halea Meese, Ibthial Alattas, Moges Ido, Iasson Yi, Tolulope Oyewumi, Michael Colman, Michael Frankel, Arthur Yancey
OBJECTIVE: Strokes are a leading cause of morbidity and mortality in the United States, especially in the "stroke belt" of the southeast. Up to 65% of stroke patients access care by calling 9-1-1. The primary objective of this study is to measure the accuracy of emergency medical dispatchers (EMD) and paramedics, in the prehospital identification of stroke. METHODS: The study was based at Grady Emergency Medical Services, which is Atlanta, Georgia's public emergency medical services (EMS) provider...
March 29, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29580724/application-of-enamel-matrix-derivative-emdogain-in-endodontic-therapy-a-comprehensive-literature-review
#15
REVIEW
Howard H Wang, Nima D Sarmast, Elham Shadmehr, Nikola Angelov, Shahrokh Shabahang, Mahmoud Torabinejad
INTRODUCTION: Enamel matrix derivative (EMD) is a protein extract used for the treatment of periodontal defects and soft tissue recession. Its use in endodontics has been a subject of exploration, especially in regenerative procedures. The aim of this review was to evaluate the current literature available on the application of EMD in the field of endodontics. METHODS: An initial literature search of databases using different combinations of the search terms yielded 1089 articles...
March 23, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29574866/surgical-treatment-of-peri-implantitis-using-enamel-matrix-derivative-an-rct-3-and-5-year-follow-up
#16
Catrine Isehed, Björn Svenson, Pernilla Lundberg, Anders Holmlund
OBJECTIVE: To assess the clinical and radiographic outcomes 3 and 5 years after the surgical treatment of peri-implantitis per se or in combination with an enamel matrix derivative (EMD). MATERIALS AND METHODS: At baseline, 29 patients were randomized to surgical treatment with adjunctive EMD or no EMD. One year after the surgical treatment of peri-implantitis, 25 patients remained eligible for survival analyses at the 3- and 5-year follow-up. The primary outcomes were implant loss and bone level (BL) change measured on radiographs, and the secondary outcomes, bleeding on probing, pus and plaque at each implant were analysed in 18 and 14 patients at the 3- and 5-year follow-up, respectively...
March 25, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29571563/-pd-l1-testing-in-non-small-cell-lung-carcinoma-guidelines-from-the-pattern-group-of-thoracic-pathologists
#17
Sylvie Lantuejoul, Julien Adam, Nicolas Girard, Mickael Duruisseaux, Audrey Mansuet-Lupo, Aurélie Cazes, Isabelle Rouquette, Laure Gibault, Stéphane Garcia, Martine Antoine, Jean Michael Vignaud, Françoise Galateau-Sallé, Christine Sagan, Cécile Badoual, Frédérique Penault-Llorca, Diane Damotte
Lung cancer is the leading cause of cancer death in France with low response rates to conventional chemotherapy. Nevertheless, new therapies have emerged recently, among which PD1 immune checkpoint inhibitors (ICI), such as nivolumab (OPDIVO® , Bristol-Myers Squibb) and pembrolizumab (KEYTRUDA® , Merck & Co), or PD-L1 ICI, such as atezolizumab (TECENTRIQ® , Genentech), durvalumab (IMFINZI® , Astra-Zeneca), and avelumab (BAVENCIO® , EMD Serono). The prescription of pembrolizumab for advanced stages non-small cell lung carcinoma (NSCLC) patients requires the demonstration of PD-L1 expression by tumor cells by immunohistochemistry (IHC) (minimum of 50% of positive tumor cells is required for first-line setting, and of 1% for second-line and beyond) and PD-L1 assay is now considered as a companion diagnostic tool for this drug...
March 20, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29562750/inhibition-of-na-h-exchanger-with-emd-87580-does-not-confer-greater-cardioprotection-beyond-preconditioning-on-ischemia-reperfusion-injury-in-normal-dogs
#18
J G Kingma
Postischemic accumulation of intracellular Na+ promotes calcium overload and contributes to cellular necrosis. Cardioprotection afforded by pharmacologic blockade of the sodium-hydrogen exchanger subtype 1 (NHE1) is thought to be more remarkable than that obtained by ischemic conditioning (IC). The window of protection provided by IC pretreatment is maintained even when performed up to 48 hours before ischemia. In addition, the perception exists that combined NHE1 inhibition plus IC produces greater than additive protection against ischemic injury...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29557754/arnica-compositum-hekla-lava-and-acidum-nitricum-together-are-superior-to-arnica-compositum-alone-in-the-local-treatment-of-symptomatic-calcific-periarthritis-of-the-shoulder-a-pilot-study
#19
Simone Zanella, Francesco Buccelletti, Francesco Franceschi, Claudio Ramponi, Federica Spagnolli, Gianpaolo Sacchetti, Giovanna Oliva
BACKGROUND: To evaluate the usefulness of Arnica compositum (AC) + Acidum nitricum (AN) + Hekla lava (HL) ointment in Emergency Medicine Department (EMD) as alternative non-pharmacological local treatment of patients with symptomatic calcific periarthritis of the shoulder (CPS) and to compare the effectiveness of this mixture against AC ointment alone. METHODS: A series of 41 consecutive patients (20 women, 19 men, median age 49 years, range 25-80 years) with non-traumatic painful unilateral CPS were randomly assigned to receive local treatment with AC+AN+HL ointment mixture (Group A, cases, N=21) or AC ointment alone (Group B, controls, N=20)...
March 19, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29550788/recovery-of-signal-loss-adopting-the-residual-bootstrap-method-in-fetal-heart-rate-dynamics
#20
Sun-Kyung Lee, Young-Sun Park, Kyung-Joon Cha
Fetal heart rate (FHR) data obtained from a non-stress test (NST) can be presented in a type of time series, which is accompanied by signal loss due to physical and biological causes. To recover or estimate FHR data, which is subjected to a high rate of signal loss, time series models [second-order autoregressive (AR(2)), first-order autoregressive conditional heteroscedasticity (ARCH(1)) and empirical mode decomposition and vector autoregressive (EMD-VAR)] and the residual bootstrap method were applied. The ARCH(1) model with the residual bootstrap technique was the most accurate [root mean square error (RMSE), 2...
March 19, 2018: Biomedizinische Technik. Biomedical Engineering
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