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Intra muscular injections

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https://www.readbyqxmd.com/read/28287603/shunt-surgery-right-heart-catheterization-and-vascular-morphometry-in-a-rat-model-for-flow-induced-pulmonary-arterial-hypertension
#1
Diederik E van der Feen, Michel Weij, Annemieke Smit-van Oosten, Lysanne M Jorna, Quint A J Hagdorn, Beatrijs Bartelds, Rolf M F Berger
In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt (MCT+Flow). The shunt is created by inserting an 18-G needle from the abdominal aorta into the adjacent caval vein. Increased pulmonary flow has been demonstrated as an essential trigger for a severe form of PAH with distinct phases of disease progression, characterized by early medial hypertrophy followed by neointimal lesions and the progressive occlusion of the small pulmonary vessels...
February 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28092335/distribution-pattern-of-the-superior-and-the-inferior-labial-arteries-impact-for-safe-upper-and-lower-lip-augmentation-procedures
#2
Cotofana Sebastian, Pretterklieber Bettina, Lucius Runhild, Frank Konstantin, Haas Maximilian, Schenck L Thilo, Gleiser Corinna, Weyers Imke, Wedel Thilo, Pretterklieber Michael
BACKGROUND: Understanding the precise position and course of the superior and inferior labial arteries within the upper and the lower lip is crucial for safe and complication free applications of volumizing materials. METHODS: 193 anatomic head specimens (56.5% females) of Caucasian ethnicity were investigated in this large multi-centric anatomical study. In total six 3cm long vertical incisions were performed on each lip (midline and 1cm medial to the angles of the mouth) to identify the position of the superior and the inferior labial arteries in relation to the orbicularis oris muscle...
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28069483/epinephrine-use-in-older-patients-with-anaphylaxis-clinical-outcomes-and-cardiovascular-complications
#3
Takahisa Kawano, Frank Xavier Scheuermeyer, Robert Stenstrom, Brian H Rowe, Eric Grafstein, Brian Grunau
BACKGROUND: There is little data describing the differences in epinephrine (epi) administration and cardiac complications among older and younger patients with anaphylaxis. METHODS: This retrospective cohort study was conducted at two urban emergency departments (ED) over a 5 year-period, and included adults who met a pre-specified criteria for anaphylaxis. Patients ≥50years of age were defined as "older". Univariate logistic regression was performed to compare the difference in frequency of epi administration between the "older" and "younger" groups...
January 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/27872157/exendin-4-increases-oxygen-consumption-and-thermogenic-gene-expression-in-muscle-cells
#4
Jin-Seung Choung, Young-Sun Lee, Hee-Sook Jun
Glucagon-like peptide-1 (GLP1) has many anti-diabetic actions and also increases energy expenditure in vivo As skeletal muscle is a major organ controlling energy metabolism, we investigated whether GLP1 can affect energy metabolism in muscle. We found that treatment of differentiated C2C12 cells with exendin-4 (Ex-4), a GLP1 receptor agonist, reduced oleate:palmitate-induced lipid accumulation and triglyceride content compared with cells without Ex-4 treatment. When we examined the oxygen consumption rate (OCR), not only the basal OCR but also the OCR induced by oleate:palmitate addition was significantly increased in Ex-4-treated differentiated C2C12 cells, and this was inhibited by exendin-9, a GLP1 receptor antagonist...
February 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27644428/piriformis-syndrome-a-case-series-of-31-bangladeshi-people-with-literature-review
#5
Md Abu Bakar Siddiq, Md Shawkat Hossain, Mohammad Moin Uddin, Israt Jahan, Moshiur Rahman Khasru, Neaz Mahmud Haider, Johannes J Rasker
AIMS: To describe a series of piriformis syndrome patient among Bangladesh people with literature review. METHODS: Consecutive 31 piriformis syndrome patients were enrolled. Besides history and clinical examination, piriformis muscle thickness was also measured with diagnostic ultrasound (3.5 MHZ). MRI of lumbar spine, X-rays of lumbo-sacral spine, and pelvis were performed in all patients. Statistical Package for the Social Sciences (SPSS), Windows 8.0, was used for statistical calculation, and univariate analysis of primary data was done...
