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HIV and cardiovascular disease

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https://www.readbyqxmd.com/read/29777448/triad-of-the-ischemic-cardiovascular-disease-in-people-living-with-hiv-association-between-risk-factors-hiv-infection-and-use-of-antiretroviral-therapy
#1
REVIEW
Hugo Ribeiro Zanetti, Edmar Lacerda Mendes, Antonio Carlos Palandri Chagas, Maria Odila Gomes Douglas, Leandro Teixeira Paranhos Lopes, Leonardo Roever, Alexandre Gonçalves, Elmiro Santos Resende
PURPOSE OF REVIEW: This review is focused on cardiovascular risk factors in HIV-infected people. RECENT FINDINGS: Antiretroviral therapy (ART) has significantly increased the life expectancy of HIV-infected people. Thus, this population has experienced non-HIV-related diseases, mainly cardiovascular diseases. Thus, in our review, we intend to understand the cardiovascular risk factors that trigger this situation. We have demonstrated that both ART and traditional cardiovascular risk factors contribute to the development of cardiovascular disease in HIV-infected people...
May 18, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29774749/excess-costs-of-non-infectious-comorbidities-among-people-living-with-hiv-estimates-from-denmark-and-sweden
#2
Frida Hjalte, Paul S Calara, Anders Blaxhult, Marie Helleberg, Karoline Wallace, Peter Lindgren
People living with HIV have an increased risk of comorbidities with non-communicable diseases such as cardiovascular disease, chronic kidney disease and osteoporotic fractures, compared to the general population. The burden of these comorbidities is expected to rise as the HIV-infected population ages. This development may require additional health care resources and it is relevant to ascertain the costs associated with these comorbidities. The population attributed risk approach was applied to estimate excess costs associated with the higher rates of comorbidities among HIV patients in Denmark and Sweden compared to their respective general populations...
May 18, 2018: AIDS Care
https://www.readbyqxmd.com/read/29771788/body-mass-index-and-the-risk-of-serious-non-aids-events-and-all-cause-mortality-in-treated-hiv-positive-individuals-d-a-d-cohort-analysis
#3
Amit C Achhra, Caroline Sabin, Lene Ryom, Camilla Hatleberg, Antonella d'Aminio Monforte, Stephane de Wit, Andrew Phillips, Christian Pradier, Rainer Weber, Peter Reiss, Wafaa El-Sadr, Fabrice Bonnet, Amanda Mocroft, Jens Lundgren, Matthew G Law
BACKGROUND: The relationship between body mass index (BMI) (weight (kg)/ height(m)) and serious non-AIDS events is not well understood. METHODS: We followed D:A:D study participants on antiretroviral therapy from their first BMI measurement to the first occurrence of the endpoint or end of follow-up (N=41,149 followed for 295,147 person-years). The endpoints were cardiovascular disease (CVD); diabetes; non-AIDS-defining cancers (NADCs) and BMI-NADCs (cancers known to be associated with BMI in general population); and all-cause mortality...
May 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771268/hiv-disease-is-associated-with-increased-biomarkers-of-endothelial-dysfunction-despite-viral-suppression-on-long-term-antiretroviral-therapy-in-botswana
#4
Mosepele Mosepele, Terence Mohammed, Lucy Mupfumi, Sikhulile Moyo, Kara Bennett, Shahin Lockman, Linda C Hemphill, Virginia A Triant
BACKGROUND: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial dysfunction among virally suppressed HIV-infected adults on long-term antiretroviral therapy (ART) have not been well studied in sub-Saharan Africa (SSA). METHODS: We enrolled 112 HIV-infected adults with virological suppression on long-term ART and 84 HIV-uninfected controls in Botswana. We measured plasma levels of markers of endothelial injury [soluble vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and E-selectin] and plasma levels of biomarkers of inflammation [interleukin 6 (IL-6)] and monocyte activation (sCD163)...
