keyword
https://read.qxmd.com/read/38534677/assessing-the-microbial-quality-of-shrimp-xiphonaeus-kroyeri-and-mussels-perna-perna-illegally-sold-in-the-vit%C3%A3-ria-region-brazil-and-investigating-the-antimicrobial-resistance-of-escherichia-coli-isolates
#1
JOURNAL ARTICLE
Daniella Tosta Link, Gustavo Guimarães Fernandes Viana, Lívia Pasolini Siqueira, Carolina Magri Ferraz, Romário Alves Rodrigues, Luis Antonio Mathias, Marita Vedovelli Cardozo, Gabriel Augusto Marques Rossi
The consumption of seafood is crucial for food security, but poor hygiene along the food production chain can result in low microbiological quality, posing significant risks for public health and seafood quality. Thus, this study aimed to assess the microbiological quality and antimicrobial sensitivity of E. coli from 69 samples of illegally marketed shrimp and mussels in the Vitória Region, Brazil. These foods exhibited poor microbiological quality due to high counts of mesophilic, psychrotrophic, and enterobacteria microorganisms...
March 6, 2024: Antibiotics
https://read.qxmd.com/read/38534662/first-report-of-colistin-resistant-escherichia-coli-carrying-mcr-1-inci2-delta-and-incx4-plasmids-from-camels-camelus-dromedarius-in-the-gulf-region
#2
JOURNAL ARTICLE
Akela Ghazawi, Nikolaos Strepis, Febin Anes, Dana Yaaqeib, Amal Ahmed, Aysha AlHosani, Mirah AlShehhi, Ashrat Manzoor, Ihab Habib, Nisar A Wani, John P Hays, Mushtaq Khan
Addressing the emergence of antimicrobial resistance (AMR) poses a significant challenge in veterinary and public health. In this study, we focused on determining the presence, phenotypic background, and genetic epidemiology of plasmid-mediated colistin resistance ( mcr ) in Escherichia coli bacteria isolated from camels farmed in the United Arab Emirates (UAE). Fecal samples were collected from 50 camels at a Dubai-based farm in the UAE and colistin-resistant Gram-negative bacilli were isolated using selective culture...
February 28, 2024: Antibiotics
https://read.qxmd.com/read/38522537/integrating-metagenomic-and-isolation-strategies-revealed-high-contamination-of-pathogenies-and-resistome-in-market-shrimps
#3
JOURNAL ARTICLE
Lianwei Ye, Zhiwei Zheng, Yaling Wang, Qiao Hu, Liang Zhong, Heng Heng, Zhihao Guo, Runsheng Li, Edward Wai Chi Chan, Sheng Chen
This study employs a comprehensive approach combining metagenomic analysis and bacterial isolation to elucidate the microbial composition, antibiotic resistance genes (ARGs), and virulence factors (VFGs) present in shrimps from market and supermarket. Metagenomic analysis of shrimps revealed a dominance of Proteobacteria and Bacteroidetes with Firmicutes notably enriched in some samples. On the other hand, the dominant bacteria isolated included Citrobacter portucalensis, Escherichia coli, Salmonella enterica, Vibrio species and Klebsiella pneumonaie...
March 22, 2024: Science of the Total Environment
https://read.qxmd.com/read/38521041/iron-nuclearity-in-mineral-fibres-unravelling-the-catalytic-activity-for-predictive-modelling-of-toxicity
#4
JOURNAL ARTICLE
Alessandro F Gualtieri, Marina Cocchi, Francesco Muniz-Miranda, Alfonso Pedone, Elena Castellini, Lorenzo Strani
Chronic inflammation induced in vivo by mineral fibres, such as asbestos, is sustained by the cyclic formation of cytotoxic/genotoxic oxidant species that are catalysed by iron. High catalytic activity is observed when iron atoms are isolated in the crystal lattice (nuclearity=1), whereas the catalytic activity is expected to be reduced or null when iron forms clusters of higher nuclearity. This study presents a novel approach for systematically measuring iron nuclearity across a large range of iron-containing standards and mineral fibres of social and economic importance, and for quantitatively assessing the relation between nuclearity and toxicity...
