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RANDOMIZED CONTROLLED TRIAL
Alexandra J Lansky, Dean J Kereiakes, Andreas Baumbach, Stephan Windecker, Yasin Hussain, Cody Pietras, Ovidiu Dressler, Ozgu Issever, Michael Curtis, Barry Bertolet, James P Zidar, Pieter C Smits, Victor Alfonso Jiménez Díaz, Brent McLaurin, Sjoerd Hofma, Ángel Cequier, Nabil Dib, Edouard Benit, Anthony Mathur, David Brogno, Jacques Berland, Joanna Wykrzykowska, Guy Piegari, Salvatore Brugaletta, Shigeru Saito, Martin B Leon
BACKGROUND: Accelerated endothelial healing after targeted antiproliferative drug delivery may limit the long-term inflammatory response of drug-eluting stents (DESs). The novel Supreme DES is designed to synchronize early drug delivery within 4 to 6 weeks of implantation, leaving behind a prohealing permanent base layer. Whether the Supreme DES is safe and effective in the short term and can improve long-term clinical outcomes is not known. METHODS: In an international, 2:1 randomized, single-blind trial, we compared treatment with Supreme DES to durable polymer everolimus-eluting stents (DP-EES) in patients with acute and chronic coronary syndromes...
June 2021: Circulation
#22
Fumika Nomoto, Sho Suzuki, Naoto Hashizume, Yusuke Kanzaki, Takuya Maruyama, Ayako Kozuka, Tatsuya Saigusa, Soichiro Ebisawa, Ayako Okada, Hirohiko Motoki, Kumiko Yahikozawa, Koichiro Kuwahara
The incidence of Dressler's syndrome after myocardial infarction (MI) has decreased in the reperfusion therapy era. Although guidelines recommend high-dose aspirin for treatment based on evidence from the pre-percutaneous coronary intervention (pre-PCI) era, bleeding and thrombotic concerns occurred upon aspirin administration after coronary stenting. A 69-year-old man with recent MI was admitted to our hospital. The patient presented with chest pain 1 week before admission. Electrocardiography revealed newly detected atrial fibrillation with no ST segment change...
March 2021: Journal of Cardiology Cases
#23
Weludo Ngwisanyi, Shirley F A P Moeng, Maeyane Moeng
INTRODUCTION AND IMPORTANCE: Cardiac injuries are associated with high mortality rates and most affected individuals succumb to their injuries before arrival to the hospital. Even though they have a higher fatality rate, penetrating cardiac injuries are relatively easy to diagnose and they have straightforward management protocols. On the other hand unexpected non-penetrating cardiac injuries, especially in haemodynamically stable patients, are not looked out for and can be difficult to diagnose...
March 2021: International Journal of Surgery Case Reports
#24
JOURNAL ARTICLE
Salahaddin Ubaid, Polyvios Demetriades, Heyman Luckraz, Benjamin Wrigley
No abstract text is available yet for this article.
December 2020: European Heart Journal. Case Reports
#25
REVIEW
Dirk Dressler, Fereshte Adib Saberi, Raymond L Rosales
Botulinum toxin (BT) is used to treat a large number of muscle hyperactivity syndromes. Its use in dystonia, however, is still one of the most important indications for BT therapy. When BT is injected into dystonic muscles, it produces a peripheral paresis which is localised, well controllable and follows a distinct and predictable time course of around 3 months. Adverse effects are always transient and usually mild, long-term application is safe. With this profile BT can be used to treat cranial dystonia, cervical dystonia and limb dystonia including writer's and musician's cramps...
