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https://www.readbyqxmd.com/read/28333468/alkyl-chain-length-dependent-structural-and-orientational-transformations-of-water-at-alcohol-water-interfaces-and-its-relevance-to-atmospheric-aerosols
#1
Jahur A Mondal, Vinu Namboodiri, Mathi Pandiyathuray, Ajay K Singh
Although the hydrophobic size of an amphiphile plays a key role in various chemical, biological, and atmospheric processes, its effect at macroscopic aqueous interfaces (e.g. air-water, oil-water, cell membrane-water, etc.) which are ubiquitous in nature is not well understood. Here we report the hydrophobic alkyl chain length dependent structural and orientational transformations of water at alcohol (CnH2n+1OH, n = 1-12)-water interfaces using interface-selective heterodyne-detected vibrational sum frequency generation (HD-VSFG) and Raman multivariate curve resolution (Raman-MCR) spectroscopic techniques...
March 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28333311/citrobacter-braakii-carrying-plasmid-borne-mcr-1-colistin-resistance-gene-from-ready-to-eat-food-from-a-market-in-the-chaco-region-of-bolivia
#2
Samanta Sennati, Vincenzo Di Pilato, Eleonora Riccobono, Tiziana Di Maggio, Ana Liz Villagran, Lucia Pallecchi, Alessandro Bartoloni, Gian Maria Rossolini, Tommaso Giani
No abstract text is available yet for this article.
March 15, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333193/increased-activity-of-colistin-in-combination-with-amikacin-against-escherichia-coli-co-producing-ndm-5-and-mcr-1
#3
Yu-Feng Zhou, Meng-Ting Tao, Youjun Feng, Run-Shi Yang, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun
Objectives: Colistin and carbapenem are two lines of last-resort antibiotics against lethal infections caused by MDR Gram-negative pathogens. The emergence of carbapenemase-positive Escherichia coli with colistin resistance poses a serious threat to public health worldwide. Here we report, for the first time (to the best of our knowledge), a novel combination therapy used for the treatment of E. coli co-producing MCR-1 and NDM-5. Methods: The MICs of colistin were determined alone and with 1-4 mg/L amikacin...
February 20, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28322714/mcr-1-in-enterobacteriaceae-from-companion-animals-beijing-china-2012-2016
#4
Lei Lei, Yang Wang, Stefan Schwarz, Timothy R Walsh, Yanran Ou, Yifan Wu, Mei Li, Zhangqi Shen
To investigate the prevalence of the recently emerging colistin resistance gene mcr-1 in Enterobacteriaceae among companion animals, we examined 566 isolates collected from cats and dogs in Beijing, China, during 2012-2016. Of these isolates, 49 (8.7%) were mcr-1-positive.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28320720/moraxella-species-as-potential-sources-of-mcr-like-polymyxin-resistance-determinants
#5
Nicolas Kieffer, Patrice Nordmann, Laurent Poirel
Plasmid-mediated resistance to polymyxins mediated by the MCR-1/-2 determinants has been recently reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella species were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were identified as potential reservoirs of mcr-like genes.
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28316780/screening-for-fecal-carriage-of-mcr-producing-enterobacteriaceae-in-healthy-humans-and-primary-care-patients
#6
Katrin Zurfluh, Roger Stephan, Andreas Widmer, Laurent Poirel, Patrice Nordmann, Hans-Jakob Nüesch, Herbert Hächler, Magdalena Nüesch-Inderbinen
BACKGROUND: The extent of the occurrence of the plasmid-encoded colistin resistance genes mcr-1 and mcr-2 among humans is currently sparsely studied in Western Europe. OBJECTIVES: To determine the occurrence of MCR-producing Enterobacteriaceae in fecal samples of healthy humans with high occupational exposure to food and primary care patients in Switzerland. METHODS: Stool samples from 1091 healthy individuals and fecal swabs from 53 primary care patients were screened for polymyxin-resistant Enterobacteriaceae using LB agar containing 4 mg/L colistin...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28304024/methionine-and-seleno-methionine-type-peptide-and-peptoid-building-blocks-synthesized-by-five-component-five-center-reactions
#7
Goran N Kaluđerović, Muhammad Abbas, Hans Christian Kautz, Mohammad A M Wadaan, Claudia Lennicke, Barbara Seliger, Ludger A Wessjohann
A first example of 5-component 5-center reactions with isonitriles [Ugi-5CRs] is described. The extended Ugi type reactions involve selenoaldehydes as well as ammonia, both challenging reactants in multicomponent (MCR) systems, to generate methionine and Se-methionine moieties and derivatives as protected building blocks or for direct ligation in peptides or peptoids. The peptoid/peptide building blocks proved to be non-cytotoxic but increased the expression of genes encoding for stress protective selenoproteins (Gpx1)...
