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Dressler's Syndrome

E Stephenson, K Savvatis, S A Mohiddin, F M Marelli-Berg
T-cell-mediated immunity has been linked not only to a variety of heart diseases, including classic inflammatory diseases such as myocarditis and post-myocardial infarction (Dressler's) syndrome, but also to conditions without an obvious inflammatory component such as idiopathic dilated cardiomyopathy and hypertensive cardiomyopathy. It has been recently proposed that in all these conditions, the heart becomes the focus of T-cell-mediated autoimmune inflammation following ischaemic or infectious injury. For example, in acute myocarditis, an inflammatory disease of heart muscle, T-cell responses are thought to arise as a consequence of a viral infection...
September 2, 2016: British Journal of Pharmacology
Nicolas Bettinger, Tullio Palmerini, Adriano Caixeta, Ovidiu Dressler, Claire Litherland, Dominic P Francese, Gennaro Giustino, Roxana Mehran, Martin B Leon, Gregg W Stone, Philippe Généreux
AIM: We sought to investigate the prognostic impact of the SYNTAX (Synergy between PCI with TAXUS and Cardiac Surgery) score (SS) on 1-year clinical outcomes in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) undergoing medical therapy only. METHODS AND RESULTS: Among the 13 819 patients enrolled in the ACUITY trial and undergoing coronary angiogram, 4491 patients were treated with medical therapy as the initial strategy. Of those, baseline SS and complete angiographic analysis were available in 1275 patients...
October 21, 2016: European Heart Journal
N Dressler, A Chandra, L Aguirre Dávila, L M Spineli, C Schippert, F von Versen-Höynck
PURPOSE: Animal and human studies suggest that vitamin D regulates functions of the reproductive system. Vitamin D deficiency is prevalent in women of reproductive age. Vitamin D status has been associated with in vitro fertilisation outcome, features of polycystic ovarian syndrome (PCOS) and endometriosis. The aims of our study were to investigate the prevalence of vitamin D deficiency of infertile women living in central Germany, to identify risk factors for vitamin D deficiency and to specify seasonal variations of vitamin D status...
April 2016: Archives of Gynecology and Obstetrics
Giora Weisz, Philippe Généreux, Andres Iñiguez, Aleksander Zurakowski, Michael Shechter, Karen P Alexander, Ovidiu Dressler, Anna Osmukhina, Stefan James, E Magnus Ohman, Ori Ben-Yehuda, Ramin Farzaneh-Far, Gregg W Stone
BACKGROUND: Incomplete revascularisation is common after percutaneous coronary intervention and is associated with increased mortality and adverse cardiovascular events. We aimed to assess whether adjunctive anti-ischaemic pharmacotherapy with ranolazine would improve the prognosis of patients with incomplete revascularisation after percutaneous coronary intervention. METHODS: We performed this multicentre, randomised, parallel-group, double-blind, placebo-controlled, event-driven trial at 245 centres in 15 countries in Europe, Israel, Russia, and the USA...
January 9, 2016: Lancet
T Eisen, A-B Loembé, Y Shparyk, N MacLeod, R J Jones, M Mazurkiewicz, G Temple, H Dressler, I Bondarenko
BACKGROUND: This exploratory study evaluated the safety/efficacy of nintedanib or sunitinib as first-line therapy in patients with advanced renal cell carcinoma (RCC). METHODS: Ninety-six patients were randomised (2:1) to either nintedanib (200 mg twice daily) or sunitinib (50 mg kg(-1) once daily (4 weeks on treatment; 2 weeks off)). Primary endpoint was progression-free survival (PFS) at 9 months. P-values reported are descriptive only; the study was not powered for such comparisons...
October 20, 2015: British Journal of Cancer
Alessandro Feola, Noè De Stefano, Bruno Della Pietra
Postinfarction pericarditis can be classified as "early," referred to as pericarditis epistenocardica, or "delayed," referred to as Dressler syndrome. The incidence of postinfarction pericarditis has decreased to <5% since the introduction of reperfusion therapies and limitation of infarct size. We report on a 57-year-old man who suffered sudden cardiac death as a result of acute myocardial infarction. Autopsy revealed an area of previous infarction and fibrinous pericarditis related to the previous infarction, leading to a diagnosis of Dressler syndrome...
2015: Case Reports in Medicine
Anastasia Dressler, Margherita Bozza, Valentina Perelli, Francesca Tinelli, Andrea Guzzetta, Giovanni Cioni, Stefania Bargagna
BACKGROUND: Down syndrome is the most commonly occurring chromosomal condition with a prevalence of 11.2-10000 life-births in Europe. The most important concern consists of various degrees of intellectual disability and sensory deficits. The overall prevalence of ophthalmologic abnormalities has been reported to be as high as 46-100%. Impairment of vision potentially hampers the capacity of learning and communication and thus of social integration. The aim of our study is to assess prospectively the occurrence of vision problems in patients with DS with special emphasis on adaptive behaviour and cognition...
