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carbon monoxide diffusing capacity DLCO

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https://www.readbyqxmd.com/read/27902753/emphysema-distribution-and-diffusion-capacity-predict-emphysema-progression-in-human-immunodeficiency-virus-infection
#1
Janice M Leung, Andrea Malagoli, Antonella Santoro, Giulia Besutti, Guido Ligabue, Riccardo Scaglioni, Darlene Dai, Cameron Hague, Jonathon Leipsic, Don D Sin, Sf Paul Man, Giovanni Guaraldi
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and emphysema are common amongst patients with human immunodeficiency virus (HIV). We sought to determine the clinical factors that are associated with emphysema progression in HIV. METHODS: 345 HIV-infected patients enrolled in an outpatient HIV metabolic clinic with ≥2 chest computed tomography scans made up the study cohort. Images were qualitatively scored for emphysema based on percentage involvement of the lung...
2016: PloS One
https://www.readbyqxmd.com/read/27888395/utility-of-fvc-dlco-ratio-to-stratify-the-risk-of-mortality-in-unselected-subjects-with-pulmonary-hypertension
#2
Lacedonia Donato, Carpagnano Giovanna Elisiana, Galgano Giuseppe, Schino Pietro, Correale Michele, Natale Daniele Brunetti, Ventura Valentina, Di Biase Matteo, Foschino Barbaro Maria Pia
In patients with systemic sclerosis, a ratio between forced vital capacity (FVC) and diffusing capacity of carbon monoxide (DLCO, FCV%/DLCO%) >1.5 might be a predictor of pulmonary hypertension (PH). The aim of this study is, therefore, to evaluate whether this index can be used in patients with PH, regardless of etiology. 83 consecutive outpatients with suspected PH at non-invasive work-up underwent spirometry and DLCO test before right heart catheterization (RHC); FVC%/DLCO% ratio was then calculated and compared with mean pulmonary-artery-pressure (mPAP) and mortality at 5-year follow-up...
November 25, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27884796/can-the-measurement-of-pulmonary-diffusing-capacity-for-nitric-oxide-replace-the-measurement-of-pulmonary-diffusing-capacity-for-carbon-monoxide
#3
Gerald S Zavorsky, Ivo van der Lee
Pulmonary diffusing capacity for carbon monoxide (DLCO) has been an important pulmonary function test used since the 1950's. It measures the uptake of CO from the alveolar space into pulmonary capillary blood, following the same path as oxygen. It's used to evaluate/follow the progress of various lung diseases. In the eighties, a new test was developed similar to the DLCO test: pulmonary diffusing capacity for nitric oxide (DLNO). About 81-90% of the variance in DLNO is shared by DLCO in patients with cardiopulmonary disease and in healthy subjects...
November 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27870589/results-of-a-prospective-study-evaluating-a-non-invasive-method-of-hemoglobin-adjustment-for-determining-the-diffusing-capacity-of-the-lung
#4
Karla E Foster, Rashmi D Sahay, Nanhua Zhang, William D Hardie
RATIONALE: Measurement of the lung diffusing capacity for carbon monoxide (DLCO) is significantly influenced by the pulmonary capillary blood volume. Consequently, measurements require adjustment for blood hemoglobin concentration (DLCOADJ) to allow meaningful clinical interpretation. Noninvasive point-of-care devices that measure hemoglobin transcutaneously provide immediate values for hemoglobin that may be useful in pulmonary function laboratories for determining DLCOADJ. OBJECTIVES: To test the hypothesis that DLCOADJ determinations obtained using a commerciallyavailable device for noninvasive, point-of-care measurement of blood hemoglobin concentrations are not importantly different from determinations obtained using hemoglobin concentrations measured conventionally on venous blood samples...
November 21, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27868303/fat-free-mass-index-predicts-survival-in-patients-with-idiopathic-pulmonary-fibrosis
#5
Osamu Nishiyama, Ryo Yamazaki, Hiroyuki Sano, Takashi Iwanaga, Yuji Higashimoto, Hiroaki Kume, Yuji Tohda
BACKGROUND AND OBJECTIVE: Detailed body composition, such as fat-free mass, has not been examined in idiopathic pulmonary fibrosis (IPF). We investigated whether the fat-free mass index (FFMI), an index of lean body mass, predicted survival. METHODS: Forty-four patients with IPF were enrolled in the study. Their body composition was assessed using direct segmental multi-frequency bioelectrical impedance analysis. The degree of correlation between variables of body composition and other variables such as forced vital capacity (FVC) and survival was examined...
