keyword
MENU ▼
Read by QxMD icon Read
search

HIV and cardiovascular disease

keyword
https://www.readbyqxmd.com/read/28645263/microbiota-dependent-metabolite-and-cardiovascular-disease-marker-trimethylamine-n-oxide-tmao-is-associated-with-monocyte-activation-but-not-platelet-function-in-untreated-hiv-infection
#1
Judith M Haissman, Anna K Haugaard, Sisse R Ostrowski, Rolf K Berge, Johannes R Hov, Marius Trøseid, Susanne D Nielsen
BACKGROUND: HIV infection is associated with increased risk of cardiovascular disease beyond that explained by traditional risk factors. Altered gut microbiota, microbial translocation, and immune activation have been proposed as potential triggers. The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) predicts myocardial infarction (MI) in the general population and has recently been shown to induce platelet hyperreactivity. In the present study, we investigated if TMAO was associated with platelet function, microbial translocation, and immune activation in both untreated and combination anti-retroviral therapy (cART) HIV infection...
June 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28641798/hiv-1-associated-atherosclerosis-unraveling-the-missing-link
#2
REVIEW
Alison Kearns, Jennifer Gordon, Tricia H Burdo, Xuebin Qin
Cardiovascular disease, including atherosclerosis and atherosclerosis-associated complications, is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV) patients in the post-antiretroviral therapy era. HIV alone accelerates atherosclerosis. Antiretroviral therapy; HIV-associated comorbidities, such as dyslipidemia, drug abuse, and opportunistic infections; and lifestyle are risk factors for HIV-associated atherosclerosis. However, our current understanding of HIV-associated atherogenesis is very limited and has largely been obtained from clinical observation...
June 27, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28641056/the-odd-couple-using-biomedical-and-intersectional-approaches-to-address-health-inequities
#3
Olena Hankivsky, Lesley Doyal, Gillian Einstein, Ursula Kelly, Janet Shim, Lynn Weber, Robin Repta
BACKGROUND: Better understanding and addressing health inequities is a growing global priority. OBJECTIVE: In this paper, we contribute to the literature examining complex relationships between biological and social dimensions in the field of health inequalities. Specifically, we explore the potential of intersectionality to advance current approaches to socio-biological entwinements. DESIGN: We provide a brief overview of current approaches to combining both biological and social factors in a single study, and then investigate the contributions of an intersectional framework to such work...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28622754/prevalence-of-non-infectious-comorbidities-in-the-hiv-positive-population-in-belgium-a-multicenter-retrospective-study
#4
Jessie Gunter, Steven Callens, Stephane De Wit, Jean-Christophe Goffard, Michel Moutschen, Gilles Darcis, Christelle Meuris, Charlotte van den Bulcke, Karine Fombellida, Marc Del Forge, Homie Razavi, Chloe Wyndham-Thomas
OBJECTIVES: In Belgium, eleven AIDS Reference Centers (ARCs) and seven AIDS Reference Laboratories diagnose and treat HIV-positive individuals and track patients under care. As AIDS-related deaths are avoided and the HIV-positive population ages, non-infectious comorbidities (NICMs), such as cardiovascular disease, renal disease and certain cancers, play a larger role in the quality and length of patients' lives. This study aims to characterize the HIV-positive population in Belgium in terms of the prevalence of key NICMs...
