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Progesterone in pregnancy

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https://www.readbyqxmd.com/read/29771940/unplanned-pregnancies-and-contraceptive-use-among-hiv-positive-women-in-care
#1
Madeline Y Sutton, Wen Zhou, Emma L Frazier
Among 230,360 women with diagnosed HIV in the United States (U.S.), ~ 8,500 give birth annually, and unplanned pregnancies (as with HIV-negative women) are prevalent. However, unplanned pregnancies and contraceptive use among HIV-positive women have been understudied. To examine unplanned pregnancies and contraceptive use among HIV-positive women, we used 2013-2014 data from the Medical Monitoring Project (MMP), an HIV surveillance system that produces national estimates for HIV-positive adults in care in the U...
2018: PloS One
https://www.readbyqxmd.com/read/29769477/enzyme-immunoassays-for-water-soluble-steroid-metabolites-in-the-urine-and-feces-of-japanese-macaques-macaca-fuscata-using-a-simple-elution-method
#2
Keiko Shimizu, Keiko Mouri
A simple, non-alcoholic extraction method for measuring estrogen and progesterone metabolites in excreta using enzyme immunoassays (EIAs) was developed in Japanese macaques. The obtained detection limits of EIAs using estrone conjugates (E1 C), pregnanediol glucuronide (PdG), and estriol glucuronide (E3 G) polyclonal antibodies with cross-reactivity to urinary and fecal steroid metabolites were 6.6 pg/ml, 2.1 ng/ml, and 0.35 ng/ml, respectively. These assays allowed the determination of E1 C, PdG, and E3 G from the excreta with good reproducibility and accuracy...
May 17, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29768247/oocyte-triggering-day-progesterone-levels-and-endometrial-appearance-in-normoresponders-undergoing-ivf-icsi-cycles-a-hypothesis-and-a-study-protocol
#3
Charalampos Siristatidis, Panagiotis Drakopoulos, Paraskevi Vogiatzi, Vasilios Karageorgiou, George Daskalakis
In this report, we propose a study protocol capable of improving IVF outcomes in subfertile women with expected normal ovarian response. This proposal derives from conflicting published data and observations in our daily practice, concerning the negative impact of progesterone (P4) elevation at the day of oocyte triggering on pregnancy outcomes. Our hypothesis points to the combination of two previous "suspects" of reduced success after assisted reproduction techniques (ART) - the endometrium ultrasonographic parameters and P4 elevation at the day of oocyte triggering on their impact on pregnancy outcomes...
May 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29767754/mid-luteal-progesterone-a-marker-of-treatment-outcomes-in-couples-with-unexplained-infertility
#4
Karl R Hansen, Esther Eisenberg, Valerie Baker, Micah J Hill, Sixia Chen, Sara Talken, Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Nanette Santoro, Heping Zhang, Robert A Wild
Context: Adequate luteal phase progesterone exposure is necessary to induce endometrial changes required for a successful pregnancy outcome. The relationship between low mid-luteal progesterone concentration and the outcome of live birth in ovarian stimulation with intrauterine insemination (OS-IUI) treatments is not defined. Objective: To determine the level of mid-luteal progesterone portending a low chance of live birth following OS-IUI in couples with unexplained infertility...
May 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766148/endogenous-luteinizing-hormone-concentration-and-ivf-outcome-during-ovarian-stimulation-in-fixed-versus-flexible-gnrh-antagonist-protocols-an-rct
#5
Raffaella Depalo, Paolo Trerotoli, Annarosa Chincoli, Margherita Patrizia Vacca, Giuseppina Lamanna, Ettore Cicinelli
Background: Luteinizing hormone (LH) is essential for normal follicular development and oocyte maturation. In particular, fluctuations of LH during the follicular phase have a significant impact on morphological and functional changes of the oocyte and determine its meiotic status and ability to be fertilized. Objective: This prospective randomized controlled trial examined effects of endogenous follicular phase LH levels on oocyte maturity and IVF outcomes in fixed vs...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29763785/exposure-to-progesterone-previous-to-the-protocol-of-ovulation-synchronization-increases-the-follicular-diameter-and-the-fertility-of-suckled-bos-indicus-cows
#6
L M S Simões, R E Orlandi, J P M Massoneto, L A Scandiuzzi, B G Freitas, M R Bastos, J C Souza, J N S Sales
The objective was to evaluate the effect of injectable progesterone previous to the timed artificial insemination (TAI) protocol on follicular growth, ovulation and pregnancy rate of suckled Bos indicus cows. In experiment 1, 10 days before the beginning to TAI protocol (D-10), 431 suckled-anestrus Nelore cows (249 multiparous and 182 primiparous), were allocated to one of three treatments groups (control, P4i and P4iGnRH). At this moment, cows in the P4i and P4iGnRH group received 150 mg of injectable progesterone intramuscularly (Sincrogest injetável® , Ouro Fino, Brazil)...
