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https://www.readbyqxmd.com/read/26915977/overhauser-enhanced-magnetic-resonance-elastography
#1
Najat Salameh, Mathieu Sarracanie, Brandon D Armstrong, Matthew S Rosen, Arnaud Comment
Magnetic resonance elastography (MRE) is a powerful technique to assess the mechanical properties of living tissue. However, it suffers from reduced sensitivity in regions with short T2 and T2 * such as in tissue with high concentrations of paramagnetic iron, or in regions surrounding implanted devices. In this work, we exploit the longer T2 * attainable at ultra-low magnetic fields in combination with Overhauser dynamic nuclear polarization (DNP) to enable rapid MRE at 0.0065 T. A 3D balanced steady-state free precession based MRE sequence with undersampling and fractional encoding was implemented on a 0...
May 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/26308867/new-3-heteroaryl-2-iminocoumarin-based-borate-complexes-synthesis-photophysical-properties-and-rational-functionalization-for-biosensing-biolabeling-applications
#2
Benoît Roubinet, Cédrik Massif, Mathieu Moreau, Frédéric Boschetti, Gilles Ulrich, Raymond Ziessel, Pierre-Yves Renard, Anthony Romieu
Members of a series of boron difluoride complexes with 3-(heteroaryl)-2-iminocoumarin ligands bearing both a phenolic hydroxyl group (acting as a fluorogenic center) and an N-aryl substituent (acting as a stabilizing moiety) have been synthesized in good yields by applying a straightforward two-step method. These novel fluorogenic dyes belong to the family of "Boricos" (D. Frath et al., Chem. Commun.- 2013, 49, 4908-4910) and are the first examples of phenol-based fluorophores of which the photophysical properties in the green-yellow spectral range are dramatically improved by N,N-chelation of a boron atom...
October 5, 2015: Chemistry: a European Journal
https://www.readbyqxmd.com/read/25196781/drug-screening-boosted-by-hyperpolarized-long-lived-states-in-nmr
#3
Roberto Buratto, Aurélien Bornet, Jonas Milani, Daniele Mammoli, Basile Vuichoud, Nicola Salvi, Maninder Singh, Aurélien Laguerre, Solène Passemard, Sandrine Gerber-Lemaire, Sami Jannin, Geoffrey Bodenhausen
Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand comprises at least two coupled spins. Herein we broaden the scope of ligand screening by LLS to arbitrary ligands by covalent attachment of a functional group, which comprises a pair of coupled protons that are isolated from neighboring magnetic nuclei...
November 2014: ChemMedChem
https://www.readbyqxmd.com/read/25046565/emergent-ion-gated-binding-of-cationic-host-guest-complexes-within-cationic-m12l24-molecular-flasks
#4
Carson J Bruns, Daishi Fujita, Manabu Hoshino, Sota Sato, J Fraser Stoddart, Makoto Fujita
"Molecular flasks" are well-defined supramolecular cages that can encapsulate one or more molecular guests within their cavities and, in so doing, change the physical properties and reactivities of the guests. Although molecular flasks are powerful tools for manipulating matter on the nanoscale, most of them are limited in their scope because of size restrictions. Recently, however, increasingly large and diverse supramolecular cages have become available with enough space in their cavities for larger chemical systems such as polymers, nanoparticles, and biomolecules...
August 27, 2014: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/24968276/effect-of-electron-spin-dynamics-on-solid-state-dynamic-nuclear-polarization-performance
#5
Ting Ann Siaw, Matthias Fehr, Alicia Lund, Allegra Latimer, Shamon A Walker, Devin T Edwards, Song-I Han
For the broadest dissemination of solid-state dynamic nuclear polarization (ssDNP) enhanced NMR as a material characterization tool, the ability to employ generic mono-nitroxide radicals as spin probes is critical. A better understanding of the factors contributing to ssDNP efficiency is needed to rationally optimize the experimental condition for the practically accessible spin probes at hand. This study seeks to advance the mechanistic understanding of ssDNP by examining the effect of electron spin dynamics on ssDNP performance at liquid helium temperatures (4-40 K)...
