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https://www.readbyqxmd.com/read/29341915/influence-of-ligands-property-and-particle-size-of-gold-nanoparticles-on-the-protein-adsorption-and-corresponding-targeting-ability
#1
Wei Xiao, Jingyuan Xiong, Shuang Zhang, Yang Xiong, Huajin Zhang, Huile Gao
Nanoparticulated vesicles were widely used for carriers of drugs and imaging probes. To improve the targeting delivery efficiency of these vesicles, ligands were often functionalized onto their surfaces. However, the interaction between vesicles and plasma proteins may cover the ligands and hinder the targeting delivery. It is important to address the potential influence of ligands modification on plasma protein adsorption and the following targeting delivery. In this study, two common used ligands were chosen as the model: transferrin and RGD peptide...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341909/nanogel-dfo-conjugates-as-a-model-to-investigate-pharmacokinetics-biodistribution-and-iron-chelation-in-vivo
#2
Yan Wang, Zhi Liu, Tien-Min Lin, Shaurya Chanana, May P Xiong
Deferoxamine (DFO) to treat iron overload (IO) has been limited by toxicity issues and short circulation times and it would be desirable to prolong circulation to improve non-transferrin bound iron (NTBI) chelation. In addition, DFO is currently unable to efficiently target the large pool of iron in the liver and spleen. Nanogel-Deferoxamine conjugates (NG-DFO) can prove useful as a model to investigate the pharmacokinetic (PK) properties and biodistribution (BD) behavior of iron-chelating macromolecules and their overall effect on serum ferritin levels...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29339188/the-enhancement-of-siplk1-penetration-across-bbb-and-its-anti-glioblastoma-activity-in-vivo-by-magnet-and-transferrin-co-modified-nanoparticle
#3
Dao-Zhou Liu, Ying Cheng, Rong-Qiao Cai, Wen-Wen Wang, Han Cui, Miao Liu, Bang-le Zhang, Qi-Bing Mei, Si-Yuan Zhou
In order to enhance the penetration of small interference RNA against the polo-like kinase I (siPLK1) across BBB to treat glioblastoma (GBM), transferrin (Tf) modified magnetic nanoparticle (Tf-PEG-PLL/MNP@siPLK1) was prepared. The in vitro experiments indicated that Tf-PEG-PLL/MNP@siPLK1 enhanced the cellular uptake of siPLK1, which resulted in an increase of gene silencing effect and cytotoxicity of Tf-PEG-PLL/MNP@siPLK1 on U87 cells. Besides, Tf-PEG-PLL/MNP@siPLK1 significantly inhibited the growth of U87 glioblastoma spheroids and markedly increased the BBB penetration efficiency of siPLK1 with the application of external magnetic field in in-vitro BBB model...
January 12, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29335588/peripheral-iron-levels-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-review-and-meta-analysis
#4
Ping-Tao Tseng, Yu-Shian Cheng, Cheng-Fang Yen, Yen-Wen Chen, Brendon Stubbs, Paul Whiteley, Andre F Carvalho, Dian-Jeng Li, Tien-Yu Chen, Wei-Cheng Yang, Chia-Hung Tang, Che-Sheng Chu, Wei-Chieh Yang, Hsin-Yi Liang, Ching-Kuan Wu, Pao-Yen Lin
There is growing recognition that the risk of attention-deficit hyperactivity disorder (ADHD) in children may be influenced by micronutrient deficiencies, including iron. We conducted this meta-analysis to examine the association between ADHD and iron levels/iron deficiency (ID). We searched for the databases of the PubMed, ScienceDirect, Cochrane CENTRAL, and ClinicalTrials.gov up to August 9th, 2017. Primary outcomes were differences in peripheral iron levels in children with ADHD versus healthy controls (HCs) and the severity of ADHD symptoms in children with/without ID (Hedges' g) and the pooled adjusted odds ratio (OR) of the association between ADHD and ID...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29332833/a-combination-of-thiol-ene-click-chemistry-and-surface-initiated-atom-transfer-radical-polymerization-fabrication-of-boronic-acid-functionalized-magnetic-graphene-oxide-composite-for-enrichment-of-glycoproteins
