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Severe malnutrition rct children

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https://www.readbyqxmd.com/read/29722846/high-dose-vitamin-d3-in-the-treatment-of-severe-acute-malnutrition-a-multicenter-double-blind-randomized-controlled-trial
#1
Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau
Background: Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency. Objective: The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition. Design: We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6-58 mo with uncomplicated severe acute malnutrition in Pakistan...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29690916/combined-protocol-for-acute-malnutrition-study-compas-in-rural-south-sudan-and-urban-kenya-study-protocol-for-a-randomized-controlled-trial
#2
Jeanette Bailey, Natasha Lelijveld, Bethany Marron, Pamela Onyoo, Lara S Ho, Mark Manary, André Briend, Charles Opondo, Marko Kerac
BACKGROUND: Acute malnutrition is a continuum condition, but severe and moderate forms are treated separately, with different protocols and therapeutic products, managed by separate United Nations agencies. The Combined Protocol for Acute Malnutrition Study (ComPAS) aims to simplify and unify the treatment of uncomplicated severe and moderate acute malnutrition (SAM and MAM) for children 6-59 months into one protocol in order to improve the global coverage, quality, continuity of care and cost-effectiveness of acute malnutrition treatment in resource-constrained settings...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29522089/malaria-and-nutritional-status-among-children-with-severe-acute-malnutrition-in-niger-a-prospective-cohort-study
#3
Catherine E Oldenburg, Philippe J Guerin, Fatou Berthé, Rebecca F Grais, Sheila Isanaka
Background: The relationship between malaria infection and nutritional status is complex and previous studies suggest malaria may increase the incidence and severity of malnutrition while malnutrition may increase the risk of malaria infection. Here, we report bi-directional associations between malaria and nutritional status among children with uncomplicated severe acute malnutrition (SAM). Methods: The present study is a secondary analysis of a randomized controlled trial for the treatment of uncomplicated SAM in Niger...
March 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29488461/effectiveness-of-a-household-water-sanitation-and-hygiene-package-on-an-outpatient-program-for-severe-acute-malnutrition-a-pragmatic-cluster-randomized-controlled-trial-in-chad
#4
Mathias Altmann, Chiara Altare, Nanette van der Spek, Jean-Christophe Barbiche, Jovana Dodos, Mahamat Bechir, Myriam Ait Aissa, Patrick Kolsteren
Water, sanitation and hygiene (WASH) interventions have a small but measurable benefit on stunting, but not on wasting. Our objective was to assess the effectiveness of a household WASH package on the performance of an Outpatient Therapeutic feeding Program (OTP) for severe acute malnutrition (SAM). We conducted a cluster-randomized controlled trial embedded in a routine OTP. The study population included 20 health centers (clusters) from Mao and Mondo districts in Chad. Both arms received the OTP. The intervention arm received an additional household WASH package (chlorine, soap, water storage container, and promotion on its use)...
April 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29149905/the-kusamala-program-for-primary-caregivers-of-children-6-59-months-of-age-hospitalized-with-severe-acute-malnutrition-in-malawi-study-protocol-for-a-cluster-randomized-controlled-trial
#5
Allison I Daniel, Meta van den Heuvel, Wieger P Voskuijl, Melissa Gladstone, Mike Bwanali, Isabel Potani, Celine Bourdon, Jenala Njirammadzi, Robert H J Bandsma
BACKGROUND: Severe acute malnutrition (SAM) is associated with high mortality rates and impairments in growth and development in children that do survive. There are complex nutritional, health, and behavioural risk factors involving severely malnourished children and their primary caregivers, requiring integrated intervention approaches. METHODS: A cluster-randomized controlled trial at the Queen Elizabeth Central Hospital in Blantyre, Malawi will be conducted to evaluate the effectiveness of a 4-day hospital-based intervention programme directed at primary caregivers...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/28934235/lipid-based-nutrient-supplements-lns-for-treatment-of-children-6-months-to-59-months-with-moderate-acute-malnutrition-mam-a-systematic-review
#6
REVIEW
Tarun Gera, Juan Pablo Pena-Rosas, Evelyn Boy-Mena, Harshpal S Sachdev
BACKGROUND: Moderate acute malnutrition is a major public health problem affecting children from low- and middle-income countries. Lipid nutrient supplements have been proposed as a nutritional intervention for its treatment. OBJECTIVES: To evaluate the effectiveness and safety of LNS for the treatment of MAM in infants and children 6 to 59 months of age. STUDY DESIGN: Systematic review of randomized-controlled trials and controlled before-after studies...
