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https://www.readbyqxmd.com/read/28920517/bleeding-control-in-palliative-care-patients-with-the-help-of-tranexamic-acid
#1
Marcus J P Geist, Jens Kessler, Susanne Frankenhauser, Hubert J Bardenheuer
BACKGROUND: Persistent bleeding is a common reason for admitting patients with advanced cancer to a palliative care unit. Several reports show a successful therapeutic use of the antifibrinolytic agent tranexamic acid in palliative care patients having hemorrhages. However, it is not administered routinely in severe bleeding situations in palliative care, and general dosing recommendations are unclear. CASE PRESENTATION: We report on 3 patients who were treated with tranexamic acid due to symptomatic hemorrhage complicating different malignant processes...
January 1, 2017: Journal of Palliative Care
https://www.readbyqxmd.com/read/28916142/effect-of-tranexamic-acid-on-gross-hematuria-a-pilot-randomized-clinical-trial-study
#2
Payman Moharamzadeh, Seyedhossein Ojaghihaghighi, Mohsen Amjadi, Farzad Rahmani, Arezoo Farjamnia
OBJECTIVE: Local forms of the tranexamic acid have been effective in treating many haemorrhagic cases. So that the aim of the current study is to assess the effectiveness of local tranexamic acid in controlling painless hematuria in patients referred to the emergency department. METHODS: This is a randomized, double-blind clinical trial study, which was conducted on 50 patients with complaints of painless lower urinary tract bleeding during June 2014 and August 2015...
September 9, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28914172/effects-of-pharmacological-inhibition-of-plasminogen-binding-on-liver-regeneration-in-rats
#3
Atsushi Miura, Kyoko Ishiguro, Kouta Koizumi, Yuki Yaita, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki
The fibrinolysis system is thought to play an important role in liver regeneration. We previously found that plasminogen (Plg) is localized to the cell surface of regenerating liver tissue as well as proliferating hepatocytes in vitro. Here, we investigated the significance of Plg binding to the cell surface during liver regeneration. Pre-administration of tranexamic acid (TXA), which is a competitive inhibitor of Plg binding, to hepatectomized rats mildly delayed restoration of liver weight in vivo. Although binding of Plg to the cell membrane decreased following TXA administration, TXA showed little effect on hepatocyte proliferation in rats...
September 15, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28912909/the-use-of-tranexamic-acid-for-upper-gastrointestinal-bleeding-by-medical-and-surgical-intensivists-a-single-center-experience
#4
Jason Chertoff, Grant Lowther, Hassan Alnuaimat, Ali Ataya
BACKGROUND: Tranexamic acid (TXA) may be beneficial in the management of upper gastrointestinal bleeding (UGIB). We sought to investigate how frequently intensivists at our academic institution use TXA for patients with UGIB, and to investigate whether the utilization rate of TXA differs between surgical and medical intensivists, and provide an updated literature review on the subject. METHODS: We performed a retrospective cohort study of patients admitted for UGIB to the surgical intensive care unit (SICU) and the medical intensive care unit (MICU) at our academic healthcare facility (University of Florida Health - Shands Hospital) from January 1, 2013 to December 31, 2016...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28912416/a-case-of-tranexamic-acid-as-adjunctive-treatment-for-chronic-subdural-hematoma-with-multiple-recurrences
#5
Ronni Mikkelsen, Thorkil Anker-Møller, Anne-Mette Hvas, Niels Sunde
BACKGROUND Chronic subdural hematoma (CSDH) is a common neurosurgical condition that is treated using a cranial burr hole evacuation procedure, but recurrence is common. The use of anticoagulant therapy can increase the risk of developing a recurrent subdural hematoma. We present a challenging case of a patient on long-term anticoagulant therapy following previous aortic and aortic valve surgery who had CSDH with multiple recurrences and was ultimately treated with tranexamic acid as an adjunct to surgery. CASE REPORT A male patient in his mid-sixties presented with a headache and bilateral CSDH...
