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https://www.readbyqxmd.com/read/29765585/a-study-of-the-effects-of-daily-physical-activity-on-memory-and-attention-capacities-in-college-students
#1
Dinh-Van Phan, Chien-Lung Chan, Ren-Hao Pan, Nan-Ping Yang, Hsiu-Chen Hsu, Hsien-Wei Ting, K Robert Lai
This study evaluated the relationship between daily physical activity (DPA) and memory capacity, as well as the association between daily activity and attention capacity, in college students in Taiwan. Participants (mean age = 20.79) wore wearable trackers for 106 days in order to collect DPA. These data were analyzed in association with their memory and attention capacities, as assessed using the spatial span test (SST) and the trail making test (TMT). The study showed significant negative correlations between memory capacity, time spent on the attention test (TSAT), calories burnt, and very active time duration (VATD) on the day before testing ( r = -0...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29744352/limitations-of-serum-ferritin-in-diagnosing-iron-deficiency-in-inflammatory-conditions
#2
REVIEW
Axel Dignass, Karima Farrag, Jürgen Stein
Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating the diagnosis. Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites...
2018: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29704093/trends-in-the-treatment-of-chronic-kidney-disease-associated-anaemia-in-a-cohort-of-haemodialysis-patients-the-irish-experience
#3
Roisin Gardiner, Davood Roshan, Ann Brennan, Denise Connolly, Susan Murray, Donal Reddan
BACKGROUND: Anaemia among haemodialysis patients is treated with iron and erythropoietin-stimulating agents (ESAs). ESAs reduce requirements for blood transfusions but are also expensive and overzealous use may be associated with adverse outcomes. Recent international trends have been characterised by reduced ESA doses and a greater reliance on intravenous (IV) iron. We determined trends in prescribing patterns of ESAs and IV iron for the treatment of anaemia in two representative Irish dialysis centres and correlated with current guidelines and international trends...
April 27, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29696062/iron-deficiency-in-a-tertiary-gastroenterology-center-in-romania-prevalence-and-significancy
#4
Carmen Monica Preda, Doina Proca, Irina Sandra, Boroka Claudia Horeanga, Larisa Elena Fulger, Teodora Manuc, Ion Bancila, Oana Elena Balas, Mircea Manuc, Mircea Diculescu, Cristian Baicus, Cristian Tieranu, Ileana Constantinescu
Introduction: Iron deficiency has been known to cause significant functional impairment, lower quality of life and higher morbidity and mortality. The aim of this study was to estimate the prevalence and significance of iron deficiency in our patients and medical staff. Material and methods: We performed a prospective cross-sectional study: In July 2016, 383 persons were screened for the presence of iron deficiency (ID): 325 patients and 58 people from the medical staff. Transferrin saturation (TSAT), serum ferritin (SF) and complete blood count were performed...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29662858/reference-values-for-serum-ferritin-and-percentage-of-transferrin-saturation-in-korean-children-and-adolescents
#5
Hea Lin Oh, Jun Ah Lee, Dong Ho Kim, Jung Sub Lim
Background: Ferritin reference values vary by age, gender, and ethnicity. We aimed to determine reference values of serum ferritin (SF) and the percentage of transferrin saturation (TSAT) for Korean children and adolescents. Methods: We analyzed data from 2,487 participants (1,311 males and 1,176 females) aged 10-20 years from the Korea National Health and Nutrition Examination Survey (2010-2012). We calculated age- and gender-stratified means and percentile values for SF and TSAT...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29574909/iron-status-in-relation-to-cancer-risk-and-mortality-findings-from-a-population-based-prospective-study
#6
Daniel A Quintana Pacheco, Disorn Sookthai, Mirja E Graf, Ruth Schübel, Theron Johnson, Verena Katzke, Rudolf Kaaks, Tilman Kühn
While experimental evidence suggests potential carcinogenic effects of increased iron load, there is a lack of data on iron status and cancer risk from epidemiological studies. Here, we evaluated pre-diagnostic serum concentrations of ferritin, iron, and transferrin as well as transferrin saturation (TSAT) in relation to cancer risk and mortality in a prospective study by multivariable Cox regression analyses. A case-cohort sample of the population-based EPIC-Heidelberg Study including a random subcohort (n=2738) and incident cases of breast cancer (n=627), prostate cancer (n=554), lung cancer (n=195), colorectal cancer (n=256), and cancer death (n=759) was used...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29407589/prognostic-implications-of-low-transferrin-saturation-in-patients-with-primary-myelofibrosis
#7
Marko Lucijanic, Zeljko Prka, Vlatko Pejsa, Tajana Stoos-Veic, Jelena Lucijanic, Rajko Kusec
OBJECTIVES: Transferrin saturation (TSAT) 20% or less is considered to represent functional iron deficiency in the context of malignant disease, phenomenon mediated through inflammatory changes of iron homeostasis. We aimed to investigate clinical and prognostic significance of low TSAT in patients with primary (PMF) and secondary myelofibrosis (SMF), malignant diseases characterized by strong inflammatory milieu. METHODS: We retrospectively analyzed 87 patients with myelofibrosis and compared TSAT with disease specific parameters...
