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https://www.readbyqxmd.com/read/28226734/prediction-of-malignant-and-benign-of-lung-tumor-using-a-quantitative-radiomic-method
#1
Jun Wang, Xia Liu, Di Dong, Jiangdian Song, Min Xu, Yali Zang, Jie Tian, Jun Wang, Xia Liu, Di Dong, Jiangdian Song, Min Xu, Yali Zang, Jie Tian, Min Xu, Jiangdian Song, Di Dong, Jie Tian, Jun Wang, Yali Zang, Xia Liu
Lung cancer is the leading cause of cancer mortality around the world, the early diagnosis of lung cancer plays a very important role in therapeutic regimen selection. However, lung cancers are spatially and temporally heterogeneous; this limits the use of invasive biopsy. But radiomics which refers to the comprehensive quantification of tumour phenotypes by applying a large number of quantitative image features has the ability to capture intra-tumoural heterogeneity in a non-invasive way. Here we carry out a radiomic analysis of 150 features quantifying lung tumour image intensity, shape and texture...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226465/in-silico-pre-clinical-trials-for-implantable-cardioverter-defibrillators
#2
Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Jackson Liang, Marco Beccani, Sanjay Dixit, Rahul Mangharam, Houssam Abbas, Zhihao Jiang, Kuk Jin Jang
Regulatory authorities require that the safety and efficacy of a new high-risk medical device be proven in a Clinical Trial (CT), in which the effects of the device on a group of patients are compared to the effects of the current standard of care. Phase III trials can run for several years, cost millions of dollars, and expose patients to an unproven device. In this paper, we demonstrate how to use a large group of synthetic patients based on computer modeling to improve the planning of a CT so as to increase the chances of a successful trial for implantable cardioverter defibrillators (ICDs)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226066/chlamydia-trachomatis-infection-in-young-pregnant-women-in-southern-brazil-a-cross-sectional-study
#3
Mariângela Freitas da Silveira, Iândora Krolow Timm Sclowitz, Ludmila Gonçalves Entiauspe, Marilia Arndt Mesenburg, Dulce Stauffert, Guilherme Lucas de Oliveira Bicca, Carine Pieniz, Adriane Brod Manta
This study estimated the prevalence of Chlamydia trachomatis infection during pregnancy in a sample of women up to 29 years of age in the city of Pelotas, Rio Grande do Sul State, Brazil, and investigated socio-demographic risk factors such as maternal age, marital status, maternal schooling, and family income. C. trachomatis infection was diagnosed with PCR using BD ProbeTecTM CT/GC Amplified DNA Assay. Socio-demographic, behavioral, and reproductive data were collected using structured questionnaires. All collections were performed by previously trained medical students...
February 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28225997/intrathoracic-stomach-mimicking-bone-metastasis-from-thyroid-cancer-in-whole-body-iodine-131-scan-diagnosed-by-spect-ct
#4
Francisco Javier García-Gómez, Pablo Antonio de la Riva-Pérez, Cinta Calvo-Morón, Cristina Buján-Lloret, Teresa Cambil-Molina, Juan Castro-Montaño
The whole-body iodine-131 scintigraphy is an imaging technique in monitoring patients with a history of thyroid cancer. Although the rate of false positives is negligible, it is not nonexistent. We report the case of an intervened and treated patient for thyroid cancer with good clinical and biochemical response. Scintigraphic findings were consistent with unsuspected bone metastasis. Fused SPECT/CT data allowed accurate diagnosis of giant diaphragmatic hernia associated with intrathoracic stomach, a very rare pathology that can lead to false positive results...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225831/whole-body-staging-of-female-patients-with-recurrent-pelvic-malignancies-ultra-fast-18f-fdg-pet-mri-compared-to-18f-fdg-pet-ct-and-ct
#5
Julian Kirchner, Lino Morris Sawicki, Saravanabavaan Suntharalingam, Johannes Grueneisen, Verena Ruhlmann, Bahriye Aktas, Cornelius Deuschl, Ken Herrmann, Gerald Antoch, Michael Forsting, Lale Umutlu