February 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27584936/nociception-contributes-to-the-formation-of-myogenic-contracture-in-the-early-phase-of-adjuvant-induced-arthritis-in-a-rat-knee
#6
Akinori Kaneguchi, Junya Ozawa, Hideki Moriyama, Kaoru Yamaoka
It is unknown how joint contracture is generated in inflamed joints. This study aimed to clarify the role of nociception on the formation of joint contracture secondary to arthritis. Monoarthritis was induced by intra-articular injections of complete Freund's adjuvant (CFA) into rat knees. On day 5 after CFA injection, the passive extension range of motion (ROM) of knee joints were measured, both before and after myotomy of knee flexors, to evaluate the extent of muscular contribution to CFA-induced joint contracture...
September 1, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27562648/liposomal-angiogenic-peptides-for-ischemic-limb-perfusion-comparative-study-between-different-administration-methods
#7
Hyosook Hwang, Hyeon-Soo Kim, Hwan-Seok Jeong, Bagalkot Tarique Rajasaheb, Minjoo Kim, Phil-Sun Oh, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
BACKGROUND: We investigated the therapeutic effectiveness of PEGylated liposomes loaded with angiogenic peptides for treating hindlimb ischemia. METHODS: Rats received a femoral artery occlusion. Red blood cells collected from the animals were labeled with technetium-99m. Limb perfusion gamma imaging was performed. PEGylated liposomes loaded with angiogenic peptides were administered intra-arterially. Technetium-99m red blood cell imaging was repeated 1 week later...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27554490/-temporomandibular-joint-arthropathy-in-situ-steroid-injection
#8
J Gagé, A Gallucci, M Arnaud, C Chossegros, J M Foletti
INTRODUCTION: Temporomandibular disorders (TMDs) affect the masticatory muscles and the temporomandibular joints (TMJs). TMDs most often result from occlusal and/or muscular disorders and are then called primary or idiopathic TMDs. Less frequently, TMDs are related to local (trauma, infection) or general (rheumatoid arthritis) causes and are then called secondary TMDs. A little known iatrogenic cause of secondary TDM is the osteoarthritis that may be induced by intra-articular cortisone injections...
September 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27506452/adaptive-immune-response-impairs-the-efficacy-of-autologous-transplantation-of-engineered-stem-cells-in-dystrophic-dogs
#9
Clementina Sitzia, Andrea Farini, Luciana Jardim, Paola Razini, Marzia Belicchi, Letizia Cassinelli, Chiara Villa, Silvia Erratico, Daniele Parolini, Pamela Bella, Joao Carlos da Silva Bizario, Luis Garcia, Marcelo Dias-Baruffi, Mirella Meregalli, Yvan Torrente
Duchenne muscular dystrophy is the most common genetic muscular dystrophy. It is caused by mutations in the dystrophin gene, leading to absence of muscular dystrophin and to progressive degeneration of skeletal muscle. We have demonstrated that the exon skipping method safely and efficiently brings to the expression of a functional dystrophin in dystrophic CD133+ cells injected scid/mdx mice. Golden Retriever muscular dystrophic (GRMD) dogs represent the best preclinical model of Duchenne muscular dystrophy, mimicking the human pathology in genotypic and phenotypic aspects...
November 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27394932/placebo-controlled-evaluation-of-a-bioengineered-cocaine-metabolizing-fusion-protein-tv-1380-albubche-in-the-treatment-of-cocaine-dependence
#10
Yossi Gilgun-Sherki, Rom E Eliaz, David J McCann, Pippa S Loupe, Eli Eyal, Kathleen Blatt, Orit Cohen-Barak, Hussein Hallak, Nora Chiang, Shwe Gyaw
BACKGROUND: TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased catalytic efficiency for cocaine metabolism compared to wild-type BChE. METHODS: Intra-muscular injections of TV-1380 (150mg or 300mg) or placebo were administered once weekly to participants (n=66-69 per group) in a randomized, double-blind study to evaluate the ability of TV-1380 to facilitate abstinence in treatment-seeking, cocaine-dependent individuals...
