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Progesterone in pregnancy

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https://www.readbyqxmd.com/read/28806625/association-of-changes-among-body-condition-score-during-the-transition-period-with-nefa-and-bhba-concentrations-milk-production-fertility-and-health-of-holstein-cows
#1
R V Barletta, M Maturana Filho, P D Carvalho, T A Del Valle, A S Netto, F P Rennó, R D Mingoti, J R Gandra, G B Mourão, P M Fricke, R Sartori, E H Madureira, M C Wiltbank
Our objective was to evaluate the association between body condition score (BCS) change during the transition period with fertility, non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) concentrations, milk yield, and health problems of Holstein cows in a retrospective cohort study. Holstein cows (n = 232) were assessed for BCS (5 point scale; 0.25 point increments) and had blood collected at 21 and 7 d before, on the day of, and 7 and 21 d after calving. Blood samples were assayed for NEFA and BHBA concentrations...
July 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28804932/kisspeptin-regulates-ovarian-steroidogenesis-during-delayed-embryonic-development-in-the-fruit-bat-cynopterus-sphinx
#2
Anuradha, Amitabh Krishna
Cynopterus sphinx, a fruit bat, undergoes delayed embryonic development during the winter months, a period that corresponds to low levels of progesterone and estradiol synthesis by the ovary. Kisspeptins (KPs) are a group of neuropeptide hormones that act via G-protein coupled receptor 54 (GPR54) to stimulate hypothalamic secretion of Gonadotropin-releasing hormone, thereby regulating ovarian steroidogenesis, folliculogenesis, and ovulation. GPR54 is also expressed in the ovary, suggesting a direct role for KPs in ovarian steroidogenesis...
August 14, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28803019/daily-lying-behavior-of-lactating-holstein-cows-during-an-estrus-synchronization-protocol-and-its-associations-with-fertility
#3
B F Silper, A M L Madureira, L B Polsky, S Soriano, A F Sica, J L M Vasconcelos, R L A Cerri
Objectives were to quantify lying behavior (LB) during an estradiol and progesterone-based synchronization protocol, to assess risk factors for ovulation, pregnancy per AI (P/AI), and degree of behavioral change at estrus, and to investigate the associations between estrus LB and walking activity. Holstein cows (43.6 ± 11.0 kg of milk/d) were fitted with leg-mounted accelerometers. Total lying time/d (L_time), bout frequency (bout_N), average lying bout duration, and relative increase in walking activity (ACT%) were evaluated for 1,411 timed artificial insemination events...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28802241/the-9-d-cidr-pg-protocol-ii-characterization-of-endocrine-parameters-ovarian-dynamics-and-pregnancy-rates-to-fixed-time-ai-following-use-of-long-term-cidr-based-estrus-synchronization-among-mature-beef-cows
#4
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, S E Poock, M F Smith, D J Patterson
An experiment was designed to evaluate endocrine parameters, ovarian dynamics, and pregnancy rates to fixed-time artificial insemination (FTAI) following the 9-d CIDR-PG protocol in comparison to the 14-d CIDR-PG protocol. While both are long-term protocols using CIDR treatment for presynchronization, the 9-d CIDR-PG protocol differs from the 14-d CIDR-PG protocol in that prostaglandin F2α (PG) is administered at CIDR insertion and removal to facilitate a decreased length of progestin treatment and potentially enhance response to the presynchronization treatment...
August 3, 2017: Theriogenology
https://www.readbyqxmd.com/read/28798085/the-association-of-falling-insulin-requirements-with-maternal-biomarkers-and-placental-dysfunction-a-prospective-study-of-women-with-pre-existing-diabetes-in-pregnancy
#5
Suja Padmanabhan, Vincent W Lee, Mark Mclean, Neil Athayde, Valeria Lanzarone, Qemer Khoshnow, Michael J Peek, N Wah Cheung
OBJECTIVE: To investigate the association of falling insulin requirements (FIR) among women with pre-existing diabetes with adverse obstetric outcomes and maternal biomarkers longitudinally in pregnancy. RESEARCH DESIGN AND METHODS: A multicenter prospective cohort study of 158 women (41 with type 1 diabetes and 117 with type 2 diabetes) was conducted. Women with FIR of ≥15% from the peak total daily dose after 20 weeks gestation were considered case subjects (n = 32)...
