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https://www.readbyqxmd.com/read/27904853/effects-of-postoperative-parenteral-nutrition-with-different-lipid-emulsions-in-patients-undergoing-major-abdominal-surgery
#1
Seher Demirer, Ali Sapmaz, Ahmet Serdar Karaca, Ilknur Kepenekci, Semih Aydintug, Deniz Balci, Pinar Sonyurek, Kenan Kose
PURPOSE: This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery. METHODS: Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27903581/the-plasma-membrane-metal-ion-transporter-zip14-contributes-to-non-transferrin-bound-iron-uptake-by-human-%C3%AE-cells
#2
Richard Coffey, Mitchell D Knutson
The relationship between iron and β cell dysfunction has long been recognized as individuals with iron overload display an increased incidence of diabetes. This link is usually attributed to the accumulation of excess iron in β cells leading to cellular damage and impaired function. Yet, the molecular mechanism(s) by which human β cells take up iron has not been determined. In the present study, we assessed the contribution of the metal-ion transporters ZIP14, ZIP8, and DMT1 to iron uptake by human β cells...
November 30, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27899655/visualization-of-self-delivering-hydrophobically-modified-sirna-cellular-internalization
#3
Socheata Ly, Deanna M Navaroli, Marie-Cécile Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F Alterman, Kevin Fogarty, Clive Standley, Lawrence M Lifshitz, Karl D Bellve, Matthieu Prot, Dimas Echeverria, Silvia Corvera, Anastasia Khvorova
siRNAs are a new class of therapeutic modalities with promising clinical efficacy that requires modification or formulation for delivery to the tissue and cell of interest. Conjugation of siRNAs to lipophilic groups supports efficient cellular uptake by a mechanism that is not well characterized. Here we study the mechanism of internalization of asymmetric, chemically stabilized, cholesterol-modified siRNAs (sd-rxRNAs(®)) that efficiently enter cells and tissues without the need for formulation. We demonstrate that uptake is rapid with significant membrane association within minutes of exposure followed by the formation of vesicular structures and internalization...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898025/identification-and-characterization-of-micrornas-in-the-liver-of-blunt-snout-bream-megalobrama-amblycephala-infected-by-aeromonas-hydrophila
#4
Lei Cui, Hongtao Hu, Wei Wei, Weimin Wang, Hong Liu
MicroRNAs (miRNAs) are small RNA molecules that play key roles in regulation of various biological processes. In order to better understand the biological significance of miRNAs in the context of Aeromonas hydrophila infection in Megalobrama amblycephala, small RNA libraries obtained from fish liver at 0 (non-infection), 4, and 24 h post infection (poi) were sequenced using Illumina deep sequencing technology. A total of 11,244,207, 9,212,958, and 7,939,157 clean reads were obtained from these three RNA libraries, respectively...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27896921/effect-of-iron-supplementation-during-lactation-on-maternal-iron-status-and-oxidative-stress-a-randomized-controlled-trial
#5
Josh M Jorgensen, Zhenyu Yang, Bo Lönnerdal, Caroline J Chantry, Kathryn G Dewey
We examined the effect of iron-containing prenatal vitamin-mineral supplements taken postpartum on biomarkers of iron status and oxidative stress. Lactating women (n = 114) were randomly assigned to consume daily one iron-free prenatal vitamin-mineral supplement plus either 27 mg of iron or placebo for approximately 3.5 months. The placebo group took the tablets between meals, while those given iron took the tablets either with (Fe-W) or between meals (Fe-B). Blood and urine samples were collected before and after the supplementation period to analyze hemoglobin (Hb), ferritin, hepcidin, transferrin saturation (TfSat), total plasma iron, and biomarkers of oxidative stress (isoprostane and 8-hydroxy-2-deoxyguanosine (8-OHdG)) and inflammation (C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP))...
