keyword
https://read.qxmd.com/read/37893875/feasibility-of-a-supervised-postpartum-exercise-program-and-effects-on-maternal-health-and-fitness-parameters-pilot-study
#21
JOURNAL ARTICLE
Carla Brites-Lagos, Liliana Ramos, Anna Szumilewicz, Rita Santos-Rocha
The postpartum period is marked by profound changes in women at physical, psychological, and physiological levels. Many of these changes persist after four to six weeks postpartum, and most women do not resume their levels of physical activity, which increases the risk of remaining inactive for many years. It is crucial to implement effective programs that promote exercise during the postpartum period. The objective of this study was to test the feasibility and analyze the effects of a structured and supervised postpartum exercise program on maternal health and fitness parameters...
October 23, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37853433/predictors-of-in-hospital-appendiceal-perforation-in-patients-with-non-perforated-acute-appendicitis-with-appendicolithiasis-at-presentation
#22
JOURNAL ARTICLE
Amir H Sohail, Hazim Hakmi, Koral Cohen, Joshua C Hurwitz, Jasmine Brite, Sawyer Cimaroli, Harry Tsou, Michael Khalife, James Maurer, Matthew Symer
INTRODUCTION: Appendicolithiasis is a risk factor for perforated acute appendicitis. There is limited inpatient data on predictors of progression in appendicolithiasis-associated non-perforated acute appendicitis. METHODS: We identified adults presenting with appendicolithiasis-associated non-perforated acute appendicitis (on computed tomography) who underwent appendectomy. Logistic regression was used to investigate predictors of in-hospital perforation (on histopathology)...
October 18, 2023: BMC Surgery
https://read.qxmd.com/read/37813359/seroprevalence-and-indexes-of-igg-antibodies-for-sars-cov-2-infection-among-people-living-with-hiv-tuberculosis-patients-and-healthcare-workers-in-salvador-brazil
#23
JOURNAL ARTICLE
Daniele Souza de Santana, Eduardo Martins Netto, Sara Nunes Vaz, Paulo Henrique Dantas, Carlos Brites
INTRODUCTION: COVID-19 can trigger different clinical presentations in distinct population groups, some of which are considered at higher risk of SARS-CoV-2 infection. Little is known about the susceptibility of certain populations to the infection. OBJECTIVES: We aimed to determine the prevalence of COVID-19 among People Living With HIV/AIDS (PLWH) attending a tertiary public hospital in Salvador, Brazil, patients with active pulmonary tuberculosis and Hospital's Healthcare Workers (HCW), and to compare their SARS-CoV-2 antibody levels...
October 6, 2023: Brazilian Journal of Infectious Diseases
https://read.qxmd.com/read/37810935/development-and-validation-of-a-transgender-health-care-humanization-scale
#24
JOURNAL ARTICLE
Ana Clara Guimarães da Silva, Liliane Lins-Kusterer, Estela Luz, Carlos Brites
PURPOSE: Stigma and discrimination against transgender people can lead to their segregation. Fighting stigma and discrimination is a crucial strategy to expand access to health services. The goals of the present study were to develop and validate a transgender health care humanization scale (THcH scale) to evaluate the perception of humanization in health care for transgender individuals. METHODS: This cross-sectional study included 340 health care providers aged ≥18 years...
October 2023: Transgender Health
https://read.qxmd.com/read/37808865/detection-of-anti-premembrane-antibody-as-a-specific-marker-of-four-flavivirus-serocomplexes-and-its-application-to-serosurveillance-in-endemic-regions
#25
Guan-Hua Chen, Yu-Ching Dai, Szu-Chia Hsieh, Jih-Jin Tsai, Ava Kristy Sy, Mario Jiz, Celia Pedroso, Carlos Brites, Eduardo Martins Netto, Phyllis J Kanki, Danielle R D Saunders, Dana L Vanlandingham, Stephen Higgs, Yan-Jang S Huang, Wei-Kung Wang
In the past few decades, several emerging/re-emerging mosquito-borne flaviviruses have resulted in disease outbreaks of public health concern in the tropics and subtropics. Due to cross-reactivities of antibodies recognizing the envelope protein of different flaviviruses, serosurveillance remains a challenge. Previously we reported that anti-premembrane (prM) antibody can discriminate between three flavivirus infections by Western blot analysis. In this study, we aimed to develop a serological assay that can discriminate infection or exposure with flaviviruses from four serocomplexes, including dengue (DENV), Zika (ZIKV), West Nile (WNV) and yellow fever (YFV) viruses, and explore its application for serosurveillance in flavivirus-endemic countries...
