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https://www.readbyqxmd.com/read/29325977/role-of-apamin-sensitive-small-conductance-calcium-activated-potassium-currents-in-long-term-cardiac-memory-in-rabbits
#1
Dechun Yin, Mu Chen, Na Yang, Adonis Z Wu, Dongzhu Xu, Wei-Chung Tsai, Yuan Yuan, Zhipeng Tian, Yi-Hsin Chan, Changyu Shen, Zhenhui Chen, Shien-Fong Lin, James N Weiss, Peng-Sheng Chen, Thomas H Everett
BACKGROUND: Apamin-sensitive small conductance calcium-activated K current (IKAS) is upregulated during ventricular pacing and masks short-term cardiac memory (CM). OBJECTIVE: - To determine the role of IKAS in long-term CM. METHODS: - CM was created with 3-5 weeks of ventricular pacing and defined by a flat or inverted T-wave off pacing. Epicardial optical mapping was performed in both paced and normal ventricles. Action potential duration (APD80) was determined during RA pacing...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29321131/efficacy-of-ranolazine-in-patients-with-symptomatic-hypertrophic-cardiomyopathy-the-restyle-hcm-randomized-double-blind-placebo-controlled-study
#2
Iacopo Olivotto, Paolo G Camici, Piera Angelica Merlini, Claudio Rapezzi, Monica Patten, Vicent Climent, Gianfranco Sinagra, Benedetta Tomberli, Francisco Marin, Philipp Ehlermann, Lars S Maier, Alessandra Fornaro, Claudius Jacobshagen, Antonello Ganau, Luciano Moretti, Antonio Hernandez Madrid, Raffaele Coppini, Giorgio Reggiardo, Corrado Poggesi, Francesco Fattirolli, Luiz Belardinelli, Gianfranco Gensini, Alessandro Mugelli
BACKGROUND: The late sodium current inhibitor ranolazine reverses the main electrophysiological and mechanical abnormalities of human hypertrophic cardiomyopathy (HCM) cardiomyocytes in vitro, suggesting potential clinical benefit. We aimed to assess the effect of ranolazine on functional capacity, symptomatic status, diastolic function, and arrhythmias in HCM. METHODS AND RESULTS: In this multicenter, double-blind, phase 2 study, 80 adult patients with nonobstructive HCM (age 53±14 years, 34 women) were randomly assigned to placebo (n=40) or ranolazine 1000 mg bid (n=40) for 5 months...
January 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29312717/predictors-of-ventricular-tachyarrhythmia-occurring-late-after-intracardiac-repair-of-tetralogy-of-fallot-combination-of-qrs-duration-change-rate-and-tricuspid-regurgitation-pressure-gradient
#3
Shuichi Shiraishi, Masashi Takahashi, Ai Sugimoto, Masanori Tsuchida
Background: To determine potential predictors of ventricular tachyarrhythmia and sudden cardiac death (SCD) occurring late after repair of tetralogy of Fallot (TOF). Methods: Since 1964, 415 patients had undergone total repair for TOF at Niigata University Hospital. Of these, 89 patients who were followed for more than 10 years at our institute were retrospectively reviewed. Results: The mean follow-up period was 24.3 years. During the study period, one patient died of cerebral bleeding, and two patients had SCD...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29310560/staged-palliation-of-cyanotic-obstructive-lesions-with-a-modified-right-ventricular-outflow-procedure
#4
Sarosh P Batlivala, Mary K Hood, Jannika Dodge-Khatami, Divya Shakti, Mary B Taylor, Makram R Ebeid, Jorge D Salazar, Ali Dodge-Khatami
BACKGROUND: Traditional palliation for biventricular cyanotic congenital heart lesions often involves staging with systemic-to-pulmonary arterial shunts to secure pulmonary blood flow (PBF) in the newborn period prior to complete repair. However, shunts may lead to life-threatening events secondary to shunt occlusion or acute coronary steal. They may be associated with morbidity secondary to diastolic runoff, systemic steal and volume loading, and do not provide pulsatile flow which has the potential to promote pulmonary artery (PA) growth...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29297193/advanced-and-traditional-electrocardiographic-risk-factors-in-pulmonary-arterial-hypertension-the-significance-of-ventricular-late-potentials
#5
Barbara Uznańska-Loch, Kamil Wikło, Ewa Trzos, Karina Wierzbowska-Drabik, Łukasz Chrzanowski, Jarosław Damian Kasprzak, Małgorzata Kurpesa
BACKGROUND: Whether non-invasive electrocardiographic parameters may be of similar relevance in pulmonary arterial hypertension (PAH) as in left ventricular heart failure (LVHF) remains unclear. AIM: To examine a profile of electrocardiographic parameters in PAH and to determine their prognostic significance. Comparison of profile in patients with pulmonary hypertension secondary to left ventricular dysfunction was planned to put PAH group results into context. METHODS: We included 41 patients with type 1...