September 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27128942/intraprostatic-botulinum-neurotoxin-type-a-injection-for-benign-prostatic-hyperplasia-a-spotlight-in-reality
#11
REVIEW
Yu-Chao Hsu, Hung-Jen Wang, Yao-Chi Chuang
Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum. It inhibits the release of acetylcholine and other neurotransmitters from the nerve terminal. Botulinum toxin, specifically toxin type A (BoNT-A) has been used since the 1970s to reduce the muscular hypercontraction disorders. The application of BoNT-A in urology field started from intra-bladder injection for overactive bladder, which has been recognized as third line therapy in many countries. Since prostate gland as well as bladder is under the influence of autonomic innervation, theorectically, injection of BoNT-A into the prostate induces chemo-denervation and modulation of prostate function, and reduces lower urinary tract symptoms (LUTS)...
April 26, 2016: Toxins
https://www.readbyqxmd.com/read/27026043/interferon-%C3%AE-1a-and-atorvastatin-in-the-treatment-of-multiple-sclerosis
#12
RANDOMIZED CONTROLLED TRIAL
Keyvan Ghasami, Fardin Faraji, Masoud Fazeli, Ali Ghazavi, Ghasem Mosayebi
BACKGROUND: Statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. OBJECTIVE: To evaluate the effects of atorvastatin in combination with Interferon-β in the treatment of multiple sclerosis (MS) in a randomized controlled clinical trial. METHODS: Multiple sclerosis patients were randomized independently, in a double blind design, into one of two treatment groups...
March 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/26994817/medicinal-plant-combretum-leprosum-mart-ameliorates-motor-biochemical-and-molecular-alterations-in-a-parkinson-s-disease-model-induced-by-mptp
#13
Livia S Moraes, Bruna Z Rohor, Lorena B Areal, Evaldo V Pereira, Alexandre M C Santos, Valdir A Facundo, Adair R S Santos, Rita G W Pires, Cristina Martins-Silva
ETHNOPHARMACOLOGICAL RELEVANCE: Combretum leprosum is a popular medicinal plant distributed in north and northeastern regions of Brazil. Many different parts of this plant are used in traditional medicine to treat several inflammatory diseases. Parkinson's disease (PD) is a disorder associated with inflammatory toxic factors and the treatments available provide merely a delay of the neurodegeneration. AIM OF THE STUDY: We investigated the potential neuroprotective properties of the C...
June 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26988923/zoonotic-trypanosomes-in-south-east-asia-attempts-to-control-trypanosoma-lewisi-using-veterinary-drugs
#14
Marc Desquesnes, Sarawut Yangtara, Pawinee Kunphukhieo, Piangjai Chalermwong, Sathaporn Jittapalapong, Stéphane Herder
A growing number of atypical human infections due to the livestock parasite Trypanosoma evansi, or to the rat parasite Trypanosoma lewisi, are reported in humans in Asia. In some cases, clinical evolutions request treatments, however, so far, there were very few attempts to control T. lewisi using trypanocidal drugs. In a study published elsewhere, the efficacy of human trypanocides is evaluated in laboratory rats, and it concludes that none of them is able to cure rats experimentally infected with T. lewisi...
June 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/26955912/evaluation-of-group-versus-individual-physiotherapy-following-lower-limb-intra-muscular-botulinum-toxin-type-a-injections-for-ambulant-children-with-cerebral-palsy-a-single-blind-randomized-comparison-trial
#15
RANDOMIZED CONTROLLED TRIAL
Rachel E Thomas, Leanne M Johnston, Leanne Sakzewski, Megan J Kentish, Roslyn N Boyd
This study aimed to evaluate efficacy of group (GRP) versus individual (IND) physiotherapy rehabilitation following lower limb intramuscular injections of Botulinum Toxin-Type A (BoNT-A) for ambulant children with cerebral palsy (CP). Following lower limb BoNT-A injections, 34 children were randomly allocated to GRP (n=17; mean age 7y8m SD 2.0; 13 males; Gross Motor Function Classification System (GMFCS) I=5, II=8, III=4) or IND physiotherapy (n=17; mean age 8y7m SD 2.0; 11 males; GMFCS I=9, II=5, III=3). Primary outcomes were the Canadian Occupational Performance Measure (COPM) and Edinburgh Visual Gait Score (EVGS) assessed at baseline, 10 and 26 weeks post intervention...