November 29, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27896919/duration-of-exclusive-breastfeeding-is-a-positive-predictor-of-iron-status-in-6-to-10-month-old-infants-in-rural-kenya
#6
Mary A Uyoga, Simon Karanja, Daniela Paganini, Colin I Cercamondi, Sophie A Zimmermann, Benjamin Ngugi, Penny Holding, Diego Moretti, Michael B Zimmermann
BACKGROUND: The prevalence of iron-deficiency anemia (IDA) is high in infants in Sub-Saharan Africa. Exclusive breastfeeding of infants to 6 months of age is recommended by the World Health Organization, but breast milk is low in iron. Some studies suggest exclusive breastfeeding, although beneficial for the infant, may increase risk for IDA in resource-limited settings. OBJECTIVE: To determine if duration of exclusive breastfeeding is associated with anemia and iron deficiency in rural Kenyan infants...
November 29, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27896572/identification-of-novel-mutations-in-hfe-hfe2-tfr2-and-slc40a1-genes-in-chinese-patients-affected-by-hereditary-hemochromatosis
#7
Yongwei Wang, Yali Du, Gang Liu, Shanshan Guo, Bo Hou, Xianyong Jiang, Bing Han, Yanzhong Chang, Guangjun Nie
Hereditary hemochromatosis (HH) is a group of inherited iron-overload disorders associated with pathogenic defects in the genes encoding hemochromatosis (HFE), hemojuvelin (HJV/HFE2), hepcidin (HAMP), transferrin receptor 2 (TfR2), and ferroportin (FPN1/SLC40A1) proteins, and the clinical features are well described. However, there have been only a few detailed reports of HH in Chinese populations. Thus, there is insufficient patient information for population-based analyses in Chinese populations or comparative studies among different ethical groups...
November 28, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27893860/blocking-synthesis-of-the-variant-surface-glycoprotein-coat-in-trypanosoma-brucei-leads-to-an-increase-in-macrophage-phagocytosis-due-to-reduced-clearance-of-surface-coat-antibodies
#8
Jackie L Y Cheung, Nadina V Wand, Cher-Pheng Ooi, Sophie Ridewood, Richard J Wheeler, Gloria Rudenko
The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a precytokinesis arrest where stalled cells persist for days in vitro with superficially intact VSG coats, but are rapidly cleared within hours in mice. We therefore investigated the role of VSG synthesis in trypanosome phagocytosis by activated mouse macrophages...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27893677/impact-of-iron-deficiency-anemia-on-the-function-of-the-immune-system-in-children
#9
Tamer Hasan Hassan, Mohamed Ahmed Badr, Nehad Ahmed Karam, Marwa Zkaria, Hosam Fathy El Saadany, Doaa Mohamed Abdel Rahman, Doaa Abdallah Shahbah, Salah Mohamed Al Morshedy, Manar Fathy, Asmaa Mohamed Hosni Esh, Amal Mohamed Selim
The importance of iron deficiency as a public health problem is based ultimately on the seriousness of its consequences on health. The most extensively investigated consequences of iron deficiency involve work performance and immune function. The significance of the effects on work performance is generally accepted. In contrast, data on the influence of iron deficiency on immune function are often perceived as being confusing and contradictory.We aimed to evaluate the effect of iron deficiency anemia on humoral, cellular, nonspecific immunity, and also the effect on the cytokines that are the key factors of many immunologic steps...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27891416/effect-of-oral-iron-on-markers-of-oxidative-stress-and-antioxidant-status-in-children-with-iron-deficiency-anaemia
#10
Zeeba Zaka-Ur-Rab, Mohammad Adnan, Syed Moiz Ahmad, Najmul Islam
INTRODUCTION: Conflicting reports are available on the relationship of Iron Deficiency Anaemia (IDA) and iron therapy with oxidative stress. AIM: To study the levels of markers of oxidative stress and anti-oxidant status in children with IDA and to assess the effect of iron therapy on the same. MATERIALS AND METHODS: This prospective, single centre, hospital based study was a sub-study of a randomized controlled trial conducted in the Department of Paediatrics, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh in collaboration with the Department of Biochemistry (of the same institution) between October 2009 to February 2011...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27881597/assessment-of-regression-models-for-adjustment-of-iron-status-biomarkers-for-inflammation-in-children-with-moderate-acute-malnutrition-in-burkina-faso
#11
Bernardette Cichon, Christian Ritz, Christian Fabiansen, Vibeke Brix Christensen, Suzanne Filteau, Henrik Friis, Pernille Kæstel
BACKGROUND: Biomarkers of iron status are affected by inflammation. In order to interpret them in individuals with inflammation, the use of correction factors (CFs) has been proposed. OBJECTIVE: The objective of this study was to investigate the use of regression models as an alternative to the CF approach. METHODS: Morbidity data were collected during clinical examinations with morbidity recalls in a cross-sectional study in children aged 6-23 mo with moderate acute malnutrition...