January 3, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29282211/late-ca2-sparks-and-ripples-during-the-systolic-ca2-transient-in-heart-muscle-cells
#6
Ewan D Fowler, Cherrie H Kong, Jules Hancox, Mark B Cannell
Rationale: The development of a refractory period for Ca2+ spark initiation after Ca2+ release in cardiac myocytes, should inhibit further Ca2+ release during the action potential (AP) plateau. However, Ca2+ release sites that did not initially activate, or which have prematurely recovered from refractoriness might release Ca2+ later during the AP and alter the cell-wide Ca2+ transient. Objective: To investigate the possibility of late Ca2+ spark (LCS) activity in intact isolated cardiac myocytes using fast confocal line scanning with improved confocality and signal to noise...
December 27, 2017: Circulation Research
https://www.readbyqxmd.com/read/29237609/diagnosis-and-prognosis-in-sudden-cardiac-arrest-survivors-without-coronary-artery-disease-utility-of-a-clinical-approach-using-cardiac-magnetic-resonance-imaging
#7
Patricia Rodrigues, Abhishek Joshi, Howell Williams, Mark Westwood, Steffen E Petersen, Filip Zemrak, Richard J Schilling, Claire Kirkby, Andrew Wragg, Charlotte Manisty, Saidi Mohiddin
BACKGROUND: Determining the pathogenesis of sudden cardiac arrest or periarrest without significant coronary artery disease is crucial for management and prognosis. Cardiovascular magnetic resonance (CMR) can detect morphological, functional, or tissue abnormalities, and we sought to evaluate the role of CMR in determining sudden cardiac arrest pathogenesis and prognosis in survivors. METHODS AND RESULTS: We retrospectively reviewed cardiac investigations and clinical outcomes in consecutive survivors of potentially fatal arrhythmias without coronary artery disease admitted to our institutions from 2008 to 2014...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29229494/classic-pattern-dyssynchrony-in-adolescents-and-adults-with-a-fontan-circulation
#8
Assami Rösner, Tigran Khalapyan, Håvard Dalen, Doff B McElhinney, Mark K Friedberg, George K Lui
BACKGROUND: Previous studies have suggested the presence of dyssynchrony in the functionally single ventricle. The aim of this study was to investigate the presence of classic-pattern dyssynchrony (CPD), characterized by typical early and late deformation of opposite walls, and its relation to QRS duration and myocardial function in patients with single-ventricle physiology after Fontan palliation. METHODS: In a retrospective cross-sectional study, 101 adolescent and adult patients with single-ventricle physiology after the Fontan procedure were investigated...
December 8, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29226547/avian-embryonic-coronary-arterio-venous-pattering-involves-the-contribution-of-different-endothelial-and-endocardial-cell-populations
#9
Paul Palmquist-Gomes, Juan Antonio Guadix, José M Pérez-Pomares
BACKGROUND: Coronary vasculature irrigates the myocardium and is crucial to late embryonic and adult heart function. Despite the developmental significance and clinical relevance of these blood vessels, the embryonic origin and the cellular and molecular mechanisms that regulate coronary arterio-venous patterning are not known in detail. In this study, we have used the avian embryo to dissect the ontogenetic origin and morphogenesis of coronary vasculature. RESULTS: We show that sinus venosus endocardial sprouts and proepicardial angioblasts pioneer coronary vascular formation, invading the developing heart simultaneously...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29207943/auxiliary-diagnostic-potential-of-ventricle-geometry-and-late-gadolinium-enhancement-in-left-ventricular-non-compaction-non-randomized-case-control-study
#10
Marko Boban, Vladimir Pesa, Ivo Darko Gabric, Sime Manola, Viktor Persic, Helena Antic-Kauzlaric, Marinko Zulj, Aleksandar Vcev
BACKGROUND: There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls. METHODS: Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital's database (3.75 years; n=1975 exams). Matching sample of controls included cases with no structural heart disease, hypertrophic or dilative cardiomyopathy, arrhythmogenic right ventricular dysplasia or subacute myocarditis...
