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https://www.readbyqxmd.com/read/29688801/genomic-characterization-of-nonclonal-mcr-1-positive-multidrug-resistant-klebsiella-pneumoniae-from-clinical-samples-in-thailand
#1
Apichai Srijan, Katie R Margulieux, Sirigade Ruekit, Erik Snesrud, Rosslyn Maybank, Oralak Serichantalergs, Rosarin Kormanee, Prawet Sukhchat, Jossin Sriyabhaya, Mary Hinkle, John M Crawford, Patrick McGann, Brett E Swierczewski
Multidrug-resistant Klebsiella pneumoniae strains are one of the most prevalent causes of nosocomial infections and pose an increasingly dangerous public health threat. The lack of remaining treatment options has resulted in the utilization of older drug classes, including colistin. As a drug of last resort, the discovery of plasmid-mediated colistin resistance by mcr-1 denotes the potential development of pandrug-resistant bacterial pathogens. To address the emergence of the mcr-1 gene, 118 gram-negative Enterobacteriaceae isolated from clinical samples collected at Queen Sirikit Naval Hospital in Chonburi, Thailand were screened for colistin resistance using automated antimicrobial susceptibility testing and conventional PCR screening...
April 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29686149/retained-activity-of-an-o25b-specific-monoclonal-antibody-against-mcr-1-producing-escherichia-coli-st131
#2
Luis M Guachalla, Katharina Ramoni, Cecilia Varga, Michele Mutti, Akela Ghazawi, Tibor Pál, Eszter Nagy, Ágnes Sonnevend, Gábor Nagy, Valéria Szijártó
Plasmid-encoded colistin resistance is emerging among extra-intestinal pathogenic Escherichia coli including the epidemic clone ST131-H30. Mcr-1 transfers a phosphoethanolamine to the lipid A portion of LPS conferring resistance to polymyxins. We investigated whether this modification changed the activity of the monoclonal antibody, ASN-4 specific to the O25b side-chain of ST131 LPS. We confirmed that, unlike colistin, ASN-4 retained its bactericidal and endotoxin neutralizing activity and therefore offer a treatment option against extremely drug-resistant ST131 isolates...
April 23, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29684908/chemometrics-assisted-investigation-of-interactions-of-tasmar-with-human-serum-albumin-at-a-glassy-carbon-disk-application-to-electrochemical-biosensing-of-electro-inactive-serum-albumin
#3
Ghobad Mohammadi, Elahe Faramarzi, Majid Mahmoudi, Sirous Ghobadi, Ali Reza Ghiasvand, Hector C Goicoechea, Ali R Jalalvand
In this work, voltammetric data recorded by a glassy carbon electrode (GCE) was used to investigate the interactions of tolcapone (Tasmar, TAS) with human serum albumin (HSA) at the electrode surface. The recorded voltammetric data was also combined with spectroscopic data to construct an augmented data matrix which was analysed by multivariate curve resolution-alternating least squares (MCR-ALS) as an efficient chemometric tool to obtain more information about TAS-HSA interactions. The results of MCR-ALS confirmed formation of one complex species (HSA-TAS2 ) and application of MCR-BANDS to the results of MCR-ALS confirmed the absence of rotational ambiguities and existing unambiguous and reliable results...
April 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684127/the-presence-of-colisitn-resistance-gene-mcr-1-and-3-in-esbl-producing-escherichia-coli-isolated-from-food-in-ho-chi-minh-city-vietnam
#4
Takahiro Yamaguchi, Ryuji Kawahara, Kazuo Harada, Shihono Teruya, Tatsuya Nakayama, Daisuke Motooka, Shota Nakamura, Phuc Do Nguyen, Yuko Kumeda, Chinh Van Dang, Kazumasa Hirata, Yoshimasa Yamamoto
Colistin is indicated for the treatment of multidrug-resistant gram-negative bacterial infections. However, the spread of colistin-resistant bacteria harboring a mcr gene has become a serious concern. This study investigated local foods in Vietnam for contamination with colistin-resistant bacteria. A total of 261 extended-spectrum β-lactamase (ESBL)- and AmpC-producing Escherichia coli isolates from 330 meat and seafood products were analyzed for colistin susceptibility and the presence of mcr genes. Approximately 24% (62/261) of ESBL- or AmpC-producing E...
