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https://www.readbyqxmd.com/read/28730149/review-of-antibiotic-resistance-in-the-indian-ocean-commission-a-human-and-animal-health-issue
#1
REVIEW
Noellie Gay, Olivier Belmonte, Jean-Marc Collard, Mohamed Halifa, Mohammad Iqbal Issack, Saindou Mindjae, Philippe Palmyre, Abdul Aziz Ibrahim, Harena Rasamoelina, Loïc Flachet, Laurent Filleul, Eric Cardinale
Antimicrobial resistance (AMR) is a major threat to human, animal health, and environment worldwide. For human, transmission occurred through a variety of routes both in health-care settings and community. In animals, AMR was reported in livestock, pets, and wildlife; transmission of AMR can be zoonotic with the probably most important route being foodborne transmission. The Indian Ocean Commission (IOC), composed of Comoros, Madagascar, Mauritius, Reunion (France), and Seychelles recognized the surveillance of AMR in both animal and human as a main public health priority for the region...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28726622/mcr-1-and-blakpc-3-in-escherichia-coli-sequence-type-744-after-meropenem-and-colistin-therapy-portugal
#2
Marta Tacão, Rafael Dos Santos Tavares, Pedro Teixeira, Inês Roxo, Elmano Ramalheira, Sónia Ferreira, Isabel Henriques
Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-blaKPC-3, already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resistance to carbapenems and polymyxins after therapy with drugs from both classes.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28724555/susceptibility-testing-for-the-polymyxins-two-steps-back-three-steps-forward
#3
Shawn Vasoo
Optimizing and standardizing susceptibility testing for the polymyxins have become a pressing issue given the rise multidrug-resistant Gram-negative bacilli. Recently both CLSI-EUCAST have recommended broth microdilution (BMD) (without polysorbate) as the reference method for polymyxin susceptibility testing. In this issue, Chew et al. (doi: https://doi.org/10.1128JCM.00268-17.) compare the performance of three commercial BMD panels and the Etest to reference BMD for polymyxin B and colistin, on 76 Enterobacteriaceae isolates (21 mcr-1 positive)...
July 19, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28721352/detection-of-mcr-1-carrying-escherichia-coli-causing-bloodstream-infection-in-a-new-york-city-hospital-avian-origins-human-concerns
#4
Nenad Macesic, Daniel Green, Zheng Wang, Sean B Sullivan, Kevin Shim, Sarah Park, Susan Whittier, E Yoko Furuya, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
The spread of mcr-1 in the United States remains poorly defined. mcr-1-producing Escherichia coli that also carried blaSHV-12 was detected in a hospitalized patient. No additional cases were identified during screening of 801 Gram-negative isolates. Genomic sequencing identified an IncX4 mcr-1- harboring plasmid and ST117 clonal background associated with avian pathogenic E coli.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28720327/asymmetric-synthesis-and-evaluation-of-epoxy-%C3%AE-acyloxycarboxamides-as-selective-inhibitors-of-cathepsin-l
#5
Deborah A Dos Santos, Anna Maria Deobald, Vivian E Cornelio, Roberta M D Ávila, Renata C Cornea, Gilberto C R Bernasconi, Marcio W Paixão, Paulo C Vieira, Arlene G Corrêa
Cathepsin L plays important roles in physiological processes as well as in the development of many pathologies. Recently the attentions were turned to its association with tumor progress what makes essential the development of more potent and selective inhibitors. In this work, epoxipeptidomimetics were investigated as new cathepsin inhibitors. This class of compounds is straightforward obtained by using a green one-pot asymmetric epoxidation/Passerini 3-MCR. A small library of 17 compounds was evaluated against cathepsin L, and among them LSPN423 showed to be the most potent...
June 29, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28713581/short-term-elevation-in-dietary-protein-intake-does-not-worsen-insulin-resistance-or-lipids-in-older-adults-with-metabolic-syndrome-a-randomized-controlled-trial
#6
Il-Young Kim, Scott E Schutzler, Gohar Azhar, Robert R Wolfe, Arny A Ferrando, Robert H Coker
BACKGROUND: There is a great deal of controversy as to whether higher protein intake improves or worsens insulin sensitivity in humans. The purpose of the study was to determine the influence of a short-term elevation in dietary protein on hepatic and peripheral insulin sensitivity in twelve older subjects (51-70 yrs) with metabolic syndrome. METHODS: Individuals were randomly assigned to one of the dietary groups: recommended protein intake (RPI, 10% of daily calorie intake) or elevated protein intake (EPI, 20% of daily calorie intake) for 4 weeks...