April 2021: Journal of Neural Transmission
#26
RANDOMIZED CONTROLLED TRIAL
Gregg W Stone, Akiko Maehara, Ziad A Ali, Claes Held, Mitsuaki Matsumura, Lars Kjøller-Hansen, Hans Erik Bøtker, Michael Maeng, Thomas Engstrøm, Rune Wiseth, Jonas Persson, Thor Trovik, Ulf Jensen, Stefan K James, Gary S Mintz, Ovidiu Dressler, Aaron Crowley, Ori Ben-Yehuda, David Erlinge
BACKGROUND: Acute coronary syndromes most commonly arise from thrombosis of lipid-rich coronary atheromas that have large plaque burden despite angiographically appearing mild. OBJECTIVES: This study sought to examine the outcomes of percutaneous coronary intervention (PCI) of non-flow-limiting vulnerable plaques. METHODS: Three-vessel imaging was performed with a combination intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) catheter after successful PCI of all flow-limiting coronary lesions in 898 patients presenting with myocardial infarction (MI)...
November 17, 2020: Journal of the American College of Cardiology
#27
JOURNAL ARTICLE
Edgar García-Cruz, Daniel Manzur-Sandoval, Emmanuel Adrián Lazcano-Díaz, Elizabeth Soria-Castro, Silvia Jiménez-Becerra
We present the case of a patient with myocardial infarction and COVID-19 disease who developed hemorrhagic pericardial effusion and cardiac tamponade. The differential diagnosis included post-infarction pericarditis and mechanical complications, thrombolysis, Dressler syndrome, and viral pericarditis. The histopathologic examination of the pericardial tissue sample and electron microscopic examination established the diagnosis. ( Level of Difficulty: Advanced. ).
October 2020: JACC. Case reports
#28
REVIEW
Anastasia Dressler, Petra Trimmel-Schwahofer
PURPOSE: Ketogenic diets (KD) are high-fat, low-carbohydrate therapies, established in the treatment for drug-resistant epilepsy in childhood since the 1920ies. This review focuses on the use of ketogenic diet therapies in young childhood with an emphasis on the most recent advances. FINDINGS: The KD has been used effectively and safely in childhood, and has increasingly been offered in infancy during the last decade. The introduction of a KD is recommended with a fixed fat/ non-fat ratio of 3:1, modified if necessary...
August 2020: Epilepsy Research
#29
JOURNAL ARTICLE
Paula Ruth L Siongco, Raymond L Rosales, Austen Peter Moore, Rainer Freynhagen, Kimiyoshi Arimura, Petr Kanovsky, Ryuji Kaji, Hubert H Fernandez, Dirk Dressler
Apart from the known efficacy of Botulinum Neurotoxin Type A (BoNT/A) in hyperactive striated and smooth muscles, different pain states have become potential targets of toxin effects. This present study determined the comparative toxin effectiveness in pain reduction among those patients injected with BoNT/A in muscle-based and in non-muscle-based conditions. Randomized controlled trials (RCTs) on the effect of BoNT/A on selected pain conditions were included. The conditions were spasticity and dystonia for muscle-based pain...
June 2020: Journal of Neural Transmission
#30
JOURNAL ARTICLE
Ariane Klein, Jens Klotsche, Boris Hügle, Kirsten Minden, Anton Hospach, Frank Weller-Heinemann, Tobias Schwarz, Frank Dressler, Ralf Trauzeddel, Markus Hufnagel, Ivan Foeldvari, Michael Borte, Jasmin Kuemmerle-Deschner, Jürgen Brunner, Prasad Thomas Oommen, Dirk Föll, Klaus Tenbrock, Andreas Urban, Gerd Horneff
OBJECTIVE: Using data from the German Biologics JIA Registry (BIKER), long-term safety of biologics for systemic-onset JIA with regard to adverse events of special interest was assessed. METHODS: Safety assessments were based on adverse event reports after first dose through 90 days after last dose. Rates of adverse event, serious adverse event and 25 predefined adverse events of special interest were analysed. Incidence rates were compared for each biologic against all other biologics combined applying a mixed-effect Poisson model...