August 10, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28797287/is-a-high-serum-copper-concentration-a-risk-factor-for-implantation-failure
#6
Hidehiko Matsubayashi, Kotaro Kitaya, Kohei Yamaguchi, Rie Nishiyama, Yukiko Takaya, Tomomoto Ishikawa
BACKGROUND: Copper-containing contraceptive devices may deposit copper ions in the endometrium, resulting in implantation failure. The deposition of copper ions in many organs has been reported in patients with untreated Wilson's disease. Since these patients sometimes exhibit subfertility and/or early pregnancy loss, copper ions were also considered to accumulate in the uterine endometrium. Wilson's disease patients treated with zinc successfully delivered babies because zinc interfered with the absorption of copper from the gastrointestinal tract...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28791263/second-trimester-cervical-length-measurement-for-prediction-spontaneous-preterm-birth-in-an-unselected-risk-population
#7
Alberto Borges Peixoto, Taciana Mara Rodrigues da Cunha Caldas, Luisa Almeida Tahan, Caetano Galvão Petrini, Wellington P Martins, Fabricio Da Silva Costa, Edward Araujo Júnior
OBJECTIVE: To assess the predictive capacity of cervical length (CL) measurement underwent during the second trimester ultrasound for prediction preterm birth <32, 34, and 37 weeks of gestation in an unselected risk population. METHODS: A retrospective cohort study was performed with 751 singleton pregnancies between 20 and 24+6 weeks of gestation. The CL measurement (mm) using the transvaginal route was obtained in a sagittal view and the calipers positioned to measure the linear distance between the triangular area of echodensity at the external os and the internal os...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28783590/vulvar-thermal-pattern-following-synchronization-of-estrus-is-linked-to-fertility-after-timed-artificial-insemination-in-goat
#8
Calogero Stelletta, Koray Tekin, Mehmet Borga Tirpan, Havva Alemdar, Beste Cil, Fatma Oztutar Stelletta, Kemal Tuna Olgac, Muhammed Enes Inanc, Ali Daskin
Aim of this study was to study the vulvar thermal pattern variation during the timed artificial insemination protocol in Angora goat and identify the relationship with the successful rate. Does (36 adult healthy females) were synchronized using PGF2α at the day 0, 11 days of progesterone impregnated sponges intra-vaginally, PMSG 48 h before sponges withdraw (day 11) and the intra-cervical inseminations were carried out 48 h later (Timed Artificial Insemination: TAI) with chilled semen. Vulvar (VST) and perivulvar (PST) areas were considered to evaluate the thermal pattern during the protocol at the day 0 and at the TAI using a thermo camera (E60, FLIR System)...
July 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28782881/from-peptide-masses-to-pregnancy-maintenance-a-comprehensive-proteomic-analysis-of-the-early-equine-embryo-secretome-blastocoel-fluid-and-capsule
#9
Aleona Swegen, Christopher Gerald Grupen, Zamira Gibb, Mark Baker, Marta de Ruijter-Villani, Nathan Druery Smith, Tom A E Stout, R John Aitken
Early pregnancy in the mare is a poorly understood, high risk period during which the embryo communicates its presence to the maternal endometrium. Remarkably, the maternal recognition of pregnancy signal is unknown in the horse. This study aimed to profile the proteins secreted by equine blastocysts into their immediate environment, along with proteins contained in the blastocoel and within the acellular embryo capsule. Embryos were recovered on day 8 after ovulation and cultured for 48 hours. Secretomes of day 9 and day 10 embryos were analyzed by LC-MS/MS and supported by analysis of blastocoel fluid and embryo capsule...
August 7, 2017: Proteomics
https://www.readbyqxmd.com/read/28780571/the-critical-role-of-uterine-cd31-as-a-post-progesterone-signal-in-early-pregnancy
#10
Seo-Ho Lee, Byung-Ju Kim, Uh-Hyun Kim
CD31 has been shown to play a role in endothelial cell migration and angiogenesis, which are critical to the formation and function of the endometrium and myometrium in uterine development during early pregnancy. However, the role of CD31 in uterine receptivity during blastocyst implantation is poorly understood. The pregnancy rate in CD31-/- female mice mated with CD31+/+ male mice was higher than that observed in CD31+/+ female mice mated with CD31+/+ male mice. During the receptive phase of implantation, uterine glands were more developed in CD31-/- mice than in CD31+/+ mice, and the uterine weights of CD31-/- mice were increased...