OBJECTIVES: To evaluate the diagnostic feasibility of an ultra-fast 18F-FDG PET/MRI protocol, including T2-w and contrast-enhanced T1-w imaging as well as metabolic assessment (PET) in comparison to 18F-FDG PET/CT and CT for whole-body staging of female patients with suspected recurrence of pelvic malignancies. METHODS: 43 female patients with suspected tumor recurrence were included in this study. Suspicion was based on clinical follow-up and abnormal findings on imaging follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28225815/different-characteristics-of-mesenchymal-stem-cells-isolated-from-different-layers-of-full-term-placenta
#6
Yoo Shin Choi, Yong-Beom Park, Chul-Won Ha, Jin A Kim, Jin-Chul Heo, Woo-Jung Han, Soo-Young Oh, Suk-Joo Choi
BACKGROUND: The placenta is a very attractive source of mesenchymal stem cells (MSCs) for regenerative medicine due to readily availability, non-invasive acquisition, and avoidance of ethical issues. Isolating MSCs from parts of placenta tissue has obtained growing interest because they are assumed to exhibit different proliferation and differentiation potentials due to complex structures and functions of the placenta. The objective of this study was to isolate MSCs from different parts of the placenta and compare their characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28225641/a-review-of-clinical-and-imaging-findings-in-eosinophilic-lung-diseases
#7
Adam Bernheim, Theresa McLoud
OBJECTIVE: The purpose of this article is to review the clinical and imaging findings associated with eosinophilic lung diseases. CONCLUSION: The spectrum of eosinophilic lung diseases comprises a diverse group of pulmonary disorders that have an association with tissue or peripheral eosinophilia. These diseases have varied clinical presentations and may be associated with several other abnormalities. Characteristic imaging findings are often detected with chest radiography, and CT best shows parenchymal abnormalities...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28225435/the-role-of-18f-fdg-pet-ct-in-staging-and-restaging-primary-bone-lymphoma
#8
Yiyan Liu
PURPOSE: Primary bone lymphoma (PBL) is one of the rarest primary bone malignancies. Very limited data are available on the role of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in PBL. PATIENTS AND METHODS: Overall, 16 relevant patients had F-FDG PET/CT for staging or staging/restaging PBL. The cases with extraskeletal lesions such as lymphadenopathy or with osseous involvements in disseminated lymphoma were excluded on the basis of the definition of PBL. F-FDG PET/CT findings were correlated to pathologic and/or anatomic image information...
February 20, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28225434/pet-ct-surveillance-detects-asymptomatic-recurrences-in-stage-iiib-and-iiic-melanoma-patients-a-prospective-cohort-study
#9
Max F Madu, Pieter Timmerman, Michel W J M Wouters, Bernies van der Hiel, Jos A van der Hage, Alexander C J van Akkooi
AJCC stage IIIB and IIIC melanoma patients are at risk for disease relapse or progression. The advent of effective systemic therapies has made curative treatment of progressive disease a possibility. As resection of oligometastatic disease can confer a survival benefit and as immunotherapy is possibly most effective in a low tumor load setting, there is a likely benefit to early detection of progression. The aim of this pilot study was to evaluate a PET/computed tomography (CT) surveillance schedule for resected stage IIIB and IIIC melanoma...
February 20, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28225155/remotely-supervised-transcranial-direct-current-stimulation-increases-the-benefit-of-at-home-cognitive-training-in-multiple-sclerosis
#10
Leigh Charvet, Michael Shaw, Bryan Dobbs, Ariana Frontario, Kathleen Sherman, Marom Bikson, Abhishek Datta, Lauren Krupp, Esmail Zeinapour, Margaret Kasschau
OBJECTIVE: To explore the efficacy of remotely-supervised transcranial direct current stimulation (RS-tDCS) paired with cognitive training (CT) exercise in participants with multiple sclerosis (MS). METHODS: In a feasibility study of RS-tDCS in MS, participants completed ten sessions of tDCS paired with CT (1.5 mA × 20 min, dorsolateral prefrontal cortex montage). RS-tDCS participants were compared to a control group of adults with MS who underwent ten 20-min CT sessions through the same remotely supervised procedures...
