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Local anesthesics

Henrique Clasen Scarparo, Raimundo Nonato Maia, Emídio Alves Dos Santos Filho, Eduardo Costa Studart Soares, Fábio Wildson Gurgel Costa, Cristiane Sá Roriz Fonteles, Tácio Pinheiro Bezerra, Thyciana Rodrigues Ribeiro, Nirla Rodrigues Romero
BACKGROUND: Local anesthesic-related systemic toxicity mainly results from elevated plasma concentrations of these drugs. We hypothesized that intraoral injection of submaximum doses of mepivacaine does not lead to toxic levels of this drug in blood. This study evaluated the plasma levels of mepivacaine in third molars surgeries. METHODS: Twenty-one patients were randomly assigned into two groups: group I (two unilateral third molars; submaximum dose of mepivacaine 108mg with epinephrine 54μg) and group II (four third molars; submaximum dose of mepivacaine 216mg with epinephrine 108μg)...
January 18, 2016: Australian Dental Journal
R L Shirole, N L Shirole, M N Saraf
ETHNOPHARMACOLOGICAL RELEVANCE: Embelia ribes Burm. f. (Fam. Myrsinaceae) locally known as Vidanga have been used for treating tumors, ascites, bronchitis, jaundice, diseases of the heart and brain in traditional Indian medicine. However, no scientific studies providing new insights in its pharmacological properties with respect to acute respiratory distress syndrome have been investigated. AIM: The present investigation aimed to elucidate the effectiveness of Embelin isolated from Embelia ribes seeds on attenuation of LPS-induced acute respiratory distress syndrome in murine models...
June 20, 2015: Journal of Ethnopharmacology
Huseyin Tarhan, Ozgur Cakmak, Elif Unal, Ilker Akarken, Sitki Un, Rahmi Gokhan Ekin, Ersin Konyalioglu, Cemal Selcuk Isoglu, Ferruh Zorlu
INTRODUCTION: We assess the effect of video-based education on patient anxiety during transrectal prostate biopsy. METHODS: A total of 246 patients who underwent transrectal prostate biopsy were prospectively enrolled in the study. Group 1 included 123 patients who received both written and video-based education, while Group 2 included 123 patients who received only written instructions regarding prostate biopsies. State-Trait Anxiety Inventory (STAI) was used to assess state and trait anxiety (STAI-S/T) After completing the STAI-S and STAI-T questionnaires, all patients in Group 1 received written information and video-based education and they again completed STAI-S before the biopsy...
November 2014: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
W Wattanapanitch, M Fee, R Sarpeshkar
This paper describes an ultralow-power neural recording amplifier. The amplifier appears to be the lowest power and most energy-efficient neural recording amplifier reported to date. We describe low-noise design techniques that help the neural amplifier achieve input-referred noise that is near the theoretical limit of any amplifier using a differential pair as an input stage. Since neural amplifiers must include differential input pairs in practice to allow robust rejection of common-mode and power supply noise, our design appears to be near the optimum allowed by theory...
June 2007: IEEE Transactions on Biomedical Circuits and Systems
K J Wagner, C M Schulz, T Sprenger, T Pieper, F Heuser, C P Hohmann, M Wermke, J Martin, A Drzezga
BACKGROUND: Fluoro-D-deoxyglucose positron emission tomography (FDG-PET) is a standard procedure for interictal assessment and accurate pre-surgical evaluation of presumed epileptogenic zone localization. Profound sedation or general anesthesia is frequently required to reduce movement artefacts in young or cognitively impaired patients during image acquisition. This study compares the impact of propofol and sevoflurane anesthesia on overall quality of PET images, detectability of a hypometabolic lesion and demarcation of the detected lesion in pediatric patients suffering from focal epilepsia...
November 2013: Minerva Anestesiologica
R Hamerschmidt, M Mocellin, A Gasperin, J L G Faria, G Wiemes, V Kutianski, L Pasinato, W Soares
OBJECTIVES: The aim of this article is to illustrate the possibility of performing a cochlear implant with local anesthesia and sedation, the anesthesic technique and the advantages of that in comparison to a general anesthesia. MATERIAL AND METHODS: We describe two successful surgeries done with local anesthesia, including the neural telemetry and the conditions the patient presented after the surgery, with a very good recovery and no complications during and after the procedure...
