keyword
MENU ▼
Read by QxMD icon Read
search

Tranexamic

keyword
https://www.readbyqxmd.com/read/29339919/effect-of-oral-tranexamic-acid-on-macular-edema-associated-with-retinal-vein-occlusion-or-diabetes
#1
Masayuki Takeyama, Fumio Takeuchi, Masahiko Gosho, Keijiro Sugita, Masahiro Zako, Masayoshi Iwaki, Motohiro Kamei
Purpose: Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can also cause a decrease in vascular permeability. We hypothesized that TXA could improve macular edema (ME) that is caused by an increase in retinal vascular permeability. The aim of this study is to evaluate the efficacy of oral TXA for ME associated with retinal vein occlusion (RVO) or diabetic ME (DME). Patients and methods: Oral TXA (1,500 mg daily for 2 weeks) was administered to patients with persistent ME secondary to RVO (7 eyes) and DME (7 eyes)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29337665/safety-of-intravenous-tranexamic-acid-in-patients-undergoing-majororthopaedic-surgery-a-meta-analysis-of-randomised-controlled-trials
#2
REVIEW
Massimo Franchini, Carlo Mengoli, Marco Marietta, Giuseppe Marano, Stefania Vaglio, Simonetta Pupella, Pier Mannuccio Mannucci, Giancarlo M Liumbruno
Among the various pharmacological options to decrease peri-operative bleeding, tranexamic acid appears to be one of the most interesting. Several trials have consistently documented the efficacy of this synthetic drug in reducing the risk of blood loss and the need for allogeneic blood transfusion in patients undergoing total hip and knee arthroplasty. The safety of intravenous tranexamic acid in major orthopaedic surgery, particularly regarding the risk of venous thromboembolism, was systematically analysed in this review...
January 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29334511/evaluation-of-recombinant-factor-viia-tranexamic-acid-and-desmopressin-to-reduce-prasugrel-related-bleeding-a-randomised-placebo-controlled-study-in-a-rabbit-model
#3
Fanny Bonhomme, Thomas Lecompte, Charles M Samama, Anne Godier, Pierre Fontana
BACKGROUND: Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE: The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs - recombinant activated factor VII (rFVIIa), tranexamic acid and desmopressin (DDAVP) - to limit blood loss after administration of prasugrel in a rabbit model of bleeding while also evaluating any prothrombotic effects...
January 13, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29324486/fibrinolysis-and-antifibrinolytic-treatment-in-the-trauma-patient
#4
Lewis S Gall, Ross A Davenport
PURPOSE OF REVIEW: The role of antifibrinolytics in trauma haemorrhage and early coagulopathy remains controversial with respect to patient selection, dosage, timing of treatment, and risk of thrombotic complications. This review presents our current understanding of the mechanisms of fibrinolysis in trauma, diagnostic evaluation, and the evidence base for treatment. RECENT FINDINGS: Excessive fibrinolysis following severe injury is a major component of acute traumatic coagulopathy and contributes to the high mortality from trauma haemorrhage...
January 10, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29321936/low-voltage-electricity-induced-lung-injury
#5
Thai Truong, Thuong Vu Le, David L Smith, Stephen P Kantrow, Van Ngoc Tran
We report a case of bilateral pulmonary infiltrates and haemoptysis following low-voltage electricity exposure in an agricultural worker. A 58-year-old man standing in water reached for an electric watering machine and sustained an exposure to 220 V circuit for an uncertain duration. The electricity was turned off by another worker, and the patient was asymptomatic for the next 10 h until he developed haemoptysis. A chest radiograph demonstrated bilateral infiltrates, and chest computed tomography (CT) revealed ground-glass opacities with interstitial thickening...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29318575/post-partum-haemorrhage-and-tranexamic-acid-a-global-issue
#6
REVIEW
Stephen P Hibbs, Ian Roberts, Haleema Shakur-Still, Beverley J Hunt
Post-partum haemorrhage (PPH) remains the major cause of maternal death worldwide, with the overwhelming majority of bleeding deaths occurring in low income countries. These bleeding deaths occur due to a complex network of biological and socioeconomic factors, including changes to haemostasis and fibrinolysis during pregnancy. Tranexamic acid (TxA) has been shown to reduce death in bleeding trauma patients safely and is effective in reducing bleeding in surgical patients, however its role in PPH has been less well established...
January 9, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29310981/is-topical-tranexamic-acid-a-better-alternative-for-selected-cases-of-anterior-epistaxis-management-in-the-emergency-department
#7
Getaw Worku Hassen, Paula Clemons, Michelle Kaplun, Hossein Kalantari
Epistaxis is a well-known problem that is mostly self-limited. In certain cases it requires packing or cauterization. Tranexamic acid has been tried and has shown promising results. Here we report a case of prolonged epistaxis in a patient on dual anti-platelet agent therapy.