August 2015: Wiener Klinische Wochenschrift
Anastasia Dressler, Petra Trimmel-Schwahofer, Eva Reithofer, Angelika Mühlebner, Gudrun Gröppel, Edith Reiter-Fink, Franz Benninger, Roland Grassl, Martha Feucht
UNLABELLED: There is strong evidence for the use of the ketogenic diet (KD) in Dravet syndrome (DS). The purpose of this study was to evaluate both effectiveness and tolerability in comparison with various antiepileptic drugs (AEDs). METHODS: 32 children (19 males) with genetically confirmed DS treated at our center since 1999 were analyzed retrospectively. Data collected from patients' files included type of mutation, age at treatment initiation and treatment lag, overall seizure frequency and frequency of different seizure types, especially prolonged seizures and status epilepticus (SE)...
January 2015: Epilepsy Research
Christoph M Happel, Kai Thorsten Laser, Matthias Sigler, Deniz Kececioglu, Eugen Sandica, Nikolaus A Haas
INTRODUCTION: In the search for a biodegradable device that leaves nothing but the tissue of the patient after complete endotheliazation and absorption, the BioSTAR® device was introduced in 2007 (CE Mark in European community and HPB in Canada) for ASD and PFO closure. It consists of a metal framework covered by a biodegradable membrane generated from a layer of porcine collagen that is broken down and absorbed over time. In a sheep model, the results were promising, showing complete closure of the defect with degradation of approximately 90% of the implanted membrane material after two years...
May 2015: Catheterization and Cardiovascular Interventions
António Tralhão, Diogo Cavaco, Marisa Trabulo, António M Ferreira
A 76-year-old woman with idiopathic dilated cardiomyopathy and left bundle branch block was admitted for biventricular pacemaker implantation. The procedure was complicated by perforation of a coronary sinus tributary vein and ensuing pericardial effusion without tamponade. Three months later, she presented with fever, pleuritic chest pain and functional class worsening. Pericardial and pleural effusions were noted. Sterile blood and pleural fluid cultures and failure to respond to antibiotic therapy led to the hypothesis of a Dressler-like syndrome...
2014: BMJ Case Reports
Johanna C M Schilder, J Gert van Dijk, Dirk Dressler, Johannes H T M Koelman, Johan Marinus, Jacobus J van Hilten
Tonic dystonia of the limbs in complex regional pain syndrome (CRPS) is associated with considerable disability. Treatment options are scarce. Botulinum toxin (BoNT) is sometimes used, but the effect is often said to be disappointing. However, this notion stems from case reports and clinicians' opinions but has never been formally studied. We therefore investigated responsiveness to BoNT in CRPS patients with tonic dystonia. We injected the extensor digitorum brevis (EDB) muscle with BoNT-A in 17 patients with CRPS and tonic dystonia to compare the response between affected and unaffected legs...
July 2014: Journal of Neural Transmission
Dirk Dressler
Identification of drug exposure as a cause for dystonia is important since cessation of the causative agent offers a chance for remission. We describe two patients with a cranial, cervical, pharyngo-laryngeal and axial dystonia, akathisia, breathing dysrhythmias together with depression and anxiety. Both patients were started on the calcium channel blocker (CCB) amlodipine 1 month before symptom onset. They symptoms were non-acute and due to CCBs well-known D2 antagonism; hence they were classified as a tardive dystonic syndrome...
April 2014: Journal of Neural Transmission
Cara Hendry, Chee K Liew, Anoop Chauhan, Joseph Zacharias
Myocardial rupture is an uncommon and life threatening event which may occur in the setting of acute myocardial infarction. In this case report we describe a rare instance of a patient presenting with signs of ventricular rupture as a late presentation of myocardial infarction. The findings of cardiac computed tomography are demonstrated as well as intra-operative images. Despite its very high attendant mortality risk, our patient's life was saved by the earlier development of Dressler's syndrome, an intense inflammatory process in the pericardium, resulting in dense adhesions, which effectively tamponaded the leak from the ventricular free wall rupture and prevented extravasation...