August 5, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28780109/comparison-of-2-protocols-to-increase-circulating-progesterone-concentration-before-timed-artificial-insemination-in-lactating-dairy-cows-with-or-without-elevated-body-temperature
#11
M H C Pereira, M C Wiltbank, T G Guida, F R Lopes, J L M Vasconcelos
Two treatments designed to increase circulating progesterone concentration (P4) during preovulatory follicle development were compared. One treatment used 2 intravaginal P4 implants (controlled internal drug-releasing inserts; CIDR) and the other used a GnRH treatment at beginning of the protocol. Lactating Holstein cows that had been diagnosed as nonpregnant were randomly assigned to receive timed artificial insemination (TAI) following 1 of 2 treatments (n = 1,638 breedings): (1) GnRH: CIDR+ 2 mg of estradiol (E2) benzoate + 100 µg of GnRH on d -11, PGF2α on d -4, CIDR withdrawal + 1...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28777967/optimal-routes-of-administration-vehicles-and-timing-of-progesterone-treatment-for-inhibition-of-delivery-during-pregnancy
#12
Dajun Fang, Mario Moreno, Robert E Garfield, Ruben Kuon, Huimin Xia
OBJECTIVES: Progestins, notably progesterone (P4) and 17 alpha hydroxyprogesterone caproate, are presently used to treat pregnant women at risk of preterm birth. The aim of this study was to assess the optimal treatment options for progesterone (P4) to delay delivery using a sensitive bioassay for progesterone. STUDY DESIGN: Pregnant rats, known to be highly sensitive to progestins, were treated with P4, including Prochieve(®) (also known as Crinone(®)), in various vehicles from day 13 of gestation and in late gestation, days 19 to 22, and delivery times noted...
June 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28776117/gnrh-antagonist-administered-twice-the-day-before-hcg-trigger-combined-with-a-step-down-protocol-may-prevent-ohss-in-ivf-icsi-antagonist-cycles-at-risk-for-ohss-without-affecting-the-reproductive-outcomes-a-prospective-randomized-control-trial
#13
Yannis Prapas, Konstantinos Ravanos, Stamatios Petousis, Yannis Panagiotidis, Achilleas Papatheodorou, Chrysoula Margioula-Siarkou, Assunta Iuliano, Giuseppe Gullo, Nikos Prapas
PURPOSE: The purpose this study is to investigate whether a double antagonist dose (0.25 mg/12 h) administered the day before hCG trigger is effective in preventing ovarian hyperstimulation syndrome (OHSS) in GnRH antagonist IVF/intracytoplasmic sperm injection (ICSI) cycles at risk for OHSS. METHODS: This is a prospective randomized control study, conducted from November 2012 to January 2016. A total of 194 patients undergoing a IVF/ICSI GnRH antagonist cycle that were at risk of OHSS and chose to proceed with embryo transfer and avoid cycle cancellation or embryo cryopreservation were allocated into two groups...
August 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28772112/semen-deposition-by-cervical-transcervical-and-intrauterine-route-for-fixed-time-artificial-insemination-ftai-in-the-ewe
#14
R Casali, A Pinczak, F Cuadro, J M Guillen-Muñoz, A Mezzalira, A Menchaca
Semen deposition through the cervix into the uterus is a difficult technique in ewes and represents the main limiting factor for insemination in this species. The objective of this study was to evaluate the pregnancy rate achieved with a new transcervical insemination method in comparison with conventional cervical and laparoscopic intrauterine techniques. A total of 586 multiparous Corriedale ewes were synchronized for fixed time artificial insemination (FTAI) performed by cervical, transcervical, or intrauterine route at 46-50 h or 52-56 h after progesterone device removal in a 3 × 2 factorial design...
July 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/28770970/oxtr-and-zeb1-expression-before-and-after-progesterone-dosing-in-pregnant-women-with-threatened-premature-labor
#15
Y-J Xu, L-D Ren, S-S Zhai, L-M Ran, L-L Hu, X-H Luo, T Hong, R Liu, Y-R Yu, Y-J Ban
OBJECTIVE: To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS: Blood samples were collected from 30 healthy pregnant women with 28- to 33+6-week gestational age and singleton pregnancy (group A) and from 30 pregnant women with singleton pregnancy and threatened premature labor before and 48 hours after progesterone dosing (groups B and C, respectively) for quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay to assess the OXTR and ZEB1 mRNA levels...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28764583/expression-and-significance-of-aquaporin-2-and-serum-hormones-in-placenta-of-patients-with-preeclampsia
#16
Yurong Zhao, Li Lin, Ailuan Lai
To evaluate the relationship between serum hormone or aquaporin-2 (AQP-2) and preeclampsia, patients with severe preeclampsia (A group), mild preeclampsia (B group), chronic hypertension (C group) and normal pregnant women (D group) were recruited and analysed. The AQP-2 level in placenta tissues was detected and the correlations of AQP-2 with serum hormone levels were analysed using linear correlation regression analysis. The differences of alpha foetal protein (AFP) and human chorionic gonadotropin (HCG) levels during mid-pregnancy, as well as the levels of AFP, HCG, unconjugated oestriol and progesterone during late pregnancy were significant among A, B, C and D groups (p < ...
