keyword
MENU ▼
Read by QxMD icon Read
search

brite

keyword
https://www.readbyqxmd.com/read/28500735/increased-expression-of-cd38-and-hladr-in-hiv-infected-patients-with-oral-lesion
#1
Liliane Lins, Érica Farias, Clara Brites-Alves, Alex Torres, Eduardo Martins Netto, Carlos Brites
Persistent immune actiation is associated with innadequate immune recovery in HIV-patients, This study assessed the relationship between frequency of expression of cell activation markers (CD38 and HLADR) and presence of oral lesions in HIV-1 infected patients. Fifty-seven HIV-infected persons, undergoing antiretroviral treatment, were divided into three groups, according to the number of CD T cells and CD4(+) / CD8(+) ratio: adequate; partial; and inadequate immune restauration. All patients underwent full mouth assessments for saliva flow measurement, oral mucosal lesion, periodontal disease, and severity of periodontitis...
May 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28498891/adipose-tissue-depots-and-inflammation-effects-on-plasticity-and-resident-mesenchymal-stem-cell-function
#2
Lina Badimon, Judit Cubedo
Adipose tissue (AT) is a highly heterogeneous organ. Beside the heterogeneity associated to different tissue types (white, brown and "brite") and its location-related heterogeneity (subcutaneous, visceral, epicardial, and perivascular, etc), AT composition, structure and functionality is highly dependent on individual-associated factors. As such, the pro-inflammatory state associated to the presence of obesity and other cardiovascular risk factors directly affects AT metabolism. Furthermore, the adipose-derived stem cells (ASCs) that reside in the stromal vascular fraction (SVF) of AT, besides being responsible for most of the plasticity attributed to AT, is an additional source of heterogeneity...
May 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28469599/the-role-of-thyrotropin-receptor-activation-in-adipogenesis-and-modulation-of-fat-phenotype
#3
Mohd Shazli Draman, Michael Stechman, David Scott-Coombes, Colin M Dayan, Dafydd Aled Rees, Marian Ludgate, Lei Zhang
Evidence from clinical and experimental data suggests that thyrotropin receptor (TSHR) signaling is involved in energy expenditure through its impact on white adipose tissue (WAT) and brown adipose tissue (BAT). TSHR expression increases during mesenchymal stem cell (MSC) differentiation into fat. We hypothesize that TSHR activation [TSHR*, elevated thyroid-stimulating hormone, thyroid-stimulating antibodies (TSAB), or activating mutation] influences MSC differentiation, which contributes to body composition changes seen in hypothyroidism or Graves' disease (GD)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28467890/brown-and-brite-adipocytes-same-function-but-different-origin-and-response
#4
REVIEW
Dinh-Toi Chu, Barbara Gawronska-Kozak
Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues. The accumulating evidence confirms the presence of active brown adipocytes, not only in newborns, but also in adult humans. In rodents, there are two populations of the Ucp1-expressing adipocytes with well characterized-thermogenic functions, classical interscapular brown adipocytes and brite/beige adipocytes (brown adipocytes that are induced in white adipose tissues)...
April 30, 2017: Biochimie
https://www.readbyqxmd.com/read/28431377/metabolic-regulation-and-the-anti-obesity-perspectives-of-human-brown-fat
#5
REVIEW
Camilla Scheele, Søren Nielsen
Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity. However, substantial reductions in body weight following BAT activation has not yet been shown in humans. This observation raise the possibility for feedback mechanisms in adult humans in terms of a brown fat-brain crosstalk, possibly mediated by batokines, factors produced by and secreted from brown fat...
April 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/28427098/opa1-in-lipid-metabolism-function-of-opa1-in-lipolysis-and-thermogenesis-of-adipocytes
#6
Dinh-Toi Chu, Yang Tao, Kjetil Taskén
OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists...
April 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28424085/the-within-host-population-dynamics-of-mycobacterium-tuberculosis-vary-with-treatment-efficacy
#7
Andrej Trauner, Qingyun Liu, Laura E Via, Xin Liu, Xianglin Ruan, Lili Liang, Huimin Shi, Ying Chen, Ziling Wang, Ruixia Liang, Wei Zhang, Wang Wei, Jingcai Gao, Gang Sun, Daniela Brites, Kathleen England, Guolong Zhang, Sebastien Gagneux, Clifton E Barry, Qian Gao
BACKGROUND: Combination therapy is one of the most effective tools for limiting the emergence of drug resistance in pathogens. Despite the widespread adoption of combination therapy across diseases, drug resistance rates continue to rise, leading to failing treatment regimens. The mechanisms underlying treatment failure are well studied, but the processes governing successful combination therapy are poorly understood. We address this question by studying the population dynamics of Mycobacterium tuberculosis within tuberculosis patients undergoing treatment with different combinations of antibiotics...