November 23, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27881232/serum-copper-zinc-and-iron-levels-and-markers-of-carbohydrate-metabolism-in-postmenopausal-women-with-prediabetes-and-type-2-diabetes-mellitus
#12
Margarita G Skalnaya, Anatoly V Skalny, Alexey A Tinkov
The objective of the present study was to evaluate serum level of copper, zinc, iron and metabolic parameters in postmenopausal women with diabetes. A total of 413 postmenopausal women were enrolled in the current study. Women were divided into 4 groups with equal age and body mass index according to glycated hemoglobin (HbA1c) levels (≤5.5; 5.5-6.0; 6.0-6.5; >6.5%). Serum Fe, Cu, and Zn levels were assessed using inductively-coupled plasma mass-spectrometry. Blood HbA1c, serum glucose, insulin, C-reactive protein (CRP), ferritin, and ceruloplasmin (Cp) were assessed using commercial kits...
November 16, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27876127/in-silico-prediction-of-specific-pathways-that-regulate-mesangial-cell-proliferation-in-iga-nephropathy
#13
Elham Sadat Mirfazeli, Sayed-Amir Marashi, Shiva Kalantari
IgA nephropathy is one of the most common forms of primary glomerulonephritis worldwide leading to end-stage renal disease. Proliferation of mesangial cells, i.e., the multifunctional cells located in the intracapillary region of glomeruli, after IgA- dominant immune deposition is the major histologic feature in IgA nephropathy. In spite of several studies on molecular basis of proliferation in these cells, specific pathways responsible for regulation of proliferation are still to be discovered. In this study, we predicted a specific signaling pathway started from transferrin receptor (TFRC), a specific IgA1 receptor on mesangial cells, toward a set of proliferation-related proteins...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27875949/treponema-iron-and-neurodegeneration
#14
A Jolivet-Gougeon, M Bonnaure Mallet
Spirochetes are suspected to be linked to the genesis of neurological diseases, including neurosyphillis or neurodegeneration (ND). Impaired iron homeostasis has been implicated in loss of function in several enzymes requiring iron as a cofactor, formation of toxic oxidative species, inflammation and elevated production of beta-amyloid proteins. This review proposes to discuss the link that may exist between the involvement of Treponema spp. in the genesis or worsening of ND, and iron dyshomeostasis. Proteins secreted by Treponema can act directly on iron metabolism, with hemin binding ability (HbpA and HbpB) and iron reductase able to reduce the central ferric iron of hemin, iron-containing proteins (rubredoxin, neelaredoxin, desulfoferrodoxin metalloproteins, bacterioferritins etc)...
