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https://www.readbyqxmd.com/read/29782041/meta-analysis-of-brain-mechanisms-of-chewing-and-clenching-movements
#1
Chia-Shu Lin
BACKGROUND: Functional magnetic resonance imaging (fMRI) is widely used for investigating brain activation patterns associated with chewing and clenching movements. Whether studies consistently identify similar brain loci engaged in these movements remains unknown. OBJECTIVE: We investigated the consistency with which specific brain loci were reported to be activated during teeth-occluding movements, using the activation likelihood estimation (ALE) meta-analysis...
May 21, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29781383/preferential-spinal-cord-volume-loss-in-primary-progressive-multiple-sclerosis
#2
Charidimos Tsagkas, Stefano Magon, Laura Gaetano, Simon Pezold, Yvonne Naegelin, Michael Amann, Christoph Stippich, Philippe Cattin, Jens Wuerfel, Oliver Bieri, Till Sprenger, Ludwig Kappos, Katrin Parmar
BACKGROUND: Little is known on longer term changes of spinal cord volume (SCV) in primary progressive multiple sclerosis (PPMS). OBJECTIVE: Longitudinal evaluation of SCV loss in PPMS and its correlation to clinical outcomes, compared to relapse-onset multiple sclerosis (MS) subtypes. METHODS: A total of 60 MS age-, sex- and disease duration-matched patients (12 PPMS, each 24 relapsing-remitting (RRMS) and secondary progressive MS (SPMS)) were analysed annually over 6 years of follow-up...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29781342/dw-mri-and-dce-mri-are-of-complementary-value-in-predicting-pathologic-response-to-neoadjuvant-chemoradiotherapy-for-esophageal-cancer
#3
Sophie E Heethuis, Lucas Goense, Peter S N van Rossum, Alicia S Borggreve, Stella Mook, Francine E M Voncken, Annemarieke Bartels-Rutten, Berthe M P Aleman, Richard van Hillegersberg, Jelle P Ruurda, Gert J Meijer, Jan J W Lagendijk, Astrid L H M W van Lier
PURPOSE: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. MATERIAL AND METHODS: Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2-3) (per) and after completion of nCRT, but prior to esophagectomy (post)...
May 21, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29780855/magnetic-resonance-imaging-and-histopathological-visualization-of-human-dural-lymphatic-vessels
#4
Seung-Kwon Ha, Govind Nair, Martina Absinta, Nicholas J Luciano, Daniel S Reich
In this protocol, we describe a method to visualize and map dural lymphatic vessels in-vivo using magnetic resonance imaging (MRI) and ex-vivo using histopathological techniques. While MRI protocols for routine imaging of meningeal lymphatics include contrast-enhanced T2-FLAIR and T1- weighted black-blood imaging, a more specific 3D mapping of the lymphatic system can be obtained by administering two distinct gadolinium-based MRI contrast agents on different days (gadofosveset and gadobutrol) and subsequently processing images acquired before and after administration of each type of contrast...
April 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29780447/fluorinated-eu-ii-based-multimodal-contrast-agent-for-temperature-and-redox-responsive-magnetic-resonance-imaging
#5
Lina A Basal, Matthew D Bailey, Jonathan Romero, Meser M Ali, Lyazat Kurenbekova, Jason Yustein, Robia G Pautler, Matthew J Allen
Magnetic resonance imaging (MRI) using redox-active, EuII -containing complexes is one of the most promising techniques for noninvasively imaging hypoxia in vivo . In this technique, positive ( T 1 -weighted) contrast enhancement persists in areas of relatively low oxidizing ability, such as hypoxic tissue. Herein, we describe a fluorinated, EuII -containing complex in which the redox-active metal is caged by intramolecular interactions. The position of the fluorine atoms enables temperature-responsive contrast enhancement in the reduced form of the contrast agent and detection of the oxidized contrast agent via MRI in vivo ...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29780249/-in-vivo-mr-imaging-of-tumor-associated-macrophages-the-next-frontier-in-cancer-imaging
#6
REVIEW
Runze Yang, Susobhan Sarkar, V Wee Yong, Jeff F Dunn
There is a complex interaction between cancer and the immune system. Tumor-associated macrophages (TAMs) can be subverted by the cancer to adopt a pro-tumor phenotype to aid tumor growth. These anti-inflammatory, pro-tumor TAMs have been shown to contribute to a worsened outcome in several different types of cancer. Various strategies aimed at combating the pro-tumor TAMs have been developed. Several therapies, such as oncolytic viral therapy and high-intensity focused ultrasound, have been shown to stimulate TAMs and suppress tumor growth...