March 11, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38515697/phenotypic-and-genotypic-characterization-of-escherichia-coli-isolated-from-the-chicken-liver-in-relation-to-slaughterhouse-conditions
#5
JOURNAL ARTICLE
Mohammad H Gharaibeh, Sahba Y Al Sheyab, Ismail M Malkawi, Farah R Al Qudsi
Avian pathogenic Escherichia coli (APEC) has been identified as a sub-group of extraintestinal pathogenic E. coli (ExPEC). Recent studies indicate APEC as a potential foodborne zoonotic pathogen and a source or reservoir of human extraintestinal infections. The slaughtering and processing of poultry in low-income countries such as Jordan occurs in two distinct ways: in informal facilities known as Natafat and in formal slaughterhouses. This study compared E. coli phenotypes and genotypes according to slaughtering conditions (formal slaughterhouses vs...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38512021/distinct-regulation-of-ascl1-by-the-cell-cycle-and-chemotherapy-in-small-cell-lung-cancer
#6
JOURNAL ARTICLE
Yuning Liu, Qingzhe Wu, Bin Jiang, Tingting Hou, Chuanqiang Wu, Ming Wu, Hai Song
Small cell lung cancer (SCLC) is an aggressive and lethal malignancy. Achaete-scute homolog 1 (ASCL1) is essential for the initiation of SCLC in mice and the development of pulmonary neuroendocrine cells (PNECs) which are the major cells of origin for SCLC. However, the regulatory mechanism of ASCL1 in SCLC remains elusive. Here, we found that ASCL1 expression gradually increases as the tumors grow in a mouse SCLC model and is regulated by the cell cycle. Mechanistically CDK2-CyclinA2 complex phosphorylates ASCL1, which results in increased proteasome-mediated ASCL1 protein degradation by E3 ubiquitin ligase HUWE1 during mitosis...
March 21, 2024: Molecular Cancer Research: MCR
https://read.qxmd.com/read/38511954/first-report-of-multidrug-resistant-carbapenemase-producing-aeromonas-caviae-co-harboring-mcr-3-43-and-mcr-7-2
#7
JOURNAL ARTICLE
Tingting Xu, Jingjie Song, Jialong Liu, Lili Huang, Zhao Li, Kai Zhou
Hospital sewage serves as a crucial reservoir for antibiotic resistance genes. As colistin and carbapenems are the last-resort antibiotics, the emergence of their resistance genes has become a significant concern in clinical settings. In this study, we found that two novel mcr alleles ( mcr-3 .43 and mcr-7 .2) with two carbapenemase genes ( bla NDM-1 and bla KPC-2 ) were encoded in a single Aeromonas caviae strain isolated from hospital sewage. Our phylogenetic analysis revealed that the mcr-3.43 gene clustered with mcr-3...
March 21, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38509444/the-effect-of-race-ethnicity-on-cancer-specific-mortality-after-trimodal-therapy
#8
JOURNAL ARTICLE
Mario de Angelis, Andrea Baudo, Carolin Siech, Letizia Maria Ippolita Jannello, Francesco Di Bello, Jordan A Goyal, Zhe Tian, Nicola Longo, Ottavio de Cobelli, Felix K H Chun, Fred Saad, Shahrokh F Shariat, Luca Carmignani, Giorgio Gandaglia, Marco Moschini, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz
INTRODUCTION: Trimodal therapy (TMT) is the most validated bladder-sparing treatment for organ-confined urothelial carcinoma of the urinary bladder (OC UCUB, namely cT2N0M0). However, it is unknown if barriers to the use of TMT or cancer-specific mortality (CSM) differences exist according to race/ethnicity. We addressed this knowledge gap. MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2020), we identified OC UCUB patients aged from 18 to 85 treated with radical cystectomy (RC) or TMT...
March 20, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38508266/deciphering-the-removal-of-antibiotics-and-the-antibiotic-resistome-from-typical-hospital-wastewater-treatment-systems
#9
JOURNAL ARTICLE
Dahai He, Jiang Li, Weihai Yu, Yingyuan Zhang, Bin Wang, Tao Wang, Huaikai Yang, Yuntao Zhang, Weijie Chen, Yancheng Li, Faming Feng, Li-An Hou
Hospital wastewater treatment systems (HWTSs) are a significant source and reservoir of antibiotic resistance genes (ARGs) and a crucial hub for transmitting ARGs from clinical to natural environments. However, there is a lack of research on the antibiotic resistome of clinical wastewater in HWTSs. In this study, we used metagenomics to analyze the prevalence and abundance of ARGs in five typical HWTSs. A total of 17 antibiotics from six categories were detected in the five HWTSs; β-lactam antibiotics were found at the highest concentrations, with up to 4074...
March 18, 2024: Science of the Total Environment
https://read.qxmd.com/read/38508087/a-molecular-overview-of-the-polymyxin-lps-interaction-in-the-context-of-its-mode-of-action-and-resistance-development
#10
REVIEW
Indira Padhy, Sambit K Dwibedy, Saswat S Mohapatra
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action and the emergence of resistance to the existing drugs. Polymyxin, a cationic antimicrobial lipopeptide, is used to treat infections by Gram-negative bacterial pathogens as a last option. Though polymyxins were identified almost seventy years back, their use has been restricted owing to toxicity issues in humans. However, their clinical use has been increasing in recent times resulting in the rise of polymyxin resistance...