March 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28303718/synthesis-of-polysubstituted-3-amino-pyrroles-via-palladium-catalyzed-multicomponent-reaction-mcr
#8
Jianwen Peng, Yang Gao, Chuanle Zhu, Bifu Liu, Yinglan Gao, Miao Hu, Wanqing Wu, Huanfeng Jiang
A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction has been developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions, assembly efficiency, readily available starting materials and good functional group tolerance. Furthermore, this process has been successfully applied to the synthesis of different 3-phenyl-1,4-dihydropyrrolo[3,2-b]indole derivatives via an intermolecular Buchwald-Hartwig cross-coupling reaction in two-step...
March 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28302788/high-quality-genome-sequence-of-an-escherichia-coli-o157-strain-carrying-an-mcr-1-resistance-gene-isolated-from-a-patient-in-the-united-states
#9
Rebecca L Lindsey, Dhwani Batra, Lori Rowe, Vladimir N Loparev, Devon Stripling, Lisley Garcia-Toledo, Kristen Knipe, Phalasy Juieng, Mili Sheth, Haley Martin, Alison Laufer Halpin
Enterobacteriaceae carrying plasmid-mediated colistin resistance have been found around the world. We report here the high-quality whole-genome sequence of an Escherichia coli O157:H48 isolate (2016C-3936C1) from Connecticut that carried the mcr-1 resistance gene on an IncX4-type plasmid.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28298679/evaluation-of-long-heating-kinetic-process-of-edible-oils-using-atr-ftir-and-chemometrics-tools
#10
Marjan Mahboubifar, Bahram Hemmateenejad, Katayoun Javidnia, Saeed Yousefinejad
Long thermal oxidative kinetic and stability of four different edible oils (colza, corn, frying, sunflower) from various brands were surveyed with the use of attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) combined with multivariate curve resolution-alternative least square (MCR-ALS). Sampling from the heated oils (at 170 °C) was performed each 3 h during a 36-h period. Changes in the ATR-FTIR spectra of the oil samples in the range of 4000-550 cm(-1) were followed as a function of heating time...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28288347/exploration-of-the-metal-coordination-region-of-concanavalin-a-for-its-interaction-with-human-norovirus
#11
Duwoon Kim, Hee-Min Lee, Kyung-Seo Oh, Ah Young Ki, Rachael A Protzman, Dongkyun Kim, Jong-Soon Choi, Min Ji Kim, Sung Hyun Kim, Bipin Vaidya, Seung Jae Lee, Joseph Kwon
Rapid methods for the detection and clinical treatment of human norovirus (HuNoV) are needed to control foodborne disease outbreaks, but reliable techniques that are fast and sensitive enough to detect small amounts of HuNoV in food and aquatic environments are not yet available. We explore the interactions between HuNoV and concanavalin A (Con A), which could facilitate the development of a sensitive detection tool for HuNoV. Biophysical studies including hydrogen/deuterium exchange (HDX) mass spectrometry and surface plasmon resonance (SPR) revealed that when the metal coordinated region of Con A, which spans Asp16 to His24, is converted to nine alanine residues (mCon A(MCR)), the affinity for HuNoV (GII...
March 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28288214/confocal-raman-imaging-and-chemometrics-applied-to-solve-forensic-document-examination-involving-crossed-lines-and-obliteration-cases-by-a-depth-profiling-study
#12
Flávia de Souza Lins Borba, Tariq Jawhari, Ricardo Saldanha Honorato, Anna de Juan
This article describes a non-destructive analytical method developed to solve forensic document examination problems involving crossed lines and obliteration. Different strategies combining confocal Raman imaging and multivariate curve resolution-alternating least squares (MCR-ALS) are presented. Multilayer images were acquired at subsequent depth layers into the samples. It is the first time that MCR-ALS is applied to multilayer images for forensic purposes. In this context, this method provides a single set of pure spectral ink signatures and related distribution maps for all layers examined from the sole information in the raw measurement...
March 13, 2017: Analyst
https://www.readbyqxmd.com/read/28287910/transferability-of-the-mcr-1-colistin-resistance-gene
#13
Valérie Dénervaud Tendon, Laurent Poirel, Patrice Nordmann
No abstract text is available yet for this article.
March 13, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28284161/identification-of-trace-additives-in-polymer-materials-by-attenuated-total-reflection-fourier-transform-infrared-mapping-coupled-with-multivariate-curve-resolution
#14
Qian Li, Yongjiao Tang, Zhiwei Yan, Pudun Zhang
Although multivariate curve resolution (MCR) has been applied to the analysis of Fourier transform infrared (FTIR) imaging, it is still problematic to determine the number of components. The reported methods at present tend to cause the components of low concentration missed. In this paper a new idea was proposed to resolve this problem. First, MCR calculation was repeated by increasing the number of components sequentially, then each retrieved pure spectrum of as-resulted MCR component was directly compared with a real-world pixel spectrum of the local high concentration in the corresponding MCR map...
