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Intra muscular injections

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https://www.readbyqxmd.com/read/28618138/expansion-of-umbilical-cord-blood-aldehyde-dehydrogenase-expressing-cells-generates-myeloid-progenitor-cells-that-stimulate-limb-revascularization
#1
David M Putman, Tyler T Cooper, Stephen E Sherman, Ayesh K Seneviratne, Mark Hewitt, Gillian I Bell, David A Hess
Uncompromised by chronic disease-related comorbidities, human umbilical cord blood (UCB) progenitor cells with high aldehyde dehydrogenase activity (ALDH(hi) cells) stimulate blood vessel regeneration after intra-muscular transplantation. However, implementation of cellular therapies using UCB ALDH(hi) cells for critical limb ischemia, the most severe form of severe peripheral artery disease, is limited by the rarity (<0.5%) of these cells. Our goal was to generate a clinically-translatable, allogeneic cell population for vessel regenerative therapies, via ex vivo expansion of UCB ALDH(hi) cells without loss of pro-angiogenic potency...
June 15, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28599837/measurement-of-testosterone-and-cortisol-metabolites-and-luteinising-hormone-in-captive-southern-hairy-nosed-wombat-lasiorhinus-latifrons-urine
#2
Z Du, T Keeley, T Janssen, V Nicolson, S D Johnston
This study reports the validation and use of enzyme immunoassays (EIA) to measure changes in plasma and urinary luteinizing hormone, testosterone metabolites (UTM) and cortisol metabolites (UCM) in captive southern hairy-nosed wombats (Lasiorhinus latifrons). GnRH agonist and ACTH agonist challenges were conducted to validate urinary testosterone (male wombat only) and cortisol (male and female wombats) EIAs. Following intra-muscular injection of 8-12μg buserelin (n=4 males), there was a significant increase in both plasma (P<0...
June 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28576565/the-expression-of-vdr-mrna-but-not-nf-%C3%AE%C2%BAb-surprisingly-decreased-after-vitamin-d-treatment-in-multiple-sclerosis-patients
#3
Zeinab Shirvani-Farsani, Majid Pahlevan Kakhki, Bahar Naghavi Gargari, Roozita Doosti, Abdorreza Naser Moghadasi, Amir Reza Azimi, Mehrdad Behmanesh
BACKGROUND AND PURPOSE: The aim of this study was to investigate the expression levels of vitamin D receptor (VDR) and NF-κB mRNAs in vitamin D (VD) supplemented multiple sclerosis (MS) patients. METHODS: RRMS patients received 50,000 IU vitamin D3/week as an intra-muscular injection for 2 months. Blood samples were obtained from 30 MS patients before and after VD supplementation and 32 healthy individuals, and then VDR and NF-κB mRNA levels were measured by real time PCR method and analyzed with independent and paired t-tests...
May 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28571943/hematological-alterations-and-splenic-t-lymphocyte-polarization-at-the-crest-of-snake-venom-induced-acute-kidney-injury-in-adult-male-mice
#4
Farhat Nasim, Sreyasi Das, Roshnara Mishra, Raghwendra Mishra
Snake venom induced acute kidney injury (SAKI) is of great clinical relevance in tropical countries. Involvement of T cell, a key mediator of AKI and its remission, is least explored in SAKI. In the present study the in vivo hematological alterations and associated splenic T cell polarization is probed in order to investigate the immune response at the crest of Russell's viper venom (RVV) induced AKI in experimental murine model. Based on a dose and time kinetic study intra muscular injection dose of 20 μg RVV/100 gm body weight of mice and incubation period of 60 h was selected for induction of SAKI...