September 25, 2023: medRxiv
https://read.qxmd.com/read/37800823/long-term-outcomes-of-highly-experienced-people-with-hiv-undergoing-salvage-therapy-with-raltegravir
#26
JOURNAL ARTICLE
Jesús Enrique Patiño Escarcina, Eduardo Martins Netto, Carlos Brites
Raltegravir and other third-line drugs have shown promise in improving outcomes in treatment-experienced patients. However, the efficacy and tolerability of these agents vary. This study assessed real-life virologic success, long-term survival, and adverse events in patients receiving raltegravir or other third-line drugs as salvage regimens. This retrospective cohort study included adults who experienced treatment failure (human immunodeficiency syndrome-1 RNA plasma viral load >1000 copies/mL) and subsequently initiated raltegravir or other third-line drugs (darunavir/ritonavir, maraviroc, or etravirine)...
October 6, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37797204/sweet-swell-of-burning-fat-emerging-role-of-high-density-lipoprotein-in-energy-homeostasis
#27
JOURNAL ARTICLE
Anatol Kontush, Maximiliano Martin, Fernando Brites
PURPOSE OF REVIEW: Metabolism of lipids and lipoproteins, including high-density lipoprotein (HDL), plays a central role in energy homeostasis. Mechanisms underlying the relationship between energy homeostasis and HDL however remain poorly studied. RECENT FINDINGS: Available evidence reveals that HDL is implicated in energy homeostasis. Circulating high-density lipoprotein-cholesterol (HDL-C) levels are affected by energy production, raising with increasing resting metabolic rate...
October 6, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37793940/impaired-hdl-associated-enzymes-and-proteins-in-children-and-adolescents-with-weight-disorders-and-their-association-with-novel-cardiometabolic-indexes
#28
JOURNAL ARTICLE
Maximiliano Martin, Belen Davico, Maria Florencia Verona, Walter Francisco Tetzlaff, Ezequiel Lozano Chiappe, Lisandro Gilligan, Graciela Jimenez, Leonardo Gomez Rosso, Gabriela Ballerini, Laura Boero, Julian Verona, Fernando Brites
BACKGROUND AND AIMS: Overweight/obesity (OW/OB) is associated with modifications in lipoprotein (Lp)-associated enzymes and proteins, such as cholesteryl ester transfer protein (CETP), Lp-associated phospholipase A2 (LpPLA2 ) and paraoxonase (PON)1. No evidence is available regarding underweight (UW). The following indexes have been proposed to better assess atherogenic risk related to weight alterations: triglycerides-glucose index (TyG), visceral adiposity index (VAI) and height-corrected lipid accumulation product (HLAP)...
September 9, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/37788801/weight-gain-in-patients-starting-dolutegravir-based-art-according-to-baseline-cd4-count-after-48-weeks-of-follow-up
#29
JOURNAL ARTICLE
Érico C Cardoso-Neto, Eduardo Martins Netto, Carlos Brites
BACKGROUND: Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. OBJECTIVES: To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. METHODS: PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in two AIDS referral centers were stratified by baseline CD4 count (lower or higher than 200 cells/mm3 ). Data on CD4 count, HIV viral load, weight/Body Mass Index (BMI), lipids and glucose levels were collected at baseline, 24 and 48 weeks of treatment...
2023: Brazilian Journal of Infectious Diseases
https://read.qxmd.com/read/37780039/delayed-presentation-of-surgically-induced-scleral-necrosis-after-i-brite-procedure-treated-with-immunosuppressive-therapy
#30
Nadim S Azar, Raul E Ruiz-Lozano, Manuel E Quiroga-Garza, Matias Soifer, Hazem M Mousa, Seitaro Komai, David L Leverenz, Victor L Perez
Surgically induced scleral necrosis (SISN) is an uncommon complication of ocular procedures. Cosmetic eye-whitening surgery involves conjunctival and Tenon's capsule dissection, cautery, and mitomycin C application. We report the case of a 36-year-old white woman referred to our clinic for severe pain, scleral inflammation, and necrosis in both eyes 9 years after I-BRITE, an elective eye-whitening procedure. An extensive workup yielded negative results. The patient improved with aggressive lubrication and topical and high-dose systemic prednisone (60 mg), with recurrence upon steroid tapering...
2023: Digital Journal of Ophthalmology: DJO
https://read.qxmd.com/read/37735435/influence-of-the-timing-of-biological-treatment-initiation-on-juvenile-idiopathic-arthritis-long-term-outcomes
#31
JOURNAL ARTICLE
Filipa Oliveira Ramos, Ana Maria Rodrigues, Ana Teresa Melo, Francisca Aguiar, Luísa Brites, Soraia Azevedo, Ana Catarina Duarte, José António Melo Gomes, Carolina Furtado, Ana Filipa Mourão, Graça Sequeira, Inês Cunha, Ricardo Figueira, Maria José Santos, João Eurico Fonseca
BACKGROUND: Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. However, it is unclear what is the long-term impact on health-related outcomes of the timing of biological disease-modifying antirheumatic drug (bDMARD) initiation in JIA. Our aim was to evaluate the long-term impact of the time between JIA onset and the initiation of a bDMARD in achieving clinical remission, on physical disability and health-related quality of life (HRQoL)...