February 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28224428/a-new-method-of-3-dimensional-localization-of-intraocular-foreign-bodies-using-ct-imaging-a-role-of-optic-nerve
#11
Qi Yao, Han-Ping Wu, Bin Xiong, Ping Han, Chuan-Sheng Zheng
Computed tomography (CT) is considered the most sensitive method for the detection of intraocular foreign bodies (IOFBs). The purpose of this study was to evaluate a new method of 3-dimentional (3D) localization of IOFBs that takes advantage of the anatomical structure of the optic nerve and to assess the clinical outcomes using this new method. Twenty-two trauma patients with IOFBs or suspected IOFBs admitted to our hospital were scanned with multislice CT (MSCT) between July and December 2003. All scanning was performed with a 16-row spiral CT in axial plane using a sequential scanning protocol...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224358/synthesis-characterization-and-dna-binding-studies-of-hydroxyl-functionalized-platinum-ii-salphen-complexes
#12
Shahratul Ain Mohd Sukri, Lee Yook Heng, Nurul Huda Abd Karim
The platinum(II) salphen complex N,N'-Bis-4-(hydroxysalicylidene)-phenylenediamine-platinum(II); (1) and its two derivatives containing hydroxyl functionalized side chains N,N'-bis-[4-[[1-(2-hydroxyethoxy)] salicylidene] phenylenediamine-platinum(II); (2) and N,N'-bis-[4-[[1-(3-hydroxypropoxy)] salicylidene] phenylenediamine-platinum(II); (3) were synthesized and characterized. The structures of the complexes were confirmed by (1)H and (13)C NMR spectroscopy, FTIR, ESI-MS and CHN elemental analyses. The effects of the hydroxyl substituent on the spectral properties and the DNA binding behaviors of the Pt(II) complexes were explored...
February 21, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28224200/plain-radiographs-can-be-used-for-routine-assessment-of-acl-reconstruction-tunnel-position-with-three-dimensional-imaging-reserved-for-research-and-revision-surgery
#13
REVIEW
Jonathan David Kosy, Vipul I Mandalia
PURPOSE: The position of the osseous tunnels and graft during anterior cruciate ligament (ACL) reconstruction has been the subject of multiple studies aiming for either anatomical placement or an alternative. The assessment of these positions, using post-operative imaging, is therefore of interest to the surgeon in both the evaluation of surgical performance and surveillance of potential complications. The purpose of this review is to identify the optimal use of imaging in both the surveillance of clinical practice and in planning revision surgery...
February 21, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28223500/activation-of-contact-dependent-antibacterial-trnase-toxins-by-translation-elongation-factors
#14
Allison M Jones, Fernando Garza-Sánchez, Jaime So, Christopher S Hayes, David A Low
Contact-dependent growth inhibition (CDI) is a mechanism by which bacteria exchange toxins via direct cell-to-cell contact. CDI systems are distributed widely among Gram-negative pathogens and are thought to mediate interstrain competition. Here, we describe tsf mutations that alter the coiled-coil domain of elongation factor Ts (EF-Ts) and confer resistance to the CdiA-CT(EC869) tRNase toxin from enterohemorrhagic Escherichia coli EC869. Although EF-Ts is required for toxicity in vivo, our results indicate that it is dispensable for tRNase activity in vitro...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28222505/cognitive-training-interventions-for%C3%A2-patients-with-alzheimer-s-disease-a%C3%A2-systematic-review
#15
Eeva-Liisa Kallio, Hanna Öhman, Hannu Kautiainen, Marja Hietanen, Kaisu Pitkälä
BACKGROUND: Cognitive training (CT) refers to guided cognitive exercises designed to improve specific cognitive functions, as well as enhance performance in untrained cognitive tasks. Positive effects of CT on cognitive functions in healthy elderly people and persons with mild cognitive impairment have been reported, but data regarding the effects of CT in patients with dementia is unclear. OBJECTIVE: We systematically reviewed the current evidence from randomized controlled trials (RCTs) to find out if CT improves or stabilizes cognition and/or everyday functioning in patients with mild and moderate Alzheimer's disease...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222269/restoring-cftr-function-reduces-airway-bacteria-and-inflammation-in-people-with-cystic-fibrosis-and-chronic-lung-infections
#16
Katherine B Hisert, Sonya L Heltshe, Christopher Pope, Peter Jorth, Xia Wu, Rachael M Edwards, Matthew Radey, Frank J Accurso, Daniel J Wolter, Gordon Cooke, Ryan J Adam, Suzanne Carter, Brenda Grogan, Jan L Launspach, Seamas C Donnelly, Charles Gallagher, James E Bruce, David Stoltz, Michael J Welsh, Lucas R Hoffman, Edward F McKone, Pradeep K Singh
RATIONALE: Previous work indicates that ivacaftor improves CFTR activity and lung function in people with cystic fibrosis (CF) and G551D-CFTR mutations, but does not reduce density of bacteria or markers of inflammation in the airway. These findings raise the possibility that infection and inflammation may progress independently of CFTR activity once CF lung disease is established. OBJECTIVES: To better understand the relationship between CFTR activity, airway microbiology and inflammation, and lung function in subjects with CF and chronic airway infections...