November 21, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27866549/-characteristics-of-lung-function-in-patients-with-asbestosis-of-different-stages
#6
X L Yang, X L Zhu, A Li, X Q Du, Y G Song, Q Ye
Objective: To investigate the characteristics of lung function in the patients with asbestosis of different stages, and analyze the correlations between the pulmonary function values and imaging score of chest X-ray. Methods: A cohort of newly diagnosed 249 asbestosis patients over a period of eight years in a single center were evaluated. Clinical data were collected from clinical charts. Radiographs were reviewed by the experts blinded to clinical data. The asbestosis patients were classified into I to III stages by chest X-ray according to the guideline...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27863863/effect-of-%C3%AE-2-adrenergic-receptor-stimulation-on-lung-fluid-in-stable-heart-failure-patients
#7
Bryan J Taylor, Eric M Snyder, Maile L Richert, Courtney M Wheatley, Steven C Chase, Lyle J Olson, Bruce D Johnson
BACKGROUND: The purpose of this study was to determine: (1) whether stable heart failure patients with reduced ejection fraction (HFrEF) have elevated extravascular lung water (EVLW) when compared with healthy control subjects; and (2) the effect of acute β2-adrenergic receptor (β2AR) agonist inhalation on lung fluid balance. METHODS: Twenty-two stable HFrEF patients and 18 age- and gender-matched healthy subjects were studied. Lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO), pulmonary capillary blood volume (Vc) (via re-breathe) and lung tissue volume (Vtis) (via computed tomography) were assessed before and within 30 minutes after administration of nebulized albuterol...
October 2, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27860036/frailty-is-common-and-strongly-associated-with-dyspnoea-severity-in-fibrotic-interstitial-lung-disease
#8
Kathryn M Milne, Joanne M Kwan, Sabina Guler, Tiffany A Winstone, Angela Le, Nasreen Khalil, Pat G Camp, Pearce G Wilcox, Christopher J Ryerson
BACKGROUND AND OBJECTIVE: Frailty is the age-related accumulation of deficits that decrease the ability to respond to biological stress. Patients with fibrotic interstitial lung disease (ILD) may be frail due to consequences of ILD, age, co-morbidities and adverse effects of pharmacotherapies. The objective of this study was to examine the prevalence and predictors of frailty in fibrotic ILD. METHODS: Fibrotic ILD patients were recruited from a specialized clinic...
November 9, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27833966/analysis-of-bronchoalveolar-lavage-fluid-in-a-first-romanian-pulmonary-alveolar-proteinosis-cohort
#9
Oana Claudia Deleanu, Ana Maria Zaharie, Aneta Şerbescu, Floarea Mimi NiŢu, Florin Dumitru MihălŢan, Oana Cristina Arghir
The features of bronchoalveolar lavage fluid (BALF) components and the severity of pulmonary alveolar proteinosis (PAP) were analyzed in the first Romanian cohort of patients admitted to "Marius Nasta" Institute of Pneumophtisiology, Bucharest, Romania. A six-year follow-up study based on bronchoalveolar lavage (BAL) data was performed between January 2007 to December 2012. Study cohort consisted in 20 inpatients diagnosed with PAP, based on BALF cytological findings and÷or on histopathological findings. Demographic, medical history, tobacco use, clinical and radiological features, disease progression with or without whole lung lavage (WLL) therapy were collected...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27826889/osteoprotegerin-srankl-signaling-system-in-pulmonary-sarcoidosis-a-bronchoalveolar-lavage-study
#10
W Naumnik, B Naumnik, W Niklińska, M Ossolińska, E Chyczewska
Osteoprotegerin (OPG), a soluble tumor necrosis factor receptor family molecule, protects endothelial cells from apoptosis in vitro and promotes neovascularization in vivo. Angiogenesis may be crucial for the course and outcome of sarcoidosis. In this study, we evaluated the clinical usefulness of OPG and its ligand, a soluble receptor activator of nuclear factor-kappaB (sRANKL), in bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis (BBS, Besniera-Boeck-Schaumann disease). We studied 22 BBS patients and 15 healthy volunteers as a control group...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27818328/clinical-features-of-smokers-with-radiological-emphysema-but-without-airway-limitation
#11
Ana B Alcaide, Pablo Sanchez, Gorka Bastarrika, Arantza Campo, Juan Berto, Maria Del Mar Ocon, Bartolome R Celli, Javier J Zulueta, Juan P de-Torres
RATIONALE: The clinical characteristics of patients with emphysema but without airway limitation remain unknown. OBJECTIVE: To compare the clinical features of current and former smokers without airflow limitation who have radiological emphysema on chest CT with a control group of current and ex-smokers without emphysema. METHODS: Subjects enrolled had anthropometrics, medical history and a low dose chest computed tomography (LDCT). The following parameters were also evaluated: pulmonary function tests (PFT) including diffusion capacity for carbon monoxide (DLCO), modified MRC dyspnea score, COPD assessment test (CAT) and 6-min walk distance (6MWD)...