September 21, 2014: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/23909563/the-doctor-of-nursing-practice-capstone-project-consensus-or-confusion
#6
Jane M Kirkpatrick, Terri Weaver
Considerable diversity exists among Doctor of Nursing Practice (DNP) programs regarding capstone projects, which reflect the knowledge gained and the competency achieved during the immersion experience. This article describes a conversation of the DNP capstone project among participants of the Committee on Institutional Collaboration DNP Invitational Conference. The focus of the dialogue was to discuss the intent and breadth of the DNP capstone project and how it demonstrates competencies, to consider in what way it differs from the PhD dissertation, and to identify the similarities and differences among multiple forms of the project in terms of scope and expected deliverables, as well as to examine other related issues...
August 2013: Journal of Nursing Education
https://www.readbyqxmd.com/read/23036688/using-social-network-analysis-to-examine-collaborative-relationships-among-phd-and-dnp-students-and-faculty-in-a-research-intensive-university-school-of-nursing
#7
Jacqueline A Merrill, Sunmoo Yoon, Elaine Larson, Judy Honig, Nancy Reame
The nursing profession has seen a dramatic rise in the number of schools offering both DNP and PhD nursing programs. Information is limited on the impact of this parallel approach in doctoral education on the quality and scope of scholarly interactions or institutional culture.The authors studied collaboration characteristics across the DNP and PhD programs of a research-intensive university school of nursing, before and after programmatic enhancements. An IRB-approved online survey was delivered to faculty and students of both programs at baseline and one year after curricular changes...
March 2013: Nursing Outlook
https://www.readbyqxmd.com/read/22668690/neonatal-nurse-practitioner-workforce-survey-executive-summary
#8
Paula Timoney, Debra Sansoucie
The Neonatal Nurse Practitioner Workforce Survey, led by Paula Timoney, DNP, ARNP, NNP-BC, and Debra Sansoucie, EdD, RN, NNP-BC, with the National Association of Neonatal Nurse Practitioners (NANNP), provides data collected from more than 600 neonatal nurse practitioners to examine workforce characteristics and needs. NANNP commissioned the survey because no comprehensive data existed for the neonatal nurse practitioner workforce. The executive summary given in this article highlights some of the survey's key findings in the areas of demographics, practice environment, scope of responsibilities, and job satisfaction...
June 2012: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/22133073/epr-analysis-and-dft-computations-of-a-series-of-polynitroxides
#9
M Francesca Ottaviani, Alberto Modelli, Olaf Zeika, Steffen Jockusch, Alberto Moscatelli, Nicholas J Turro
Polynitroxides with varying numbers of nitroxide groups (one to four) derived from different aromatic core structures show intramolecular electron spin-spin coupling. The scope of this study is to establish an easy methodology for extracting structural, dynamical, and thermodynamical information from the EPR spectra of these polynitroxides which might find use as spin probes in complex systems, such as biological and host/guest systems, and as polarizing agents in dynamic nuclear polarization (DNP) applications...
January 12, 2012: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/22041143/assessment-of-chiral-stationary-phases-for-suitability-for-combined-enantiomeric-impurity-related-substances-assays
#10
R Wimal H Perera, W John Lough
Chiral stationary phases (CSP) for LC had a major impact on pharmaceutical R&D when they first became commercially available in the 1980s. Even although the use of CSP in pharmaceutical R&D is now very much a mature area, there is still scope for using CSP more effectively to bring about efficiencies. One such instance is the possibility of combining the chiral LC test for the level of a trace enantiomeric impurity in a chiral drug substance and the LC test for related substances into one test. It was envisaged that this could be achieved by carrying out reversed-phase LC on an ODS silica/CSP coupled column system...
December 2, 2011: Journal of Chromatography. A
https://www.readbyqxmd.com/read/21855299/polarizing-agents-and-mechanisms-for-high-field-dynamic-nuclear-polarization-of-frozen-dielectric-solids
#11
REVIEW
Kan-Nian Hu
This article provides an overview of polarizing mechanisms involved in high-frequency dynamic nuclear polarization (DNP) of frozen biological samples at temperatures maintained using liquid nitrogen, compatible with contemporary magic-angle spinning (MAS) nuclear magnetic resonance (NMR). Typical DNP experiments require unpaired electrons that are usually exogenous in samples via paramagnetic doping with polarizing agents. Thus, the resulting nuclear polarization mechanism depends on the electron and nuclear spin interactions induced by the paramagnetic species...
September 2011: Solid State Nuclear Magnetic Resonance
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