September 21, 2023: Arthritis Research & Therapy
https://read.qxmd.com/read/37729225/cytogenetic-changes-in-oral-mucosal-cells-of-human-immunodeficiency-virus-infected-children-and-adolescents-undergoing-antiretroviral-treatment
#32
JOURNAL ARTICLE
Maria Esther Suarez Alpire, Daniel Vitor de Souza, Carolina Marquez da Costa Brites Masutti, Marcos Montani Caseiro, Daniel Araki Ribeiro
OBJECTIVE: The objective of this study was to evaluate possible cytogenetic changes in children and adolescents with human immunodeficiency virus on antiretroviral therapy, through the micronucleus test in oral mucosa. METHODS: This was a prospective study consisted of 40 individuals, of whom 21 comprised the human immunodeficiency virus group and 19 comprised the control group. Children and adolescents with human immunodeficiency virus were enrolled. The inclusion criteria were <18 years old and consent in participating in the study...
2023: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/37728117/the-idiopathic-inflammatory-myopathies-module-of-the-rheumatic-diseases-portuguese-register
#33
JOURNAL ARTICLE
Eduardo Dourado, Ana Teresa Melo, Raquel Campanilho-Marques, Matilde Bandeira, Patrícia Martins, Vanessa Fraga, José Luís Ferraro, André Saraiva, Marlene Sousa, Hugo Parente, Catarina Soares, Ana Margarida Correia, Diogo Esperança Almeida, Sara Paiva Dinis, Ana Sofia Pinto, Filipe Oliveira Pinheiro, Maria Seabra Rato, Tiago Beirão, Beatriz Samões, Bernardo Santos, Carolina Mazeda, Ana Teodósio Chícharo, Margarida Faria, Agna Neto, Maria Helena Lourenço, Luísa Brites, Marília Rodrigues, Joana Silva-Dinis, João Madruga Dias, Filipe C Araújo, Nádia Martins, Maura Couto, Ana Valido, Maria José Santos, Sofia Barreira, João Eurico Fonseca
AIMS: To characterise the idiopathic inflammatory myopathies (IIM) module of the Rheumatic Diseases Portuguese Register (Reuma.pt/myositis) and the patients in its cohort. METHODS: Reuma.pt is a web-based system with standardised patient files gathered in a registry. This was a multicentre open cohort study, including patients registered in Reuma.pt/myositis up to January 2022. RESULTS: Reuma.pt/myositis was designed to record all relevant data in clinical practice and includes disease-specific diagnosis and classification criteria, clinical manifestations, immunological data, and disease activity scores...
2023: ARP Rheumatol
https://read.qxmd.com/read/37719033/extending-the-palette-of-luminescent-primary-thermometers-yb-3-pr-3-co-doped-fluoride-phosphate-glasses
#34
JOURNAL ARTICLE
Fernando E Maturi, Anuraag Gaddam, Carlos D S Brites, Joacilia M M Souza, Hellmut Eckert, Sidney J L Ribeiro, Luís D Carlos, Danilo Manzani
The unique tunable properties of glasses make them versatile materials for developing numerous state-of-the-art optical technologies. To design new optical glasses with tailored properties, an extensive understanding of the intricate correlation between their chemical composition and physical properties is mandatory. By harnessing this knowledge, the full potential of vitreous matrices can be unlocked, driving advancements in the field of optical sensors. We herein demonstrate the feasibility of using fluoride phosphate glasses co-doped with trivalent praseodymium (Pr3+ ) and ytterbium (Yb3+ ) ions for temperature sensing over a broad range of temperatures...
September 12, 2023: Chemistry of Materials: a Publication of the American Chemical Society
https://read.qxmd.com/read/37716606/impaired-reverse-cholesterol-transport-is-associated-with-changes-in-fatty-acid-profile-in-children-and-adolescents-with-abdominal-obesity
#35
JOURNAL ARTICLE
Martin Maximiliano, Impa Condori Anabel, Davico Belén, Gómez Rosso Leonardo, Gaete Laura, Tetzlaff Walter, Lozano Chiappe Ezequiel, Sáez María Soledad, Lorenzon González María Victoria, Godoy María Fernanda, Osta Viviana, Trifone Liliana, Ballerini María Gabriela, Cherñavsky Alejandra, Boero Laura, Tonietti Miriam, Feliu Susana, Brites Fernando
BACKGROUND: Abdominal obesity is an important cardiovascular risk factor. Plasma fatty acids display a complex network of both pro and antiatherogenic effects. High density lipoproteins (HDL) carry out the antiatherogenic pathway called reverse cholesterol transport (RCT), which involves cellular cholesterol efflux (CCE), and lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) activities. OBJECTIVE: Our aim was to characterize RCT and its relation to fatty acids present in plasma in pediatric abdominal obesity...