2017: PloS One
https://www.readbyqxmd.com/read/28912050/pancreatic-enzyme-replacement-therapy-in-children-with-severe-acute-malnutrition-a-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Rosalie H Bartels, Céline Bourdon, Isabel Potani, Brian Mhango, Deborah A van den Brink, John S Mponda, Anneke C Muller Kobold, Robert H Bandsma, Michael Boele van Hensbroek, Wieger P Voskuijl
OBJECTIVE: To assess the benefits of pancreatic enzyme replacement therapy (PERT) in children with complicated severe acute malnutrition. STUDY DESIGN: We conducted a randomized, controlled trial in 90 children aged 6-60 months with complicated severe acute malnutrition at the Queen Elizabeth Central Hospital in Malawi. All children received standard care; the intervention group also received PERT for 28 days. RESULTS: Children treated with PERT for 28 days did not gain more weight than controls (13...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28814393/soya-maize-and-sorghum-based-ready-to-use-therapeutic-food-with-amino-acid-is-as-efficacious-as-the-standard-milk-and-peanut-paste-based-formulation-for-the-treatment-of-severe-acute-malnutrition-in-children-a-noninferiority-individually-randomized-controlled
#8
RANDOMIZED CONTROLLED TRIAL
Paluku Bahwere, Peter Akomo, Mwawi Mwale, Hitoshi Murakami, Chrissy Banda, Sylvester Kathumba, Chimwemwe Banda, Solomon Jere, Kate Sadler, Steve Collins
Background: Development of more cost-effective ready-to-use therapeutic food (RUTF) is a global public health priority. To date, previous lower-cost recipes have been less effective than the standard peanut and milk (PM)-based RUTF, particularly in children aged <24 mo.Objective: We aimed to compare the efficacy of the PM-RUTF to a milk-free soya, maize, and sorghum (FSMS)-RUTF enriched with crystalline amino acids without cow milk powder and a milk, soya, maize, and sorghum (MSMS)-RUTF containing 9.3% skim cow milk powder...
October 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28667722/randomized-controlled-trial-evaluating-probiotics-in-children-with-severe-acute-malnutrition-pediatric-gastroenterologist-s-viewpoint
#9
COMMENT
Rohan Malik
No abstract text is available yet for this article.
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28667721/randomized-controlled-trial-evaluating-probiotics-in-children-with-severe-acute-malnutrition-pediatrician-s-viewpoint
#10
COMMENT
Praveen Kumar
No abstract text is available yet for this article.
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28667720/randomized-controlled-trial-evaluating-probiotics-in-children-with-severe-acute-malnutrition-evidence-based-medicine-viewpoint
#11
COMMENT
J L Mathew
No abstract text is available yet for this article.