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29309319/tranexamic-acid-dosing-for-cardiac-surgical-patients-with-chronic-renal-dysfunction-a-new-dosing-regimen
#8
Angela Jerath, Qi Joy Yang, K Sandy Pang, Nikita Looby, Nathaly Reyes-Garces, Tijana Vasiljevic, Barbara Bojko, Janusz Pawliszyn, Duminda Wijeysundera, W Scott Beattie, Terrence M Yau, Marcin Wąsowicz
BACKGROUND: Tranexamic acid (TXA) is a common antifibrinolytic agent used to minimize bleeding in cardiac surgery. Up to 50% cardiac surgical patients have chronic renal dysfunction (CRD). Optimal dosing of TXA in CRD remains poorly investigated. This is important as TXA is renally eliminated with accumulation in CRD. High TXA doses are associated with postoperative seizures. This study measures plasma TXA concentrations in CRD cardiac surgical patients for pharmacokinetic modeling and dose adjustment recommendations...
January 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29306228/emergency-coronary-bypass-surgery-in-patients-under-the-influence-of-dualantiplatelet-therapy-effects-of-tranexamic-acid-and-desmopressin-acetate
#9
Gökalp Altun, Doğuş Hemşinli, Zerrin Pulathan, Ali Civelek
Background/aim: Bleeding in patients undergoing coronary artery bypass grafting (CABG) while using dual antiplatelet therapy (DAPT) is a cause of significant morbidity and mortality. The aim of this study is to examine the perioperative hemostatic effects of tranexamic acid (TnX-A) and desmopressin acetate (Des) in these patients. Materials and methods: This clinical study was planned in a prospective and randomized manner. Fifty-four patients were enrolled and classified into 4 different groups. They were compared in terms of various bleeding and transfusion parameters...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303065/clinical-research-of-combined-intravenous-administration-and-topical-application-of-tranexamic-acid-to-a-surgical-wound-during-posterior-lumbar-fusion
#10
Yufu Ou, Jianxun Wei, Rongzhu Li, Bin Liang, Dezan Qiu, Minke Wei, Xiaoping Mu, Zhuhai Li
BACKGROUND: The safety and effectiveness of combined intravenous and topical administration of tranexamic acid (TXA) on the reduction of blood loss in patients undergoing posterior lumbar fusion are not yet clear. The study aimed to investigate the safety and effectiveness of the combined intravenous and topical administration of TXA on the reduction of blood loss in patients undergoing posterior lumbar fusion. METHOD: One hundred and eighteen patients who underwent double-segment posterior lumbar decompression and fusion from February 2014 to May 2016 in our hospital were retrospectively reviewed...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29298240/increased-risk-of-fibrinolysis-shutdown-among-severely-injured-trauma-patients-receiving-tranexamic-acid
#11
Jonathan P Meizoso, Roman Dudaryk, Michelle B Mulder, Juliet J Ray, Charles A Karcutskie, Sarah A Eidelson, Nicholas Namias, Carl I Schulman, Kenneth G Proctor
BACKGROUND: The association between tranexamic acid (TXA) and fibrinolysis shutdown is unknown. We hypothesize that TXA is associated with fibrinolysis shutdown in critically injured trauma patients. METHODS: 218 critically injured adults admitted to the intensive care unit (ICU) at an urban level 1 trauma center from 08/2011-01/2015 who had thromboelastography performed upon ICU admission were reviewed. Groups were stratified based on fibrinolysis shutdown, which was defined as LY30<0...
January 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29296720/x-ray-crystal-structure-of-plasmin-with-tranexamic-acid-derived-active-site-inhibitors
#12
Ruby H P Law, Guojie Wu, Eleanor W W Leung, Koushi Hidaka, Adam J Quek, Tom T Caradoc-Davies, Devadharshini Jeevarajah, Paul J Conroy, Nigel M Kirby, Raymond S Norton, Yuko Tsuda, James C Whisstock
The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemorrhagic disorders or thrombotic vascular occlusion. Accordingly, inhibitors of this system are clinically important. Currently, tranexamic acid (TXA), a molecule that prevents plasminogen activation through blocking recruitment to target substrates, is the most widely used inhibitor for the plasminogen/plasmin system in therapeutics...
May 9, 2017: Blood Advances
https://www.readbyqxmd.com/read/29287733/tranexamic-acid-use-in-cardiac-surgery-hemostasis-seizures-or-a-little-of-both
#13
EDITORIAL
Neal S Gerstein, Lev Deriy, Prakash A Patel
No abstract text is available yet for this article.