November 21, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27872081/novel-effects-of-lapatinib-revealed-in-the-african-trypanosome-using-hypothesis-generating-proteomics-and-chemical-biology-strategies
#15
Paul J Guyett, Ranjan Behera, Yuko Ogata, Michael Pollastri, Kojo Mensa-Wilmot
Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei Lapatinib, a human epidermal growth factor receptor (EGFR) inhibitor, can cure 25% of trypanosome-infected mice, although the parasite lacks EGFR-like tyrosine kinases. Four trypanosome protein kinases associate with lapatinib, suggesting the drug may be a multi-targeted inhibitor of phosphoprotein signaling in the bloodstream trypanosome. Phosphoprotein signaling pathways in T. brucei have diverged significantly from those in humans...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27871472/an-immunohistochemical-study-of-placental-syncytiotrophoblasts-in-neonatal-hemochromatosis
#16
Aiko Shimono, Yuko Imoto, Haruhiko Sakamoto, Yoichi Chiba, Koichi Matsumoto, Machi Kawauchi, Takashi Kusaka, Hirokazu Tanaka, Toshiyuki Hata, Yoshio Kushida, Masaki Ueno
INTRODUCTION: Neonatal hemochromatosis (NH) is a rare neonatal disorder that results in liver cirrhosis with hemosiderin deposition in the liver and other organs, similarly to hereditary hemochromatosis. Excess iron is transferred from the mother to fetus through the placenta in NH. We examined the expression of iron metabolism-related substances in placental syncytiotrophoblasts (STB) by immunostaining to clarify how the transfer of iron through STB increases in NH. METHODS: Immunostaining was performed using formalin-fixed, paraffin-embedded sections of placentae from three NH cases, four gestational age-matched controls, and, depending on the antibody examined, five to seven full-term controls...
December 2016: Placenta
https://www.readbyqxmd.com/read/27870894/identification-of-stages-of-erythroid-differentiation-in-bone-marrow-and-erythrocyte-subpopulations-in-blood-circulation-that-are-preferentially-lost-in-autoimmune-hemolytic-anemia-in-mouse
#17
Sreoshi Chatterjee, Nitin Bhardwaj, Rajiv K Saxena
Repeated weekly injections of rat erythrocytes produced autoimmune hemolytic anemia (AIHA) in C57BL/6 mice after 5-6 weeks. Using the double in vivo biotinylation (DIB) technique, recently developed in our laboratory, turnover of erythrocyte cohorts of different age groups during AIHA was monitored. Results indicate a significant decline in the proportion of reticulocytes, young and intermediate age groups of erythrocytes, but a significant increase in the proportion of old erythrocytes in blood circulation...
2016: PloS One
https://www.readbyqxmd.com/read/27865117/catalytic-iron-in-acute-myocardial-infarction-complicated-by-cardiogenic-shock-a-biomarker-substudy-of-the-iabp-shock-ii-trial
#18
Georg Fuernau, Florian Traeder, Suhas S Lele, Mohan M Rajapurkar, Banibrata Mukhopadhyay, Suzanne de Waha, Steffen Desch, Ingo Eitel, Gerhard Schuler, Volker Adams, Holger Thiele
BACKGROUND: Catalytic iron (CI) is unbound ferric iron with the potential to generate reactive oxygen species with further deleterious vascular effects. In acute coronary syndromes, high levels of CI are linked to all-cause mortality. The prognostic impact of CI and iron metabolism in cardiogenic shock (CS) is currently undetermined. Aims of this study were to investigate the prognostic impact of CI and to identify predictors of high CI levels in patients with CS complicating acute myocardial infarction...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27864173/salad-leaf-juices-enhance-salmonella-growth-fresh-produce-colonisation-and-virulence
#19
Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, Primrose Freestone
: We show in this report that traces of juices released from salad leaves as they became damaged can significantly enhance Salmonella enterica salad leaf colonisation. Salad juices in water increased Salmonella growth by 110% over the un-supplemented control, and in host-like serum based media by more than 2400-fold over controls. In serum based media salad juices induced growth of Salmonella via provision of Fe from transferrin, and siderophore production was found to be integral to the growth induction process...
November 18, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27863761/iron-deficiency-in-cancer-patients
#20
Flávio Augusto Naoum
Anemia is a frequent complication in cancer patients, both at diagnosis and during treatment, with a multifactorial etiology in most cases. Iron deficiency is among the most common causes of anemia in this setting and can develop in nearly half of patients with solid tumors and hematologic malignancies. Surprisingly, this fact is usually neglected by the attending physician in a way that proper and prompt investigation of the iron status is either not performed or postponed. In cancer patients, functional iron deficiency is the predominant mechanism, in which iron availability is reduced due to disease or the therapy-related inflammatory process...
October 2016: Revista Brasileira de Hematologia e Hemoterapia
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