March 2018: Leukemia Research
https://www.readbyqxmd.com/read/29382661/definition-of-iron-deficiency-based-on-the-gold-standard-of-bone-marrow-iron-staining-in-heart-failure-patients
#8
Niels Grote Beverborg, IJsbrand T Klip, Wouter C Meijers, Adriaan A Voors, Eline L Vegter, Haye H van der Wal, Dorine W Swinkels, Joost van Pelt, Andre B Mulder, Sjoerd K Bulstra, Edo Vellenga, Massimo A Mariani, Rudolf A de Boer, Dirk J van Veldhuisen, Peter van der Meer
BACKGROUND: The most commonly used definition of iron deficiency (ID; ferritin <100 ng/mL or ferritin 100-300 ng/mL and transferrin saturation [TSAT] <20%) has not been validated in patients with heart failure (HF). We aimed to define and validate the biomarker-based definition of ID in HF, using bone marrow iron staining as the gold standard. Second, we aimed to assess the prognostic value of the optimized definition. METHODS AND RESULTS: Bone marrow aspiration with iron staining was performed in 42 patients with HF and a reduced left ventricular ejection fraction (≤45%) undergoing median sternotomy for coronary artery bypass grafting...
February 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29357391/iron-deficiency-across-chronic-kidney-disease-stages-is-there-a-reverse-gender-pattern
#9
Mabel Aoun, Rita Karam, Ghassan Sleilaty, Leony Antoun, Walid Ammar
In non-dialysis chronic kidney disease patients, looking for iron deficiency is highly variable in practice and there is a great variability regarding the cutoffs used to treat iron deficiency. The aim of this study is to investigate the degree of iron deficiency in non-dialysis chronic kidney disease patients on erythropoiesis-stimulating agents. We included all non-dialysis chronic kidney disease patients that applied to the Lebanese Ministry of Public Health for erythropoiesis-stimulating agents' coverage during a 5-month period...