2017: BMC Nutrition
https://www.readbyqxmd.com/read/28706905/a-nuanced-view-of-extrapleural-pneumonectomy-for-malignant-pleural-mesothelioma
#7
REVIEW
Isabelle Opitz, Walter Weder
Multimodality treatment including macroscopic complete resection (MCR) is currently the most effective therapy for patients with malignant pleural mesothelioma (MPM). However, the allocation to one of the possible combinations has to be discussed individually since various factors influence the decision making process. In the past years, relevant new information about the disease and the outcome of different treatment modalities have been generated, which allows a more individual allocation to the best treatment...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28705756/emergence-of-colistin-resistant-escherichia-coli-clinical-isolates-harboring-mcr-1-in-vietnam
#8
Tatsuya Tada, Pham Hong Nhung, Kayo Shimada, Mitsuhiro Tsuchiya, Doan Mai Phuong, Nguyen Quoc Anh, Norio Ohmagari, Teruo Kirikae
The mcr-1 was first detected on a plasmid in colistin-resistant Escherichia coli from livestock and patients in China. We described here the emergence of colistin-resistant E. coli clinical isolates harboring mcr-1 on the chromosomes in Vietnam. To our knowledge, this is the first report of hospital-acquired E. coli isolates harboring mcr-1 in a medical setting in Vietnam.
July 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28705468/association-of-anti-inflammatory-cytokine-il10-polymorphisms-with-motoric-cognitive-risk-syndrome-in-an-ashkenazi-jewish-population
#9
Sanish Sathyan, Nir Barzilai, Gil Atzmon, Sofiya Milman, Emmeline Ayers, Joe Verghese
Motoric cognitive risk (MCR) syndrome is a newly described predementia syndrome characterized by the presence of cognitive complaints and slow gait, which is associated with increased risk of conversion to dementia. The underlying biological mechanisms for MCR have not yet been established. Neuroinflammation mediated through cytokines plays a pivotal role in the pathogenesis of dementia. Hence, our objective was to prospectively examine whether variations in cytokine genes (CRP, IFNG, IL1A, IL1B, IL4, IL6, IL10, IL18, TNF, and IL12A) play a role in MCR incidence in 530 community-dwelling Ashkenazi Jewish adults aged 65 years and older without MCR or dementia at baseline enrolled in the LonGenity study...
June 19, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28699792/novel-approaches-to-the-design-of-bioavailable-melanotropins
#10
Yang Zhou, Minying Cai
The melanocortin system is a primordial and critical system for survival, involved in a wide variety of physiological functions. It includes melanocortin receptors (MCRs) and melanotropin ligands (MCLs). MCRs are important drug targets that can regulate several key physiological processes. Extensive efforts have been made to develop peptide and peptidomimetics targeting melanocortin receptors including MC1R, MC3R, MC4R and MC5R. Most research is focused on developing potent and selective melanotropins. However, developing bioavailable melanotropins remains challenging...
July 12, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28699781/application-of-bacillus-megaterium-mcr-8-improved-phytoextraction-and-stress-alleviation-of-nickel-in-vinca-rosea
#11
Waheed Ullah Khan, Sajid Rashid Ahmad, Nasim Ahmad Yasin, Aamir Ali, Aqeel Ahmad, Waheed Akram
The current research was performed to evaluate the effect of Bacillus megaterium MCR-8 on mitigation of nickel (Ni) stress in Vinca rosea grown on Ni-contaminated soil (50, 100, and 200 mg Ni kg(-1) soil). The treated plants exhibited reduced growth, biomass, gas exchange capacity, and chlorophyll (Chl) content under Ni stress. The inoculated plants growing in Ni-contaminated media exhibited relatively higher growth, total soluble protein, and proline contents. Similarly, bacterial inoculation improved the activity of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX) under Ni stress...
September 2, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28698568/an-allelic-variant-of-the-pmrb-sensor-kinase-responsible-for-colistin-resistance-in-an-escherichia-coli-strain-of-clinical-origin
#12
Antonio Cannatelli, Tommaso Giani, Noemi Aiezza, Vincenzo Di Pilato, Luigi Principe, Francesco Luzzaro, Cesira L Galeotti, Gian Maria Rossolini
We investigated the colistin resistance mechanism in an Escherichia coli strain (LC711/14) isolated in Italy in 2014, from an urinary tract infection, which was previously shown to express a colistin resistance mechanism different from mcr-1. LC711/14 was found to carry a novel mutation in the pmrB gene, resulting in a leucine to proline amino acid substitution at position 10 of the PmrB sensor kinase component of the PmrAB signal transduction system. The role of this substitution in colistin resistance was documented by expression of the wild-type and mutated alleles in a pmrB deletion derivative of the E...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689922/detection-of-the-colistin-resistance-gene-mcr-1-in-pathogenic-escherichia-coli-from-pigs-affected-by-post-weaning-diarrhoea-in-italy
#13
Ludovica Curcio, Andrea Luppi, Paolo Bonilauri, Yuri Gherpelli, Giovanni Pezzotti, Michele Pesciaroli, Chiara Francesca Magistrali
OBJECTIVES: The aim of this study was to investigate the presence of plasmid-mediated colistin resistance genes in Escherichia coli from pigs affected by post-weaning diarrhoea (PWD). METHODS: DNA samples collected from 51 E. coli isolates from Italian pigs affected by PWD in 2015-2016 were studied. Isolates were classified as presumptively resistant to colistin by routine susceptibility testing and were investigated for the presence of the mcr-1 gene of plasmid origin by PCR...