April 19, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29667494/discovery-of-a-mcr-1-bearing-plasmid-in-commensal-colistin-resistant-escherichia-coli-from-healthy-broilers-in-faisalabad-pakistan
#5
Jiali Lv, Mashkoor Mohsin, Sheng Lei, Swaminath Srinivas, Raja Talish Wiqar, Jingxia Lin, Youjun Feng
No abstract text is available yet for this article.
April 18, 2018: Virulence
https://www.readbyqxmd.com/read/29665883/plasmid-mediated-colistin-resistance-in-animals-current-status-and-future-directions
#6
Jian Sun, Ximin Zeng, Xing-Ping Li, Xiao-Ping Liao, Ya-Hong Liu, Jun Lin
Colistin, a peptide antibiotic belonging to the polymyxin family, is one of the last effective drugs for the treatment of multidrug resistant Gram-negative infections. Recent discovery of a novel mobile colistin resistance gene, mcr-1, from people and food animals has caused a significant public health concern and drawn worldwide attention. Extensive usage of colistin in food animals has been proposed as a major driving force for the emergence and transmission of mcr-1; thus, there is a worldwide trend to limit colistin usage in animal production...
December 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29661868/spread-of-clonally-related-escherichia-coli-harboring-an-inca-c-1-plasmid-encoding-imp-8-and-its-recruitment-into-an-unrelated-mcr-1-containing-isolate
#7
Alan Elena, Daniela Cejas, Francisco Magariños, Virginia Jewtuchowicz, Andrea Facente, Gabriel Gutkind, José Di Conza, Marcela Radice
Ten IMP-8-producing Escherichia coli isolates were recovered from the surveillance cultures of a neonatal intensive care unit, of which eight were clonally related. A 168.2-kb- bla IMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13. This plasmid was detected in all isolates, even in those no clonally related. One unrelated isolate was also resistant to colistin and positive for mcr-1. This marker was located in a 62.7-kb-IncI2 plasmid, which was also fully sequenced...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29659855/mobile-colistin-resistance-gene-mcr-5-in-porcine-aeromonas-hydrophila
#8
Shizhen Ma, Chengtao Sun, Anette Hulth, Jiyun Li, Lennart E Nilsson, Yuqing Zhou, Stefan Börjesson, Zhenwang Bi, Zhenqiang Bi, Qiang Sun, Yang Wang
Objectives: To characterize the mobile colistin resistance gene mcr-5 in Aeromonas hydrophila from backyard pigs in rural areas of China. Methods: Pig faecal samples from 194 households were directly tested for the presence of mcr-5 by PCR assay and the phenotypic antimicrobial susceptibility profiles of the mcr-5-positive isolates were determined using the broth dilution method. The genomic location and transferability of mcr-5 were analysed by S1-PFGE with Southern blotting and DNA hybridization, and natural transformation, respectively...
April 11, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29648934/understanding-prediabetes-in-a-medicare-advantage-population-using-data-adaptive-techniques
#9
Pravin S Kamble, Jenna Collins, Raymond A Harvey, Todd Prewitt, Ed Kimball, Tony Deluzio, Elsie Allen, Jonathan R Bouchard
The objective was to identify individuals with undiagnosed prediabetes from administrative data using adaptive techniques. The data source was a national Medicare Advantage Prescription Drug (MAPD) plan administrative data set. A retrospective, cross-sectional study developed and evaluated data adaptive logistic regression, decision tree, neural network, and ensemble predictive models for metabolic syndrome and prediabetes using 3 mutually exclusive cohorts (N = 279,903). The misclassification rate (MCR), average squared error (ASE), c-statistics, sensitivity (SN), and false positive (FP) rates were compared to select the final predictive models...
April 12, 2018: Population Health Management
https://www.readbyqxmd.com/read/29626525/whole-genome-sequence-of-an-mcr-1-carrying-esbl-producing-escherichia-coli-st746-isolate-recovered-from-community-acquired-urinary-tract-infection
#10
Lingjiao Wu, Jing Chen, Li Wang, Zhe Wu
OBJECTIVES: Colistin is regarded as one of the last-resort antimicrobials for severe infections. Plasmid-borne mobile colistin resistance gene (mcr-1)-carrying isolates were rarely reported in community-acquired infections. Here we report the draft genome sequence of an MCR-1-carrying, extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate from community-acquired urinary tract infection. MTHODS: Antimicrobial susceptibility tests (AST) were determined by the broth microdilution method...