June 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/26929555/a-single-pre-operative-dose-of-sub-mucosal-dexamethasone-is-effective-in-improving-post-operative-quality-of-life-in-the-surgical-management-of-impacted-third-molars-a-comparative-randomised-prospective-study
#16
K Saravanan, R Kannan, Reena Rachel John, C Nantha Kumar
OBJECTIVE: The aim of the study was to observe and compare the effects of dexamethasone on pain, swelling and trismus administered as one dose preoperatively sub mucosal (study group 2) versus intramuscular injection (study group 1) keeping control as those who received no dose of steroid in the management of third molar surgery. MATERIALS AND METHODS: The group 2 (20 patients) is the study group in which all the patients had single dose of pre-operative sub mucosal dexamethasone of 4 mg/2 ml...
March 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/26847305/comparison-between-steroid-injection-and-stretching-exercise-on-the-scalene-of-patients-with-upper-extremity-paresthesia-randomized-cross-over-study
#17
RANDOMIZED CONTROLLED TRIAL
Yong Wook Kim, Seo Yeon Yoon, Yongbum Park, Won Hyuk Chang, Sang Chul Lee
PURPOSE: To compare the therapeutic effects on upper extremity paresthesia of intra-muscular steroid injections into the scalene muscle with those of stretching exercise only. MATERIALS AND METHODS: Twenty patients with upper extremity paresthesia who met the criteria were recruited to participate in this single-blind, crossover study. Fourteen of 20 patients were female. The average age was 45.0 ± 10.5 years and duration of symptom was 12.2 ± 8.7 months. Each participant completed one injection and daily exercise program for 2 weeks...
March 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/26797873/vaccination-with-a-co-expression-dna-plasmid-containing-gad65-fragment-gene-and-il-10-gene-induces-regulatory-cd4-t-cells-that-prevent-experimental-autoimmune-diabetes
#18
Xinyuan Liu, Song Zhang, Xia Li, Peilin Zheng, Fang Hu, Zhiguang Zhou
BACKGROUND: The non-obese diabetic (NOD) mouse is a commonly used animal model for studying type 1 diabetes (T1D). The aims of our study were to explore the diabetes-preventive effect in NOD mice and the potential mechanisms of an optimized co-expression DNA vaccine containing GAD65 fragment gene with the IL-10 gene (SGAD65190-315 /IL-10). METHODS: Female NOD mice at the age of 3-4 weeks old were randomly divided into two groups and received intra-muscular injection of either blank pBudCE4...
September 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/26738673/pulmonary-artery-denervation-attenuates-pulmonary-arterial-remodeling-in-dogs-with-pulmonary-arterial-hypertension-induced-by-dehydrogenized-monocrotaline
#19
Ling Zhou, Juan Zhang, Xiao-Min Jiang, Du-Jiang Xie, Jin-Song Wang, Li Li, Bin Li, Zhi-Mei Wang, Alexander M K Rothman, Allan Lawrie, Shao-Liang Chen
OBJECTIVES: This study aimed to investigate sympathetic nerve (SN) ultrastructural changes and hemodynamic and pulmonary artery (PA) pathological improvements by pulmonary arterial denervation (PADN) in animals with pulmonary arterial hypertension (PAH), as well as the underlying mechanisms. BACKGROUND: SN overactivity plays a role in PAH. Previous studies have reported short-term improvements in pulmonary arterial pressure (PAP) and cardiac function by PADN, but PA remodeling and the associated mechanisms remain unclear...
December 28, 2015: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26645160/usefulness-of-intra-articular-botulinum-toxin-injections-a-systematic-review
#20
REVIEW
Hichem Khenioui, Eric Houvenagel, Jean François Catanzariti, Marc Alexandre Guyot, Olivier Agnani, Cécile Donze
UNLABELLED: Botulinum toxin is a proven and widely used treatment for numerous conditions characterized by excessive muscular contractions. Recent studies have assessed the analgesic effect of botulinum toxin in joint pain and started to unravel its mechanisms. LITERATURE-SEARCH-METHODOLOGY: We searched the international literature via the Medline database using the term "intraarticular botulinum toxin injection" combined with any of the following terms: "knee", "ankle", "shoulder", "osteoarthritis", "adhesive capsulitis of the shoulder"...
March 2016: Joint, Bone, Spine: Revue du Rhumatisme
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