May 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29762856/vitamin-d-a-steroid-hormone-with-progesterone-like-activity
#7
G Monastra, S De Grazia, L De Luca, S Vittorio, V Unfer
OBJECTIVE: This review is aimed at demonstrating the progesterone-like activity exerted by the active form of vitamin D, or calcitriol (1,25(OH)2D). To achieve this outcome, we compared the effects in vivo and in vitro exerted by progesterone and vitamin D, with a special focus on the female reproductive system and pregnancy. MATERIALS AND METHODS: This is a literature review of the most important articles published in English on vitamin D as a hormone, mainly found by MEDLINE...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29755412/association-between-progesterone-elevation-on-the-day-of-human-chronic-gonadotropin-trigger-and-pregnancy-outcomes-after-fresh-embryo-transfer-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles
#8
REVIEW
Sandro C Esteves, Gautam Khastgir, Jatin Shah, Kshitiz Murdia, Shweta Mittal Gupta, Durga G Rao, Soumyaroop Dash, Kundan Ingale, Milind Patil, Kunji Moideen, Priti Thakor, Pavitra Dewda
Progesterone elevation (PE) during the late follicular phase of controlled ovarian stimulation in fresh embryo transfer in vitro fertilization (IVF)/intracytoplasmic sperm injection cycles has been claimed to be associated with decreased pregnancy rates. However, the evidence is not unequivocal, and clinicians still have questions about the clinical validity of measuring P levels during the follicular phase of stimulated cycles. We reviewed the existing literature aimed at answering four relevant clinical questions, namely (i) Is gonadotropin type associated with PE during the follicular phase of stimulated cycles? (ii) Is PE on the day of human chorionic gonadotropin (hCG) associated with negative fresh embryo transfer IVF/intracytoplasmic sperm injection (ICSI) cycles outcomes in all patient subgroups? (iii) Which P thresholds are best to identify patients at risk of implantation failure due to PE in a fresh embryo transfer? and (iv) Should a freeze all policy be adopted in all the cycles with PE on the day of hCG? The existing evidence indicates that late follicular phase progesterone rise in gonadotropin releasing analog cycles is mainly caused by the supraphysiological stimulation of granulosa cells with exogenous follicle-stimulating hormone...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29754425/effects-of-oestradiol-for-luteal-phase-support-in-fresh-embryo-transfer-cycles-a-retrospective-cohort-study
#9
Wei Zhao, Yifeng Liu, Peng Xu, Yiqing Wu, Kai Chen, Xiaoyan Guo, Fan Zhang, Yun Huang, Linlin Zhu, Runjv Zhang, Dan Zhang
OBJECTIVE: Any benefit of oestradiol supplementation with progesterone for luteal support after fresh embryo transfer in in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycles remains controversial. In this study, we further addressed this question in cycles using gonadotropin-releasing hormone (GnRH) agonist for ovarian stimulation. DESIGN: A retrospective cohort study in a tertiary teaching and research hospital. PATIENT(S): A total of 1602 patients were given oestradiol valerate (E) in addition to progesterone(P) as luteal support...
