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https://www.readbyqxmd.com/read/28108264/iron-accumulation-and-microglia-activation-contribute-to-substantia-nigra-hyperechogenicity-in-the-6-ohda-induced-rat-model-of-parkinson-s-disease
#1
Yaqin Zhu, Bao Wang, Kai Tao, Hengli Yang, Yixiao Wang, Tian Zhou, Yilin Yang, Lijun Yuan, Xi Liu, Yunyou Duan
INTRODUCTION: This study aims to explain the mechanisms for the formation of sonographic features of Parkinson's disease (PD) using a 6-hydroxydopamine (6-OHDA) rat model of PD. The iron chelator deferiprone (DFP) was used in the PD model rat to examine the relationship between iron and the echo signal. METHODS: Rat models were created using stereotactic injections of 6-OHDA. DFP was administered intragastrically. Transcranial sonography (TCS) was performed to observe the substantia nigra (SN) echo signal of the brain...
January 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28106740/chemical-composition-and-antioxidant-properties-of-powders-obtained-from-different-plum-juice-formulations
#2
Anna Michalska, Aneta Wojdyło, Grzegorz P Łysiak, Adam Figiel
Among popular crops, plum (Prunus domestica L.) has received special attention due to its health-promoting properties. The seasonality of this fruit makes it impossible to consume it throughout the year, so new products in a powder form may offer an alternative to fresh consumption and may be used as high-quality natural food ingredients. A 100% plum (cultivar "Valor") juice was mixed with three different concentrations of maltodextrin or subjected to sugars removal by amberlite-XAD column, and dried using the freeze, spray, and vacuum (40, 60, and 80 °C) drying techniques...
January 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28100199/antioxidant-and-hepatoprotective-potential-of-lawsonia-inermis-l-leaves-against-2-acetylaminofluorene-induced-hepatic-damage-in-male-wistar-rats
#3
Manish Kumar, Paramjeet Kaur, Madhu Chandel, Amrit Pal Singh, Arpana Jain, Satwinderjeet Kaur
BACKGROUND: Lawsonia inermis (Lythraceae) is an ethnomedicinal plant, traditionally known for curing several ailments such as skin diseases, bacterial infections, jaundice, renal lithiases and inflammation etc. The present work deals with assessment of in vitro antioxidant and in vivo hepatoprotective potential of butanolic fraction (But-LI) of Lawsonia inermis L. leaves. METHODS: Antioxidant activity was evaluated using deoxyribose degradation, lipid peroxidation inhibition and ferric reducing antioxidant power (FRAP) assay...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28100069/the-effect-of-n-acetylcysteine-supplementation-on-serum-homocysteine-levels-and-hepatic-and-renal-oxidative-stress-in-homocysteine-thiolactone-treated-rats
#4
Gamze Kondakçı, A Fatih Aydın, Semra Doğru-Abbasoğlu, Müjdat Uysal
The effect of N-acetylcysteine (NAC) (1 g/kg body weight/day) on serum homocysteine (Hcy) levels, insulin resistance (IR), and hepatic and renal prooxidant-antioxidant balance was evaluated in rats treated with homocysteine thiolactone (HcyT) (500 mg/kg body weight/day for 6 weeks). Reactive oxygen species (ROS), malondialdehyde (MDA), glutathione, ferric reducing antioxidant power, and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined in the liver and kidney. HcyT elevated serum Hcy levels and caused IR, but liver and kidney function tests remained unchanged...
