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https://www.readbyqxmd.com/read/28443246/genetic-and-dietary-iron-overload-differentially-affect-the-course-of-salmonella-typhimurium-infection
#1
Manfred Nairz, Andrea Schroll, David Haschka, Stefanie Dichtl, Piotr Tymoszuk, Egon Demetz, Patrizia Moser, Hubertus Haas, Ferric C Fang, Igor Theurl, Günter Weiss
Genetic and dietary forms of iron overload have distinctive clinical and pathophysiological features. HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. In contrast, excessive dietary iron intake results in iron deposition in macrophages. However, the functional consequences of genetic and dietary iron overload for the control of microbes are incompletely understood. Using Hfe(+/+) and Hfe(-/-) mice in combination with oral iron overload in a model of Salmonella enterica serovar Typhimurium infection, we found animals of either genotype to induce hepcidin antimicrobial peptide expression and hypoferremia following systemic infection in an Hfe-independent manner...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28439984/effects-of-energy-supply-and-nicotinic-acid-supplementation-on-serum-anti-oxidative-capacity-and-on-expression-of-oxidative-stress-related-genes-in-blood-leucocytes-of-periparturient-primi-and-pluriparous-dairy-cows
#2
S Bühler, J Frahm, R Tienken, S Kersten, U Meyer, K Huber, S Dänicke
The periparturient period is accompanied by metabolic and oxidative stress. Niacin is known to decrease lipolysis but is also reported to have anti-oxidative effects. Therefore, we examined the effects of energy supply and a nicotinic acid (NA) supplementation on anti-oxidative serum parameters and on the expression of oxidative stress-related genes in blood leucocytes of periparturient dairy cows, differing in parity. Twenty-nine pluriparous and 18 primiparous cows were allocated to four different feeding groups 42 days before expected parturition until 100 days postpartum and fed a ration with either a low concentrate proportion of 30% (LC) or a high concentrate proportion of 60% (HC)...
April 25, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28439287/rattlesnake-crotalus-molossus-nigrescens-venom-induces-oxidative-stress-on-human-erythrocytes
#3
David Meléndez-Martínez, Juan Manuel Muñoz, Guillermo Barraza-Garza, Martha Sandra Cruz-Peréz, Ana Gatica-Colima, Emilio Alvarez-Parrilla, Luis Fernando Plenge-Tellechea
BACKGROUND: Globally, snake envenomation is a well-known cause of death and morbidity. In many cases of snakebite, myonecrosis, dermonecrosis, hemorrhage and neurotoxicity are present. Some of these symptoms may be provoked by the envenomation itself, but others are secondary effects of the produced oxidative stress that enhances the damage produced by the venom toxins. The only oxidative stress effect known in blood is the change in oxidation number of Fe (from ferrous to ferric) in hemoglobin, generating methemoglobin but not in other macromolecules...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28439033/genome-wide-identification-of-resd-nsrr-and-fur-binding-in-bacillus-subtilis-during-anaerobic-fermentative-growth-by-in-vivo-footprinting
#4
Onuma Chumsakul, Divya P Anantsri, Tai Quirke, Taku Oshima, Kensuke Nakamura, Shu Ishikawa, Michiko M Nakano
Upon oxygen limitation, the Bacillus subtilis ResE sensor kinase and its cognate ResD response regulator play primary roles in transcriptional activation of genes functioning in anaerobic respiration. The nitric oxide (NO)-sensitive NsrR repressor controls transcription to support nitrate respiration. In addition, the ferric uptake repressor (Fur) can modulate transcription under anaerobic conditions. However, whether these controls are direct or indirect has been investigated only in a gene-specific manner...
April 24, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28438977/47-years-of-iai-a-glance-in-the-mirror-and-the-road-ahead
#5
Ferric C Fang
Infection and Immunity was born in January 1970 (1), the same year that the first Ford Pinto rolled off the assembly line.….
April 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28437695/fe-iii-promoted-transformation-of-%C3%AE-lactam-antibiotics-hydrolysis-vs-oxidation
#6
Jiabin Chen, Ying Wang, Yajie Qian, Tianyin Huang
The widely used β-lactam antibiotics are susceptible to oxidative and/or hydrolytic degradation promoted by some metal ions (e.g., Cu(II)). Ferric ions (Fe(III)) are among the most common metal ions, but their role in the environmental transformation and fate of β-lactam antibiotics is still unknown. This study elucidates that Fe(III) can promote degradation of β-lactam antibiotics under environmental aquatic conditions. Degradation rate constants of ampicillin (AMP) linearly increased with increasing Fe(III) concentration, but were independent of AMP concentration when AMP was higher than Fe(III) concentration...