September 1, 2020: Rheumatology
#31
RANDOMIZED CONTROLLED TRIAL
Dietrich Wilhelm Beelen, Rudolf Trenschel, Matthias Stelljes, Christoph Groth, Tamás Masszi, Péter Reményi, Eva-Maria Wagner-Drouet, Beate Hauptrock, Peter Dreger, Thomas Luft, Wolfgang Bethge, Wichard Vogel, Fabio Ciceri, Jacopo Peccatori, Friedrich Stölzel, Johannes Schetelig, Christian Junghanß, Christina Grosse-Thie, Mauricette Michallet, Hélène Labussiere-Wallet, Kerstin Schaefer-Eckart, Sabine Dressler, Goetz Ulrich Grigoleit, Stephan Mielke, Christof Scheid, Udo Holtick, Francesca Patriarca, Marta Medeot, Alessandro Rambaldi, Maria Caterina Micò, Dietger Niederwieser, Georg-Nikolaus Franke, Inken Hilgendorf, Nils Rudolf Winkelmann, Domenico Russo, Gérard Socié, Régis Peffault de Latour, Ernst Holler, Daniel Wolff, Bertram Glass, Jochen Casper, Gerald Wulf, Helge Menzel, Nadezda Basara, Maria Bieniaszewska, Gernot Stuhler, Mareike Verbeek, Sandra Grass, Anna Paola Iori, Juergen Finke, Fabio Benedetti, Uwe Pichlmeier, Claudia Hemmelmann, Michael Tribanek, Anja Klein, Heidrun Anke Mylius, Joachim Baumgart, Monika Dzierzak-Mietla, Miroslaw Markiewicz
BACKGROUND: Further improvement of preparative regimens before allogeneic haemopoietic stem cell transplantation (HSCT) is an unmet medical need for the growing number of older or comorbid patients with acute myeloid leukaemia or myelodysplastic syndrome. We aimed to evaluate the efficacy and safety of conditioning with treosulfan plus fludarabine compared with reduced-intensity busulfan plus fludarabine in this population. METHODS: We did an open-label, randomised, non-inferiority, phase 3 trial in 31 transplantation centres in France, Germany, Hungary, Italy, and Poland...
January 2020: Lancet Haematology
#32
JOURNAL ARTICLE
Henryk Dreger, Marcel Haug, Martin Möckel
No abstract text is available yet for this article.
August 9, 2019: Deutsches Ärzteblatt International
#33
JOURNAL ARTICLE
Isabel Durães Campos, Alberto Salgado, Pedro Azevedo, Catarina Vieira
A 46-year-old man was admitted to the emergency department with fever and pleuritic thoracic pain. Six weeks prior to admission, the patient had undergone cardiac surgery. The ECG showed diffuse ST segment elevation and PR segment depression. The blood tests revealed increased inflammatory markers and negative myocardial necrosis markers. Pericardial and left-sided pleural effusion were noted. Sterile blood cultures were negative. Hence, the hypothesis of Dressler's syndrome was established. The patient improved clinically and analytically with a short course of anti-inflammatory therapy and was discharged with colchicine and acetylsalicylic acid...
May 21, 2019: BMJ Case Reports
#34
RANDOMIZED CONTROLLED TRIAL
Anastasia Dressler, Franz Benninger, Petra Trimmel-Schwahofer, Gudrun Gröppel, Barbara Porsche, Klaus Abraham, Angelika Mühlebner, Sharon Samueli, Christoph Male, Martha Feucht
OBJECTIVE: To compare the efficacy and safety of the ketogenic diet (KD) with standard adrenocorticotropic hormone (ACTH) treatment in infants with West syndrome. METHODS: In this parallel-cohort (PC) randomized controlled trial (RCT), infants were randomly allocated to KD or high-dose ACTH. Those who could not be randomized were followed in a PC. Primary end point was electroclinical remission at day 28. Secondary end points were time to electroclinical remission, relapse after initial response, seizure freedom at last follow-up, adverse effects, and developmental progress...
March 2019: Epilepsia
#35
JOURNAL ARTICLE
Sharon Samueli, Anastasia Dressler, Gudrun Gröppel, Theresa Scholl, Martha Feucht
Tuberous sclerosis complex (TSC) is the most common cause of West syndrome (WS). Currently available treatment options are ineffective in the majority of affected infants and/or associated with potential serious side effects. Based on the assumption that mTOR overactivation results in increased neuroexcitability in TSC, mTOR inhibitors have been studied as antiseizure therapy. As a result, everolimus recently received approval for the adjunctive treatment of patients aged ≥2 years with refractory TSC-associated focal and secondary generalized seizures...