January 19, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28098196/enhanced-removal-of-as-v-from-aqueous-solution-using-modified-hydrous-ferric-oxide-nanoparticles
#5
Lijuan Huo, Xibai Zeng, Shiming Su, Lingyu Bai, Yanan Wang
Hydrous ferric oxide (HFO) is most effective with high treatment capacity on arsenate [As(V)] sorption although its transformation and aggregation nature need further improvement. Here, HFO nanoparticles with carboxymethyl cellulose (CMC) or starch as modifier was synthesized for the purpose of stability improvement and As(V) removal from water. Comparatively, CMC might be the optimum stabilizer for HFO nanoparticles because of more effective physical and chemical stability. The large-pore structure, high surface specific area, and the non-aggregated nature of CMC-HFO lead to increased adsorption sites, and thus high adsorption capacities of As(V) without pre-treatment (355 mg·g(-1)), which is much greater than those reported in previous studies...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097162/antioxidant-activity-of-polyphenolic-myricetin-in-vitro-cell-free-and-cell-based-systems
#6
Abolfazl Barzegar
Myricetin (Myc) is one of the most important flavonoids in diet due to its abundance in foods with the highest antioxidant activity. The antioxidant activity of Myc was studied in cell-free and cell-based systems to evaluate the ROS protection efficiency of Myc. The studies were based on the assessment of reducing power of Myc according to ferric ion reduction and intracellular ROS level measurement by assaying the cellular fluorescence intensity using dichlorodihydrofluorescein (DCF) probe as an indicator for ROS in cells...
June 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28095881/renal-function-in-patients-with-non-dialysis-chronic-kidney-disease-receiving-intravenous-ferric-carboxymaltose-an-analysis-of-the-randomized-find-ckd-trial
#7
Iain C Macdougall, Andreas H Bock, Fernando Carrera, Kai-Uwe Eckardt, Carlo Gaillard, David Van Wyck, Yvonne Meier, Sylvain Larroque, Simon D Roger
BACKGROUND: Preclinical studies demonstrate renal proximal tubular injury after administration of some intravenous iron preparations but clinical data on renal effects of intravenous iron are sparse. METHODS: FIND-CKD was a 56-week, randomized, open-label, multicenter study in which patients with non-dialysis dependent chronic kidney disease (ND-CKD), anemia and iron deficiency without erythropoiesis-stimulating agent therapy received intravenous ferric carboxymaltose (FCM), targeting either higher (400-600 μg/L) or lower (100-200 μg/L) ferritin values, or oral iron...
January 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28095695/frontier-molecular-orbital-contributions-to-chlorination-versus-hydroxylation-selectivity-in-the-non-heme-iron-halogenase-syrb2
#8
Martin Srnec, Edward I Solomon
The ability of an Fe(IV)=O intermediate in SyrB2 to perform chlorination vs. hydroxylation was computationally evaluated for different substrates that had been studied experimentally. The π-trajectory for H-atom abstraction (Fe(IV)=O oriented perpendicular to the C-H bond of substrate) was found to lead to the S = 2 five-coordinate HO-Fe(III)-Cl complex with the C• of the substrate, π-oriented relative to both the Cl(-) and OH(-) ligands. From this ferric intermediate, hydroxylation is thermodynamically favored, but chlorination is intrinsically more reactive due to the energy splitting between two key redox-active dπ* frontier molecular orbitals (FMOs)...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28095310/ilex-paraguariensis-supplementation-may-be-an-effective-nutritional-approach-to-modulate-oxidative-stress-during-perimenopause
#9
Ariana Aparecida Ferreira Pereira, Keny Gonçalves Tirapeli, Antonio Hernandes Chaves Neto, Matheus da Silva Brasilino, Cláudia Quintino da Rocha, Adriane Belló-Klein, Suzana Francisca Llesuy, Rita Cássia Menegati Dornelles, Ana Cláudia de Melo Stevanato Nakamune
Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that results in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant supplementation may be an effective approach to minimizing this stress. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense...
January 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28092401/randomized-clinical-trial-of-preoperative-oral-versus-intravenous-iron-in-anaemic-patients-with-colorectal-cancer
#10
B D Keeler, J A Simpson, O Ng, H Padmanabhan, M J Brookes, A G Acheson
BACKGROUND: Treatment of preoperative anaemia is recommended as part of patient blood management, aiming to minimize perioperative allogeneic red blood cell transfusion. No clear evidence exists outlining which treatment modality should be used in patients with colorectal cancer. The study aimed to compare the efficacy of preoperative intravenous and oral iron in reducing blood transfusion use in anaemic patients undergoing elective colorectal cancer surgery. METHODS: Anaemic patients with non-metastatic colorectal adenocarcinoma were recruited at least 2 weeks before surgery and randomized to receive oral (ferrous sulphate) or intravenous (ferric carboxymaltose) iron...