#5
Jie Su, Xiwen He, Langxing Chen, Yukui Zhang
An efficient glycoproteins enrichment platform is one of vital preprocessing steps in biomarker research and in particular glycoproteomics. In this work, a well-defined boronic acid functionalized magnetic graphene oxide nanocomposite (Fe3O4-GO@PAAPBA) was synthesized for the selective enrichment of glycoproteins from complex biological samples via a novel strategy based on the "thiol-ene" click chemistry and surface initiated atom transfer radical polymerization (SI-ATRP). The initiator of ATRP was anchored to the surface of substrate through "thiol-ene" click reaction...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29330784/tacrolimus-concentration-in-saliva-of-kidney-transplant-recipients-factors-influencing-the-relationship-with-whole-blood-concentrations
#6
Mwlod Ghareeb, Reginald Y Gohh, Fatemeh Akhlaghi
OBJECTIVE: The objective of this study was to examine the association between tacrolimus concentration in oral fluids and in whole blood and to investigate the various factors that influence this relationship. PATIENTS AND METHODS: Forty-six adult kidney transplant recipients were included in the study. Study A (ten patients) included the collection of several paired oral fluid samples by passive drool over a 12-h post-dose period. Study B (36 patients) included the collection of oral fluids pre-dose and at 2 h after the tacrolimus dose under three conditions: un-stimulated, after stimulation with a tart candy, and after mouth rinsing...
January 12, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29330222/increased-sympathovagal-imbalance-evaluated-by-heart-rate-variability-is-associated-with-decreased-cardiac-t2-and-lv-function-in-transfusion-dependent-thalassemia-patients
#7
Sintip Pattanakuhar, Arintaya Phrommintikul, Adisak Tantiworawit, Sasikarn Konginn, Somdet Srichairattanakool, Siriporn C Chattipakorn, Nipon Chattipakorn
Early detection of iron overload cardiomyopathy is an important strategy in decreasing the mortality rate of patients with transfusion dependent thalassemia (TDT).  Although cardiac magnetic resonance (CMR) T2* is effective in detecting cardiac iron deposition, it is costly and not generally available.  We investigated whether heart rate variability (HRV) can be used as a screening method of iron overload cardiomyopathy in TDT patients.  HRV, evaluated by 24-hour Holter monitoring, non-transferrin bound iron (NTBI), serum ferritin, left ventricular ejection fraction (LVEF), and CMR-T2* were determined...
January 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29327005/vivo-complexes-with-antibacterial-quinolone-ligands-and-their-interaction-with-serum-proteins
#8
Daniele Sanna, Valeria Ugone, Giuseppe Sciortino, Péter Buglyó, Zsolt Bihari, Péter László Parajdi-Losonczi, Eugenio Garribba
Quinolone derivatives are among the most commonly prescribed antibacterials in the world and could also attract interest as organic ligands in the design of metal complexes with potential pharmacological activity. In this study, five compounds, belonging to the first (nalidixic acid or Hnal), second (ciprofloxacin or Hcip, and norfloxacin or Hnor) and third generation (levofloxacin or Hlev, and sparfloxacin or Hspar) of quinolones, were used as ligands to bind the VIVO2+ ion. In aqueous solution, mono- and bis-chelated species were formed as a function of pH, with cis-[VOHxL2(H2O)]x+ and [VOHxL2]x+, x = 0-2, being the major complexes at pH 7...
