Shola Michelle Richards, Caroline Gubser Keller, Robert Kreutzer, Géraldine Greiner, Svenja Ley, Arno Doelemeyer, Valerie Dubost, Thierry Flandre, Susan Kirkland, Walter Carbone, Rishika Pandya, Judith Knehr, Guglielmo Roma, Sven Schuierer, Laure Bouchez, Klaus Seuwen, Alexandra Aebi, David Westhead, Gabriele Hintzen, Giorgia Jurisic, Imtiaz Hossain, Marilisa Neri, Nenad Manevski, Kamal Kumar Balavenkatraman, Pierre Moulin, Annette Begrich, Barbara Bertschi, Roland Huber, Tewis Bouwmeester, Vickie R Driver, Moritz von Schwabedissen, Dirk Schaefer, Barbara Wettstein, Reto Wettstein, Heinz Ruffner
A limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various common chronic ulcer types to facilitate drug discovery strategies. We conducted a comprehensive analysis of leg ulcers (LUs), encompassing venous and arterial ulcers, foot ulcers (FUs), pressure ulcers (PUs), and compared them with surgical wound healing complications (WHCs). To explore the pathophysiological mechanisms and identify similarities or differences within wounds, we dissected wounds into distinct subregions, including the wound bed, border, and peri-wound areas, and compared them against intact skin...
December 27, 2023: International Wound Journal