2011: Revue de Laryngologie—Otologie—Rhinologie
Masahiro Sato, Eri Akasaka, Issei Saitoh, Masato Ohtsuka, Satoshi Watanabe
Ovarian follicle development is a complex process mediated by interactions between oocytes and surrounding follicular cells. In an ovary, oocytes are ultimately released from Graafian follicles, which develop from antral follicles localized near the surface of an ovary. To examine the molecular interaction between these 2 cell types, direct gene transfer to follicular cells as well as oocytes appears to be a promising approach, but few studies have applied this technique. The aim of the present study was to develop a technique for gene transfer to antral follicle cells based on their accessibility near the surface of an ovary...
June 2012: Systems Biology in Reproductive Medicine
C Balalau, F Popa, Carolina Negrei, P Andreianu
UNLABELLED: There are medical conditions where the etiology is not at the level of digestive system, but as a result of a distant lesion, determined by head trauma. The latter is a severe impact on the whole body, not only locally; it produces damages in the gastro-duodenal area mainly as acute stress ulcer. MATERIAL AND METHODS: Our study includes 4 cases of patients with multiple trauma, admitted in the "St. Pantelimon" Emergency Hospital, where, despite medication, they subsequently developed stress ulcer (Cushing ulcer)...
October 2011: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
O P Adudu, I Isa, F O Longway
BACKGROUND: New drugs and new modalities for intraoperative pain relief is the current trend in pain management. Aim : The study aims at examining the current trend in intraoperative pain relief in patients of pediatric age at the University of Benin Teaching Hospital (UBTH) and its implications for a developing economy such as Nigeria. MATERIALS AND METHODS: A retrospective study of 652 patients of pediatric age undergoing various surgical procedures was carried out in UBTH, Nigeria from January 2006 to June 2008...
July 2011: Annals of African Medicine
L Dubois, J de Lange, E Baas, J Van Ingen
Placement of dental implants in the interforaminal region of the edentulous mandible is considered a safe and routine surgical procedure. Hemorrhage in the floor of the mouth has been reported as a rare, potentially life-threatening complication related to the placement of implants in this region. In this case report the authors present an immediate and a delayed case of massive bleeding in the floor of the mouth after implant placement. This highly vascularized region is vulnerable and bleeding can be induced easily by instrumentation, causing a vascular trauma, usually by perforation of lingual periostium...
April 2010: International Journal of Oral and Maxillofacial Surgery
A L Santos Rodrigues, A C Silva Santana, L Crociati Meguins, D Felgueiras Rolo, M Lobato Ferreira, C A Ribeiro Braga
The subcapsular hematoma of the liver (SHL) are the results of injuries such as liver needle biopsy, liver trauma, pregnancy illnesses, parasitic diseases and others. The approach of these lesions depends on the various clinical presentations of subcapsular hematoma of the liver because it may be small with minimal clinical repercussion, managed only by ultrasound observation. In some situations the SHL may present large dimensions with hemodinamic instability. A case of subcapsular hematoma of the liver secondary to anesthetic intercostal blockade to control the postoperative pain after cholecystectomy is reported...
August 2009: Il Giornale di Chirurgia
A Alberte-González, R Gallego-Pinazo, M D Pinazo-Durán
No abstract text is available yet for this article.
May 2009: Archivos de la Sociedad Española de Oftalmología
Nilson Lopes da Fonseca Júnior, Lucia Miriam Dumont Lucci, Marianne Peixoto Sobral Giroldo Badessa, José Ricardo Carvalho Lima Rehder
PURPOSE: To compare pain on injection of two modified anesthetic lidocaine solutions for use in upper blepharoplasty: 2% lidocaine with 1:100,000 epinephrine, and 2% lidocaine with 1:100,000 epinephrine buffered 9:1 with 8.4% sodium bicarbonate. METHODS: In this prospective, double-masked study, 25 consecutive patients undergoing upper blepharoplasty were submitted to the anesthesic procedure. Each eyelid received one of two modified lidocaine solutions. Heart rate, systemic arterial pressure and oxygen saturation level were obtained before, during and after injection of two different anesthetic solutions...