April 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28437686/synthesis-optical-properties-and-application-of-a-set-of-novel-pyrazole-nopinone-derivatives
#7
Jinlai Yang, Xu Xu, Jian Rui, Zhonglong Wang, Yan Zhang, Shifa Wang, Liangru Wu
Pyrazole derivatives (4-6) were directly synthesized from β-pinene derivative nopinone, and they were characterized by Fourier transform infrared (FTIR) spectoscope, nuclear magnetic resonance (NMR), and mass spectrometry. Their optical properties were investigated by ultraviolet-visible spectroscopy and fluorescence spectroscopy. The three compounds emitted strong blue fluorescence in ethanol. Using a fluorescence quenching method, compound 4 could be used to detect the content (100.57%) of copper sulfate pentahydrate (≥99%) with a RSD of 1...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28437101/ground-state-and-excited-state-tuning-in-ferric-dipyrrin-complexes-promoted-by-ancillary-ligand-exchange
#8
Claudia Kleinlein, Shao-Liang Zheng, Theodore A Betley
Three ferric dipyrromethene complexes featuring different ancillary ligands were synthesized by one electron oxidation of ferrous precursors. Four-coordinate iron complexes of the type ((Ar)L)FeX2 [(Ar)L = 1,9-(2,4,6-Ph3C6H2)2-5-mesityldipyrromethene] with X = Cl or (t)BuO were prepared and found to be high-spin (S = (5)/2), as determined by superconducting quantum interference device magnetometry, electron paramagnetic resonance, and (57)Fe Mössbauer spectroscopy. The ancillary ligand substitution was found to affect both ground state and excited properties of the ferric complexes examined...
April 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28436221/the-iron-chaperone-protein-cyay-from-vibrio-cholerae-is-a-heme-binding-protein
#9
Takeshi Uchida, Noriyuki Kobayashi, Souichiro Muneta, Koichiro Ishimori
CyaY is an iron transport protein for Fe-S cluster biosynthetic systems and a ferrochelatase that catalyzes insertion of Fe(2+) into protoporphyrin IX. Here, we found that CyaY has the ability to bind heme as well as iron, exhibiting a dissociation constant for heme of 21 ± 6 nM. Absorption and resonance Raman spectra revealed that both ferric and ferrous forms of heme were bound to an anionic ligand (e.g., tyrosine and/or cysteine). Consistent with this, mutagenesis studies showed that Tyr67 and Cys78 are possible heme ligands of CyaY...
April 24, 2017: Biochemistry
https://www.readbyqxmd.com/read/28436136/effects-of-ferric-carboxymaltose-on-hospitalisations-and-mortality-rates-in-iron-deficient-heart-failure-patients-an-individual-patient-data-meta-analysis
#10
Stefan D Anker, Bridget-Anne Kirwan, Dirk J van Veldhuisen, Gerasimos Filippatos, Josep Comin-Colet, Frank Ruschitzka, Thomas F Lüscher, Gregory P Arutyunov, Michael Motro, Claudio Mori, Bernard Roubert, Stuart J Pocock, Piotr Ponikowski
AIMS: Iron deficiency (ID) is a common co-morbidity in patients with heart failure (HF) and has been suggested to be associated with poor prognosis. Recently completed double-blind randomised controlled trials (RCTs) studying HF patients with ID have shown improvements in functional capacity, symptoms and quality of life when treated with i.v. ferric carboxymaltose (FCM). This individual patient data meta-analysis investigates the effect of FCM vs. placebo on recurrent hospitalisations and mortality in HF patients with ID...