December 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29197461/ineffective-and-prolonged-apical-contraction-is-associated-with-chest-pain-and-ischaemia-in-apical-hypertrophic-cardiomyopathy
#11
Edward Stephenson, Pierre Monney, Francesca Pugliese, James Malcolmson, Steffen E Petersen, Charles Knight, Peter Mills, Andrew Wragg, Constantinos O'Mahony, Neha Sekhri, Saidi A Mohiddin
OBJECTIVES: To investigate the hypothesis that persistence of apical contraction into diastole is linked to reduced myocardial perfusion and chest pain. BACKGROUND: Apical hypertrophic cardiomyopathy (HCM) is defined by left ventricular (LV) hypertrophy predominantly of the apex. Hyperdynamic contractility resulting in obliteration of the apical cavity is often present. Apical HCM can lead to drug-refractory chest pain. METHODS: We retrospectively studied 126 subjects; 76 with apical HCM and 50 controls (31 with asymmetrical septal hypertrophy (ASH) and 19 with non-cardiac chest pain and culprit free angiograms and structurally normal hearts)...
January 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29193078/termination-of-reentrant-atrial-tachycardia-via-optogenetic-stimulation-with-optimized-spatial-targeting-insights-from-computational-models
#12
Patrick M Boyle, Michael J Murphy, Thomas V Karathanos, Sohail Zahid, Robert C Blake, Natalia A Trayanova
Optogenetics has emerged as a potential alternative to electrotherapy for treating arrhythmia, but feasibility studies have been limited to ventricular defibrillation via epicardial light application. Here, we assess the efficacy of optogenetic atrial tachycardia (AT) termination in human hearts using a strategy that targets for illumination specific regions identified in an automated manner. In three patient-specific models reconstructed from late gadolinium-enhanced MRI scans, we simulated channelrhodopsin-2 (ChR2) expression via gene delivery...
November 28, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29182757/super-response-to-cardiac-resynchronization-therapy-may-predict-late-phrenic-nerve-stimulation
#13
Justo Juliá, María López-Gil, Adolfo Fontenla, Álvaro Lozano, Lola Villagraz, Rafael Salguero, Fernando Arribas
Aims: Changes in the anatomical relationship between left phrenic nerve and coronary veins may occur due to the reverse remodelling observed in super-responders to cardiac resynchronization therapy (CRT) and might be the underlying mechanism in patients developing late-onset phrenic nerve stimulation (PNS) without evidence of lead dislodgement (LD). In this study, we sought to evaluate the role of super-response (SR) to CRT as a potential predictor of late-onset PNS. Methods and results: Consecutive patients implanted with a left ventricular (LV) lead in a single centre were retrospectively analysed...
November 22, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29164000/late-ventricular-potentials-in-familial-mediterranean-fever-with-and-without-aa-amyloidosis
#14
Udi Nussinovitch, Avi Livneh
Objective: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by episodic and chronic inflammation that may lead to both accelerated coronary atherosclerosis and cardiac AA amyloidosis. We hypothesized that late ventricular potentials (LPs), an established electrocardiographic susceptibility marker of ventricular arrhythmias, will be more common in FMF than in the adjusted normal population due to these two types of inflammation-associated cardiac effects...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29127493/late-sodium-current-associated-cardiac-electrophysiological-and-mechanical-dysfunction
#15
REVIEW
Shandong Yu, Gang Li, Christopher L-H Huang, Ming Lei, Lin Wu
Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacological cardiovascular conditions, including bradycardia, myocardial ischemia, reperfusion injury, and heart failure...