January 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29325459/is-cord-blood-hepcidin-influenced-by-the-low-grade-acute-phase-response-occurring-during-delivery-%C3%A2-a-small-scale-longitudinal-study
#9
Michael Hoppe, Lena Hulthén, Gösta Samuelson
AIM: To measure serum hepcidin in late pregnancy and in cord blood, and to analyze relationship between hepcidin, interleukin-6 and biomarkers of fetal iron status. MATERIALS AND METHODS: Data from 15 uncomplicated singleton pregnancies were analyzed longitudinally in trimester 3 (T3) and at birth. RESULTS: In T3, S-ferritin (median 14 µg/L) and transferrin (median 4.0 g/L) indicated low iron status, whereas the median soluble transferrin receptor (sTfR) was 4...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29324643/nutritional-status-of-bariatric-surgery-candidates
#10
Aliaa Al-Mutawa, Alfred Kojo Anderson, Salman Alsabah, Mohammad Al-Mutawa
Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29323739/fasudil-alleviates-pressure-overload-induced-heart-failure-by-activating-nrf2-mediated-antioxidant-responses
#11
Peng Guan, Yingran Liang, Na Wang
The RhoA/Rho-kinase cascade plays an important role in many aspects of cardiovascular function. This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats. Pressure overload induced heart failure was induced in SD rats by banding the abdominal aorta for 8 weeks. The rats were divided into four groups: Sham, TAC, TAC plus low dose of fasudil and TAC plus high dose of fasudil group. Low dose and high dose fasudil were 5 mg/kg/day and 10 mg/kg/day respectively...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29323384/tracking-iron-associated-proteomes-in-pathogens-by-a-fluorescence-approach
#12
Nan Jiang, Tianfan Cheng, Minji Wang, Godfrey Chi-Fung Chan, Lijian Jin, Hongyan Li, Hongzhe Sun
Porphyromonas gingivalis is a key oral anaerobic bacterium involved in human periodontitis, which may affect up to 15% adults worldwide. Using the membrane permeable fluorescent probe Fe-TRACER, we identified 17 iron-associated proteins in Porphyromonas gingivalis. We demonstrated the specific binding of the probe towards iron-associated proteins using transferrin as an example and provided an X-ray structure of the fluorescent probe-bound transferrin. Our study provides a basis for the understanding of iron homeostasis in pathogens, and our approach based on the integration of fluorescence imaging with proteomics and bioinformatics can be readily extended to mine other metalloproteomes in microbials...
January 11, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29318945/relationship-between-obesity-and-iron-deficiency-anemia-is-there-a-role-of-hepcidin
#13
Ertan Sal, Idil Yenicesu, Nurullah Celik, Hatice Pasaoglu, Bulent Celik, Ozge Tugce Pasaoglu, Zühre Kaya, Ulker Kocak, Orhun Camurdan, Aysun Bideci, Peyami Cinaz
OBJECTIVES: Iron deficiency is common in obese children although the underlying mechanism is unclear. The aim of this study was to investigate the associations between iron parameters, leptin, hepcidin and adiponectin levels in obese children. METHODS: A total of 237 children, ranging in age from 5 to 18 years, 180 with primary obesity and 57 healthy children and adolescents, were enrolled. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, leptin, hepcidin and adiponectin levels were studied...
January 10, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29318368/increased-levels-of-advanced-glycation-end-products-positively-correlate-with-iron-overload-and-oxidative-stress-markers-in-patients-with-%C3%AE-thalassemia-major
#14
Maryam Sadat Mirlohi, Hamid Yaghooti, Saeed Shirali, Ali Aminasnafi, Samaneh Olapour
The impaired biosynthesis of the β-globin chain in β-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major β-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects...