March 2009: Arquivos Brasileiros de Oftalmologia
Jean-Marc Boivin, Ludivine Poupon-Lemarquis, Wafae Iraqi, Renaud Fay, Claudine Schmitt, Patrick Rossignol
BACKGROUND AND AIMS: The multiplicity of vaccine injections during childhood leads to iterative painful and stressful experiences which may lead in turn to anticipated pain and then possibly to a true needle phobia. We aimed at evaluating a multifactorial strategy of pain management combining pharmacological and non-pharmacological approaches during vaccination, as compared to usual care, in 4- to 12-year-old children. METHODS: In all, 239 children were enrolled by 25 family practitioners in an open-label study...
December 2008: Family Practice
G Hick, M Kirsch, M Janssens, R Larbuisson, J Joris, M Lamy
The one day clinic possesses its own structure and organisation; patient management is also specific. Preoperative visit and assessment are programmed at least 48 hours before anesthesia. Preoperative examinations and choice of anesthetic technique (sedation associated with local anesthesia or not, general anesthesia, locoregional anesthesia, or hypnosedation) are discussed and determined depending upon medical history, clinical examination, and type of procedure. General recommandations, instructions about fasting, interruption of some therapies, and introduction of new medication(s) are explained orally and also provided in a written document...
May 2007: Revue Médicale de Liège
R Luque Mialdea, R Martin-Crespo Izquierdo, L Díaz Gómez, L Moreno, C Carrero, J Cebrian
OBJECTIVES: Description of the retroperitoneoscopic approach in the conventional pyeloplasty for ureteropelvic junction obstruction in children. MATERIAL AND METHODS: From 1998 pyeloplasty assisted by retroperitoneoscopic approach (PARA) was performed in 30 patients. TECHNIQUE: Position in latero-dorsal decubitus and incision of 1 cm in angle costolumbar. We made retroperitoneoscopic space by ball dissection technique and 11 mm Hg pressure...
April 2007: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
I Dojcinovic, M Hugentobler, M Richter
INTRODUCTION: Ninety percent of oro-facial infections arise from a dental origin. The remaining 10% are the consequence of oro-pharyngeal, cutaneous or iatrogenic problems, such as in the present case. CASE REPORT: A 24-year-old patient consulted the emergency room because of a left mandibular swelling, accompagnied by trismus. Four days earlier, extraction of the 38 was performed under inferior alveolar nerve block anesthesia. A first drainage by vestibular approach was performed under general anesthesia...
November 2006: Revue de Stomatologie et de Chirurgie Maxillo-faciale
Vladimir Vegh, Jozef Cizmarik, Klaus Hahnenkamp
PURPOSE OF REVIEW: The aim of this review is to describe the pharmacology, toxicology and chemistry of the new group of local anesthetics of phenylcarbamic acid type. RECENT FINDINGS: Basic esters of alkoxy-substituted phenylcarbamic acid have shown high local anesthetic potency, while maintaining a relatively safe toxicity profile. Their potency uniquely increases with the decreasing pH of the external medium. This is of importance when using local anesthesics in inflamed tissues, where the action of common local anesthetics is often problematic...
October 2006: Current Opinion in Anaesthesiology
Laura Bracci, Irene Canini, Massimo Venditti, Massimo Spada, Simona Puzelli, Isabella Donatelli, Filippo Belardelli, Enrico Proietti
Type I IFN is a cytokine family endowed with multiple biological activities. In recent years, type I IFN has been demonstrated to play a crucial role in innate immunity, in dendritic cell maturation/differentiation and in the priming of primary antibody responses, especially when administered i.m. with a purified influenza vaccine. Due to the increasing interest in mucosal vaccination especially for respiratory infections, we investigated two different IFN-adjuvanted immunization protocols against influenza...
April 12, 2006: Vaccine
Nishant Kumar, Sharmila Jivan, Peter Thomas, Hamish McLure
PURPOSE: To review the frequency of hemorrhagic complications with sub-Tenon's anesthesia in patients on aspirin, warfarin or clopidogrel. SETTING: St. James's University Hospital, Leeds, United Kingdom. METHODS: Data were collected prospectively for patients having elective phacoemulsification under sub-Tenon's anesthesia. Seventy-five patients were on aspirin, 65 were on warfarin, and 40 were on clopidogrel. Seventy-five patients on no anticoagulants were used as the control group...
June 2006: Journal of Cataract and Refractive Surgery
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