December 5, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29280698/haematological-factors-in-the-management-of-adult-epistaxis-systematic-review
#14
REVIEW
A Williams, A Biffen, N Pilkington, L Arrick, R J Williams, M E Smith, M Smith, J Birchall
BACKGROUND: The management of epistaxis requires an understanding of haematological factors that may complicate its treatment. This systematic review includes six distinct reviews examining the evidence supporting epistaxis-specific management strategies relating to warfarin, direct oral anticoagulants, heparin, antiplatelet agents, tranexamic acid and transfusion. METHOD: A systematic review of the literature was performed using a standardised methodology and search strategy...
December 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29275579/-risk-factors-associated-with-massive-drainage-after-posterior-spinal-orthopaedic-surgery-for-adolescent-scoliosis
#15
N Li, R Jia, X P Gu, Z L Ma
Objective: To identify risk factors that influence the massive drainage after posterior spinal orthopaedic surgery for adolescent scoliosis. Methods: A total of 1 461 patients from 11 to 18 years old diagnosed with adolescent scoliosis who underwent first posterior spinal orthopaedic surgery in affiliated Drum Tower Hospital, Medical School of Nanjing University between November 2010 and October 2015 were retrospectively reviewed. Patients were categorized on the basis of massive or normal drainage, with the boundary 30(th) percentile of drainage/estimated blood volume...
November 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29273349/nebulized-tranexamic-acid-as-a-therapeutic-alternative-in-pulmonary-hemorrhage
#16
Alejandro González-Castro, Juan Carlos Rodriguez-Borregán, Enrique Chicote, Patricia Escudero, Diego Ferrer
No abstract text is available yet for this article.
December 19, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29250350/a-copper-ii-paddle-wheel-structure-of-tranexamic-acid-di-chloro-tetra-kis-%C3%AE-4-ammonio-meth-yl-cyclo-hexane-1-carboxyl-ato-o-o-dicopper-ii-dichloride-hexa-hydrate
#17
Muhammad Altaf, Helen Stoeckli-Evans
Tranexamic acid [systematic name: trans-4-(amino-meth-yl)cyclo-hexane-1-carb-oxy-lic acid], is an anti-fibrinolytic amino acid that exists as a zwitterion [trans-4-(ammonio-meth-yl)cyclo-hexane-1-carboxyl-ate] in the solid state. Its reaction with copper chloride leads to the formation of a compound with a copper(II) paddle-wheel structure that crystallizes as a hexa-hydrate, [Cu2Cl2(C8H15NO2)4]2+·2Cl-·6H2O. The asymmetric unit is composed of a copper(II) cation, two zwitterionic tranexamic acid units, a coordinating Cl- anion and a free Cl- anion, together with three water mol-ecules of crystallization...
October 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29249226/tranexamic-acid-prophylaxis-in-hip-and-knee-joint-replacement
#18
Matthias Goldstein, Carsten Feldmann, Hinnerk Wulf, Thomas Wiesmann
BACKGROUND: The antifibrinolytic agent tranexamic acid (TXA) is widely used for the prevention and treatment of hyperfibrinolytic states, such as in severe polytrauma. It can also be used for the systemic prevention of hemorrhage in elective orthopedic procedures. In this review, we assess the efficacy and risks of the prophylactic administration of tranexamic acid before major endoprosthetic surgery of the hip and knee. METHODS: This review is based on pertinent articles retrieved by a selective literature search in the PubMed and Cochrane Library databases...
December 1, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29249225/tranexamic-acid-in-endoprosthesis
#19
EDITORIAL
Marc Maegele
No abstract text is available yet for this article.
December 1, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29246849/can-tranexamic-acid-conserve-blood-and-save-operative-time-in-spinal-surgeries-a-meta-analysis
#20
Shangyi Hui, Derong Xu, Zhinan Ren, Xin Chen, Lin Sheng, Qianyu Zhuang, Shugang Li
BACKGROUND CONTEXT: It is widely accepted that tranexamic acid (TXA) effectively reduces blood losses and transfusions in major surgeries. However, limited studies investigated the role of TXA in conserving blood and saving operative time in spine surgeries. Purpose This meta-analysis was conducted to gather scientific evidences for TXA efficacy on conserving blood and saving operative time in spine surgeries. STUDY DESIGN: A meta analysis. Patient Sample Eighteen RCTs and 18 non-RCT studies involving 2,572 patients were included in the final analyses, comparing the effectiveness of intravenous TXA with a placebo/no treatment group...
December 12, 2017: Spine Journal: Official Journal of the North American Spine Society
keyword
keyword
11325
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"