November 3, 2016: Chest
https://www.readbyqxmd.com/read/27816444/use-of-mycophenolate-mofetil-or-azathioprine-for-the-management-of-chronic-hypersensitivity-pneumonitis
#12
Julie Morisset, Kerri A Johannson, Eric Vittinghoff, Carlos Aravena, Brett M Elicker, Kirk D Jones, Charlene D Fell, Helene Manganas, Bruno-Pierre Dubé, Paul J Wolters, Harold R Collard, Christopher J Ryerson, Brett Ley
BACKGROUND: The treatment of chronic hypersensitivity pneumonitis (cHP) often includes systemic oral corticosteroids, but the optimal pharmacologic management remains unclear. The morbidity associated with prednisone has motivated the search for alternative therapies. We aimed to determine the effect of treatment with mycophenolate mofetil (MMF) or azathioprine (AZA) on lung function in patients with cHP. METHODS: Patients with cHP treated with either MMF or AZA were retrospectively identified from four interstitial lung disease centers...
November 2, 2016: Chest
https://www.readbyqxmd.com/read/27803750/alterations-of-pulmonary-function-in-patients-with-inflammatory-bowel-diseases
#13
Xiao-Qing Ji, Yan-Bo Ji, Shan-Xin Wang, Cai-Qing Zhang, De-Gan Lu
AIM: The aim of this study was to investigate the alterations of pulmonary function tests (PFTs) and their relationship with disease activity in inflammatory bowel diseases (IBDs). METHODS: Sixty-four IBD patients (31 Crohn's disease [CD] and 33 ulcerative colitis [UC]) and thirty healthy individuals (controls) were studied with regard to the following parameters of PFTs: Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), their ratio, mid-forced expiratory flow of 25-75% (FEF 25-75), residual volume, total lung capacity, and diffusing capacity of the lung for carbon monoxide (DLCO)...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27788297/progressive-decline-of-lung-function-in-rheumatoid-arthritis-associated-interstitial-lung-disease
#14
Jorge A Zamora-Legoff, Megan L Krause, Cynthia S Crowson, Jay H Ryu, Eric L Matteson
OBJECTIVE: Interstitial lung disease (ILD) is associated with substantial morbidity in rheumatoid arthritis (RA), but very little is known about its long-term progression. METHODS: All patients with RA-ILD seen at Mayo Clinic in 1998-2014 with at least 4 weeks follow-up and at least 1 pulmonary function test (PFT) were identified and manually screened for study inclusion. Progression was defined as a diffusing capacity for carbon monoxide (DLCO) <40% predicted or too ill to perform, or a forced vital capacity (FVC) <50% predicted...
October 27, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27783103/changes-in-pulmonary-function-and-influencing-factors-after-high-dose-intrathoracic-radio-chemo-therapy
#15
Christina Schröder, Rita Engenhart-Cabillic, Hilke Vorwerk, Michael Schmidt, Winfried Huhnt, Eyck Blank, Dietrich Sidow, André Buchali
PURPOSE: Using prospectively collected patient-related, dose-related, and pulmonary function test (PFT) data before radiotherapy (RT) and at several follow-up visits after RT, the time course of PFT changes after high-dose radio(chemo)therapy and influencing factors were analyzed. MATERIALS AND METHODS: From April 2012 to October 2015, 81 patients with non-small-cell lung carcinoma (NSCLC), small cell lung carcinoma (SCLC), or esophageal carcinoma where treated with high-dose radio(chemo)therapy...