March 12, 2024: Microbiological Research
https://read.qxmd.com/read/38506252/the-use-of-5-hydroxymethylfurfural-5-hmf-in-multi-component-hantzsch-dihydropyridine-synthesis
#11
JOURNAL ARTICLE
Jingjing Jiang, Yves Queneau, Florence Popowycz
The renewable 5-hydroxymethylfurfural (5-HMF) has gained a wide interest from the chemistry community as a valuable biobased platform opening the way to further functionalization. Despite an impressive number of publications reporting either its preparation or its functionalization, its direct use in fine chemistry, and especially in multi-component reaction (MCR), is less reported. Here, we report a complete study of the use of 5-HMF in the Hantzsch dihydropyridines synthesis. The strategy was applied to a scope of β-dicarbonyl molecules (including b-ketoesters and 1,3-diketones) in a 3-component procedure leading to a series of symmetrical 1,4-dihydropyridines derived from 5-HMF in excellent yields...
March 20, 2024: ChemSusChem
https://read.qxmd.com/read/38503805/in-depth-analysis-of-klebsiella-aerogenes-resistome-virulome-and-plasmidome-worldwide
#12
JOURNAL ARTICLE
Sergio Morgado, Érica Fonseca, Fernanda Freitas, Raquel Caldart, Ana Carolina Vicente
Klebsiella aerogenes is an emergent pathogen associated with outbreaks of carbapenem-resistant strains. To date, studies focusing on K. aerogenes have been small-scale and/or geographically restricted. Here, we analyzed the epidemiology, resistome, virulome, and plasmidome of this species based on 561 genomes, spanning all continents. Furthermore, we sequenced four new strains from Brazil (mostly from the Amazon region). Dozens of STs occur worldwide, but the pandemic clones ST93 and ST4 have prevailed in several countries...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38499909/antimicrobial-resistance-in-wildlife-detection-of-antimicrobial-resistance-genes-in-apennine-wolves-canis-lupus-italicus-altobello-1921-from-central-italy
#13
JOURNAL ARTICLE
A Di Francesco, D Salvatore, A Ranucci, M Gobbi, B Morandi
The aim of this study was to molecularly investigate the presence of antimicrobial resistance genes (ARGs) in organ samples from 11 Apennine wolves (Canis lupus italicus) collected in Central Italy. Samples from lung, liver, spleen, kidney, tongue and intestine were investigated by PCRs targeting the following genes: tet(A), tet(B), tet(C), tet(D), tet(E), tet(G), tet(K), tet(L), tet(M), tet(O), tetA(P), tet(Q), tet(S), tet(X), sul1, sul2, sul3, blaCTX-M , blaSHV , blaTEM and mcr-1. A PCR positivity was highlighted for 13 out of the 21 tested genes; no positive results were obtained for tet(C), tet(D), tet(E), tet(G), sul3, blaCTX , blaSHV and mcr-1 genes...
March 19, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38499204/formation-characterization-of-humin-mediated-anaerobic-granular-sludge-and-enhanced-methanogenic-performance
#14
JOURNAL ARTICLE
Ningli Zhou, Zhixing Xiao, Dan Chen
This study presents a novel method for accelerating the granulation of methanogenic anaerobic granular sludge (AnGS) in an upflow anaerobic sludge blanket (UASB) reactor using solid-phase humin (HM). The results demonstrated that HM-mediated AnGS (HM-AnGS) formed rapidly within 50 days. The increase in particle size, settling velocity and mechanical strength was attributed to the rapid granulation of the HM-AnGS. The maximum methane yield of the HM-AnGS was 5-fold higher than that of the control group...
March 16, 2024: Bioresource Technology
https://read.qxmd.com/read/38494989/trimodal-therapy-effect-on-survival-in-urothelial-vs-non-urothelial-bladder-cancer
#15
JOURNAL ARTICLE
Mario de Angelis, Andrea Baudo, Carolin Siech, Letizia Maria Ippolita Jannello, Francesco Di Bello, Jordan A Goyal, Zhe Tian, Nicola Longo, Ottavio de Cobelli, Felix K H Chun, Fred Saad, Shahrokh F Shariat, Luca Carmignani, Giorgio Gandaglia, Marco Moschini, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz
OBJECTIVE: To address cancer-specific mortality free-survival (CSM-FS) differences in patients with urothelial carcinoma of the urinary bladder (UCUB) vs non-UCUB who underwent trimodal therapy (TMT), according to organ confined (OC: T2N0M0) vs non-organ confined (NOC: T3-4NanyM0 or TanyN1-3M0) clinical stages. PATIENTS AND METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2020), we identified patients with cT2-T4N0-N3M0 bladder cancer treated with TMT, defined as the combination of transurethral resection of bladder tumour, chemotherapy, and radiotherapy...