June 16, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28614245/wellens-syndrome-in-hiv-infected-patients-two-case-reports
#5
Bowei Tan, Carlos Morales-Mangual, Dan Zhao, Abdullah Khan, Hal Chadow
BACKGROUND: Wellens syndrome is a pattern of electrocardiographic (ECG) changes in the context of unstable angina characterized with deep inverted T-waves or biphasic T-waves in the precordial leads. These specific ECG changes are highly suggestive of stenosis in the left anterior descending artery (LAD), which can result in acute myocardial infarction, left ventricular dysfunction, or death. Human immunodeficiency virus (HIV) infection is known as an independent risk factor for the cardiovascular disease...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28606104/unlocking-echocardiogram-measurements-for-heart-disease-research-through-natural-language-processing
#6
Olga V Patterson, Matthew S Freiberg, Melissa Skanderson, Samah J Fodeh, Cynthia A Brandt, Scott L DuVall
BACKGROUND: In order to investigate the mechanisms of cardiovascular disease in HIV infected and uninfected patients, an analysis of echocardiogram reports is required for a large longitudinal multi-center study. IMPLEMENTATION: A natural language processing system using a dictionary lookup, rules, and patterns was developed to extract heart function measurements that are typically recorded in echocardiogram reports as measurement-value pairs. Curated semantic bootstrapping was used to create a custom dictionary that extends existing terminologies based on terms that actually appear in the medical record...
June 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28606059/observed-versus-predicted-cardiovascular-events-and-all-cause-death-in-hiv-infection-a-longitudinal-cohort-study
#7
Giuseppe Vittorio De Socio, Giacomo Pucci, Franco Baldelli, Giuseppe Schillaci
BACKGROUND: The aim of the study was to assess the applicability of an algorithm predicting 10-year cardiovascular disease (CVD) generated in the setting of the Framingham Heart Study to a real-life, contemporary Italian cohort of HIV-positive subjects. METHODS: The study was an observational longitudinal cohort study. The probability for 10-year CVD events according to the Framingham algorithm was assessed in 369 consecutive HIV-positive participants free from overt CVD enrolled in 2004, who were followed for a median of 10...
June 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28606026/subclinical-myocardial-disease-by-cardiac-magnetic-resonance-imaging-and-spectroscopy-in-healthy-hiv-hepatitis-c-virus-coinfected-persons
#8
Kara W Chew, Chia-Ying Liu, Bharath Ambale-Venkatesh, Diana Liao, Tamara B Horwich, João A C Lima, David A Bluemke, J Paul Finn, Adeel A Butt, Judith S Currier
Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown. The objective was to characterize cardiac function and morphology in HIV-treated coinfected persons. Methods In a cross-sectional study, HIV-infected patients virologically suppressed on antiretroviral therapy without known cardiovascular disease or diabetes mellitus underwent cardiac magnetic resonance imaging and spectroscopy for measures of cardiac function, myocardial fibrosis, and steatosis...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28605504/projecting-10-yr-20-yr-and-lifetime-risks-of-cardiovascular-disease-in-persons-living-with-hiv-in-the-us
#9
E Losina, E P Hyle, E D Borre, B P Linas, P E Sax, M C Weinstein, C Rusu, A L Ciaranello, R P Walensky, K A Freedberg
Background: Cardiovascular disease (CVD) is an increasing cause of morbidity among persons living with HIV (PLWH). We projected cumulative CVD risk in PLWH in care compared to the US general population and persons HIV-uninfected, but at high risk for HIV. Methods: We used a mathematical model to project cumulative CVD incidence. We simulated a male and female cohort for each of three populations: 1) US general population; 2) HIV-uninfected, at high risk for HIV; and 3) PLWH...
June 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28598792/croi-2017-complications-and-comorbidities-of-hiv-disease-and-its-treatment
#10
Judith S Currier, Diane V Havlir
Complications of HIV disease remained a major focus at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI), and included studies focused on noncommunicable chronic diseases (eg, cardiovascular disease, obesity, bone disease, and malignancies) and opportunistic infections (Mycobacterium tuberculosis and cryptococcosis). Progress in identifying predictors of specific complications as well as interventions for the prevention and treatment of these comorbidities are summarized below.
