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GLUT expression mononuclear cells

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https://www.readbyqxmd.com/read/24786779/effect-of-antihypertensive-treatments-on-insulin-signalling-in-lympho-monocytes-of-essential-hypertensive-patients-a-pilot-study
#1
Carolina De Ciuceis, Vincenzo Flati, Claudia Rossini, Anna Rufo, Enzo Porteri, Jacopo Di Gregorio, Beatrice Petroboni, Elisa La Boria, Carlotta Donini, Evasio Pasini, Enrico Agabiti Rosei, Damiano Rizzoni
It was previously demonstrated that metabolic syndrome in humans is associated with an impairment of insulin signalling in circulating mononuclear cells. At least in animal models of hypertension, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) may correct alterations of insulin signalling in the skeletal muscle. In the first study, we investigated the effects of a 3-month treatment with an ARB with additional PPARγ agonist activity, telmisartan, or with a dihydropyridine calcium channel blocker, nifedipine, on insulin signalling in patients with mild-moderate essential hypertension...
December 2014: Blood Pressure
https://www.readbyqxmd.com/read/22901485/changes-in-glucose-transporter-expression-in-monocytes-of-periparturient-dairy-cows
#2
N J O'Boyle, G A Contreras, S A Mattmiller, L M Sordillo
The transition period of dairy cows is characterized by dramatic changes in metabolism and immune cell function that contributes to increased susceptibility to several economically important diseases. Monocyte and macrophage populations increase in blood and tissues of cows during the transition period and have enhanced inflammatory responses that may contribute to increased severity of disease. Glucose is a major energy source for activated monocytes and glucose uptake is facilitated by glucose transporters (GLUT)...
October 2012: Journal of Dairy Science
https://www.readbyqxmd.com/read/21082287/differentiating-of-banked-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-into-insulin-secreting-cells
#3
Pham Van Phuc, Truong Hai Nhung, Dang Thi Tung Loan, Doan Chinh Chung, Phan Kim Ngoc
Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) are multipotent cells. They are able to differentiate into functional cells from not only mesoderm but also endoderm. Many researches showed that cells derived from fresh human UCB could transdifferentiate into insulin-secreting cells. In this study, transdifferentiating potential of cryopreserved human UCB-derived MSCs into insulin-secreting cell was investigated. Fresh human UCB was enriched the mononuclear cells by Ficoll-Paque centrifugation...
January 2011: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/18283716/hypoxia-inducible-factor-is-expressed-in-giant-cell-tumour-of-bone-and-mediates-paracrine-effects-of-hypoxia-on-monocyte-osteoclast-differentiation-via-induction-of-vegf
#4
H J Knowles, N A Athanasou
Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1alpha and HIF-2alpha in the multi-nucleated, osteoclast-like giant cells and the mononuclear stromal component of giant cell tumour of bone (GCTB), a locally osteolytic primary bone tumour. HIF induction was observed in culture in the osteoblastic MG-63 cell line, primary GCTB stromal cells, and monocyte-derived osteoclasts following stimulation with hypoxia (0...
May 2008: Journal of Pathology
https://www.readbyqxmd.com/read/18165263/clinical-and-immunopathologic-alterations-in-rhesus-macaques-affected-with-globoid-cell-leukodystrophy
#5
Juan T Borda, Xavier Alvarez, Mahesh Mohan, Marion S Ratterree, Kathrine Phillippi-Falkenstein, Andrew A Lackner, Bruce A Bunnell
Globoid cell leukodystrophy, or Krabbe's disease, is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Herein, we describe the clinical, neuropathological, histochemical, and immunohistological features observed in rhesus macaques affected with Krabbe's disease. Clinical signs included pronounced muscle tremors of head and limbs, difficulty ambulating, ataxia, hypermetria, proprioceptive deficits, and respiratory abnormalities. Histopathologically, all animals presented with evidence of demyelination in the peripheral and central nervous systems and accumulation of mononuclear and multinuclear globoid cells in the cerebral and cerebellar white matter associated with severe gliosis...
January 2008: American Journal of Pathology
https://www.readbyqxmd.com/read/14600816/global-profiling-of-double-stranded-rna-and-ifn-gamma-induced-genes-in-rat-pancreatic-beta-cells
#6
J Rasschaert, D Liu, B Kutlu, A K Cardozo, M Kruhøffer, T F ØRntoft, D L Eizirik
AIMS/HYPOTHESIS: Viral infections and local production of IFN-gamma might contribute to beta-cell dysfunction/death in Type 1 Diabetes. Double stranded RNA (dsRNA) accumulates in the cytosol of viral-infected cells, and exposure of purified rat beta cells to dsRNA (tested in the form of polyinosinic-polycytidylic acid, PIC) in combination with IFN-gamma results in beta-cell dysfunction and apoptosis. To elucidate the molecular mechanisms involved in PIC + IFN-gamma-effects, we determined the global profile of genes modified by these agents in primary rat beta cells...
December 2003: Diabetologia
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