October 25, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27780366/coexisting-copd-in-elderly-asthma-with-fixed-airflow-limitation-assessment-by-dlco-predicted-and-hrct
#16
Tsutomu Tamada, Hisatoshi Sugiura, Tsuneyuki Takahashi, Kazuto Matsunaga, Keiji Kimura, Uichiro Katsumata, Ken Ohta, Masakazu Ichinose
BACKGROUND: Asthma patients with fixed airflow limitation (FL) are theoretically classified into two phenotypes, that is, coexisting chronic obstructive pulmonary disease (COPD) and asthmatic airway remodeling. However, the precise percentages of such patients are not known. OBJECTIVE: To assess the prevalence of patients with both FL and COPD components in elderly asthma. METHODS: We evaluated patients by lung diffusion impairment and emphysematous findings in high-resolution computed tomography (HRCT) as candidates for COPD components, as a multicenter, cross-sectional survey...
October 26, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27773996/albuterol-improves-alveolar-capillary-membrane-conductance-in-healthy-humans
#17
Natalie E Taylor, Sarah E Baker, Thomas P Olson, Sophie Lalande, Bruce D Johnson, Eric M Snyder
BACKGROUND: Beta-2 adrenergic receptors (β2ARs) are located throughout the body including airway and alveolar cells. The β2ARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect of an inhaled β2-agonist (albuterol) on alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC) in healthy humans. METHODS: We assessed the diffusing capacity of the lungs for carbon monoxide (DLCO) and nitric oxide (DLNO) at baseline, 30 minutes, and 60 minutes following nebulized albuterol (2...
2016: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/27761978/validation-of-the-prognostic-value-of-mmp-7-in-idiopathic-pulmonary-fibrosis
#18
Argyris Tzouvelekis, Jose D Herazo-Maya, Martin Slade, Jen-Hwa Chu, Giuseppe Deiuliis, Changwan Ryu, Qin Li, Koji Sakamoto, Gabriel Ibarra, Hongyi Pan, Mridu Gulati, Danielle Antin-Ozerkis, Erica L Herzog, Naftali Kaminski
BACKGROUND AND OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and variable clinical course. Although matrix metalloproteinase-7 (MMP-7) is emerging as an important IPF biomarker, reproducibility across studies is unclear. We aimed to determine whether a previously reported prognostic threshold for MMP-7 was predictive of mortality in an independent cohort of IPF patients. METHODS: MMP-7 concentrations obtained from heparinized plasma samples were determined by ELISA in 97 patients with IPF and 41 healthy controls...
October 19, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27754815/referral-to-palliative-care-infrequent-in-patients-with-idiopathic-pulmonary-fibrosis-admitted-to-an-intensive-care-unit
#19
Zhan Liang, Leslie A Hoffman, Mehdi Nouraie, Daniel J Kass, Michael P Donahoe, Kevin F Gibson, Melissa I Saul, Kathleen O Lindell
BACKGROUND: Palliative care has been recommended as a means to assist patients with idiopathic pulmonary fibrosis (IPF) in managing symptom burden and advanced care planning. Timing of referral is important because although most patients display a gradually progressive course, a minority experience acute deterioration, an outcome associated with high mortality. AIM: To describe characteristics of IPF patients referred to a specialty lung disease center over a 10-year period who experienced acute deterioration and subsequent intensive care unit (ICU) admission, including frequency and timing of referral to palliative care...
October 18, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27746429/influence-of-smoking-in-interstitial-pneumonia-presenting-with-a-non-specific-interstitial-pneumonia-pattern
#20
Tetsuro Sawata, Masashi Bando, Masayuki Nakayama, Naoko Mato, Hideaki Yamasawa, Yukihiko Sugiyama
Objective The influence of smoking on the pathogenesis and clinical course of interstitial pneumonia has recently attracted attention. To clarify the influence of smoking on the clinical patient characteristics and therapeutic effects in patients with interstitial pneumonia presenting with a non-specific interstitial pneumonia (NSIP) pattern, we compared the clinical patient characteristics and therapeutic effects in smokers and nonsmokers in this study. Methods We divided 31 NSIP (16 idiopathic nonspecific interstitial pneumonia and 15 collagen vascular disease-associated nonspecific interstitial pneumonia) patients into smoker and non-smoker groups for each case...
2016: Internal Medicine
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