May 14, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29770747/cd16-expressing-monocytes-correlate-with-arterial-stiffness-in-hiv-infected-art-na%C3%A3-ve-men
#5
Ling Luo, Yang Han, Xiaojing Song, Ting Zhu, Yong Zeng, Taisheng Li
Objectives To determine the association of the markers of monocyte activation and arterial stiffness among HIV-infected antiretroviral therapy (ART)-naïve men. Methods Sixty HIV-infected ART-naïve men and 20 HIV-uninfected male controls without symptoms or history of cardiovascular disease were recruited. Pulse wave velocity (PWV) were used as the marker of arterial stiffness and determined using a pulse pressure analyzer. The percentage of CD16-expressing monocytes was used as a marker of monocyte activation...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29769110/prevalence-and-determinants-of-selected-cardio-metabolic-risk-factors-among-people-living-with-hiv-aids-and-receiving-care-in-the-south-west-regional-hospitals-of-cameroon-a-cross-sectional-study
#6
Roland Cheofor Ngu, Simeon-Pierre Choukem, Christian Akem Dimala, Julius N Ngu, Gottlieb Lobe Monekosso
OBJECTIVE: Metabolic disorders and cardiovascular risk factors are not routinely assessed in the care of HIV patients in developing countries, known to have the highest disease burden. We described the prevalence and factors associated with major cardio-metabolic risk factors (obesity, diabetes and hypertension) in HIV/AIDS patients. RESULTS: The prevalence of diabetes, hypertension and obesity were 11.3% (95% CI 8.10-15.43), 24.8% (95% CI 20.1-30.0) and 14.5% (95% CI 11...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29761330/a-review-of-long-term-toxicity-of-antiretroviral-treatment-regimens-and-implications-for-an-aging-population
#7
REVIEW
Anita Chawla, Christina Wang, Cody Patton, Miranda Murray, Yogesh Punekar, Annemiek de Ruiter, Corklin Steinhart
Human immunodeficiency virus (HIV) is a chronic infectious disease currently requiring lifelong antiretroviral therapy (ART). People living with HIV (PLWH) face an increased risk of comorbidities associated with aging, chronic HIV, and the toxicity arising from long-term ART. A literature review was conducted to identify the most recent evidence documenting toxicities associated with long-term ART, particularly among aging PLWH. In general, PLWH are at a greater risk of developing fractures, osteoporosis, renal and metabolic disorders, central nervous system disorders, cardiovascular disease, and liver disease...
May 14, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29752699/hiv-and-cardiovascular-disease-update-on-clinical-events-special-populations-and-novel-biomarkers
#8
REVIEW
Kaku So-Armah, Matthew S Freiberg
PURPOSE OF REVIEW: The objective of this review is to provide an update on the link between HIV infection and cardiovascular disease (CVD). We will focus our review mainly on literature describing clinical CVD events and understudied topics of importance. RECENT FINDINGS: Heart failure, peripheral artery disease, and stroke are CVD modalities deserving more attention in the context of HIV infection in the highly active antiretroviral therapy era. Incidence data on clinical CVD from HIV populations in low- and middle-income countries are limited...
May 11, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29750855/pharmacological-and-nutritional-effects-of-natural-coumarins-and-their-structure-activity-relationships
#9
REVIEW
Jing-Jing Zhu, Jian-Guo Jiang
Coumarins are fused benzene and pyrone ring systems with a wide spectrum of bioactivities including anti-tumor, anti-inflammation, antiviral and antibacterial effects. In this paper, the current development of coumarins-based drugs is introduced, and their structure-activity relationship is discussed by reviewing the relevant literatures published in the past twenty years. Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification. The ortho-phenolic hydroxyl on the benzene ring had remarkable antioxidant and anti-tumor activities...