April 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28435871/recovery-of-an-oxidized-majorite-inclusion-from-earth-s-deep-asthenosphere
#11
Cheng Xu, Jindřich Kynický, Renbiao Tao, Xi Liu, Lifei Zhang, Miroslav Pohanka, Wenlei Song, Yingwei Fei
Minerals recovered from the deep mantle provide a rare glimpse into deep Earth processes. We report the first discovery of ferric iron-rich majoritic garnet found as inclusions in a host garnet within an eclogite xenolith originating in the deep mantle. The composition of the host garnet indicates an ultrahigh-pressure metamorphic origin, probably at a depth of ~200 km. More importantly, the ferric iron-rich majoritic garnet inclusions show a much deeper origin, at least at a depth of 380 km. The majoritic nature of the inclusions is confirmed by mineral chemistry, x-ray diffraction, and Raman spectroscopy, and their depth of origin is constrained by a new experimental calibration...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28432891/modification-of-an-existing-in%C3%A2-vitro-method-to-predict-relative-bioavailable-arsenic-in-soils
#12
Shane Whitacre, Nicholas Basta, Brooke Stevens, Valerie Hanley, Richard Anderson, Kirk Scheckel
The soil matrix can sequester arsenic (As) and reduces its exposure by soil ingestion. In vivo dosing studies and in vitro gastrointestinal (IVG) methods have been used to predict relative bioavailable (RBA) As. Originally, the Ohio State University (OSU-IVG) method predicted RBA As for soils exclusively from mining and smelting sites with a median of 5,636 mg As kg(-1). The objectives of the current study were to (i) evaluate the ability of the OSU-IVG method to predict RBA As for As contaminated soils with a wider range of As content and As contaminant sources, and (ii) evaluate a modified extraction procedure's ability to improve prediction of RBA As...
April 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28431495/iron-regulated-small-rna-expression-as-neisseria-gonorrhoeae-fa-1090-transitions-into-stationary-phase-growth
#13
Lydgia A Jackson, Michael Day, Jennie Allen, Edgar Scott, David W Dyer
BACKGROUND: For most pathogens, iron (Fe) homeostasis is crucial for maintenance within the host and the ability to cause disease. The primary transcriptional regulator that controls intracellular Fe levels is the Fur (ferric uptake regulator) protein, which exerts its action on transcription by binding to a promoter-proximal sequence termed the Fur box. Fur-regulated transcriptional responses are often fine-tuned at the post-transcriptional level through the action of small regulatory RNAs (sRNAs)...
April 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28431006/regulation-of-oxidized-platelet-lipidome-implications-for-coronary-artery-disease
#14
Madhumita Chatterjee, Dominik Rath, Jörg Schlotterbeck, Johannes Rheinlaender, Britta Walker-Allgaier, Nada Alnaggar, Monika Zdanyte, Iris Müller, Oliver Borst, Tobias Geisler, Tilman E Schäffer, Michael Lämmerhofer, Meinrad Gawaz
Aims: Hyperlipidaemia enhances susceptibility to thrombosis, while platelet oxidixed LDL (oxLDL) binding in acute coronary syndrome (ACS) correlates with activation status. This study explores the platelet lipidome in symptomatic coronary artery disease (CAD) patients and the functional consequences of the chemokine CXCL12 and its receptors CXCR-4/-7 on lipid uptake in platelets. Methods and results: Platelet-oxLDL detected by flow cytometry was enhanced (P = 0...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28430950/effects-of-dissolved-oxygen-concentration-and-iron-addition-on-immediate-early-gene-expression-of-magnetospirillum-gryphiswaldense-msr-1
#15
Shiwen Zhuang, Diana Chinyere Anyaogu, Takeshi Kasama, Mhairi Workman, Uffe Hasbro Mortensen, Timothy John Hobley
We report effects of dissolved oxygen (DO) concentration and iron addition on gene expression of Magnetospirillum gryphiswaldense MSR-1 cells during fermentations, focusing on 0.25-24 h after iron addition. The DO was strictly controlled at 0.5% or 5% O2, and compared with aerobic condition. Uptake of iron (and formation of magnetosomes) was only observed in the 0.5% O2 condition where there was little difference in cell growth and carbon consumption compared to the 5% O2 condition. Quantitative reverse transcription PCR analysis showed a rapid (within 0...