September 2018: Epilepsia
#36
JOURNAL ARTICLE
Gabrielle Dressler, Sarah A Kelly
Patients are increasingly turning to medical crowdfunding as a way to cover their healthcare costs. In the case of Charlie Gard, an infant born with encephalomyopathic mitochondrial DNA depletion syndrome, crowdfunding was used to finance experimental nucleoside therapy. Although this treatment was not provided in the end, we will argue that the success of the Gard family's crowdfunding campaign reveals a number of potential ethical concerns. First, this case shows that crowdfunding can change the way in which communal healthcare resources are allocated...
July 2018: Journal of Medical Ethics
#37
JOURNAL ARTICLE
Dirk Dressler, Roongroj Bhidayasiri, Saeed Bohlega, Pedro Chana, Hsin Fen Chien, Tae Mo Chung, Carlo Colosimo, Markus Ebke, Klemens Fedoroff, Bernd Frank, Ryuji Kaji, Petr Kanovsky, Serdar Koçer, Federico Micheli, Olga Orlova, Sebastian Paus, Zvezdan Pirtosek, Maja Relja, Raymond L Rosales, José Alberto Sagástegui-Rodríguez, Paul W Schoenle, Gholam Ali Shahidi, Sofia Timerbaeva, Uwe Walter, Fereshte Adib Saberi
Spasticity is a symptom occurring in many neurological conditions including stroke, multiple sclerosis, hypoxic brain damage, traumatic brain injury, tumours and heredodegenerative diseases. It affects large numbers of patients and may cause major disability. So far, spasticity has merely been described as part of the upper motor neurone syndrome or defined in a narrowed neurophysiological sense. This consensus organised by IAB-Interdisciplinary Working Group Movement Disorders wants to provide a brief and practical new definition of spasticity-for the first time-based on its various forms of muscle hyperactivity as described in the current movement disorders terminology...
April 2018: Journal of Neurology
#38
REVIEW
F F Dressler, J Brado, K E Odening
In the healthy heart, physiological heterogeneities in structure and in electrical and mechanical activity are crucial for normal, efficient excitation and pumping. Alterations of heterogeneity have been linked to arrhythmogenesis in various cardiac disorders such as long QT syndrome (LQTS). This inherited arrhythmia disorder is caused by mutations in different ion channel genes and is characterized by (heterogeneously) prolonged cardiac repolarization and increased risk for ventricular tachycardia, syncope and sudden cardiac death...
March 2018: Herzschrittmachertherapie & Elektrophysiologie
#39
JOURNAL ARTICLE
Leonida Compostella, Caterina Compostella, Nicola Russo, Tiziana Setzu, Sabino Iliceto, Fabio Bellotto
During outpatient cardiac rehabilitation after an acute coronary syndrome or after an episode of congestive heart failure, a careful, periodic evaluation of patients' clinical and hemodynamic status is essential. Simple and traditional cardiac auscultation could play a role in providing useful prognostic information.Reduced intensity of the first heart sound (S1), especially when associated with prolonged apical impulse and the appearance of added sounds, may help identify left ventricular (LV) dysfunction or conduction disturbances, sometimes associated with transient myocardial ischemia...
August 4, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
#40
COMPARATIVE STUDY
Benjamin Berte, Christine Attenhofer Jost, Dominik Maurer, Anja Fäh-Gunz, Xavier Pillois, Barbara Naegeli, Monica Pfyffer, Gabor Sütsch, Christoph Scharf
AIMS: The use of left atrial appendage (LAA) occluders in atrial fibrillation is increasing. There are few data on the comparison between transesophageal echocardiography (TEE) and computed tomography (MDCT) assessing peridevice flow and outcome of electrical cardioversion (ECV) in these patients. METHODS AND RESULTS: Single-center prospective registry from 2009 to 2015 including all LAA occluders to analyze success and complications during implantation and follow-up...
October 2017: Journal of Cardiovascular Electrophysiology
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