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https://www.readbyqxmd.com/read/28551820/cd147-expression-in-peritoneal-injury
#1
Harald Seeger, Joerg Latus, Daniel Kitterer, M Dominik Alscher, Dagmar Biegger, Jin Chen, Ilka Edenhofer, Rudolf P Wüthrich, Stephan Segerer
BACKGROUND: Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracellular matrix via induction of matrix metalloproteinases, cell adhesion, and regulation of immune reactions. We hypothesized that CD 147 plays a role in the peritoneal cavity...
May 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28551552/standardized-mori-ramulus-extract-improves-insulin-secretion-and-insulin-sensitivity-in-c57blks-j-db-db-mice-and-ins-1-cells
#2
Soo-Yeon Park, Bora Jin, Jae-Ho Shin, Sirichai Adisakwattana, Oran Kwon
Abnormalities in the hyperbolic relationship between insulin sensitivity and insulin secretion may cause oxidative stress and non-enzymatic glycation, resulting in an increased risk of type 2 diabetes. Here, we performed a 14-week study to investigate the effects of ethanolic extract of Mori ramulus (MRE; 0, 800, and 1600mg/kg body weight) and its signature component oxyresveratrol (OXY; 800mg/kg body weight) on β-cell dysfunction and insulin resistance in C57BLKS/J db/db mice fed with a high-fat diet. Compared with the diabetic control group, the high-dose MRE group showed a significant decrease in fasting blood glucose (p=0...
May 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28551508/fat-like-cadherins-in-cell-migration-leading-from-both-the-front-and-the-back
#3
REVIEW
Sally Horne-Badovinac
When cells migrate through the body, their motility is continually influenced by interactions with other cells. The Fat-like cadherins are cell-cell signaling proteins that promote migration in multiple cell types. Recent studies suggest, however, that Fat-like cadherins influence motility differently in mammals versus Drosophila, with the cadherin acting at the leading edge of mammalian cells and the trailing edge of Drosophila cells. As opposed to this being a difference between organisms, it is more likely that the Fat-like cadherins are highly versatile proteins that can interact with the migration machinery in multiple ways...
May 25, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28551194/effects-of-shortening-the-close-up-period-length-coupled-with-increased-supply-of-metabolizable-protein-on-performance-and-metabolic-status-of-multiparous-holstein-cows
#4
T Amirabadi Farahani, H Amanlou, M Kazemi-Bonchenari
This experiment was conducted to compare conventional (CON; 21 d) and shortened (SH; 10 d) close-up period, and evaluate the effect of shortened close-up period combined with feeding different metabolizable protein (MP) levels on dry matter (DM) intake, metabolic status, and performance of dairy cows. Forty-eight multiparous Holstein cows with similar parity, body weight (BW), and previous lactation milk yield were divided into 2 groups. The first group (n = 24) received the far-off diet from -60 to -21 d (CON), and the second group (n = 24) received same far-off diet from -60 to -10 d (SH) relative to expected parturition...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28549989/overweight-in-elderly-people-induces-impaired-autophagy-in-skeletal-muscle
#5
Yaiza Potes, Beatriz de Luxán-Delgado, Susana Rodriguez-González, Marcela Rodrigues Moreira Guimarães, Juan J Solano, María Fernández-Fernández, Manuel Bermúdez, Jose A Boga, Ignacio Vega-Naredo, Ana Coto-Montes
Sarcopenia is the gradual loss of skeletal muscle mass, strength and quality associated with aging. Changes in body composition, especially in skeletal muscle and fat mass are crucial steps in the development of chronic diseases. We studied the effect of overweight on skeletal muscle tissue in elderly people without reaching obesity to prevent this extreme situation. Overweight induces a progressive protein breakdown reflected as a progressive withdrawal of anabolism against the promoted catabolic state leading to muscle wasting...
May 23, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28549747/increased-dipeptidyl-peptidase-4-accelerates-diet-related-vascular-aging-and-atherosclerosis-in-apoe-deficient-mice-under-chronic-stress
#6
Yanna Lei, Guang Yang, Lina Hu, Limei Piao, Aiko Inoue, Haiying Jiang, Takeshi Sasaki, Guangxian Zhao, Maimaiti Yisireyili, Chenglin Yu, Wenhu Xu, Kyosuke Takeshita, Kenji Okumura, Masafumi Kuzuya, Xian Wu Cheng
OBJECTIVES: Exposure to psychosocial stress is a risk factor for cardiovascular disease. Given that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways associated with glucagon-like peptide-1 (GLP-1) metabolism, we investigated the role of DPP4 in stress-related vascular senescence and atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice. METHODS AND RESULTS: ApoE(-/-) mice fed a high-fat (HF) diet were randomly assigned to one of non-stress and immobilized stress groups for 12weeks...