August 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28439156/diclofenac-transdermal-patch-a-potential-ingress-to-maxillofacial-surgery
#5
Anisha Perepa, Brig Ramen Sinha, Uday Kiran Uppada, Avss Subramanya Kumar
PURPOSE: To evaluate the analgesic efficacy of a diclofenac transdermal patch with diclofenac intra muscular injection in the immediate postoperative period in patients undergoing major oral surgical procedures. MATERIALS AND METHODS: Subjects who underwent bijaw surgeries for surgical correction of various dentofacial deformities were included. Sixty such patients who belonged to the above entity were randomly categorized into two groups from Jan 2012-Aug 2015...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28431886/innate-resistance-of-new-zealand-paua-to-abalone-viral-ganglioneuritis
#6
Serge Corbeil, Kenneth A McColl, Lynette M Williams, Joanne Slater, Mark St J Crane
The susceptibility of New Zealand paua (Haliotis iris) to infection by abalone herpesvirus (Haliotid herpesvirus 1; HaHV) and to the disease abalone viral ganglioneuritis (AVG) was determined. Infection challenges performed by intra-muscular injection and by immersion in infectious water containing HaHV demonstrated that New Zealand paua were highly resistant to infection by Haliotid herpesvirus 1 and were fully resistant to the disease AVG.
April 18, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28412011/-nicolau-livedoid-dermatitis-with-severe-neurological-involvement-in-a-child
#7
F-Z Elfatoiki, A Ennajdi, W Gueddari, S Chiheb
BACKGROUND: Nicolau syndrome is a rare condition consisting in tissue ischemia and necrosis following intramuscular, intra-articular or subcutaneous injection. PATIENTS AND METHODS: Immediately after gluteal intramuscular injection of benzathine-penicillin, a 10-year-old male child presented an extensive painful violaceous lesion on the left buttock associated with urinary incontinence and left lower-limb paresis. Additional underlying muscular damage was supported by high serum levels of creatine kinase and lactate dehydrogenase...
April 12, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28397996/preliminary-investigations-into-a-novel-long-acting-injectable-intramuscular-formulation-of-omeprazole-in-the-horse
#8
B W Sykes, K Kathawala, Y Song, S Garg, S W Page, C Underwood, P C Mills
BACKGROUND: Pilot investigations have suggested that a novel, long-acting, injectable i.m. formulation of omeprazole (LA-OMEP) can induce acid suppression for up to 7 days following a single injection. OBJECTIVES: To investigate the pharmacodynamics and assess the clinical efficacy of the LA-OMEP formulation. STUDY DESIGN: Part A comprised a pharmacodynamic study. Part B consisted of a pilot clinical trial. METHODS: Part A enrolled six adult Thoroughbred horses with percutaneous gastrotomy tubes...
April 11, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28391056/influence-of-long-term-high-dose-dexamethasone-administration-on-proliferation-and-apoptosis-in-porcine-hepatocytes
#9
Mateusz Mikiewicz, Iwona Otrocka-Domagała, Katarzyna Paździor-Czapula, Tadeusz Rotkiewicz
The aim of this study was to examine the influence of long-term, high-dose dexamethasone administration on the liver, with particular emphasis on hepatocyte proliferation and apoptosis, using a swine model. The study included 48 large, female Polish breed pigs aged 3months (weighing ca. 30kg) divided into groups I (control; n=24) and II (dexamethasone; n=24) that receiving intra-muscular injections of monosodium phosphate dexamethasone for 29days. The pigs were euthanized on days subsequent to the experiment...
April 2, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28367421/coadministration-of-dexamethasone-and-melissa-officinalis-has-neuroprotective-effects-in-rat-animal-model-with-spinal-cord-injury
#10
Seyed Ruhollah Hosseini, Gholamreza Kaka, Mohammad Taghi Joghataei, Mehdi Hooshmandi, Seyed Homayoon Sadraie, Kayvan Yaghoobi, Korosh Mansoori, Alireza Mohammadi
OBJECTIVE: Spinal cord injury (SCI) causes inflammation, deformity and cell loss. It has been shown that Melissa officinalis (MO), as herbal medicine, and dexamethasone (DEX) are useful in the prevention of various neurological diseases. The present study evaluated combinational effects of DEX and MO on spinal cord injury. MATERIALS AND METHODS: Thirty six adult male Wistar rats were used in this experimental study. The weight-drop contusion method was employed to induce spinal cord injury in rats...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28287603/shunt-surgery-right-heart-catheterization-and-vascular-morphometry-in-a-rat-model-for-flow-induced-pulmonary-arterial-hypertension
#11
Diederik E van der Feen, Michel Weij, Annemieke Smit-van Oosten, Lysanne M Jorna, Quint A J Hagdorn, Beatrijs Bartelds, Rolf M F Berger
In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt (MCT+Flow). The shunt is created by inserting an 18-G needle from the abdominal aorta into the adjacent caval vein. Increased pulmonary flow has been demonstrated as an essential trigger for a severe form of PAH with distinct phases of disease progression, characterized by early medial hypertrophy followed by neointimal lesions and the progressive occlusion of the small pulmonary vessels...