March 7, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28277683/hydration-shell-transformation-of-thermo-sensitive-aqueous-polymers
#15
Kenji Mochizuki, Dor Ben-Amotz
Although water plays a key role in the coil-globule transition of polymers and biomolecules, it is not clear if a change in water structure drives or follows polymer collapse. Here, we address this question by using Raman multivariate curve resolution (Raman-MCR) spectroscopy to investigate the hydration shell structure around poly(N-isopropylacrylamide) (PNIPAM) and poly(propyleneoxide) (PPO) both below and above the cloud point temperature at which the polymers collapse and form meso-scopic polymer-rich aggregates...
March 9, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28275006/polymyxins-antibacterial-activity-susceptibility-testing-and-resistance-mechanisms-encoded-by-plasmids-or-chromosomes
#16
REVIEW
Laurent Poirel, Aurélie Jayol, Patrice Nordmann
SUMMARYPolymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria...
April 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28270404/pbx1-haploinsufficiency-leads-to-syndromic-congenital-anomalies-of-the-kidney-and-urinary-tract-cakut-in-humans
#17
Pauline Le Tanno, Julie Breton, Marie Bidart, Véronique Satre, Radu Harbuz, Pierre F Ray, Caroline Bosson, Klaus Dieterich, Sylvie Jaillard, Sylvie Odent, Gemma Poke, Rachel Beddow, Maria Christina Digilio, Antonio Novelli, Laura Bernardini, Maria Antonietta Pisanti, Luisa Mackenroth, Karl Hackmann, Ida Vogel, Rikke Christensen, Siv Fokstuen, Frédérique Béna, Florence Amblard, Francoise Devillard, Gaelle Vieville, Alexia Apostolou, Pierre-Simon Jouk, Fitsum Guebre-Egziabher, Hervé Sartelet, Charles Coutton
BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) represent a significant healthcare burden since it is the primary cause of chronic kidney in children. CNVs represent a recurrent molecular cause of CAKUT but the culprit gene remains often elusive. Our study aimed to define the gene responsible for CAKUT in patients with an 1q23.3q24.1 microdeletion. METHODS: We describe eight patients presenting with CAKUT carrying an 1q23.3q24.1 microdeletion as identified by chromosomal microarray analysis (CMA)...
March 7, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28264851/mcr-1-3-a-new-mcr-variant-carried-by-an-incp-plasmid-in-a-colistin-resistant-salmonella-enterica-serovar-typhimurium-isolated-from-a-healthy-individual
#18
Xin Lu, Yongfei Hu, Ming Luo, Haijian Zhou, Xiaoxun Wang, Yu Du, Zhenpeng Li, Jialiang Xu, Baoli Zhu, Xuebin Xu, Biao Kan
In this study, we reported a novel mcr-1 gene variant, named mcr-1.3, carried by an IncP plasmid in a colistin-resistant Salmonella Typhimurium from a healthy person. Compared with mcr-1, the mcr-1.3 gene contained two SNPs; one of them resulted in an arginine to histidine variation (Arg536->His). The plasmid carrying mcr-1.3 gene was designated pMCR1.3_P053, and was highly similar to a recently discovered mcr-1-bearing plasmid found in Klebsiella pneumoniae.
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28264767/spatial-navigation-and-risk-of-cognitive-impairment-a-prospective-cohort-study
#19
Joe Verghese, Richard Lipton, Emmeline Ayers
INTRODUCTION: Spatial navigation deficits are reported in dementia, but their temporal relationship to cognitive decline is not established. METHODS: This is a prospective cohort study in 442 nondemented adults (mean age 79.9 years). Spatial navigation measured with the Floor Maze Test and reported as immediate maze time (IMT) and delayed maze time (DMT). Predementia syndromes, mild cognitive impairment syndrome (MCI) and motoric cognitive risk syndrome (MCR), were primary outcomes...
March 3, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28264015/mcr-1-identified-in-avian-pathogenic-escherichia-coli-apec
#20
Nicolle Lima Barbieri, Daniel W Nielsen, Yvonne Wannemuehler, Tia Cavender, Ashraf Hussein, Shi-Gan Yan, Lisa K Nolan, Catherine M Logue
Antimicrobial resistance associated with colistin has emerged as a significant concern worldwide threatening the use of one of the most important antimicrobials for treating human disease. Here, we examined a collection (n = 980) of Avian Pathogenic Escherichia coli (APEC) isolated from poultry with colibacillosis from the US and internationally for the presence of mcr-1 and mcr-2, genes known to encode colistin resistance. Included in the analysis was an additional set of avian fecal E. coli (AFEC) (n = 220) isolates from healthy birds for comparative analysis...
2017: PloS One
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