2018: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/29780233/spinal-meningeal-melanocytoma-in-a-5-year-old-child-a-case-report-and-review-of-literature
#7
Ahmed M Salah El-Din, Hashem M Aboul-Ela, Mohamed F Alsawy, Ahmed Koheil, Ahmed H Ashry
Background: Meningeal melanocytoma is considered a rare lesion arising from leptomeningeal melanocytes. Nearly two thirds of meningeal melanocytomas were reported in the intracranial compartment and the remaining one third in the spine. Spinal melanocytomas can be extradural or intradural, with extradural variant being more common, and the majority of cases have been single reports. Methods: A 5-year-old male presented with a 4-month history of non-radiating low back pain persistent at rest, with otherwise non-remarkable medical history...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29779960/comparison-of-hemodialysis-arteriovenous-fistula-blood-flow-rates-measured-by-doppler-ultrasound-and-phase-contrast-magnetic-resonance-imaging
#8
Yong He, Yan-Ting Shiu, Daniel B Pike, Prabir Roy-Chaudhury, Alfred K Cheung, Scott A Berceli
OBJECTIVE: The objective of this study was to compare blood flow rates measured by Doppler ultrasound (DUS) and phase-contrast magnetic resonance imaging (MRI) in patients having a hemodialysis arteriovenous fistula (AVF) and to identify scenarios in which there was significant discordance between these two approaches. METHODS: Blood flow rates in the proximal artery (PA) and draining vein (DV) of newly created upper extremity AVFs were measured and compared using DUS and phase-contrast MRI at 1 day, 6 weeks, and 6 months postoperatively...
May 17, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29779758/assessing-venous-thrombus-in-renal-cell-carcinoma-preliminary-results-for-unenhanced-3d-ssfp-mri
#9
L C Adams, B Ralla, G Engel, G Diederichs, B Hamm, J Busch, F Fuller, M R Makowski
AIM: To test the potential of unenhanced cardiac- and respiratory-motion-corrected three-dimensional steady-state free precession (3D-SSFP) magnetic resonance imaging (MRI) for the assessment of inferior vena cava (IVC) thrombus in patients with clear-cell renal cell carcinoma (cRCC), compared to standard contrast-enhanced (CE)-MRI and CE-computed tomography (CT). MATERIALS AND METHODS: Eighteen patients with cRCC and IVC thrombus, who received CE-MRI and 3D-SSFP at 1...
May 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29779258/hyperpolarized-porous-silicon-nanoparticles-potential-theragnostic-material-for-%C3%A2-%C3%A2-si-magnetic-resonance-imaging
#10
Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy Son Luu, Shivanand Pudakalakatti, Caitlin McCowan, Yaewon Kim, Niki Zacharias, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for ²⁹Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their ²⁹Si MR signals; the particles demonstrated long ²⁹Si spin-lattice relaxation (T₁) times (~ 25 mins), which suggests potential applicability for medical imaging...
May 20, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29778557/nanotechnological-foundations-of-a-%C3%A2-new%C3%A2-nephrology
#11
M Laura Sorian, Alberto Rodríguez-Benot, Miguel Valcárcel
After contextualising the generic frameworks of nanotechnology and nanomedicine, the 2disciplines are discussed in the field of Nephrology. The potential downside to nanonephrology is the renal clearance of nanoparticles, the use of which is ever-increasing both for nanomedicinal purposes and in nanofoods. The positive impact of nanotechnology in Nephrology is centred on the development of renal nanodiagnostics for basic renal function studies, the early diagnosis of acute kidney injury, reliable and simple follow-up of chronic kidney disease and the improvement of magnetic resonance imaging...
May 16, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29777863/comparison-of-histological-and-morphometrical-changes-underlying-subchondral-bone-abnormalities-in-inflammatory-and-degenerative-musculoskeletal-disorders-a-systematic-review
#12
REVIEW
M Loef, S van Beest, F P B Kroon, J L Bloem, O M Dekkers, M Reijnierse, J W Schoones, M Kloppenburg
OBJECTIVE: Subchondral bone abnormalities (SBAs) on magnetic resonance imaging (MRI) are observed frequently and associated with disease course in various musculoskeletal disorders. This review aims to map the existing knowledge of their underlying histological features, and to identify needs for future research. DESIGN: We conducted a systematic review following PRISMA guidelines until September 2017, including all studies correlating histological features to on MRI defined SBAs in patients with osteoarthritis (OA), rheumatoid arthritis (RA), spondyloarthritis (SpA) and degenerative disc disease (DDD)...
May 16, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29777820/accuracy-and-precision-of-quantitative-dce-mri-parameters-how-should-one-estimate-contrast-concentration
#13
Nicole Wake, Hersh Chandarana, Henry Rusinek, Koji Fujimoto, Linda Moy, Daniel K Sodickson, Sungheon Gene Kim
INTRODUCTION: Pharmacokinetic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) data are sensitive to acquisition and post-processing techniques, which makes it difficult to compare results obtained using different methods. In particular, one of the most important factors affecting estimation of model parameters is how to convert MRI signal intensities to contrast agent concentration. The purpose of our study was to quantitatively compare a linear signal-to-concentration conversion (LC) as an approximation and a non-linear conversion (NLC) based on the MRI signal equation, in terms of the accuracy and precision of the pharmacokinetic parameters in T1 -weighted DCE-MRI...