February 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28092335/distribution-pattern-of-the-superior-and-inferior-labial-arteries-impact-for-safe-upper-and-lower-lip-augmentation-procedures
#12
Sebastian Cotofana, Bettina Pretterklieber, Runhild Lucius, Konstantin Frank, Maximilian Haas, Thilo L Schenck, Corinna Gleiser, Imke Weyers, Thilo Wedel, Michael Pretterklieber
BACKGROUND: Understanding the precise position and course of the superior and inferior labial arteries within the upper lip and the lower lip is crucial for safe and complication-free applications of volumizing materials. METHODS: One hundred ninety-three anatomical head specimens (56.5 percent female cadavers) of Caucasian ethnicity were investigated in this large multicenter anatomical study. In total, six 3-cm-long vertical incisions were performed on each lip (midline and 1 cm medial to the angles of the mouth) to identify the position of the superior and inferior labial arteries in relation to the orbicularis oris muscle...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28069483/epinephrine-use-in-older-patients-with-anaphylaxis-clinical-outcomes-and-cardiovascular-complications
#13
Takahisa Kawano, Frank Xavier Scheuermeyer, Robert Stenstrom, Brian H Rowe, Eric Grafstein, Brian Grunau
BACKGROUND: There is little data describing the differences in epinephrine (epi) administration and cardiac complications among older and younger patients with anaphylaxis. METHODS: This retrospective cohort study was conducted at two urban emergency departments (ED) over a 5 year-period, and included adults who met a pre-specified criteria for anaphylaxis. Patients ≥50years of age were defined as "older". Univariate logistic regression was performed to compare the difference in frequency of epi administration between the "older" and "younger" groups...
March 2017: Resuscitation
https://www.readbyqxmd.com/read/27872157/exendin-4-increases-oxygen-consumption-and-thermogenic-gene-expression-in-muscle-cells
#14
Jin-Seung Choung, Young-Sun Lee, Hee-Sook Jun
Glucagon-like peptide-1 (GLP1) has many anti-diabetic actions and also increases energy expenditure in vivo As skeletal muscle is a major organ controlling energy metabolism, we investigated whether GLP1 can affect energy metabolism in muscle. We found that treatment of differentiated C2C12 cells with exendin-4 (Ex-4), a GLP1 receptor agonist, reduced oleate:palmitate-induced lipid accumulation and triglyceride content compared with cells without Ex-4 treatment. When we examined the oxygen consumption rate (OCR), not only the basal OCR but also the OCR induced by oleate:palmitate addition was significantly increased in Ex-4-treated differentiated C2C12 cells, and this was inhibited by exendin-9, a GLP1 receptor antagonist...
February 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27644428/piriformis-syndrome-a-case-series-of-31-bangladeshi-people-with-literature-review
#15
REVIEW
Md Abu Bakar Siddiq, Md Shawkat Hossain, Mohammad Moin Uddin, Israt Jahan, Moshiur Rahman Khasru, Neaz Mahmud Haider, Johannes J Rasker
AIMS: To describe a series of piriformis syndrome patient among Bangladesh people with literature review. METHODS: Consecutive 31 piriformis syndrome patients were enrolled. Besides history and clinical examination, piriformis muscle thickness was also measured with diagnostic ultrasound (3.5 MHZ). MRI of lumbar spine, X-rays of lumbo-sacral spine, and pelvis were performed in all patients. Statistical Package for the Social Sciences (SPSS), Windows 8.0, was used for statistical calculation, and univariate analysis of primary data was done...