2018: PloS One
https://www.readbyqxmd.com/read/29284229/iron-status-in-obese-women
#10
Hanna Stankowiak-Kulpa, Angelika Kargulewicz, Arkadiusz Styszyński, Ewelina Swora-Cwynar, Marian Grzymisławski
INTRODUCTION AND OBJECTIVE: A decreased concentration of iron, and consecutively haemoglobin, ferritin and decreased level of saturated transferrin, were observed in obese individuals more often than in healthy subjects. The purpose of this study was to determine whether iron, ferritin, transferrin saturation are significantly diminished in obese female patients compared to non-obese counterparts, and whether excess adiposity and inflammation were associated with depleted iron. MATERIAL AND METHODS: Female patients (n=48) diagnosed with obesity (BMI > 30 kg/m<sup>2</sup>), aged 18-40 were accepted for the study...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29248829/iron-loaded-transferrin-tf-is-detrimental-whereas-iron-free-tf-confers-protection-against-brain-ischemia-by-modifying-blood-tf-saturation-and-subsequent-neuronal-damage
#11
Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull
Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29227972/serum-hepcidin-and-iron-indices-affect-anemia-status-differently-according-to-the-kidney-function-of-non-dialysis-chronic-kidney-disease-patients-korean-cohort-study-for-outcome-in-patients-with-chronic-kidney-disease-know-ckd
#12
Sung Woo Lee, Yeong Hoon Kim, Wookyung Chung, Sue K Park, Dong Wan Chae, Curie Ahn, Yong-Soo Kim, Su Ah Sung
BACKGROUND/AIMS: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. METHODS: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-2016) and excluded 198 patients with missing data regarding serum hepcidin, hemoglobin, transferrin saturation (TSAT), ferritin, and usage of erythropoiesis-stimulating agents (ESA) or supplemental iron and 363 patients using ESA or supplemental iron...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29193288/characterization-of-tumor-vascular-permeability-using-natural-dextrans-and-cest-mri
#13
Yuguo Li, Yuan Qiao, Hanwei Chen, Renyuan Bai, Verena Staedtke, Zheng Han, Jiadi Xu, Kannie W Y Chan, Nirbhay Yadav, Jeff W M Bulte, Shibin Zhou, Peter C M van Zijl, Guanshu Liu
PURPOSE: To investigate the use of natural dextrans as nano-sized chemical exchange saturation transfer (CEST) MRI probes for characterizing size-dependent tumor vascular permeability. METHODS: Dextrans of different molecular weight (10, 70, 150, and 2000 kD) were characterized for their CEST contrast. Mice (N = 5) bearing CT26 subcutaneous colon tumors were injected intravenously with 10 kD (D10, 6 nm) and 70 kD (D70, 12 nm) dextran at a dose of 375 mg/kg...
February 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29190715/a-history-of-repetitive-cesarean-section-is-a-risk-factor-of-anemia-in-healthy-perimenopausal-women-the-korea-national-health-and-nutrition-examination-survey-2010-2012
#14
Jee Yoon Park, Sung Woo Lee
BACKGROUND AND OBJECTIVES: To determine whether the delivery method is associated with the rate of anemia in later life, using the data from the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: This study used data from the KNHANES 2010-2012. Among 25,534 participants, 8,126 cases were included in this study after exclusion of males and other inappropriate data. The study population was divided into three groups according to the delivery modes: vaginal delivery (VD) only group, single cesarean delivery (SCD) group and repetitive cesarean delivery (RCD) group...
2017: PloS One
https://www.readbyqxmd.com/read/29165637/a-controlled-study-of-the-effects-of-ferric-carboxymaltose-on-bone-and-haematinic-biomarkers-in-chronic-kidney-disease-and-pregnancy
#15
Louis L Huang, Darren Lee, Stefanie M Troster, Annette B Kent, Matthew A Roberts, Iain C Macdougall, Lawrence P McMahon
Background: Intravenous (IV) iron can modulate fibroblast growth factor 23 (FGF23) concentrations and cause transient but significant hypophosphataemia. However, it is unknown what other markers might be involved, especially in different patient groups. This study aimed to determine changes in bone and haematinic biomarkers following IV ferric carboxymaltose (FCM) and to identify risk factors for hypophosphataemia in pregnant subjects and those with chronic kidney disease (CKD). Methods: Changes in bone [serum FGF23, fractional excretion of phosphate urinary fractional excretion of phosphate (FEPi), serum phosphate and serum vitamin D derivatives] and haematinic [plasma hepcidin, serum ferritin and transferrin saturation (TSAT)] biomarkers after 1 g of IV FCM were followed in iron-deficient pregnant and CKD patients and compared with controls (estimated glomerular filtration rate > 60 mL/min/1...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29121874/evaluating-the-effectiveness-of-iv-iron-dosing-for-anemia-management-in-common-clinical-practice-results-from-the-dialysis-outcomes-and-practice-patterns-study-dopps
#16
Bruce M Robinson, Maria Larkina, Brian Bieber, Werner Kleophas, Yun Li, Francesco Locatelli, Keith P McCullough, Jackie G Nolen, Friedrich K Port, Ronald L Pisoni
BACKGROUND: Anemia management protocols in hemodialysis (HD) units differ conspicuously regarding optimal intravenous (IV) iron dosing; consequently, patients receive markedly different cumulative exposures to IV iron and erythropoiesis-stimulating agents (ESAs). Complementary to IV iron safety studies, our goal was to gain insight into optimal IV iron dosing by estimating the effects of IV iron doses on Hgb, TSAT, ferritin, and ESA dose in common clinical practice. METHODS: 9,471 HD patients (11 countries, 2009-2011) in the DOPPS, a prospective cohort study, were analyzed...