May 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29777389/iron-based-metal-organic-frameworks-as-a-theranostic-carrier-for-local-tuberculosis-therapy
#14
Gabriela Wyszogrodzka, Przemysław Dorożyński, Barbara Gil, Wieslaw J Roth, Maciej Strzempek, Bartosz Marszałek, Władysław P Węglarz, Elżbieta Menaszek, Weronika Strzempek, Piotr Kulinowski
PURPOSE: The purpose of the study was initial evaluation of applicability of metal organic framework (MOF) Fe-MIL-101-NH2 as a theranostic carrier of antituberculous drug in terms of its functionality, i.e. drug loading, drug dissolution, magnetic resonance imaging (MRI) contrast and cytotoxic safety. METHODS: Fe-MIL-101-NH2 was characterized using X-ray powder diffraction, FTIR spectrometry and scanning electron microscopy. The particle size analysis was determined using laser diffraction...
May 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29777140/different-responses-of-left-atrium-and-left-atrial-appendage-to-radiofrequency-catheter-ablation-of-atrial-fibrillation-a-follow-up-mri-study
#15
Yun Gi Kim, Jaemin Shim, Suk-Kyu Oh, Hee-Soon Park, Kwang-No Lee, Sung Ho Hwang, Jong-Il Choi, Young-Hoon Kim
Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who underwent cardiac magnetic resonance imaging (MRI) evaluation before and after RFCA in Korea University Anam Hospital. LA and LAA volume were measured before and after RFCA based on cardiac MRI. Baseline LA volume was 99...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777107/differentiation-of-periapical-granulomas-and-cysts-by-using-dental-mri-a-pilot-study
#16
Alexander Juerchott, Thorsten Pfefferle, Christa Flechtenmacher, Johannes Mente, Martin Bendszus, Sabine Heiland, Tim Hilgenfeld
The purpose of this pilot study was to evaluate whether periapical granulomas can be differentiated from periapical cysts in vivo by using dental magnetic resonance imaging (MRI). Prior to apicoectomy, 11 patients with radiographically confirmed periapical lesions underwent dental MRI, including fat-saturated T2-weighted (T2wFS) images, non-contrast-enhanced T1-weighted images with and without fat saturation (T1w/T1wFS), and contrast-enhanced fat-saturated T1-weighted (T1wFS+C) images. Two independent observers performed structured image analysis of MRI datasets twice...
May 17, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29777103/bacterial-encapsulins-as-orthogonal-compartments-for-mammalian-cell-engineering
#17
Felix Sigmund, Christoph Massner, Philipp Erdmann, Anja Stelzl, Hannes Rolbieski, Mitul Desai, Sarah Bricault, Tobias P Wörner, Joost Snijder, Arie Geerlof, Helmut Fuchs, Martin Hrabĕ de Angelis, Albert J R Heck, Alan Jasanoff, Vasilis Ntziachristos, Jürgen Plitzko, Gil G Westmeyer
We genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzymatic reactions and size-constrained metal biomineralization. The shell protein (EncA) from Myxococcus xanthus auto-assembles into nanocompartments inside mammalian cells to which sets of native (EncB,C,D) and engineered cargo proteins self-target enabling localized bimolecular fluorescence and enzyme complementation. Encapsulation of the enzyme tyrosinase leads to the confinement of toxic melanin production for robust detection via multispectral optoacoustic tomography (MSOT)...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29776653/accuracy-of-phase-contrast-velocity-mapping-proximal-and-distal-to-stent-artifact-during-cardiac-magnetic-resonance-imaging
#18
Catherine M Avitabile, Matthew A Harris, Ravi S Doddasomayajula, Steven G Chopski, Matthew J Gillespie, Yoav Dori, Andrew C Glatz, Mark A Fogel, Kevin K Whitehead
Little data are available on the accuracy of phase-contrast magnetic resonance imaging (PC-MRI) velocity mapping in the vicinity of intravascular metal stents other than nitinol stents. Therefore, we sought to determine this accuracy using in vitro experiments. An in vitro flow phantom was used with 3 stent types: (1) 316L stainless steel, (2) nitinol self-expanding, and (3) platinum-iridium. Steady and pulsatile flow was delivered with a magnetic resonance imaging-compatible pump (CardioFlow 5000, Shelley Medical, London, Ontario, Canada)...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29776427/rheumatoid-meningitis-developed-in-patient-with-stable-rheumatoid-arthritis-and-myasthenia-gravis-detailed-analysis-of-intracranial-inflammation-using-flow-cytometry
#19
Miki Oono, Yoshimasa Fujita, Nobuaki Uchida, Ukichiro Kawai, Michiyo Fujita-Nakata, Megumi Nakanishi, Mitsuru Sanada, Shigemi Nagayama, Makoto Matsui
BACKGROUND: Rheumatoid meningitis (RM) is a rare disorder that often develops during a remission phase of rheumatoid arthritis (RA). This is the first study to demonstrate differences in regard to immunological disturbance between blood and cerebrospinal fluid (CSF) samples obtained from a patient with RM using flow cytometry. CASE PRESENTATION: A 36-year-old woman with RA and generalized myasthenia gravis (MG) developed RM during a remission phase. Although both RA and MG were stable and well controlled, she noticed fever, headache, and transient sensory disturbance...
May 18, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#20
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
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