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GLUT1 mononuclear cells

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https://www.readbyqxmd.com/read/26790725/inhibition-of-glucose-transporter-1-induces-apoptosis-and-sensitizes-multiple-myeloma-cells-to-conventional-chemotherapeutic-agents
#1
Taichi Matsumoto, Shiro Jimi, Keisuke Migita, Yasushi Takamatsu, Shuuji Hara
Despite the recent development of anti-myeloma drugs, the prognosis of high-risk multiple myeloma remains poor. Therefore, new effective treatment strategies for this disease are needed. It has been reported that high intensity of 18-fluorodeoxyglucose positron emission tomography is high-risk factor in myeloma, suggesting that glucose uptake can be therapeutic target in high-risk myeloma. In this study, we addressed the utility of glucose transporter 1 (GLUT1) as a therapeutic target for myeloma with increased glucose uptake...
February 2016: Leukemia Research
https://www.readbyqxmd.com/read/25804265/brain-derived-circulating-endothelial-cells-in-peripheral-blood-of-newborn-infants-with-seizures-a-potential-biomarker-for-cerebrovascular-injury
#2
Massroor Pourcyrous, Shyamali Basuroy, Dilyara Tcheranova, Kristopher L Arheart, Mohamad T Elabiad, Charles W Leffler, Helena Parfenova
Neonatal seizures have been associated with cerebrovascular endothelial injury and neurological disabilities. In a piglet model, the long-term loss of endothelial regulation of cerebral blood flow coincides with the surge of brain-derived circulating endothelial cells (BCECs) in blood. We hypothesized that BCECs could serve as a noninvasive biomarker of cerebrovascular injury in neonates with seizures. In a prospective pilot feasibility study, we enrolled newborn infants with confirmed diagnoses of perinatal asphyxia and intraventricular hemorrhage (IVH); both are commonly associated with seizures...
March 2015: Physiological Reports
https://www.readbyqxmd.com/read/24641416/hif-1%C3%AE-and-glut1-gene-expression-is-associated-with-chemoresistance-of-acute-myeloid-leukemia
#3
Kui Song, Min Li, Xiao-Jun Xu, Li Xuan, Gui-Nian Huang, Xiao-Ling Song, Qi-Fa Liu
AIMS: Much evidence suggests that increased glucose metabolism in tumor cells might contribute to the development of acquired chemoresistance. However, the molecular mechanisms are not fully clear. Therefore, we investigated a possible correlation of mRNA expression of HIF-1α and GLUT1 with chemoresistance in acute myeloid leukemia (AML). METHODS: Bone marrow samples were obtained from newly diagnosed and relapsed AML (M3 exclusion) cases. RNA interference with short hairpin RNA (shRNA) was used to stably silence GLUT1 or HIF-1α gene expression in an AML cell line and HIF-1α and GLUT1 mRNA expression was measured by real-time quantitative polymerase chain reaction assay (qPCR)...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/22901485/changes-in-glucose-transporter-expression-in-monocytes-of-periparturient-dairy-cows
#4
N J O'Boyle, G A Contreras, S A Mattmiller, L M Sordillo
The transition period of dairy cows is characterized by dramatic changes in metabolism and immune cell function that contributes to increased susceptibility to several economically important diseases. Monocyte and macrophage populations increase in blood and tissues of cows during the transition period and have enhanced inflammatory responses that may contribute to increased severity of disease. Glucose is a major energy source for activated monocytes and glucose uptake is facilitated by glucose transporters (GLUT)...
October 2012: Journal of Dairy Science
https://www.readbyqxmd.com/read/15624558/increased-circulating-ac133-cd34-endothelial-progenitor-cells-in-children-with-hemangioma
#5
Mark E Kleinman, Oren M Tepper, Jennifer M Capla, Kirit A Bhatt, Daniel J Ceradini, Robert D Galiano, Francine Blei, Jamie P Levine, Geoffrey C Gurtner
UNLABELLED: Hemangioma is the most common soft-tissue tumor of infancy. Despite the frequency of these vascular tumors, the origin of hemangioma-endothelial cells is unknown. Circulating endothelial progenitor cells (EPCs) have recently been identified as vascular stem cells with the capacity to contribute to postnatal vascular development. We have attempted to determine whether circulating EPCs are increased in hemangioma patients and thereby provide insight into the role of EPCs in hemangioma growth...
2003: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/8177047/regulation-of-glucose-transport-and-expression-of-glut3-transporters-in-human-circulating-mononuclear-cells-studies-in-cells-from-insulin-dependent-diabetic-and-nondiabetic-individuals
#6
D E Estrada, E Elliott, B Zinman, I Poon, Z Liu, A Klip, D Daneman
We have previously shown that human circulating mononuclear cells (CMCs) respond to physiological concentrations of insulin with a rapid increase in glucose transport rate. The responding cells were found to be the monocytes, and cells derived from individuals with insulin-dependent diabetes mellitus (IDDM) had lower basal and insulin-stimulated glucose transport rates. Of interest, both cell types were found to express the GLUT1 but not the typical insulin-responsive GLUT4 transporter isoform. To further study the mechanisms responsible for stimulation of transport in these cells, we investigated (1) the response to insulin-like growth factor-I (IGF-I) and insulin-mimetic agents, and (2) the expression of other glucose transporter isoforms in CMCs of nondiabetic and IDDM individuals...
May 1994: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/1733814/insulin-stimulated-glucose-transport-in-circulating-mononuclear-cells-from-nondiabetic-and-iddm-subjects
#7
D Daneman, B Zinman, M E Elliott, P J Bilan, A Klip
The objectives of this study were 1) to evaluate glucose transport and its regulation by insulin in easily accessible human cells, 2) to investigate the glucose transporter isoforms involved, and 3) to establish whether a defect in glucose transport is associated with peripheral insulin resistance, which is common in insulin-dependent diabetes mellitus (IDDM) patients. We measured 2-deoxyglucose (2-DG) uptake in circulating mononuclear cells from 23 nondiabetic adults, 16 adults with IDDM, and 10 children with IDDM...
February 1992: Diabetes
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