May 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28578613/suboptimal-primary-and-secondary-cardiovascular-disease-prevention-in-hiv-positive-individuals-on-antiretroviral-therapy
#11
Rosan A van Zoest, Marc van der Valk, Ferdinand W Wit, Ilonca Vaartjes, Katherine W Kooij, Joppe W Hovius, Maria Prins, Peter Reiss
Background We aimed to identify the prevalence of cardiovascular risk factors, and investigate preventive cardiovascular medication use and achievement of targets as per Dutch cardiovascular risk management guidelines among human immunodeficiency virus (HIV)-positive and HIV-negative individuals. Design The design was a cross-sectional analysis within an ongoing cohort study. Methods Data on medication use and cardiovascular disease prevalence were available for 528 HIV-positive and 521 HIV-negative participants...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28562067/hypertension-in-hiv-infected-adults-compared-with-similar-but-uninfected-adults-in-china-body-mass-index-dependent-effects-of-nadir-cd4-count
#12
Yingying Ding, Haijiang Lin, Xing Liu, Yucheng Zhang, Frank Wong, Yan Sun, Vincent Marconi, Na He
BACKGROUND: Hypertension is a growing problem in HIV-infected population. The global association between nadir CD4 count and hypertension in the HIV-infected population is well documented. However, the effect of nadir CD4 on hypertension due to different body mass index (BMI) has yet to be fully elucidated. METHODS: In this cross-sectional study, 345 HIV-infected participants aged ≥ 40 years were recruited, and frequency matched on age, sex, and education with HIV-uninfected adults (N = 345)...
May 31, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28553846/the-effects-of-cd4-nadirs-on-vessel-stiffness-in-hiv-patients-undergoing-antiretroviral-therapy
#13
Tomasz Mikuła, Paweł Balsam, Michał Peller, Magdalena Suchacz, Bartosz Puchalski, Łukasz Kołtowski, Kacper Maciejewski, Alicja Wiercińska-Drapało, Grzegorz Opolski, Krzysztof J Filipiak
BACKGROUND: Many factors are associated with HIV (the human immunodeficiency virus) patients having a greater risk of cardiovascular diseases. HIV damages vessel endothelium through chronic inflammation which combined with dyslipidemia, arterial hypertension and antiretroviral therapy leads to the progression of atherosclerotic changes. AIM: Our goal was to determine if a CD4 nadir along with immunologic, inflammatory, biochemical and metabolic markers can be associated with higher vessel stiffness and therefore an increased risk of cardiovascular diseases in patients undergoing antiretroviral therapy for HIV...
May 29, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28553430/plasma-level-of-soluble-st2-in-chronically-infected-hiv-1-patients-with-suppressed-viremia
#14
Mehwish Younas, Christina Psomas, Vikram Mehraj, Renaud Cezar, Pierre Portales, Edouard Tuaillon, Adeline Guigues, Jacques Reynes, Pierre Corbeau, Jean-Pierre Routy
INTRODUCTION: Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease. OBSERVATION: Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation. RESULTS: Here we show that it is not the case in patients with suppressed viremia...
2017: Open AIDS Journal
https://www.readbyqxmd.com/read/28543215/fib-4-stage-of-liver-fibrosis-predicts-incident-heart-failure-among-hiv-infected-and-uninfected-patients
#15
Kaku A So-Armah, Joseph K Lim, Vincent Lo Re, Janet P Tate, H Chang Chung-Chou, Adeel A Butt, Cynthia L Gibert, David Rimland, Vincent C Marconi, Matthew B Goetz, Maria C Rodriguez-Barradas, Michael E DeBakey, Matthew J Budoff, Hilary A Tindle, Jeffrey H Samet, Amy C Justice, Matthew S Freiberg
Liver fibrosis is common, particularly in human immunodeficiency virus infected (HIV+) people. HIV+ people have excess congestive heart failure (CHF) risk compared to uninfected people. It remains unknown if stage of liver fibrosis influences the CHF risk or if HIV or hepatitis C virus (HCV) infection modifies this association. Our objectives were to assess whether: 1) stage of liver fibrosis is independently associated with incident CHF; 2) the association between stage of liver fibrosis and incident CHF is modified by HIV/HCV status...