May 12, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29754108/knowledge-of-women-issues-and-epilepsy-among-doctors-in-sudan
#10
Awab K Elnaeim, Mohamed K Elnaeim, Ismat B A Babiker
OBJECTIVE: The objective of this study was to assess the knowledge of doctors in Sudan about women issues related to epilepsy. METHODS: In this cross-sectional study that was conducted in Sudan during the period from October 2017 to December 2017, we used Google forms to collect data from 154 doctors using Knowledge of Women Issues and Epilepsy (KOWIE) II standardized questionnaire. RESULTS: Our studied group included house officers (n = 34), medical officers (n = 60), registrars (n = 52), and specialists (n = 8)...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29751813/ruptured-caesarean-scar-ectopic-pregnancy-a-diagnostic-dilemma-in-a-resource-limited-setting
#11
Atem Bethel Ajong, Bruno Kenfack, Valirie Ndip Agbor, Philip Nana Njotang
BACKGROUND: Caesarean scar pregnancy (CSP) remains a very rare form of ectopic pregnancy associated with serious life threatening obstetric complications and even death in case of late diagnosis and treatment. CASE PRESENTATION: We report a case of a ruptured caesarean scar pregnancy in a 29 year-old gravida 5, para 3 with a past obstetric history of two consecutive caesarean sections done 9 and 5 years ago respectively. The patient presented with intermittent lower abdominal pains on a 20 weeks gestation associated with mild epigastralgia and 2 previous episodes of mild pervaginal bleeding (2 and 1 months ago respectively before consultation) managed with injectable progesterone...
May 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29738749/the-vaginal-eukaryotic-dna-virome-and-preterm-birth
#12
Kristine M Wylie, Todd N Wylie, Alison G Cahill, George A Macones, Methodius G Tuuli, Molly J Stout
BACKGROUND: Despite decades of attempts to link infectious agents to preterm birth, an exact causative microbe or community of microbes remains elusive. Culture-independent sequencing of vaginal bacterial communities demonstrates community characteristics are associated with preterm birth, although none are specific enough to apply clinically. Viruses are important components of the vaginal microbiome and have dynamic relationships with vaginal bacterial communities. We hypothesized that vaginal eukaryotic DNA viral communities (the "vaginal virome") either alone or in the context of bacterial communities are associated with preterm birth...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29730813/predictive-factors-of-gestational-diabetes-in-pregnancies-following-assisted-reproductive-technology-a-nested-case-control-study
#13
Azam Kouhkan, Mohammad E Khamseh, Ashraf Moini, Reihaneh Pirjani, Ameneh Ebrahim Valojerdi, Arezoo Arabipoor, Roya Hosseini, Hamid Reza Baradaran
PURPOSE: To evaluate predictive factors for gestational diabetes mellitus (GDM) in singleton pregnancy following assisted reproductive technology (ART). METHODS: This nested case-control study was performed during October 2016-June 2017. Pregnant women who conceived following ART procedures referred to infertility clinic were selected and categorized into GDM and non-GDM based on ADA/IAPDSG criteria. The study variables including age, educational status, first-degree family history of chronic diseases, systolic and diastolic blood pressure, previous obstetric and perinatal outcomes, infertility history, and ART cycle characteristics were collected from medical records...
May 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29730538/sequential-concentrations-of-placental-growth-factor-and-haptoglobin-and-their-relation-to-oestrone-sulphate-and-progesterone-in-pregnant-spanish-purebred-mare
#14
K Satué, M Marcilla, P Medica, A Ferlazzo, E Fazio
The objectives of this study were to establish reference values for serum concentrations of placental growth factor (PlGF) and haptoglobin (Hp), and to analyze whether the levels of oestrone sulphate (E1 S) and progesterone (P4 ) are physiologically involved in the dynamic modifications of the above parameters in pregnant mares. A total of 30 healthy Spanish Purebred mares ranging in age 9.33 ± 3.31 years were studied during the 11 months of gestation. Serum concentrations of PlGF were detected by EIA, Hp using commercial Phase Haptoglobin assay and E1 S and P4 levels through RIA...
April 27, 2018: Theriogenology
https://www.readbyqxmd.com/read/29730033/incidence-and-biomarkers-of-pregnancy-spontaneous-abortion-and-neonatal-loss-during-an-environmental-stressor-implications-for-female-reproductive-suppression-in-the-cooperatively-breeding-meerkat
#15
Kristin A Dimac-Stohl, Charli S Davies, Nicholas M Grebe, Alexandra C Stonehill, Lydia K Greene, Jessica Mitchell, Tim Clutton-Brock, Christine M Drea
Meerkats are group-living, insectivorous herpestids in which subordinate members provide extensive care for the dominant female's young. In contrast to some cooperative breeders, subordinate female meerkats are physiologically able to reproduce and occasionally do so successfully; their attempts are more frequently 'suppressed' via eviction or infanticide by the dominant female. Spontaneous abortion and neonatal loss occur with some regularity, further negatively impacting reproductive success. Here, we compared the reproductive outcomes and endocrine profiles, including of serum progesterone (P4 ), serum estradiol (E2 ), and fecal glucocorticoid metabolites (fGCm), of dominant and subordinate dams residing within their clans in the Kalahari Desert of South Africa...