September 14, 2023: Journal of Nutrition
https://read.qxmd.com/read/37711609/genes-inflammatory-response-tolerance-and-resistance-to-virus-infections-in-migratory-birds-bats-and-rodents
#36
REVIEW
Patrick Douglas Corrêa Pereira, Daniel Guerreiro Diniz, Emanuel Ramos da Costa, Nara Gyzely de Morais Magalhães, Anderson de Jesus Falcão da Silva, Jéssica Gizele Sousa Leite, Natan Ibraim Pires Almeida, Kelle de Nazaré Cunha, Mauro André Damasceno de Melo, Pedro Fernando da Costa Vasconcelos, José Antonio Picanço Diniz, Dora Brites, Daniel Clive Anthony, Cristovam Wanderley Picanço Diniz, Cristovam Guerreiro-Diniz
Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37703635/a-new-era-of-understanding-in-vivo-metabolic-flux-in-thermogenic-adipocytes
#37
REVIEW
John A Haley, Cholsoon Jang, David A Guertin
Nonshivering thermogenesis by brown adipose tissue (BAT) is an adaptive mechanism for maintaining body temperature in cold environments. BAT is critical in rodents and human infants and has substantial influence on adult human metabolism. Stimulating BAT therapeutically is also being investigated as a strategy against metabolic diseases because of its ability to function as a catabolic sink. Thus, understanding how brown adipocytes and the related brite/beige adipocytes use nutrients to fuel their demanding metabolism has both basic and translational implications...
September 11, 2023: Current Opinion in Genetics & Development
https://read.qxmd.com/read/37686955/sub-bandgap-sensitization-of-perovskite-semiconductors-via-colloidal-quantum-dots-incorporation
#38
JOURNAL ARTICLE
G Ribeiro, G Ferreira, U D Menda, M Alexandre, M J Brites, M A Barreiros, S Jana, H Águas, R Martins, P A Fernandes, P Salomé, M J Mendes
By taking advantage of the outstanding intrinsic optoelectronic properties of perovskite-based photovoltaic materials, together with the strong near-infrared (NIR) absorption and electronic confinement in PbS quantum dots (QDs), sub-bandgap photocurrent generation is possible, opening the way for solar cell efficiencies surpassing the classical limits. The present study shows an effective methodology for the inclusion of high densities of colloidal PbS QDs in a MAPbI3 (methylammonium lead iodide) perovskite matrix as a means to enhance the spectral window of photon absorption of the perovskite host film and allow photocurrent production below its bandgap...
August 29, 2023: Nanomaterials
https://read.qxmd.com/read/37588057/hdac-6-inhibition-ameliorates-the-early-neuropathology-in-a-mouse-model-of-krabbe-disease
#39
JOURNAL ARTICLE
Sandra O Braz, Marlene M Morgado, Marta I Pereira, Ana C Monteiro, Olga Golonzhka, Matthew Jarpe, Pedro Brites, Monica M Sousa, Joana Nogueira-Rodrigues
INTRODUCTION: In Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine. This neurologic condition is characterized by a severe and progressive demyelination together with neuron-autonomous defects and degeneration. Twitcher mice mimic the infantile form of KD, which is the most common form of the human disease. The Twitcher CNS and PNS present demyelination, axonal loss and neuronal defects including decreased levels of acetylated tubulin, decreased microtubule stability and impaired axonal transport...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/37575936/qtl-discovery-for-resistance-to-black-spot-and-cercospora-leaf-spot-and-defoliation-in-two-interconnected-f1-bi-parental-tetraploid-garden-rose-populations
#40
JOURNAL ARTICLE
Jeekin Lau, Haramrit Gill, Cristiane H Taniguti, Ellen L Young, Patricia E Klein, David H Byrne, Oscar Riera-Lizarazu
Garden roses are an economically important horticultural crop worldwide, and two major fungal pathogens, black spot ( Diplocarpon rosae F.A. Wolf) and cercospora leaf spot of rose ( Rosisphaerella rosicola Pass.), affect both the health and ornamental value of the plant. Most studies on black spot disease resistance have focused on diploid germplasm, and little work has been performed on cercospora leaf spot resistance. With the use of newly developed software tools for autopolyploid genetics, two interconnected tetraploid garden rose F1 populations (phenotyped over the course of 3 years) were used for quantitative trait locus (QTL) analysis of black spot and cercospora leaf spot resistance as well as plant defoliation...
2023: Frontiers in Plant Science
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