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28567278/psychosocial-stimulation-interventions-for-children-with-severe-acute-malnutrition-a-systematic-review
#12
REVIEW
Allison I Daniel, Robert H Bandsma, Lyubov Lytvyn, Wieger P Voskuijl, Isabel Potani, Meta van den Heuvel
BACKGROUND: The WHO Guidelines for the inpatient treatment of severely malnourished children include a recommendation to provide sensory stimulation or play therapy for children with severe acute malnutrition (SAM). This systematic review was performed to synthesize evidence around this recommendation. Specifically, the objective was to answer the question: "In children with severe acute malnutrition, does psychosocial stimulation improve child developmental, nutritional, or other outcomes?" METHODS: A review protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO 2016: CRD42016036403)...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28446221/effectiveness-of-three-commonly-used-transition-phase-diets-in-the-inpatient-management-of-children-with-severe-acute-malnutrition-a-pilot-randomized-controlled-trial-in-malawi
#13
RANDOMIZED CONTROLLED TRIAL
Christian J Versloot, Wieger Voskuijl, Sara J van Vliet, Meta van den Heuvel, Jane C Carter, Ajib Phiri, Marko Kerac, Geert Tom Heikens, Patrick F van Rheenen, Robert H J Bandsma
BACKGROUND: The case fatality rate of severely malnourished children during inpatient treatment is high and mortality is often associated with diarrhea. As intestinal carbohydrate absorption is impaired in severe acute malnutrition (SAM), differences in dietary formulations during nutritional rehabilitation could lead to the development of osmotic diarrhea and subsequently hypovolemia and death. We compared three dietary strategies commonly used during the transition of severely malnourished children to higher caloric feeds, i...
April 26, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/27996088/oral-zinc-for-treating-diarrhoea-in-children
#14
REVIEW
Marzia Lazzerini, Humphrey Wanzira
BACKGROUND: In developing countries, diarrhoea causes around 500,000 child deaths annually. Zinc supplementation during acute diarrhoea is currently recommended by the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF). OBJECTIVES: To evaluate oral zinc supplementation for treating children with acute or persistent diarrhoea. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (the Cochrane Library 2016, Issue 5), MEDLINE, Embase, LILACS, CINAHL, mRCT, and reference lists up to 30 September 2016...
December 20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26984485/cereals-and-pulse-based-ready-to-use-therapeutic-food-as-an-alternative-to-the-standard-milk-and-peanut-paste-based-formulation-for-treating-severe-acute-malnutrition-a-noninferiority-individually-randomized-controlled-efficacy-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Paluku Bahwere, Bisimwa Balaluka, Jonathan C K Wells, Chobohwa N Mbiribindi, Kate Sadler, Peter Akomo, Michèle Dramaix-Wilmet, Steve Collins
BACKGROUND: The cost of current standard ready-to-use therapeutic food (RUTF) is among the major obstacles to scaling up community-based management of acute malnutrition (CMAM), an important child survival strategy. Identifying a cheaper alternative is a global public health priority. OBJECTIVE: We sought to compare the efficacy of soya-maize-sorghum RUTF (SMS-RUTF) with that of standard peanut paste-based RUTF (P-RUTF). DESIGN: We used a nonblinded, parallel-group, simple randomized controlled trial along with a day care approach that enrolled 2 groups of children aged 6-23 and 24-59 mo, respectively, with severe acute malnutrition (SAM)...
April 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26905278/mortality-morbidity-and-developmental-outcomes-in-infants-born-to-women-who-received-either-mefloquine-or-sulfadoxine-pyrimethamine-as-intermittent-preventive-treatment-of-malaria-in-pregnancy-a-cohort-study
#16
RANDOMIZED CONTROLLED TRIAL
María Rupérez, Raquel González, Ghyslain Mombo-Ngoma, Abdunoor M Kabanywanyi, Esperança Sevene, Smaïla Ouédraogo, Mwaka A Kakolwa, Anifa Vala, Manfred Accrombessi, Valérie Briand, John J Aponte, Rella Manego Zoleko, Ayôla A Adegnika, Michel Cot, Peter G Kremsner, Achille Massougbodji, Salim Abdulla, Michael Ramharter, Eusébio Macete, Clara Menéndez
BACKGROUND: Little is known about the effects of intermittent preventive treatment of malaria in pregnancy (IPTp) on the health of sub-Saharan African infants. We have evaluated the safety of IPTp with mefloquine (MQ) compared to sulfadoxine-pyrimethamine (SP) for important infant health and developmental outcomes. METHODS AND FINDINGS: In the context of a multicenter randomized controlled trial evaluating the safety and efficacy of IPTp with MQ compared to SP in pregnancy carried out in four sub-Saharan countries (Mozambique, Benin, Gabon, and Tanzania), 4,247 newborns, 2,815 born to women who received MQ and 1,432 born to women who received SP for IPTp, were followed up until 12 mo of age...