September 15, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28910469/prehospital-administration-of-tranexamic-acid-by-ground-forces-in-afghanistan-the-prehospital-trauma-registry-experience
#6
Steven G Schauer, Michael D April, Jason F Naylor, Jonathan Wiese, Kathy L Ryan, Andrew D Fisher, Cord W Cunningham, Noah Mitchell, Mark A Antonacci
BACKGROUND: Tranexamic acid (TXA) was shown to reduce overall mortality and death secondary to hemorrhage in a large prospective study. This intervention is time sensitive. As such, the Tactical Combat Casualty Care (TCCC) guidelines recommend use of this low-cost, safe intervention among patients with possible hemorrhagic shock, penetrating trauma to the thorax or trunk, or extremity amputation. OBJECTIVE: Prehospital administration of TXA by ground forces in the Afghanistan combat theater is described...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28906369/the-efficacy-of-tranexamic-acid-in-reducing-blood-loss-in-total-shoulder-arthroplasty-a-meta-analysis
#7
Jing He, Xi-E Wang, Guo-Hong Yuan, Lian-Hai Zhang
BACKGROUND: The purpose of this meta-analysis is to compare the efficacy of tranexamic acid (TXA) versus placebo after a total shoulder arthroplasty (TSA). METHODS: In April 2017, a systematic computer-based search was conducted in the databases of PubMed, Embase, Web of Science, Cochrane Library, and Google. Studies comparing TXA versus placebo in reducing blood loss after TSA were included. The endpoints were the need for transfusion, blood loss in drainage, hemoglobin drop, and total blood loss...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28902659/tranexamic-acid-in-shoulder-arthroplasty-a-systematic-review-and-meta-analysis
#8
Jacob M Kirsch, Asheesh Bedi, Nolan Horner, J Michael Wiater, Leo Pauzenberger, Denise M Koueiter, Bruce S Miller, Mohit Bhandari, Moin Khan
BACKGROUND: The role of tranexamic acid (TXA) in reducing blood loss following primary shoulder arthroplasty has been demonstrated in small retrospective and controlled clinical trials. This study comprehensively evaluates current literature on the efficacy of TXA to reduce perioperative blood loss and transfusion requirements following shoulder arthroplasty. METHODS: PubMed, MEDLINE, CENTRAL, and Embase were searched from the database inception date through October 27, 2016, for all articles evaluating TXA in shoulder arthroplasty...
September 12, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/28895645/most-effective-regimen-of-tranexamic-acid-for-reducing-bleeding-and-transfusions-in-primary-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#9
Wen-Li Dai, Ai-Guo Zhou, Hua Zhang, Jian Zhang
No abstract text is available yet for this article.
September 11, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28889070/tranexamic-acid-for-refractory-gastrointestinal-bleeds-a-cohort-study
#10
Joanna L Stollings, Janna S Landsperger, Matthew W Semler, Todd W Rice
No abstract text is available yet for this article.
August 24, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28887767/management-of-spontaneous-intracerebral-hemorrhage
#11
REVIEW
Roland Veltkamp, Jan Purrucker
PURPOSE OF REVIEW: We review the current evidence for medical and surgical treatments of spontaneous intracerebral hemorrhage (ICH). RECENT FINDINGS: Therapy with hemostatic agents (e.g. factor VIIa and tranexamic acid) if started early after bleeding onset may reduce hematoma expansion, but their clinical effectiveness has not been shown. Rapid anticoagulation reversal with prothrombin concentrates (PCC) plus vitamin K is the first choice in vitamin K antagonist-related ICH...
September 8, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28887640/clinical-and-instrumental-evaluation-of-two-different-regimens-of-tranexamic-acid-in-total-hip-arthroplasty-a-single-centre-prospective-randomized-study-with-80-patients
#12
Nicola Piolanti, Andrea Del Chiaro, Fabrizio Matassi, Angelo Graceffa, Lorenzo Nistri, Massimiliani Marcucci
PURPOSE: The use of tranexamic acid (TXA) in total hip arthroplasty (THA) can significantly reduce blood losses with many clinical and economical advantages. However, no consensus has been reached regarding the optimal regimen for TXA administration. The aim of this study is to analyse and compare the haemostatic effect of two different intravenous (IV) regimens of TXA. MATERIALS AND METHODS: We planned a single-centre, prospective, randomized study including 80 patients who underwent primary unilateral minimally invasive THA because of a hip osteoarthritic degeneration...