February 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27584936/nociception-contributes-to-the-formation-of-myogenic-contracture-in-the-early-phase-of-adjuvant-induced-arthritis-in-a-rat-knee
#16
Akinori Kaneguchi, Junya Ozawa, Hideki Moriyama, Kaoru Yamaoka
It is unknown how joint contracture is generated in inflamed joints. This study aimed to clarify the role of nociception on the formation of joint contracture secondary to arthritis. Monoarthritis was induced by intra-articular injections of complete Freund's adjuvant (CFA) into rat knees. On day 5 after CFA injection, the passive extension range of motion (ROM) of knee joints were measured, both before and after myotomy of knee flexors, to evaluate the extent of muscular contribution to CFA-induced joint contracture...
September 1, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27562648/liposomal-angiogenic-peptides-for-ischemic-limb-perfusion-comparative-study-between-different-administration-methods
#17
Hyosook Hwang, Hyeon-Soo Kim, Hwan-Seok Jeong, Bagalkot Tarique Rajasaheb, Minjoo Kim, Phil-Sun Oh, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
BACKGROUND: We investigated the therapeutic effectiveness of PEGylated liposomes loaded with angiogenic peptides for treating hindlimb ischemia. METHODS: Rats received a femoral artery occlusion. Red blood cells collected from the animals were labeled with technetium-99m. Limb perfusion gamma imaging was performed. PEGylated liposomes loaded with angiogenic peptides were administered intra-arterially. Technetium-99m red blood cell imaging was repeated 1 week later...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27554490/-temporomandibular-joint-arthropathy-in-situ-steroid-injection
#18
J Gagé, A Gallucci, M Arnaud, C Chossegros, J M Foletti
INTRODUCTION: Temporomandibular disorders (TMDs) affect the masticatory muscles and the temporomandibular joints (TMJs). TMDs most often result from occlusal and/or muscular disorders and are then called primary or idiopathic TMDs. Less frequently, TMDs are related to local (trauma, infection) or general (rheumatoid arthritis) causes and are then called secondary TMDs. A little known iatrogenic cause of secondary TDM is the osteoarthritis that may be induced by intra-articular cortisone injections...
September 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27506452/adaptive-immune-response-impairs-the-efficacy-of-autologous-transplantation-of-engineered-stem-cells-in-dystrophic-dogs
#19
Clementina Sitzia, Andrea Farini, Luciana Jardim, Paola Razini, Marzia Belicchi, Letizia Cassinelli, Chiara Villa, Silvia Erratico, Daniele Parolini, Pamela Bella, Joao Carlos da Silva Bizario, Luis Garcia, Marcelo Dias-Baruffi, Mirella Meregalli, Yvan Torrente
Duchenne muscular dystrophy is the most common genetic muscular dystrophy. It is caused by mutations in the dystrophin gene, leading to absence of muscular dystrophin and to progressive degeneration of skeletal muscle. We have demonstrated that the exon skipping method safely and efficiently brings to the expression of a functional dystrophin in dystrophic CD133+ cells injected scid/mdx mice. Golden Retriever muscular dystrophic (GRMD) dogs represent the best preclinical model of Duchenne muscular dystrophy, mimicking the human pathology in genotypic and phenotypic aspects...
November 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27394932/placebo-controlled-evaluation-of-a-bioengineered-cocaine-metabolizing-fusion-protein-tv-1380-albubche-in-the-treatment-of-cocaine-dependence
#20
Yossi Gilgun-Sherki, Rom E Eliaz, David J McCann, Pippa S Loupe, Eli Eyal, Kathleen Blatt, Orit Cohen-Barak, Hussein Hallak, Nora Chiang, Shwe Gyaw
BACKGROUND: TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased catalytic efficiency for cocaine metabolism compared to wild-type BChE. METHODS: Intra-muscular injections of TV-1380 (150mg or 300mg) or placebo were administered once weekly to participants (n=66-69 per group) in a randomized, double-blind study to evaluate the ability of TV-1380 to facilitate abstinence in treatment-seeking, cocaine-dependent individuals...
September 1, 2016: Drug and Alcohol Dependence
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