April 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29614617/-transformation-of-endogenous-reactive-oxygen-species-participates-into-bacterial-antibiotic-resistance
#11
X Li, Y L Zhong, Y J Feng
A growing body of diversified antibiotic resistances raises a significant challenge to anti-infection clinical therapeutics. The emergence of superbugs carrying MCR-1/2 or NDM-1 determinants underlines the importance and urgency in elucidation of molecular mechanisms shared by antibiotic resistances. It is aware that different classes of bactericidal antibiotics consistently stimulate the production of deleterious reactive oxygen species (ROS), which are accompanied with metabolic disturbance. The different destinations of ROS determine its consequence on bacterial fate...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29614603/-serotype-distribution-and-antimicrobial-resistance-of-salmonella-isolates-from-retail-chicken-carcasses-in-six-provinces-of-china
#12
Y J Hu, Y Y He, Y R Wang, C Liu, M M Wang, X Gan, W Wang, S F Yan, Y Bai, Z X Peng, F Q Li, J Xu
Objective: To obtain the serotype diversity and antimicrobial resistance of Salmonella isolates recovered from retail chicken carcasses for sale in six regions of China. Methods: From August 2010 to March 2012, each month 20 retail chicken carcasses including freshly slaughtered, chilled and frozen samples were collected from supermarkets and farmer's markets in 7 monitoring sites in Beijing, Jilin province, Inner Mongolia Autonomous, Shanxi province, Jiangsu province and Guangdong province, respectively. Samples were routinely collected for 12 months for each site...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29613809/one-pot-regiospecific-synthesis-of-indolizines-a-solvent-free-metal-free-three-component-reaction-of-2-pyridin-2-yl-acetates-ynals-and-alcohols-or-thiols
#13
Daji Yang, Yue Yu, Yuanheng Wu, Huiyi Feng, Xuechen Li, Hua Cao
A novel approach for the synthesis of indolizines from 2-(pyridin-2-yl)acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under the solvent- and metal-free conditions has provided a straightforward path to construct indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, and high efficiency.
April 3, 2018: Organic Letters
https://www.readbyqxmd.com/read/29608599/prevalence-of-mcr-type-genes-among-colistin-resistant-enterobacteriaceae-collected-in-2014-2016-as-part-of-the-inform-global-surveillance-program
#14
Mark G Wise, Mark A Estabrook, Daniel F Sahm, Gregory G Stone, Krystyna M Kazmierczak
A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli, 1 Klebsiella pneumoniae and 1 Enterobacter cloacae. Twenty-four isolates possessed genes from the mcr-1 family, including the original mcr-1 (n = 22), as well as mcr-1.2 (n = 1) and mcr-1.5 (n = 1), which each differ from mcr-1 by encoding single amino acid variations...
2018: PloS One
https://www.readbyqxmd.com/read/29605997/development-of-novel-melanocortin-receptor-agonists-based-on-the-cyclic-peptide-framework-of-sunflower-trypsin-inhibitor-1
#15
Thomas Durek, Philipp M Cromm, Andrew M White, Christina I Schroeder, Quentin Kaas, Joachim Weidmann, Abdullah Ahmad Fuaad, Olivier Cheneval, Peta J Harvey, Norelle L Daly, Yang Zhou, Anita Dellsén, Torben Österlund, Niklas Larsson, Laurent Knerr, Udo Bauer, Horst Kessler, Minying Cai, Victor J Hruby, Alleyn T Plowright, David J Craik
Ultra-stable cyclic peptide frameworks offer great potential for drug design due to their improved bioavailability compared to their linear analogues. Using the sunflower trypsin inhibitor-1 (SFTI-1) peptide scaffold in combination with systematic N-methylation of the grafted pharmacophore led to the identification of novel subtype selective melanocortin receptor (MCR) agonists. Multiple bicyclic peptides were synthesized and tested towards their activity at MC1R and MC3-5R. Double N-methylated compound 18 showed a pKi of 8...