April 19, 2017: Genome Biology
https://www.readbyqxmd.com/read/28377149/evaluation-of-an-association-of-alpha-cypermethrin-and-flufenoxuron-for-tick-control-in-an-area-at-risk-of-brazilian-spotted-fever
#8
José Brites-Neto, Jardel Brasil, Jeferson de Andrade, Gabriele Luciana Saqui
Brazilian spotted fever (BSF) is an endemic anthropozoonosis caused by Gram-negative bacteria (Rickettsia rickettsii) that is associated with the risk of human infection by ticks. In the city of Americana, São Paulo (SP), Brazil, there were 12 cases (67% lethal) between 2004 and 2015. This study evaluated the effectiveness of control over tick infestations in an area at risk of BSF, in a field trial on an association of alpha-cypermethrin (3%) and flufenoxuron (3%) (Tenopa(®)) conducted in Americana. The infestation levels of the target species (Amblyomma sculptum and Amblyomma dubitatum) in the field trial were evaluated through acarological surveys (CO2 traps) on days 0, 22, 43 and 62 after treatment, both in the treatment area and in a control area...
March 27, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28375193/uva1-for-diffuse-cutaneous-systemic-sclerosis-in-a-fitzpatrick-skin-type-vi-patient-outcomes-in-the-modified-rodnan-skin-score
#9
Bárbara Roque Ferreira, Ana Rita Gameiro, Maria Manuel Brites, Hugo Schönenberger Oliveira, José Pedro Reis
INTRODUCTION: Cutaneous sclerosis can lead to important mobility impairment. Ultraviolet (UV) A1 phototherapy may improve skin sclerosis, although most of the studies have been with Caucasian patients. MATERIAL AND METHODS: A 44-year-old patient, Fitzpatrick skin type VI, was being followed up with the diagnosis of diffuse cutaneous systemic sclerosis. He had significant mobility impairment, especially of the right hand and arm. In 2015 he started UVA1 phototherapy daily, Monday until Friday (Waldmann® 7001 UVA cabin equipped with 40 Philips TL/10R lamps - spectral irradiation between 340 and 400 nm)...
January 31, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28369607/the-influence-of-hiv-on-the-evolution-of-mycobacterium-tuberculosis
#10
Anastasia Koch, Daniela Brites, David Stucki, Joanna C Evans, Ronnett Seldon, Alexa Heekes, Nicola Mulder, Mark Nicol, Tolu Oni, Digby F Warner, Valerie Mizrahi, Julian Parkhill, Sebastien Gagneux, Darren P Martin, Robert J Wilkinson
HIV significantly affects the immunological environment during tuberculosis co-infection, and therefore may influence the selective landscape upon which M. tuberculosis evolves. To test this hypothesis whole genome sequences were determined for 169 South African M. tuberculosis strains from HIV-1 co-infected and uninfected individuals and analysed using two Bayesian codon-model based selection analysis approaches: FUBAR which was used to detect persistent positive and negative selection (selection respectively favouring and disfavouring nonsynonymous substitutions); and MEDS which was used to detect episodic directional selection specifically favouring nonsynonymous substitutions within HIV-1 infected individuals...
March 21, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28363087/geolocalization-of-hiv-1-subtypes-and-resistance-mutations-of-patients-failing-antiretroviral-therapy-in-salvador-brazil
#11
Antonio Walter de Oliveira Filho, Carlos Brites
BACKGROUND: Geographical distribution of HIV variants is an important way to understand the circulation and spread of such viral strains. OBJECTIVES: To evaluate the spatial distribution of HIV-1 variants in patients failing antiretroviral therapy, in Salvador, Brazil. METHODS: We performed a cross-sectional evaluation of HIV resistance test reports of patients who underwent genotyping tests in a referral center in Salvador, Brazil, for the years 2008-2014...
April 5, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28334068/the-dyslexia-susceptibility-protein-kiaa0319-inhibits-axon-growth-through-smad2-signaling
#12
Filipa Franquinho, Joana Nogueira-Rodrigues, Joana M Duarte, Sofia S Esteves, Christin Carter-Su, Anthony P Monaco, Zoltán Molnár, Antonio Velayos-Baeza, Pedro Brites, Mónica M Sousa
KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that KIAA0319 participates in functions unrelated to neuronal migration. Supporting this hypothesis, overexpression of KIAA0319 repressed axon growth in hippocampal and dorsal root ganglia neurons; the intracellular domain of KIAA0319 was sufficient to elicit this effect...
March 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28324146/beliefs-about-the-potential-impacts-of-exploiting-non-timber-forest-products-predict-voluntary-participation-in-monitoring
#13
Alice Dantas Brites, Carla Morsello
Harvesting and trading non-timber forest products is advocated as a win-win strategy for conservation and development, yet it can produce negative ecological and socioeconomic impacts. Hence, monitoring exploitation outcomes is essential, and participatory monitoring has been suggested to be the most suitable approach. Among possible approaches, participatory monitoring is preferred because it is likely to increase people's awareness and beliefs regarding impacts or potential impacts, thus inducing behavioral changes, although the evidence in this regard is contradictory...