May 11, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29745457/subclinical-cardiovascular-disease-in-patients-starting-contemporary-protease-inhibitors
#10
A González-Cordón, M Doménech, M Camafort, M Martínez-Rebollar, B Torres, M Laguno, J Rojas, M Loncà, J L Blanco, J Mallolas, J M Gatell, E de Lazzari, E Martínez
OBJECTIVES: The aim of the study was to assess changes in and factors associated with anatomical [carotid artery intima-media thickness (CIMT)] and functional (arterial stiffness) markers of subclinical cardiovascular disease progression in antiretroviral-naïve patients starting triple combination antiretroviral therapy containing contemporary protease inhibitors. METHODS: This was a planned substudy of the ATADAR (Metabolic Effects of Atazanavir/Ritonavir Versus Darunavir/Ritonavir in Combination With Tenofovir/Emtricitabine in naïve HIV-1 Infected Patients) clinical trial (ClinicalTrials...
May 10, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29739413/the-role-of-hiv-tat-protein-in-hiv-related-cardiovascular-diseases
#11
REVIEW
Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae, Yunlong Bai
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which not only promotes the transcription of HIV, but it is also involved in the pathogenesis of HIV-related complications. This review is aimed at summarizing the current understanding of Tat in HIV-related cardiovascular diseases.
May 8, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29733939/ethnic-differences-and-comorbidities-of-909-prurigo-nodularis-patients
#12
Emily Boozalis, Olive Tang, Shivani Patel, Yevgeniy R Semenov, Manuel P Pereira, Sonja Stander, Sewon Kang, Shawn G Kwatra
BACKGROUND: Prurigo Nodularis (PN) is a poorly understood, understudied pruritic dermatosis that reduces quality of life. OBJECTIVE: To characterize the demographics and comorbidities associated with PN. METHODS: Cross-sectional study of patients ≥ 18 years old seen at the Johns Hopkins Health System (JHHS) between 12/6/2012-12/6/2017. RESULTS: Over the last five years, 909 patients with PN were seen at JHHS. African-American patients were 3...
May 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29731408/hiv-and-cardiovascular-disease-defining-the-unmeasured-risk
#13
Padraig M C McGettrick, Patrick W G Mallon
No abstract text is available yet for this article.
May 3, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29731407/cardiovascular-disease-and-use-of-contemporary-protease-inhibitors-the-d-a-d-international-prospective-multicohort-study
#14
Lene Ryom, Jens D Lundgren, Wafaa El-Sadr, Peter Reiss, Ole Kirk, Matthew Law, Andrew Phillips, Rainer Weber, Eric Fontas, Antonella d' Arminio Monforte, Stéphane De Wit, Francois Dabis, Camilla I Hatleberg, Caroline Sabin, Amanda Mocroft
BACKGROUND: Although earlier protease inhibitors have been associated with increased risk of cardiovascular disease, whether this increased risk also applies to more contemporary protease inhibitors is unknown. We aimed to assess whether cumulative use of ritonavir-boosted atazanavir and ritonavir-boosted darunavir were associated with increased incidence of cardiovascular disease in people living with HIV. METHODS: The prospective Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study consists of people living with HIV-1 from 11 cohorts in Australia, Europe, and the USA...
May 3, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29731256/antiretroviral-therapy-potentiates-high-fat-diet-induced-obesity-and-glucose-intolerance
#15
Mark E Pepin, Lindsey E Padgett, Ruth E McDowell, Ashley R Burg, Manoja K Brahma, Cassie Holleman, Teayoun Kim, David Crossman, Olaf Kutsch, Hubert M Tse, Adam R Wende, Kirk M Habegger
OBJECTIVE: Breakthroughs in HIV treatment, especially combination antiretroviral therapy (ART), have massively reduced AIDS-associated mortality. However, ART administration amplifies the risk of non-AIDS defining illnesses including obesity, diabetes, and cardiovascular disease, collectively known as metabolic syndrome. Initial reports suggest that ART-associated risk of metabolic syndrome correlates with socioeconomic status, a multifaceted finding that encompasses income, race, education, and diet...