April 19, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28428688/modulation-of-angiogenesis-proliferative-response-and-apoptosis-by-%C3%AE-sitosterol-in-rat-model-of-renal-carcinogenesis
#16
Ramalingam Sharmila, Ganapathy Sindhu
As expanded understanding of molecular tumor characteristics, which drive renal cancer growth and progression gives a promising future for renal carcinoma therapy. The objective of the present study was designed to examine the effect of β-sitosterol on a rat model of experimental renal carcinogenesis. Renal carcinogenesis was induced in rats treated with N-diethylnitrosamine (DEN; 200 mg/kg bw single i.p., injection) and ferric nitrilotriacetate (Fe-NTA; 9 mg Fe/kg bw i.p., twice a week for 16 weeks). β-sitosterol pretreatment (20 mg/kg bw in 0...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28427041/the-efficacy-of-donepezil-administration-on-acetylcholinesterase-activity-and-altered-redox-homeostasis-in-alzheimer-s-disease
#17
Pinar Atukeren, Mahir Cengiz, Hakan Yavuzer, Remise Gelisgen, Esma Altunoglu, Sena Oner, Fusun Erdenen, Damla Yuceakın, Himmet Derici, Ufuk Cakatay, Hafize Uzun
Alzheimer's disease (AD) is a serious multifactorial disorder with progressive neurodegenerative outcomes related with impaired redox homeostasis. Inhibition of the enzyme acetylcholinesterase (AChE), as one of the major therapeutic strategies, is considered to be offering only symptomatic relief and moderate disease modifying effect. We intended to investigate the effects of acetylcholinesterase inhibition via donepezil on protein carbonyl (PCO), advanced protein oxidation products (AOPP) and ischemia modified albumin (IMA) as protein oxidation markers and ferric reducing antioxidant power (FRAP), prooxidant-antioxidant balance (PAB), total thiol (T-SH), protein thiol (P-SH) as antioxidant status markers and also kynurenine (KYN), N-formyl kynurenine (N-FKYN) and protein bound dityrosine (DT) levels all in one demonstrating the redox homeostasis in Alzheimer patients also correlated with AChE activity...
April 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28426241/extracellular-heme-uptake-and-the-challenge-of-bacterial-cell-membranes
#18
Weiliang Huang, Angela Wilks
Iron is essential for the survival of most bacteria but presents a significant challenge given its limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain physiological iron levels within a narrow concentration range requires sophisticated systems to sense, regulate, and transport iron. Most bacteria have evolved mechanisms to chelate and transport ferric iron (Fe(3+)) via siderophore receptor systems, and pathogenic bacteria have further lowered this barrier by employing mechanisms to utilize the host's hemoproteins...
April 19, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28425857/antioxidant-properties-of-fractions-for-unripe-fruits-of-capsicum-annuum-l-var-conoides
#19
Chung-Yi Chen, Ching-Yu Yen, Gao-Mai Shen, Tzu-Jung Yu, Yi-Shin Liao, Ru-In Jian, Sheng-Chieh Wang, Jen-Yang Tang, H-W Chang
BACKGROUND: Capsicum plant, especially for C. annuum, is an abundant resource for bioactive antioxidants, but few studies have examined the unripe fruit part of the Capsicum plant. OBJECTIVE: MeOH extract of unripe fruits of C. annuum L. var. conoides (UFCA) was chromatographed over a silica gel column using a gradient of CH2Cl2/MeOH as eluent to produce 9 fractions. Antioxidant activities are evaluated along with cell viabilities of 9 fractions of UFCA. METHOD: The antioxidant properties were analyzed in terms of total phenol content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, ferric reducing, and ferrous ion-chelating ability...
April 19, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28424737/gc-ms-based-metabolite-profiling-antioxidant-and-antimicrobial-properties-of-different-solvent-extracts-of-malaysian-plectranthus-amboinicus-leaves
#20
Mallappa Kumara Swamy, Greetha Arumugam, Ravinder Kaur, Ali Ghasemzadeh, Mazina Mohd Yusoff, Uma Rani Sinniah
This study evaluates the phytochemistry, antioxidant, and antimicrobial effects of Plectranthus amboinicus leaves extracted in different solvents. The methanol extract contained the highest total phenolic (94.37 ± 1.24 mg GAE/g) and flavonoid contents (26.90 ± 1.35 mg RE/g) and exhibited the highest DPPH scavenging activity (90.13 ± 3.32%) followed by the acetone extract (80.23 ± 3.26%) at 500 μg/mL concentration. Similarly, the highest ferric ion reduction potential (849.63 ± 30.95 μM of Fe (II)/g dry weight) was exhibited by the methanol extract followed by the acetone extract (695...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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