February 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28221196/fdg-brain-pet-ct-revealing-bilateral-thalamostriatal-activation-during-a-symptomatic-episode-in-a-patient-with-kleine-levin-syndrome
#17
Clément Drouet, Olivier Morel, Antoine Verger, Eric Guedj, Hatem Boulahdour
We report the case of a 14-year-old girl with clinically diagnosed Kleine-Levin syndrome. Electroencephalogram and brain MRI were unremarkable. An FDG PET/CT scan was acquired during a symptomatic episode, while she was asleep, and another PET scan was obtained when she was asymptomatic, awake, and quiet. Comparison of both examinations demonstrated a bilateral activation of thalami, caudate nuclei, and lenticular nuclei. These findings may be linked to the implication of thalamostriatal structures in the regulation of sleep and wakefulness...
February 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28220303/estimation-of-stature-from-femur-length-measured-using-computed-tomography-after-the-analysis-of-three-dimensional-characteristics-of-femur-bone-in-korean-cadavers
#18
Sookyoung Lee, Ho-Hyeon Gong, Jin-Young Hyun, Hyung-Nam Koo, Han-Young Lee, Nak-Eun Chung, Young-Shik Choi, Kyung-Moo Yang, Byung Ha Choi
Estimation of stature is a basic and important forensic procedure in identifying decomposed or skeletonized bodies. Due to advances in radiologic equipment, forensic science frequently uses computed tomography (CT) and software to apply these findings to investigations. Technical developments have increased the accuracy of the measurement of various bones. However, there are still some inaccuracies, such as defining correct landmarks in three-dimensional (3D) images. Femur length is frequently used for calculation of stature, but because it is a 3D structure, the digital image may not always correlate with the femur length measured with an osteometric board...
February 20, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28220262/imaging-pancreatic-cysts-with-ct-and-mri
#19
REVIEW
R Brooke Jeffrey
CT and MRI are the imaging modalities of choice to guide the clinical management of incidentally discovered pancreatic cysts. Most of these lesions are mucinous cysts with varying degrees of malignant potential. This article reviews the CT and MRI findings that help differentiate a potentially aggressive lesion that requires EUS or surgery from a lesion of low malignant potential that is appropriate for imaging surveillance. The imaging-based societal guidelines for these cysts are reviewed.
February 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28218349/mri-and-18f-fdg-pet-ct-in-a-rare-case-of-early-precursor-b-lymphoblastic-leukaemia-with-bone-involvement-as-initial-manifestation
#20
Angelina Cistaro, Vincenzo La Delfa, Gianpaolo Di Rosa, Maurizio Cogoni, Natale Quartuccio
A 4-year old girl presenting gait difficulty was referred for spine X-ray and Magnetic Resonance Imaging (MRI). MRI showed several diffuse hypointense signals in sacral and lumbar vertebrae. In order to exclude a possible lymphoproliferative disease a 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) was requested. The PET/CT scan confirmed the MRI findings and demonstrated additional findings in the sternum. Therefore, a bone marrow biopsy was performed and a diagnosis of acute lymphoblastic leukaemia - early B type was made...
2017: Nuclear Medicine Review. Central & Eastern Europe
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