November 10, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29125109/impact-of-myocardial-bridge-mural-coronary-artery-on-myocardial-functions
#16
Xin-Bin Zhao, Yu Fu, Jie Li, Meng Sun, He-Liang Zhao
Objective To study the impact of myocardial bridge (MB)-mural coronary artery (MCA) on myocardial functions.Methods Totally 82 patients presenting with chest tightness and chest pain who were diagnosed with the MB in the left anterior descending artery by CT coronary angiography were enrolled as the MB group,in which the thickness and length of MB and the systolic stenosis degree of MCA were measured.In addition,82 healthy subjects,as confirmed by health check-up,were set as the control group.The age,gender,body mass index (BMI),heart rate (HR),smoking history,interventricular septal thickness,left ventricular posterior wall thickness,diameter of left atrium,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular ejection fraction,and the cases of E'/A'<1 were compared between MB group and control group...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29112315/reverse-double-inversion-recovery-improving-motion-robustness-of-cardiac-t2-weighted-dark-blood-turbo-spin-echo-sequence
#17
Chenxi Hu, Steffen Huber, Syed R Latif, Guido Santacana-Laffitte, Hamid R Mojibian, Lauren A Baldassarre, Dana C Peters
BACKGROUND: Cardiac dark-blood turbo spin-echo (TSE) imaging is sensitive to through-plane motion, resulting in myocardial signal reduction. PURPOSE: To propose and validate reverse double inversion-recovery (RDIR)-a dark-blood preparation with improved motion robustness for the cardiac dark-blood TSE sequence. STUDY TYPE: Prospective. POPULATION: Healthy volunteers (n = 10) and patients (n = 20). FIELD STRENGTH: 1...
November 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29090492/late-potentials-and-their-correlation-with-ventricular-structure-in-patients-with-ventricular-arrhythmias
#18
Peter Marstrand, Anna Axelsson, Jens Jakob Thune, Niels Vejlstrup, Steen Pehrson, Henning Bundgaard, Juliane Theilade
INTRODUCTION: The presence of late potentials (LP) may indicate a predisposition to ventricular arrhythmias and sudden cardiac death. We investigated the association between presence of LP and structural cardiac anomalies assessed by magnetic resonance (CMR) in patients presenting with ventricular arrhythmias. METHODS: We included 42 patients admitted with ventricular tachycardia or fibrillation who had undergone both signal-averaged ECG recording and CMR imaging...
November 1, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29072259/barbaloin-inhibits-ventricular-arrhythmias-in-rabbits-by-modulating-voltage-gated-ion-channels
#19
Zhen-Zhen Cao, You-Jia Tian, Jie Hao, Pei-Hua Zhang, Zhi-Pei Liu, Wan-Zhen Jiang, Meng-Liu Zeng, Pei-Pei Zhang, Ji-Hua Ma
Barbaloin (10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone) is extracted from the aloe plant and has been reported to have anti-inflammatory, antitumor, antibacterial, and other biological activities. Here, we investigated the effects of barbaloin on cardiac electrophysiology, which has not been reported thus far. Cardiac action potentials (APs) and ionic currents were recorded in isolated rabbit ventricular myocytes using whole-cell patch-clamp technique. Additionally, the antiarrhythmic effect of barbaloin was examined in Langendorff-perfused rabbit hearts...
October 26, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29063221/high-t2-weighted-signal-intensity-for-risk-prediction-of-sudden-cardiac-death-in-hypertrophic-cardiomyopathy
#20
D H Frank Gommans, G Etienne Cramer, Jeannette Bakker, Hendrik-Jan Dieker, Michelle Michels, Michael A Fouraux, Carlo L M Marcelis, Freek W A Verheugt, Janneke Timmermans, Marc A Brouwer, Marcel J M Kofflard
In search of improved risk stratification in hypertrophic cardiomyopathy (HCM), CMR imaging has been implicated as a potential tool for prediction of sudden cardiac death (SCD). In follow-up of the promising results with extensive late gadolinium enhancement (LGE), high signal-intensity on T2-weighted imaging (HighT2) has become subject of interest given its association with markers of adverse disease progression, such as LGE, elevated troponin and non-sustained ventricular tachycardia. In lack of follow-up cohorts, we initiated an exploratory study on the association between HighT2 and the internationally defined risk categories of SCD...
October 23, 2017: International Journal of Cardiovascular Imaging
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