May 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28540084/body-composition-and-metabolic-syndrome-components-on-lipodystrophy-different-subtypes-associated-with-hiv
#16
Livia Bertazzo Sacilotto, Paulo Câmara Marques Pereira, João Paulo Vieira Manechini, Sílvia Justina Papini
HIV-associated lipodystrophy syndrome (HALS) is characterized by body fat redistribution as a consequence of the antiretroviral therapy (ART) introduction, associated with an increased risk of cardiovascular disease development. Subjective diagnosis, classified between three subtypes according to the body region on which fat is lost and/or accumulated, named lipoatrophy, lipohypertrophy, and mixed lipodystrophy, is possibly accompanied with metabolic alterations. Forty people living with HIV/AIDS (PLHA), with clinical diagnosis of HALS and from both genders, were assessed...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28537935/cardiovascular-toxicity-of-abacavir-a-clinical-controversy-in-need-of-a-pharmacological-explanation
#17
Angeles Alvarez, Samuel Orden, Isabel Andújar, Victor Collado-Diaz, Sara Núñez-Delgado, Maria Jose Galindo, Vicente Estrada, Nadezda Apostolova, Juan V Esplugues
: There is a long-lasting controversy surrounding an association between Abacavir (ABC) and an increased risk of cardiovascular (CV) disease in HIV-positive subjects. While differing in their specifics, a number of published cohort studies and clinical trials support such an association, usually relating it to recent exposure to the drug, independently of traditional predisposing factors. However, other clinical trials have failed to reveal such a relation, and have pointed to methodological differences to explain discrepancies...
May 23, 2017: AIDS
https://www.readbyqxmd.com/read/28536104/development-and-validation-of-qrisk3-risk-prediction-algorithms-to-estimate-future-risk-of-cardiovascular-disease-prospective-cohort-study
#18
Julia Hippisley-Cox, Carol Coupland, Peter Brindle
Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors.Design Prospective open cohort study.Setting General practices in England providing data for the QResearch database.Participants 1309 QResearch general practices in England: 981 practices were used to develop the scores and a separate set of 328 practices were used to validate the scores. 7.89 million patients aged 25-84 years were in the derivation cohort and 2...
May 23, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28534890/hypertension-in-hiv-management-and-treatment
#19
Claudio Ucciferri, Katia Falasca, Jacopo Vecchiet
Hypertension is among the leading risk factors for cardiovascular disease and accounts for 6% of adult deaths worldwide. It is estimated that in 2013, hypertension was responsible for at least 45% of deaths due to heart disease and 51% of deaths due to stroke. Accordingly, management of hypertension and its long-term complications in HIV-infected subjects is a significant component of routine care. The choice of an effective anti-hypertensive therapy in HIV-infected patients is important and must be made carefully in order to prevent cardiovascular mortality and morbidity in these patients...
May 23, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28533305/changes-in-cardiovascular-disease-risk-factors-with-immediate-versus-deferred-antiretroviral-therapy-initiation-among-hiv-positive-participants-in-the-start-strategic-timing-of-antiretroviral-treatment-trial
#20
Jason V Baker, Shweta Sharma, Amit C Achhra, Jose Ignacio Bernardino, Johannes R Bogner, Daniel Duprez, Sean Emery, Brian Gazzard, Jonathan Gordin, Greg Grandits, Andrew N Phillips, Siegfried Schwarze, Elsayed Z Soliman, Stephen A Spector, Giuseppe Tambussi, Jens Lundgren
INTRODUCTION: HIV infection and certain antiretroviral therapy (ART) medications increase atherosclerotic cardiovascular disease risk, mediated, in part, through traditional cardiovascular disease risk factors. METHODS AND RESULTS: We studied cardiovascular disease risk factor changes in the START (Strategic Timing of Antiretroviral Treatment) trial, a randomized study of immediate versus deferred ART initiation among HIV-positive persons with CD4(+) cell counts >500 cells/mm(3)...
May 22, 2017: Journal of the American Heart Association
keyword
keyword
113308
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"