July 6, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28683827/expanding-landscapes-of-the-diversified-mcr-1-bearing-plasmid-reservoirs
#14
Qingjing Wang, Jian Sun, Jun Li, Youfa Ding, Xing-Ping Li, Jingxia Lin, Bachar Hassan, Youjun Feng
BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinical use. METHODS: The mcr-1-harboring plasmids were acquired from swine and human Escherichia coli isolated in China, from 2015 to 2016, and subjected to Illumina PacBio RSII and Hi-Seq2000 for full genome sequencing...
July 6, 2017: Microbiome
https://www.readbyqxmd.com/read/28682397/copper-i-catalyzed-oxidative-hydrolysis-of-ugi-3-component-and-ugi-azide-reaction-products-towards-2%C3%A2-%C3%AE-ketoamides-and-%C3%AE-ketotetrazoles
#15
Jurriën W Collet, Christopher Foley, Arthur Y Shaw, Romano V A Orru, Eelco Ruijter, Christopher Hulme
Herein, a two-step MCR-oxidation methodology accessing decorated 2° α-ketoamides and α-ketotetrazoles is described via a catalytic copper(i)-mediated C-N oxidation/acidic hydrolysis of Ugi-three-component and Ugi-azide reaction products. The ability to install diversity from aldehyde and isocyanide synthons allows rapid complexity generation. Of note, (1) 2° α-ketoamides are traditionally difficult to access and more so reminiscent of the endogenous peptide bonds. (2) The route to α-keto-tetrazoles is significantly shorter than that in previous reports...
July 6, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28678874/molecular-characteristics-of-mcr-1-carrying-plasmids-and-new-mcr-1-variant-recovered-from-polyclonal-clinical-escherichia-coli-from-argentina-and-canada
#16
Nathalie Tijet, Diego Faccone, Melina Rapoport, Christine Seah, Fernando Pasterán, Paola Ceriana, Ezequiel Albornoz, Alejandra Corso, Alejandro Petroni, Roberto G Melano
We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins...
2017: PloS One
https://www.readbyqxmd.com/read/28678223/spatial-and-spectral-resolution-of-carbonaceous-material-from-hematite-%C3%AE-fe2o3-using-multivariate-curve-resolution-alternating-least-squares-mcr-als-with-raman-microspectroscopic-mapping-implications-for-the-search-for-life-on-mars
#17
Joseph P Smith, Frank C Smith, Karl S Booksh
The search for evidence of extant or past life on Mars is a primary objective of both the upcoming Mars 2020 rover (NASA) and ExoMars 2020 rover (ESA/Roscosmos) missions. This search will involve the detection and identification of organic molecules and/or carbonaceous material within the Martian surface environment. For the first time on a mission to Mars, the scientific payload for each rover will include a Raman spectrometer, an instrument well-suited for this search. Hematite (α-Fe2O3) is a widespread mineral on the Martian surface...
July 5, 2017: Analyst
https://www.readbyqxmd.com/read/28675305/express-multivariate-curve-resolution-alternating-least-squares-mcr-als-with-raman-imaging-applied-to-lunar-meteorites
#18
Joseph Paul Smith, Frank C Smith, Karl Booksh
No abstract text is available yet for this article.
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28674313/first-detection-of-escherichia-coli-harboring-mcr-1-gene-from-retail-domestic-chicken-meat-in-japan
#19
Yusuke Ohsaki, Wataru Hayashi, Satomi Saito, Shunsuke Osaka, Yui Taniguchi, Shota Koide, Kumiko Kawamura, Yukiko Nagano, Yoshichika Arakawa, Noriyuki Nagano
Global spread of plasmid-mediated colistin resistance gene, mcr-1 poses a public health concern because colistin is the last-line-of-defense against severe infections due to multidrug-resistant Gram- negative bacteria. In Japan, a few studies have reported the prevalence of mcr-1 among food animal-derived Escherichia coli isolates, but the epidemiology of mcr-1 from retail meats is not well known. We report here the first detection of mcr-1 from retail chicken meats. A total of 70 ESBL-producing E. coli isolates recovered from retail chicken meats collected between August 2015 and June 2016 were screened for mcr-1, which resulted in positive for one isolate of CTX-M-1 producing E...
July 1, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28671537/the-distribution-of-carbapenem-and-colistin-resistance-in-gram-negative-bacteria-from-the-tamil-nadu-region-in-india
#20
Prasanth Manohar, Thamaraiselvan Shanthini, Ramankannan Ayyanar, Bulent Bozdogan, Aruni Wilson, Ashok J Tamhankar, Ramesh Nachimuthu, Bruno S Lopes
PURPOSE: The occurrence of carbapenem- and colistin-resistance among Gram-negative bacteria is increasing worldwide. The aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in Tamil Nadu, India. METHODOLOGY: The clinical isolates (n=89) used in this study were collected from two diagnostic centres in Tamil Nadu, India. The bacterial isolates were screened for meropenem- and colistin-resistance. Further, resistance genes blaNDM-1, blaOXA-48-like, blaIMP, blaVIM, blaKPC, mcr-1 and mcr-2 and integrons were studied...
July 3, 2017: Journal of Medical Microbiology
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