September 2012: European Heart Journal. Acute Cardiovascular Care
Christian Dorfer, Thomas Czech, Angelika Mühlebner-Fahrngruber, Aygül Mert, Gudrun Gröppel, Klaus Novak, Anastasia Dressler, Edith Reiter-Fink, Tatjana Traub-Weidinger, Martha Feucht
OBJECT: Outcomes following functional hemispherotomy in patients with drug-resistant epilepsy have been well described. However, studies reporting long-term longitudinal outcomes after subhemispheric disconnective epilepsy surgery are still limited. METHODS: The authors conducted a retrospective review of prospectively collected data of 10 children who underwent temporoparietooccipital (TPO) disconnective surgery at the Vienna Pediatric Epilepsy Center. RESULTS: There were 3 males and 7 females (median age 8...
June 2013: Neurosurgical Focus
Ana Westenberger, Raymond L Rosales, Sascha Heinitz, Karen Freimann, Lilian V Lee, Roland D Jamora, Arlene R Ng, Aloysius Domingo, Katja Lohmann, Uwe Walter, Uta Gölnitz, Arndt Rolfs, Inga Nagel, Gabriele Gillessen-Kaesbach, Reiner Siebert, Dirk Dressler, Christine Klein
BACKGROUND: Recessive X-linked dystonia-parkinsonism almost exclusively affects men. We investigated the genetic mechanisms causing this disorder in a female patient. METHODS: We confirmed the presence of an X-linked dystonia-parkinsonism-specific change in our patient by sequencing. In addition, we employed quantitative real-time PCR and array comparative genomic hybridization to determine the patient's X-chromosome copy number. RESULTS: The patient's sequence electropherogram suggested a higher amount of the mutated allele compared with the wild-type allele...
May 2013: Movement Disorders: Official Journal of the Movement Disorder Society
Kathleen Goossens, Axel Caenepeel, Yves De Greef
Percutaneous catheter ablation is now a well-established, efficient and effective treatment strategy for recurrent, symptomatic atrial fibrillation (AF). Major complications though occur in up to 5.9% of procedures. New complications still continue to emerge. Delayed tamponade is only recently recognized as a major complication after ablation. We present a 68-year-old female patient who develops cardiac tamponade requiring pericardiocentesis 12 days after AF ablation. Subsequently, the tamponade triggers a Dressler syndrome with repetitive pleural effusions only adequately responsive to corticosteroids...
October 2012: Acta Cardiologica
T A Ryzhova, N A Bichan
AIM: to elucidate risk factors and special features of myocardial infarction (MI) in elderly women. MATERIAL AND METHODS: We included into the study 217 women aged 34 to 89 years who had Q-wave or non Q-wave MI and were admitted for treatment in the cardiology department. These patients were divided into two age groups - younger than 60 years (n=79, mean age 51.6+/-5.9 years) and more or equal 60 years (n=138, mean age 71.7+/-6.9 years). RESULTS: The following risk factors were more frequent among older women: hypertension (95...
2012: Kardiologiia
Gagangeet Sandhu, Pavan Mankal, Isha Gupta, Adrian Tagani, Aditi Ranade, James Jones, Anip Bansal
We present here a case of an asymptomatic end-stage renal disease (ESRD) patient, who had an unexplained persistent mild leukocytosis in the setting of an extremely high ferritin level (8,997 ng/ml; reference range: 12 - 300 ng/ml) 3 weeks after she suffered from a myocardial infarction (MI). Infection as the cause of these laboratory abnormalities was ruled out. A week later, the patient was noted to have asymptomatic hypotension (100/60 mmHg; her baseline blood pressure was 120/70 mmHg) during a maintenance hemodialysis session...
July 2014: Clinical Nephrology
HuiJuan Lv, Myra A Lipes
For more than a half century, autoimmunity has been linked to a diverse array of heart diseases, including rheumatic carditis, myocarditis, Chagas' cardiomyopathy, post-myocardial infarction (Dressler's) syndrome, and idiopathic dilated cardiomyopathy. Why the heart is targeted by autoimmunity in these seemingly unrelated conditions has remained enigmatic. Here, we discuss our recent studies indicating that this susceptibility is mediated by impaired negative selection of autoreactive α-myosin heavy-chain-specific CD4(+) T cells in the thymus of both mice and humans...
July 2012: Trends in Cardiovascular Medicine
E I Schwarz, C Giambarba
A 63-year-old man was admitted with fever and bilateral pulmonary infiltrates accompanied by pleural effusion a few days after ST-segment elevation myocardial infarction treated with primary angioplasty and stent implantation. The diagnosis of early postmyocardial infarction syndrome (Dressler's syndrome) with pulmonary infiltrates was made after ruling out possible differential diagnosis such as pneumonia and congestive heart failure. Infiltrates and markers of inflammation resolved rapidly with systemic steroid therapy...
August 8, 2012: Praxis
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