January 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29317695/alterations-in-the-properties-of-the-cell-membrane-due-to-glycosphingolipid-accumulation-in-a-model-of-gaucher-disease
#15
Gyula Batta, Lilla Soltész, Tamás Kovács, Tamás Bozó, Zoltán Mészár, Miklós Kellermayer, János Szöllősi, Peter Nagy
Gaucher disease is a lysosomal storage disease characterized by the malfunction of glucocerebrosidase resulting in the accumulation of glucosylceramide and other sphingolipids in certain cells. Although the disease symptoms are usually attributed to the storage of undigested substrate in lysosomes, here we show that glycosphingolipids accumulating in the plasma membrane cause profound changes in the properties of the membrane. The fluidity of the sphingolipid-enriched membrane decreased accompanied by the enlargement of raft-like ordered membrane domains...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316680/effect-of-low-molecular-weight-oligopeptides-isolated-from-sea-cucumber-on-diabetic-wound-healing-in-db-db-mice
#16
Di Li, Lin Li, Teng Xu, Tianxing Wang, Jinwei Ren, Xinran Liu, Yong Li
Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divided into five groups, including the model control group, whey protein group (0.50 g/kg) and three SCCOPs dose groups (0.25 g/kg, 0.50 g/kg and 1.00 g/kg). Additionally, 18 db/m male mice were used as normal control group...
January 8, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29315261/novel-pamam-peg-peptide-conjugates-for-sirna-delivery-targeted-to-the-transferrin-and-epidermal-growth-factor-receptors
#17
Koldo Urbiola, Laura Blanco-Fernández, Manfred Ogris, Wolfgang Rödl, Ernst Wagner, Conchita Tros de Ilarduya
The transferrin (TfR) and epidermal growth factor receptors (EGFR) are known to be overexpressed on the surface of a wide variety of tumor cells. Therefore, the peptides B6 (TfR specific) and GE11 (targeted to the EGFR) were linked to the PAMAM (polyamidoamine) structure via a polyethylenglycol (PEG) 2 kDa chain with the aim of improving the silencing capacity of the PAMAM-based dendriplexes. The complexes showed an excellent binding capacity to the siRNA with a maximal condensation at nitrogen/phosphate (N/P) 2...
January 9, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29313518/transferrin-and-lactoferrin-human-iron-sources-for-enterococci
#18
Paweł Lisiecki
To overcome limitations in iron acquisition, enterococci have evolved a number of mechanisms to scavenge iron from the host iron-binding proteins - transferrin (TR) and lactoferrin (LF). The aim of this study was to demonstrate the mechanisms by which enterococci utilize human TR and LF bound iron. The study included two strains of Enterococcus faecalis grown in iron-deficient and iron-excess media respectively. The binding activity of both proteins was monitored using proteins labelled with 125I. The uptake of iron by enterococci was determined using 59Fe labelled proteins...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29313480/malaria-and-iron-load-at-the-first-antenatal-visit-in-the-rural-south-kivu-democratic-republic-of-the-congo-is-iron-supplementation-safe-or-could-it-be-harmful
#19
Esto Bahizire, Umberto D'Alessandro, Michèle Dramaix, Nicolas Dauby, Fabrice Bahizire, Kanigula Mubagwa, Philippe Donnen
We investigated the relationship between malaria infection and iron status in 531 pregnant women in South Kivu, Democratic Republic of the Congo. Sociodemographic data, information on morbidity, and clinical data were collected. A blood sample was collected at the first antenatal visit to diagnose malaria and measure serum ferritin (SF), soluble transferrin receptor, C-reactive protein, and α1-acid-glycoprotein. Malaria prevalence was 7.5%. Median (interquartile range) SF (adjusted for inflammation) was significantly higher in malaria-infected (82...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29305826/hepcidin-soluble-transferrin-receptor-and-il-6-levels-in-obese-children-and-adolescents-with-and-without-type-2-diabetes-mellitus-impaired-glucose-tolerance-and-their-association-with-obstructive-sleep-apnea
#20
S Shalitin, V Deutsch, R Tauman
PURPOSE: Obesity, type 2 diabetes mellitus (T2DM), and obstructive sleep apnea (OSA) are associated with chronic low-grade inflammation. Iron metabolism is linked with insulin-resistant states and with OSA in adults. The association of body iron status with T2DM in children remains undefined. We aimed to evaluate plasma interleukin-6 (IL-6), hepcidin, and soluble transferrin receptor (sTfR) levels in obese patients with T2DM or impaired glucose tolerance (IGT) and in those without, and the contribution of OSA to their levels...
January 5, 2018: Journal of Endocrinological Investigation
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