André Lamy, Dmitry A Sirota, Frederic Jacques, Ahmad Poostizadeh, Nicolas Noiseux, Sergey Efremov, Philippe Demers, Boris Akselrod, Chew Yin Wang, Rakesh C Arora, Piotr Branny, Shay P McGuinness, Craig D Brown, Hugues Jeanmart, Qiang Zhao, Haibo Zhang, Emilie P Belley-Côté, Richard P Whitlock, Austin Browne, Ingrid Copland, Jessica Vincent, Rutaba Khatun, Kumar Balasubramanian, Shrikant I Bangdiwala, Michael H McGillion, Alison E Fox-Robichaud, Jessica Spence, Salim Yusuf, P J Devereaux
BACKGROUND: Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared to intravenous tranexamic acid, which may lower the risk of seizures. We aimed to determine whether topical tranexamic acid reduces the risk of in-hospital seizure without increasing the risk of transfusion among cardiac surgery patients. METHODS: We conducted a multicenter, double dummy, blinded, randomized controlled trial of patients recruited by convenience sampling in academic hospitals undergoing cardiac surgery with cardiopulmonary bypass...
April 8, 2024: Circulation