January 16, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28089715/ameliorating-effects-of-herbal-formula-hemomine-on-experimental-subacute-hemorrhagic-anemia-in-rats
#11
Sae Kwang Ku, Hyemee Kim, Joo Wan Kim, Ki Sung Kang, Hae-Jeung Lee
ETHNOPHARMACOLOGICAL RELEVANCE: Hemomine (HM) is an herbal mixture consisting of 5 varieties of the hematopoietic herbal extracts (Angelica gigas Nakai, Cnidium officinale Makino, Paeonia lactiflora Pall., Rehmannia glutinosa Liboschitz ex Stueudel, Glycyrrhiza uralensis Fischer). AIM OF THE STUDY: Anemia has been treated with iron supplements, whereas it could cause adverse side effects such as digestive discomfort. In the present study, HM was applied to SHA rats to test for several activities so as to verify its therapeutic potentials on anemia and digestive discomfort...
January 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28088731/biological-properties-of-citral-and-its-potential-protective-effects-against-cytotoxicity-caused-by-aspirin-in-the-iec-6-cells
#12
Hafsia Bouzenna, Najla Hfaiedh, Marie-Agnès Giroux-Metges, Abdelfattah Elfeki, Hélène Talarmin
Citral, 3,7-dimethyl-2,6-octadienal, is a key component of several essential oils extracted from lemon-scented herbal plants. The present study was designed to investigate the antioxidant activities of citral and assess its possible protective effects against aspirin-induced toxicity in vitro. We used IEC-6 cells (rat small intestine epithelial cells). The antioxidant activities were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH), β-carotene/linoleic acid and Ferric reducing antioxidant power (FRAP). Cytotoxicity was evaluated by cell viability, anti-oxidant enzyme activities, malondialdehyde (MDA) production and by the expression of MAPKs (Mitogen-Activated Protein Kinases) pathways...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28087802/cytochrome-c-peroxidase-ccp-is-a-molecular-determinant-of-the-oxidative-stress-response-in-the-extreme-acidophilic-leptospirillum-sp-cf-1
#13
C Zapata, B Paillavil, R Chávez, P Álamos, G Levicán
Bioleaching processes are used to recover metals from sulfidic ores. Biofilm formation on ores is important for bioleaching because the attached microorganisms start the leaching process by concentrating ferric ions in the extracellular matrix. It has been shown that hydrogen peroxide is spontaneously generated on the surface of ores and that it negatively influences the growth and activity of microorganisms. However, the mechanism by which bioleaching microorganisms tolerate exogenous H2O2 as an adaptive trait remains elusive...
January 12, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28087384/epidermal-growth-factor-egf-fragment-guided-anticancer-theranostic-particles-for-ph-responsive-release-of-doxorubicin
#14
Myun Koo Kang, Wei Mao, Jun Bae Lee, Hyuk Sang Yoo
EGF fragment (EGFfr) and doxorubicin were chemically co-decorated on single magnetic nanoparticles (MNPs) for concomitant cancer targeting and treatment. Magnetic nanoparticles were prepared by the precipitation of ferric chloride hydrates in an ammonia solution and subsequent surface-functionalization with amines. The terminal thiol group of the EGF fragment was first conjugated to surface amines of the MNPs using a heterofunctional crosslinker, and doxorubicin was sequentially conjugated to the MNPs via a hydrazone linker, where the degree of subsitution of the surface amines to EGFfr was varied from 1% to 40%...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28081526/phosphomolybdic-acid-and-ferric-iron-as-efficient-electron-mediators-for-coupling-biomass-pretreatment-to-produce-bioethanol-and-electricity-generation-from-wheat-straw
#15
Yi Ding, Bo Du, Xuebing Zhao, J Y Zhu, Dehua Liu
Phosphomolybdic acid (PMo12) was used as an electron mediator and proton carrier to mediate biomass pretreatment for ethanol production and electricity generation from wheat straw. In the pretreatment, lignin was oxidized anaerobically by PMo12 with solubilization of a fraction of hemicelluloses, and the PMo12 was simultaneously reduced. In an external liquid flow cell, the reduced PMo12 was re-oxidized with generation of electricity. The effects of several factors on pretreatment were investigated for optimizing the conditions...