March 31, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29602149/chromatographic-fingerprinting-through-chemometric-techniques-for-herbal-slimming-pills-a-way-of-adulterant-identification
#16
Nafiseh Shekari, Maryam Vosough, Kourosh Tabar Heidar
In the current study, gas chromatography-mass spectrometry (GC-MS) fingerprinting of herbal slimming pills assisted by chemometric methods has been presented. Deconvolution of two-way chromatographic signals of nine herbal slimming pills into pure chromatographic and spectral patterns was performed. The peak clusters were resolved using multivariate curve resolution-alternating least squares (MCR-ALS) by employing appropriate constraints. It was revealed that more useful chemical information about the composition of the slimming pills can be obtained by employing sophisticated GC-MS method coupled with proper chemometric tools yielding the extended number of identified constituents...
March 19, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29601905/theranostic-pdt-with-the-antibody-anti-isoform-4-sod-mitocondrial-labeled-with-ppix-in-the-lung-cancer-cell-line-a-549
#17
Claudia Martínez-García, Yolanda Medina-Flores, José Manuel de la Rosa-Vázquez, Eva Elda Soriano-Pérez, Juan Ramón Villalobos-Hernández, Eva Ramón-Gallegos
BACKGROUND: In this work, a drug product composed of an IgM antibody derived from a hybridoma subclone 4C1F6D5G7B8 was prepared and further labeled with PpIX to be used in cell lines A-549 and MRC-5. The aim of this work was to evaluate the potential theranostic activity of the obtained product together with photodynamic therapy (PDT). METHODS: The IgM antibody labeled with PpIX was used in different concentrations to perform theranostics with PDT in cell lines A-549 and MRC-5 in order to identify the specificity of IgM antibody in lung cancer cells by means of a LED-irradiation system set at 630 nm...
March 27, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29601793/novel-univariate-and-multivariate-regression-methods-for-the-simultaneous-analysis-of-ternary-mixture-of-1-4-benzodiazepines-in-dosage-forms-and-human-urine
#18
F Belal, F Ibrahim, Z A Sheribah, H Alaa
In this paper, novel univariate and multivariate regression model updating methods were developed and validated for the simultaneous determination of ternary mixture of bromazepam, diazepam and clonazepam. The univariate methods used are the mean centering of ratio spectra spectrophotometric method and iso-absorptive point coupled with ratio-subtraction and ratio difference spectrophotometric method. Linearity, ranges, precision and accuracy of these methods were determined. The multivariate methods adopted are the principal component regression and partial least-squares...
March 27, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29599718/re-evaluation-of-adrenocorticotropic-hormone-and-melanocyte-stimulating-hormone-activation-of-gpr139-in-vitro
#19
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq -coupling. The in vitro affinity and potency values of L-Trp and L-Phe are within the physiological concentration ranges of L-Trp and L-Phe. A recent paper suggests that adrenocorticotropic hormone (ACTH), α and β melanocyte stimulating hormones (α-MSH and β-MSH) and derivatives α-MSH1-9 /α-MSH1-10 can also activate GPR139 in vitro ...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29597168/design-and-synthesis-of-novel-pyrrolo-2-3-a-carbazoles-7-chloro-2-oxo-3a-2-oxo-2-3-dihydro-1-h-indol-3-yl-2-3-3a-4-5-10-hexahydro-pyrrolo-3-2-a-carbazole-1-carbonitrile-as-an-efficient-anticancer-agent
#20
Perumal Sathiyachandran, Prasath Manogaran, Vladimir N Nesterov, Viswanadha Vijaya Padma, Karnam Jayarampillai Rajendra Prasad
Highly efficient poly functionalized pyrrolo[3,2-a]carbazoles via ring contraction through rearrangement and intramolecular Michael addition reaction using one pot multicomponent reaction (MCR) is reported for the first time. Free radical scavenging and anticancer activities were determined by DPPH and MTT assays respectively. Of these, compound 8d exhibited most potent activity against HCT-15 human colon cancer cell lines with an IC50 value of 9.9 μM and low toxicity toward normal human red blood cells...
March 21, 2018: European Journal of Medicinal Chemistry
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