May 2, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29727537/-testicular-histology-does-not-affect-the-clinical-outcomes-of-icsi-in-men-with-non-obstructive-azoospermia
#16
Yan-Rong Kuai, Zhan-Ju He, Sheng Wang, Kai Zhang, Cheng Zeng, Liang Chen, Qing Xue, Jing Shang, Hui-Xia Yang, Yang Xu
Objective: To investigate whether testicular histology influences the clinical outcomes of intracytoplasmic sperm injection (ICSI) in men with non-obstructive azoospermia (NOA). METHODS: We retrospectively analyzed the clinical data about 73 cases of NOA undergoing ICSI, including 105 ICSI cycles and 79 embryo transfer cycles. The infertility of the patients was attributed to male factors only or both male and female tube factors and the females' age was ≤38 years...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726999/insulin-regulates-glycogen-synthesis-in-human-endometrial-glands-through-increased-gys2
#17
Clare A Flannery, Gina H Choe, Andrew G Fleming, Katherine M Cooke, Caitlin C Radford, Pinar H Kodaman, Michael J Jurczak, Richard G Kibbey, Hugh S Taylor
Context: Glycogen synthesis is a critical metabolic function of the endometrium to prepare for successful implantation and sustain embryo development. Yet regulation of endometrial carbohydrate metabolism is poorly characterized. While glycogen synthesis is attributed to progesterone, we previously found that the metabolic B isoform of insulin receptor is maximally expressed in secretory phase endometrium indicating a potential role of insulin in glucose metabolism. Objective: We sought to determine whether insulin or progesterone regulates glycogen synthesis in human endometrium...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29724668/rationale-for-current-and-future-progestin-based-therapies-to-prevent-preterm-birth
#18
REVIEW
Megan Weatherborn, Sam Mesiano
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. The only medicinal therapy currently recommended to prevent PTB is prophylactic progestin therapy in the form of micronized progesterone (P4) administered daily via vaginal suppository from the 24th to the 34th week of gestation or 17α-hydroxyprogesterone caproate in oil administered weekly from the 16th to the 36th week of gestation via an intramuscular injection. These therapies decrease the risk of PTB in women with an elevated risk of PTB indicated by a history of PTB or by a short cervix measured by sonography at mid-gestation...
April 11, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29705756/cohort-profile-china-respiratory-illness-surveillance-among-pregnant-women-crisp-2015-2018
#19
Liling Chen, Suizan Zhou, Zhongwei Zhang, Yan Wang, Lin Bao, Yayun Tan, Falin Sheng, Ying Song, Ran Zhang, A Danielle Iuliano, Mark G Thompson, Carolyn M Greene, Jun Zhang
PURPOSE: We established the China Respiratory Illness Surveillance among Pregnant women (CRISP) to conduct active surveillance for influenza-associated respiratory illness during pregnancy in China from 2015 to 2018. Among annual cohorts of pregnant women, we assess the incidence of acute respiratory illness (ARI), influenza-like illness (ILI), laboratory-confirmed influenza virus infection and the seroconversion proportion during the winter influenza season. We also plan to examine the effect of influenza virus infection on adverse pregnancy, delivery and infant health outcomes with cumulative data from the three annual cohorts...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29705365/progesterone-receptor-regulation-of-uterine-adaptation-for-pregnancy
#20
REVIEW
San-Pin Wu, Rong Li, Francesco J DeMayo
Progesterone acts through the progesterone receptor to direct physiological adaption of the uterus in preparation and completion of pregnancy. Genome-wide transcriptome and cistrome analyses have uncovered new members and novel modifiers of the progesterone signaling pathway. Genetically engineered mice allow functional assessment of newly identified genes in vivo and provide insights on the impact of progesterone receptor-dependent molecular mechanisms on pregnancy at the organ system level. Progesterone receptor isoforms collectively mediate progesterone signaling via their distinct and common downstream target genes, which makes the stoichiometry of isoforms relevant in modifying the progesterone activity...
April 25, 2018: Trends in Endocrinology and Metabolism: TEM
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