February 2016: PLoS Medicine
https://www.readbyqxmd.com/read/26423737/severe-and-moderate-acute-malnutrition-can-be-successfully-managed-with-an-integrated-protocol-in-sierra-leone
#17
RANDOMIZED CONTROLLED TRIAL
Amanda Maust, Aminata S Koroma, Caroline Abla, Nneka Molokwu, Kelsey N Ryan, Lauren Singh, Mark J Manary
BACKGROUND: Global acute malnutrition (GAM) is the sum of moderate acute malnutrition (MAM) and severe acute malnutrition (SAM). The use of different foods and protocols for MAM and SAM treatment can be cumbersome in emergency settings. OBJECTIVE: Our objective was to determine the recovery and coverage rates for GAM of an integrated protocol with a single food product, ready-to-use therapeutic food (RUTF), compared with standard management. METHODS: This was a cluster-randomized controlled trial in Sierra Leone conducted in 10 centers treating GAM in children aged 6-59 mo...
November 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/26360970/unconditional-cash-transfers-for-assistance-in-humanitarian-disasters-effect-on-use-of-health-services-and-health-outcomes-in-low-and-middle-income-countries
#18
REVIEW
Frank Pega, Sze Yan Liu, Stefan Walter, Stefan K Lhachimi
BACKGROUND: Unconditional cash transfers (UCTs) are a common social protection intervention that increases income, a key social determinant of health, in disaster contexts in low- and middle-income countries (LMICs). OBJECTIVES: To assess the effects of UCTs in improving health services use, health outcomes, social determinants of health, health care expenditure, and local markets and infrastructure in LMICs. We also compared the relative effectiveness of UCTs delivered in-hand with in-kind transfers, conditional cash transfers, and UCTs paid through other mechanisms...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26314308/safety-and-efficacy-of-low-osmolarity-ors-vs-modified-rehydration-solution-for-malnourished-children-for-treatment-of-children-with-severe-acute-malnutrition-and-diarrhea-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Ruchika Kumar, Praveen Kumar, S Aneja, Virendra Kumar, Harmeet S Rehan
World Health Organization-recommended rehydration solution for malnourished children (ReSoMal) for rehydrating severe acute malnourished children is not available in India. In present study, 110 consecutive children aged 6-59 months with severely acute malnourishment and acute diarrhea were randomized to low-osmolarity oral rehydration solution (ORS) (osmolarity: 245, sodium: 75) with added potassium (20 mmol/l) or modified ReSoMal (osmolarity: 300, sodium: 45). In all, 15.4% of modified ReSoMal group developed hyponatremia as compared with 1...
December 2015: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/26301790/nutritional-support-in-children-and-young-people-with-cancer-undergoing-chemotherapy
#20
REVIEW
Evelyn J Ward, Lisa M Henry, Amanda J Friend, Simone Wilkins, Robert S Phillips
BACKGROUND: It is well documented that malnutrition is a common complication of paediatric malignancy and its treatment. Malnutrition can often be a consequence of cancer itself or a result of chemotherapy. Nutritional support aims to reverse malnutrition seen at diagnosis, prevent malnutrition associated with treatment and promote weight gain and growth. The most effective and safe forms of nutritional support in children and young people with cancer are not known. OBJECTIVES: To determine the effects of any form of parenteral (PN) or enteral (EN) nutritional support, excluding vitamin supplementation and micronutrient supplementation, in children and young people with cancer undergoing chemotherapy and to determine the effect of the nutritional content of PN and EN...
August 24, 2015: Cochrane Database of Systematic Reviews
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