April 20, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29726941/hiv-and-cardiovascular-disease-much-ado-about-nothing
#16
Gary S Ma, Bruno R Cotter
No abstract text is available yet for this article.
May 3, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29720501/bilirubin-is-inversely-associated-with-cardiovascular-disease-among-hiv-positive-and-hiv-negative-individuals-in-vacs-veterans-aging-cohort-study
#17
Vincent C Marconi, Meredith S Duncan, Kaku So-Armah, Vincent Lo Re, Joseph K Lim, Adeel A Butt, Matthew Bidwell Goetz, Maria C Rodriguez-Barradas, Charles W Alcorn, Jeffrey Lennox, Joshua A Beckman, Amy Justice, Matthew Freiberg
BACKGROUND: Bilirubin may protect against cardiovascular disease (CVD) by reducing oxidative stress. Whether elevated bilirubin reduces the risk of CVD events among HIV+ individuals and if this differs from uninfected individuals remain unclear. We assessed whether bilirubin independently predicted the risk of CVD events among HIV+ and uninfected participants in VACS (Veterans Aging Cohort Study). METHODS AND RESULTS: We conducted a prospective cohort study using VACS participants free of baseline CVD...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29712976/impact-of-hiv-and-type-2-diabetes-on-gut-microbiota-diversity-tryptophan-catabolism-and-endothelial-dysfunction
#18
Hedda Hoel, Malene Hove-Skovsgaard, Johannes R Hov, Julie Christine Gaardbo, Kristian Holm, Martin Kummen, Knut Rudi, Felix Nwosu, Jørgen Valeur, Marco Gelpi, Ingebjørg Seljeflot, Per Magne Ueland, Jan Gerstoft, Henrik Ullum, Pål Aukrust, Susanne Dam Nielsen, Marius Trøseid
HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition and related metabolites, and a potential relation to endothelial dysfunction in individuals with HIV-infection only (n = 23), diabetes only (n = 16) or both conditions (n = 21), as well as controls (n = 24). Fecal microbiota was analyzed by Illumina sequencing of the 16 S rRNA gene...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29689541/management-of-long-term-complications-of-hiv-disease-focus-on-cardiovascular-disease
#19
Judith S Currier
HIV-infected individuals on effective antiretroviral therapy experience a number of non-AIDS noncommunicable diseases, such as cardiovascular disease, more frequently than uninfected individuals. Common pathways for such diseases are chronic immune activation and inflammation, including the prolonged inflammation associated with lower nadir CD4+ cell count. Prevention and treatment of non-AIDS conditions include treatment of traditional risk factors, lifestyle interventions, earlier initiation of antiretroviral therapy, and potentially therapies specifically targeting inflammation and immune activation (eg, statins)...
April 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29687016/dietary-patterns-and-physical-activity-correlate-with-total-cholesterol-independently-of-lipid-lowering-drugs-and-antiretroviral-therapy-in-aging-people-living-with-human-immunodeficiency-virus
#20
Alex Marzel, Roger D Kouyos, Sara Reinschmidt, Katharina Balzer, Fabienne Garon, Monica Spitaleri, Nicolas Matthes, Paolo Suter, Rainer Weber, Cornelia Staehelin, Thanh Doco Lecompte, Philip Tarr, Helen Kovari
Background: Hypercholesterolemia is a well established risk factor for coronary heart disease and is highly prevalent among human immunodeficiency virus (HIV)-positive persons. Antiretroviral therapy (ART) can both directly modify total cholesterol and have drug-drug interactions with statins. This makes investigating modifiable behavioral predictors of total cholesterol a pertinent task. Methods: To explore the association between diet and physical activity with cross-sectionally measured total cholesterol, we administered a validated Food-Frequency-Questionnaire to participants of the Swiss HIV Cohort Study ≥45 years old...
April 2018: Open Forum Infectious Diseases
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