March 18, 2024: BJU International
https://read.qxmd.com/read/38494251/emergence-of-carbapenem-resistant-gram-negative-pathogens-with-high-rate-of-colistin-resistance-in-egypt-a-cross-sectional-study-to-assess-resistance-trends-during-the-covid-19-pandemic
#16
JOURNAL ARTICLE
Fatma A Afify, Ahmed H Shata, Nirmeen Aboelnaga, Dina Osama, Salma W Elsayed, Nehal A Saif, Shaimaa F Mouftah, Sherine M Shawky, Ahmed A Mohamed, Omar Loay, Mohamed Elhadidy
The current study investigated the temporal phenotypic and genotypic antimicrobial resistance (AMR) trends among multi-drug resistant and carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa recovered from Egyptian clinical settings between 2020 and 2021. Bacterial identification and antimicrobial sensitivity of 111 clinical isolates against a panel of antibiotics were performed. Molecular screening for antibiotic resistance determinants along with integrons and associated gene cassettes was implemented...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38490574/establishment-and-application-of-recombinase-polymerase-amplification-combined-with-lateral-flow-dipstick-for-detection-of-mcr-1-in-unculture-clinical-samples
#17
JOURNAL ARTICLE
Jun Feng, Zhen Xu, Yuan Zhuang, Jiayuan Luo, Yong Chen, Yitong Wu, Jiayi Fei, Mingxiang Liu, Jiahui Xia, Jing Zhang, Meihua Liu, Xiaohong Xie, Zhengan Yuan, Min Chen
OBJECTIVES: The rapid dissemination of the mcr-1 gene via plasmid-mediated transfer has raised concerns regarding the efficacy of colistin as a last-resort treatment for multidrug-resistant Gram-negative bacterial infections. Current mcr-1 gene detection methods mainly focus on cultured bacterial which suffer from complexity, time-consuming process, and skilled personnel requirements, making them unsuitable for field analysis. METHODS: A rapid detection technique combining recombinase polymerase amplification (RPA) with lateral flow dipstick (LFD) targeting on uncultured clinical samples was developed...
March 13, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38488456/vasorin-exocytosed-from-glioma-cells-facilitates-angiogenesis-via-vegfr2-akt-signaling-pathway
#18
JOURNAL ARTICLE
Ying Zhong, Hui Kang, Ziqing Ma, Jiayu Li, Zixi Qin, Zixuan Zhang, Peiwen Li, Ying Zhong, Lihui Wang
Glioma is a highly vascularized tumor of the central nervous system. Angiogenesis plays a predominant role in glioma progression and is considered an important therapeutic target. Our previous study showed that vasorin (VASN), a transmembrane protein, is overexpressed in glioma and promotes angiogenesis; however, the potential mechanism remains unclear. In this study, we found that human vascular endothelial cells (hECs) co-cultured with VASN-overexpressing glioma cells exhibited accelerated migration ability and increased expression of VASN originated from glioma cells...
March 15, 2024: Molecular Cancer Research: MCR
https://read.qxmd.com/read/38485761/characterisation-of-colistin-resistance-in-gram-negative-microbiota-of-pregnant-women-and-neonates-in-nigeria
#19
JOURNAL ARTICLE
E A R Portal, K Sands, C Farley, I Boostrom, E Jones, M Barrell, M J Carvalho, R Milton, K Iregbu, F Modibbo, S Uwaezuoke, C Akpulu, L Audu, C Edwin, A H Yusuf, A Adeleye, A S Mukkadas, D Maduekwe, S Gambo, J Sani, T R Walsh, O B Spiller
A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing prevalence across South-East Asia. Here we survey the presence of mcr genes in 4907 rectal swabs from mothers and neonates from three hospital sites across Nigeria; a country with limited availability or history of colistin use clinically. Forty mother and seven neonatal swabs carried mcr genes in a range of bacterial species: 46 Enterobacter spp. and single isolates of; Shigella, E. coli and Klebsiella quasipneumoniae...
March 14, 2024: Nature Communications
https://read.qxmd.com/read/38484804/synthesis-and-biological-evaluation-of-hydantoin-derivatives-as-potent-antiplasmodial-agents
#20
JOURNAL ARTICLE
Ee-Zhen Chin, Wei-Jin Chang, Hui-Yin Tan, Sook Yee Liew, Yee-Ling Lau, Yee-Ling Ng, Mohd Azlan Nafiah, Thomas Kurz, Siow-Ping Tan
Malaria, a devastating disease, has claimed numerous lives and caused considerable suffering, with young children and pregnant women being the most severely affected group. However, the emergence of multidrug-resistant strains of Plasmodium and the adverse side effects associated with existing antimalarial drugs underscore the urgent need for the development of novel, well-tolerated, and more efficient drugs to combat this global health threat. To address these challenges, six new hydantoins derivatives were synthesized and evaluated for their in vitro antiplasmodial activity...
March 12, 2024: Bioorganic & Medicinal Chemistry Letters
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