September 8, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28885402/tranexamic-acid-for-the-management-of-obstetric-hemorrhage
#13
Luis D Pacheco, Gary D V Hankins, Antonio F Saad, Maged M Costantine, Giuseppe Chiossi, George R Saade
Obstetric hemorrhage remains the most common cause of maternal mortality worldwide. It is believed that increased fibrinolytic activity, secondary to release and activation of endothelial tissue plasminogen activator, is involved in its pathogenesis. Tranexamic acid (TXA), an antifibrinolytic agent, has been shown to be beneficial in trauma patients if used within 3 hours of injury. A recent large randomized controlled trial showed that TXA given to hemorrhaging women within 3 hours after delivery was associated with decreased risk of death resulting from bleeding with no increase in thromboembolic complications...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28877540/evidence-for-the-use-of-tranexamic-acid-in-subarachnoid-and-subdural-hemorrhage-a-systematic-review
#14
Thorkil Anker-Møller, Anne Troldborg, Niels Sunde, Anne-Mette Hvas
No abstract text is available yet for this article.
September 6, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28865948/a-new-topical-hemostatic-agent-tt-173-reduces-blood-loss-in-a-sheep-model-of-total-knee-arthroplasty
#15
Alberto Centeno, Santiago Rojas, Belén Arias, Ignasi Miquel, Pilar Sánchez, Claudia Ureta, Esther Rincón, Ramón López, Jesús Murat
BACKGROUND: Total knee arthroplasty is associated with blood loss during the intervention and may require allogenic blood transfusion. Treatments such as tranexamic acid and fibrin sealants improved the bleeding control in several clinical trials, but the hemorrhage associated with the intervention is still significant. Thus far, very few studies have evaluated hemostatic treatments in animal models of total knee arthroplasty. This work describes a sheep model of bleeding associated with total knee arthroplasty and investigates a new class of hemostatic treatment based on recombinant tissue factor...
August 30, 2017: Knee
https://www.readbyqxmd.com/read/28861213/idiopathic-non-histaminergic-acquired-angioedema-a-case-series-and-discussion-of-published-clinical-trials
#16
Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling, Urs Christian Steiner
BACKGROUND: Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatment options have been proposed. In this paper, we have evaluated the most effective therapies for InH-AAE on the basis of current literature and report the therapeutic effect of omalizumab in three patients with InH-AAE. METHODS: Literature was searched with a combination of MeSH/EMTREE terms and freetext search for angioedema and therapy/omalizumab in the databases Medline (Ovid), PubMed/Premedline, Embase, Cochrane library and Scopus with no time or language restrictions...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28858904/tranexamic-acid-administration-during-on-pump-cardiac-surgery-a-survey-of-current-practices-among-canadian-anesthetists-working-in-academic-centers
#17
Jessica Spence, Steven Long, Antonella Tidy, Karen Raymer, P J Devereaux, Andre Lamy, Richard Whitlock, Summer Syed
BACKGROUND: Tranexamic acid (TXA) is commonly administered during on-pump cardiac surgery to minimize bleeding. However, an optimal dosing regimen has not been described, and recent studies suggest that higher doses may be associated with seizure. Little is known about current practice among cardiac anesthetists. METHODS: We contacted all academic anesthesia departments in Canada to identify cardiac anesthetists, who represent the majority of practitioners. This group constituted our sampling frame...
August 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28857806/reversing-dabigatran-anticoagulation-with-prothrombin-complex-concentrate-versus-idarucizumab-as-part-of-multimodal-hemostatic-intervention-in-an-animal-model-of-polytrauma
#18
Markus Honickel, Till Braunschweig, Rolf Rossaint, Christian Stoppe, Hugo Ten Cate, Oliver Grottke
BACKGROUND: Although idarucizumab is the preferred treatment for urgent dabigatran reversal, it is not always available. Prothrombin complex concentrate (PCC) may be an alternative and, with bleeding in trauma, additional hemostatic therapy may be required. The authors investigated multimodal treatment in a preclinical polytrauma model. METHODS: Dabigatran etexilate (30 mg/kg twice daily) was given orally to 45 male pigs for 3 days. On day 4, animals received a dabigatran infusion before blunt liver injury and bilateral femur fractures...
August 30, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28854305/could-tranexamic-acid-bias-the-optimal-ratio-of-fresh-frozen-plasma-to-red-blood-cells-during-massive-transfusion-reply
#19
D Dante Yeh, Tomaz Mesar, Walter Dzik
No abstract text is available yet for this article.
August 30, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28854295/could-tranexamic-acid-bias-the-optimal-ratio-of-fresh-frozen-plasma-to-red-blood-cells-during-massive-transfusion
#20
Yoann Launey, Thomas Lebouvier, Philippe Seguin
No abstract text is available yet for this article.
August 30, 2017: JAMA Surgery
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