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28759837/dynamics-of-pre-and-post-insemination-progesterone-profiles-and-insemination-outcomes-determined-by-an-in-line-milk-analysis-system-in-primiparous-and-multiparous-canadian-holstein-cows
#17
Tony C Bruinjé, Mohanathas Gobikrushanth, Marcos G Colazo, Divakar J Ambrose
The objective was to evaluate in-line milk progesterone (mP4) data to determine dynamics of pre- and post-insemination mP4 profiles and their associations with parity and outcomes of artificial insemination (AI) in Holstein cows. Milk progesterone (ng/mL) was quantified at pre-determined time points before and after AI through an automated in-line milk analysis system (Herd Navigator™, DeLaval International, Tumba, Sweden). Only AI (∼d0; n = 605) preceded by an mP4-decline (at least two samples of mP4 ≥5 ng/mL followed by at least one sample <5 ng/mL; d-2) were evaluated...
May 28, 2017: Theriogenology
https://www.readbyqxmd.com/read/28754971/in-vivo-raman-spectral-analysis-of-impaired-cervical-remodeling-in-a-mouse-model-of-delayed-parturition
#18
Christine M O'Brien, Jennifer L Herington, Naoko Brown, Isaac J Pence, Bibhash C Paria, James C Slaughter, Jeff Reese, Anita Mahadevan-Jansen
Monitoring cervical structure and composition during pregnancy has high potential for prediction of preterm birth (PTB), a problem affecting 15 million newborns annually. We use in vivo Raman spectroscopy, a label-free, light-based method that provides a molecular fingerprint to non-invasively investigate normal and impaired cervical remodeling. Prostaglandins stimulate uterine contractions and are clinically used for cervical ripening during pregnancy. Deletion of cyclooxygenase-1 (Cox-1), an enzyme involved in production of these prostaglandins, results in delayed parturition in mice...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28754906/kras-activation-and-over-expression-of-sirt1-bcl6-contributes-to-the-pathogenesis-of-endometriosis-and-progesterone-resistance
#19
Jung-Yoon Yoo, Tae Hoon Kim, Asgerally T Fazleabas, Wilder A Palomino, Soo Hyun Ahn, Chandrakant Tayade, David P Schammel, Steven L Young, Jae-Wook Jeong, Bruce A Lessey
Endometriosis is an inflammatory condition that is associated with progesterone resistance and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously demonstrated phosphorylation of STAT3 in eutopic endometrium of infertile women with this disorder leading to over-expression of the oncogene BCL6 and stabilization of hypoxia-induced factor 1 alpha (HIF-1α). Here we report coordinated activation of KRAS and over-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silencer, in the eutopic endometrium from women with endometriosis throughout the menstrual cycle...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753545/adjuvant-administration-of-17-%C3%AE-hydroxy-progesterone-caproate-in-women-with-three-or-more-second-trimester-pregnancy-losses-undergoing-cervical-cerclage-is-no-more-effective-than-cerclage-alone
#20
Fernand D Samson, Amanda L Merriman, Danielle L Tate, Katherine Apostolakis-Kyrus, Luis M Gomez
OBJECTIVE: To investigate the role of adjuvant 17-α-hydroxy-progesterone caproate (17OHP-C) in reducing the risk of preterm delivery <34 weeks and adverse perinatal outcomes in women with ≥3 second trimester pregnancy losses attributed to cervical insufficiency undergoing prophylactic cerclage. MATERIAL AND METHODS: Retrospective cohort study of women with prophylactic cerclage placed between 2006 and 2014 divided into a cohort of (i) those receiving adjuvant 17OHP-C (n=43), and (ii) controls with cerclage alone (n=59)...
July 28, 2017: Journal of Perinatal Medicine
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