Yasaman Esmaeili, Arezou Dabiri, Fariba Mashayekhi, Ilnaz Rahimmanesh, Elham Bidram, Saeed Karbasi, Mohammad Rafienia, Shaghayegh Haghjooy Javanmard, Yavuz Nuri Ertas, Ali Zarrabi, Laleh Shariati
This study introduces an innovative co-delivery approach using the MCM-co-polymerized nanosystem, integrating chitosan and polyethylene glycol, and targeted by the MUC-1 aptamer (MCM@CS@PEG-APT). This system enables simultaneous delivery of the GFP plasmid and doxorubicin (DOX). The synthesis of the nanosystem was thoroughly characterized at each step, including FTIR, XRD, BET, DLS, FE-SEM, and HRTEM analyses. The impact of individual polymers (chitosan and PEG) on payload retardation was compared to the co-polymerized MCM@CS@PEG conjugation...
March 19, 2024: Biomedicine & Pharmacotherapy