November 9, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29120989/validity-and-reliability-of-a-new-test-of-planned-agility-in-elite-taekwondo-athletes
#17
Helmi Chaabene, Yassine Negra, Laura Capranica, Raja Bouguezzi, Younés Hachana, Mohamed Ali Rouahi, Bessem Mkaouer
This study aimed to examine the validity, reliability, and sensitivity of a new test of planned agility in elite taekwondo athletes and to establish its relationship with sprint-time, jumping ability, and dynamic balance. Twenty-seven (20 males and 7 females) taekwondo athletes participated to this study. They performed taekwondo-specific agility test (TSAT) in two occasions (i.e., test-retest). Additionally, they performed jumping ability (i.e., squat jump, countermovement jump, standing long jump, and three-hop jump), sprint-time (5-m and 20-m dash), and dynamic balance (i...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29119631/safety-and-efficacy-of-early-start-of-iron-chelation-therapy-with-deferiprone-in-young-children-newly-diagnosed-with-transfusion-dependent-thalassemia-a-randomized-controlled-trial
#18
Mohsen Saleh Elalfy, Amira Adly, Hanem Awad, Mohamed Tarif Salam, Vasilios Berdoukas, Fernando Tricta
Iron overload is inevitable in patients who are transfusion dependent. In young children with transfusion-dependent thalassemia (TDT), current practice is to delay the start of iron chelation therapy due to concerns over toxicities, which have been observed when deferoxamine was started too early. However, doing so may increase the risk of iron accumulation that will be manifested as toxicities later in life. This study investigated whether deferiprone, a chelator with a lower affinity for iron than deferoxamine, could postpone transfusional iron overload while maintaining a good safety profile...
February 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29083385/iron-profile-and-glycaemic-control-in-patients-with-type-2-diabetes-mellitus
#19
Gunjan Misra, Surendra Kumar Bhatter, Ajai Kumar, Varsha Gupta, Mohd Y Khan
Iron overload is increasingly being connected to insulin resistance in Type 2 Diabetes Mellitus (T2DM) patients. Free iron causes the assembly of reactive oxygen species that invariably steer the body's homeostasis towards oxidative stress-mediated diabetic complications. This study aims to assess the serum iron, total iron binding capacity (TIBC), and percentage transferrin saturation (Tsat) of 150 subjects divided into three groups (I,II,III) of 50. Healthy individuals (controls) constituted Group I. Group II consisted of T2DM patients with optimal glycaemic control...
December 9, 2016: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/28792166/evaluation-of-effect-of-ascorbic-acid-on-ferritin-and-erythropoietin-resistance-in-patients-of-chronic-kidney-disease
#20
N Nand, A R Deshmukh, R Mittal
OBJECTIVE: This study was planned to evaluate the effect of short term intravenous ascorbic acid on reducing ferritin and erythropoietin resistance in patients of chronic kidney disease (CKD) on maintenance haemodialysis (MHD). METHODS: Forty adult patients [20 patients in group A with increased serum ferritin level (>500 ng/ml), transferrin saturation (TSAT) ≤20% and 20 patients in group B with normal serum ferritin level (<200 ng/ml), TSAT ≤20%] of end stage renal disease (ESRD) with erythropoietin hyporesponsiveness undergoing maintenance hemodialysis were included in the study...
July 2017: Journal of the Association of Physicians of India
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