March 21, 2017: Environmental Management
https://www.readbyqxmd.com/read/28302705/brown-and-beige-adipose-tissues-phenotype-and-metabolic-potential-in-mice-and-men
#14
Kanta Chechi, Wouter David van Marken Lichtenbelt, Denis Richard
With the recent re-discovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit and activate classic brown fat stores in humans, identification of beige/brite adipocytes has also raised the possibility of browning our white fat stores. Whether such transformation of human white fat depots can be achieved in order to enhance the whole-body oxidative potential remains to be seen. Evidence to-date, however, largely points towards a major oxidative role only for classic brown fat depots in rodents and in humans (e...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28257939/cold-exposure-induces-the-acquisition-of-brown-adipocyte-gene-expression-profiles-in-cattle-inguinal-fat-normalized-with-a-new-set-of-reference-genes-for-qrt-pcr
#15
K X Cao, D Hao, J Wang, W W Peng, Y J Yan, H X Cao, F Sun, H Chen
The last few years have seen great advances in our understanding of browning in white adipose tissue (WAT) where white adipocytes take on characteristics of brown adipocytes. At present, the economic significance of browning for animal husbandry is beginning to be realized with the emerging evidence that browning affects body weight not only in human and rodent but in farm animals. Quantitative RT-PCR provides a quick and sensitive way to preliminary determine browning of WAT. However, there have been no established condition specific reference genes for browning of cattle WAT...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28257111/a-cubesat-payload-for-exoplanet-detection
#16
Marcella Iuzzolino, Domenico Accardo, Giancarlo Rufino, Ernesto Oliva, Andrea Tozzi, Pietro Schipani
The search for undiscovered planets outside the solar system is a scientific topic that is rapidly spreading into the astrophysical and engineering communities. In this framework, the design of an innovative payload to detect exoplanets from a nano-sized space platform, like a 3U cubesat, is presented. The selected detection method is photometric transit, and the payload aims to detect flux decrements down to ~0.01% with a precision of 12 ppm. The payload design is also aimed at false positive recognition. The solution consists of a four-facets pyramid on the top of the payload, to allow for measurement redundancy and low-resolution spectral dispersion of the star images...
March 2, 2017: Sensors
https://www.readbyqxmd.com/read/28253476/virological-suppression-in-children-and-adolescents-is-not-influenced-by-genotyping-but-depends-on-optimal-adherence-to-antiretroviral-therapy
#17
Juliana Costa de Abreu, Sara Nunes Vaz, Eduardo Martins Netto, Carlos Brites
OBJECTIVE: To evaluate the virological outcomes in children and adolescents infected with HIV-1 in Salvador, Bahia according to genotyping results. METHODS: We retrospectively evaluated the rates of virological suppression of children and adolescents submitted to HIV-1 genotyping test from January/2008 to December/2012. The participants were followed in the two referral centers for pediatric AIDS care, in Salvador, Brazil. Resistance mutations, drug sensitivity profiles, and viral subtypes were analyzed using the Stanford HIV-1 Drug Resistance Database...
February 27, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28244038/flow-cytometric-isolation-and-differentiation-of-adipogenic-progenitor-cells-into-brown-and-brite-beige-adipocytes
#18
Jochen Steinbring, Antonia Graja, Anne-Marie Jank, Tim J Schulz
Aside from mature adipocytes, adipose tissue harbors several distinct cell populations including immune cells, endothelial cells, and adipogenic progenitor cells (AdPCs). AdPCs represent the reservoir of regenerative cells that replenishes adipocytes during normal cellular turnover and during times of increased demand for triglyceride-storage capacity. The worldwide increase in pathologies associated with the metabolic syndrome, such as obesity and type-2 diabetes, has heightened public and scientific interest in adipose tissues and the cell biological processes of adipose tissue formation and function...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28223294/the-%C3%AE-3-adrenergic-receptor-is-dispensable-for-browning-of-adipose-tissues
#19
Jasper M A de Jong, René T F Wouters, Nathalie Boulet, Barbara Cannon, Jan Nedergaard, Natasa Petrovic
Brown and brite/beige adipocytes are attractive therapeutic targets to treat metabolic diseases. To maximally utilize their functional potential, further understanding is required about their identities and their functional differences. Recent studies with β3-adrenergic receptor knockout mice reported that brite/beige adipocytes, but not classical brown adipocytes, require the β3-adrenergic receptor for cold-induced transcriptional activation of thermogenic genes. We aimed to further characterize this requirement of the β3-adrenergic receptor as a functional distinction between classical brown and brite/beige adipocytes...
February 21, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28220393/common-and-distinct-regulation-of-human-and-mouse-brown-and-beige-adipose-tissues-a-promising-therapeutic-target-for-obesity
#20
REVIEW
Xuejiao Liu, Christopher Cervantes, Feng Liu
Obesity, which underlies various metabolic and cardiovascular diseases, is a growing public health challenge for which established therapies are inadequate. Given the current obesity epidemic, there is a pressing need for more novel therapeutic strategies that will help adult individuals to manage their weight. One promising therapeutic intervention for reducing obesity is to enhance energy expenditure. Investigations into human brown fat and the recently discovered beige/brite fat have galvanized intense research efforts during the past decade because of their pivotal roles in energy dissipation...
February 20, 2017: Protein & Cell
keyword
keyword
113238
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"