January 3, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28081365/visualizing-arsenate-reactions-and-encapsulation-in-a-single-zero-valent-iron-nanoparticle
#16
Lan Ling, Wei-Xian Zhang
A nanostructure-based mechanism is presented on the enrichment, separation and immobilization of arsenic with nanoscale Zero-Valent Iron (nZVI). The As-Fe reactions are studied with Spherical Aberration Corrected Scanning Transmission Electron Microscopy (Cs-STEM). Near atomic-resolution (<1 nm3) electron tomography discovers a thin continuous layer (23±3 Å) of elemental arsenic sandwiched between the iron oxide shell and the zero-valent iron core. This points to a unique mechanism of nano-encapsulation and proves that the outer layer, especially the Fe(0)/oxide interface is the edge of the As-Fe reactions...
January 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28078600/net-budgetary-impact-of-ferric-citrate-as-a-first-line-phosphate-binder-for-the-treatment-of-hyperphosphatemia-a-markov-microsimulation-model
#17
Steven M Brunelli, Scott P Sibbel, David Van Wyck, Amit Sharma, Andrew Hsieh, Glenn M Chertow
Ferric citrate (FC) has demonstrated efficacy as a phosphate binder and reduces the requirements for erythropoiesis-stimulating agents (ESAs) and intravenous (IV) iron in dialysis patients. We developed a net budgetary impact model to evaluate FC vs. other phosphate binders from the vantage of a large dialysis provider. We used a Markov microsimulation model to simulate mutually referential longitudinal effects between serum phosphate and phosphate binder dose; categories of these defined health states. Health states probabilistically determined treatment attendance and utilization of ESA and IV iron...
January 11, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28077697/point-counterpoint-what-is-the-optimal-approach-for-detection-of-clostridium-difficile-infection
#18
Ferric C Fang, Christopher R Polage, Mark H Wilcox
In 2010, we published an initial point-counterpoint on laboratory diagnosis of C. difficile infection (CDI). At that time, nucleic acid amplification tests (NAATs) were just becoming commercially available, and the idea of algorithmic approaches to CDI was being explored. Now there are numerous NAATs in the marketplace and based on recent proficiency test surveys, they have become the predominant method used for CDI diagnosis in the United States. At the same time, there is a body of literature that suggests that NAATs lack clinical specificity and thus inflate CDI rates...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28074004/signaling-by-two-component-system-noncognate-partners-promotes-intrinsic-tolerance-to-polymyxin-b-in-uropathogenic-escherichia-coli
#19
Kirsten R Guckes, Erin J Breland, Ellisa W Zhang, Sarah C Hanks, Navleen K Gill, Holly M S Algood, Jonathan E Schmitz, Charles W Stratton, Maria Hadjifrangiskou
Bacteria use two-component systems (TCSs) to react appropriately to environmental stimuli. Typical TCSs comprise a sensor histidine kinase that acts as a receptor coupled to a partner response regulator that coordinates changes in bacterial behavior, often through its activity as a transcriptional regulator. TCS interactions are typically confined to cognate pairs of histidine kinases and response regulators. We describe two distinct TCSs in uropathogenic Escherichia coli (UPEC) that interact to mediate a response to ferric iron...
January 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28071801/formation-and-characterization-of-green-tea-extract-loaded-liposomes
#20
Damla Dag, Mecit Halil Oztop
Green tea extract was encapsulated into liposomes to enhance bioavailability and stability of catechins by protecting their functional properties simultaneously. Encapsulation was achieved by dispersing 1% (w/v) soy lecithin through high pressure homogenization (microfluidization) and ultrasonication. Effects of homogenization type and pH of the dispersing medium on the physical properties and stability of the liposomes during 1-mo storage period were investigated. Mean particle size, total phenolic content by Folin-Ciocalteu method and antioxidant activity by 2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reducing-antioxidant power methods, and transmission electron microscopy (TEM) experiments were conducted for characterization...
January 10, 2017: Journal of Food Science
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