May 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28549585/cystamine-mediated-inhibition-of-protein-disulfide-isomerase-triggers-aggregation-of-misfolded-orexin-a-in-the-golgi-apparatus-and-prevents-extracellular-secretion-of-orexin-a
#7
Issei Fujita, Mizuki Nobunaga, Takahiro Seki, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki
Orexins (orexin-A and orexin-B) are neuropeptides that are reduced in narcolepsy, a sleep disorder that is characterized by excessive daytime sleepiness, sudden sleep attacks and cataplexy. However, it remains unclear how orexins in the brain and orexin neurons are reduced in narcolepsy. Orexin-A has two closely located intramolecular disulfide bonds and is prone to misfolding due to the formation of incorrect disulfide bonds. Protein disulfide isomerase (PDI) possesses disulfide interchange activity. PDI can modify misfolded orexin-A to its native form by rearrangement of two disulfide bonds...
May 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28549200/effects-of-cell-death-inducing-dff45-like-effector-b-on-meat-quality-traits-in-berkshire-pigs
#8
G E Yu, S Kwon, J H Hwang, S M An, D H Park, D G Kang, T W Kim, I-S Kim, H C Park, J Ha, C W Kim
Cell death-inducing DFF45-like effector (CIDE) B is a member of the CIDE family of apoptosis-inducing factors. In the present study, we detected a single nucleotide polymorphism (SNP), c.414G>A, which corresponds to the synonymous SNP 414Arg, in CIDE-B in the Berkshire pigs. We also analyzed the relationships between the CIDE-B SNP and various meat quality traits. The SNP was significantly associated with post-mortem pH24h, water-holding capacity (WHC), fat content, protein content, drip loss, post-mortem temperature at 12 h (T12) and 24 h (T24) in a co-dominant model (P < 0...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28548972/assessment-of-adult-malnutrition-and-prognosis-with-bioelectrical-impedance-analysis-phase-angle-and-impedance-ratio
#9
Henry C Lukaski, Ursula G Kyle, Jens Kondrup
PURPOSE OF REVIEW: Malnutrition affects prognosis in many groups of patients. Although screening tools are available to identify adults at risk for poor nutritional status, a need exists to improve the assessment of malnutrition by identifying the loss of functional tissues that can lead to frailty, compromised physical function, and increased risk of morbidity and mortality, particularly among hospitalized and ill patients and older adults. Bioimpedance analysis (BIA) offers a practical approach to identify malnutrition and prognosis by assessing whole-body cell membrane quality and depicting fluid distribution for an individual...
May 25, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28548969/transcriptome-profiling-in-preadipocytes-identifies-long-noncoding-rnas-as-sam68-targets
#10
Naomi Li, Steven Hébert, Jingwen Song, Claudia L Kleinman, Stéphane Richard
The KH-type RNA binding protein Sam68 is required for adipogenesis. We have previously shown that Sam68-deficient mice have a lean phenotype and are protected against dietary-induced obesity due to defects in mTOR and S6K1 alternative splicing. Herein we profiled the transcriptome of Sam68 wild type and deficient 3T3-L1 mouse preadipocytes. We identified 652 protein-coding genes and 9 ncRNAs that were significantly altered with the loss of Sam68. As expected, downregulated genes were significantly associated with GO terms linked to cell migration, motility, and fat cell differentiation, while upregulated genes were mostly associated with GO terms linked to neurogenesis...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28546423/overexpression-of-kinase-dead-mtor-impairs-glucose-homeostasis-by-regulating-insulin-secretion-and-not-%C3%AE-cell-mass
#11
Emilyn U Alejandro, Nadejda Bozadjieva, Manuel Blandino-Rosano, Michelle Ann Wasan, Lynda Elghazi, Suryakiran Vadrevu, Leslie Satin, Ernesto Bernal-Mizrachi
Regulation of glucose homeostasis by insulin depends on β-cell growth and function. Nutrients and growth factors stimuli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two complexes mTORC1 and mTORC2. To understand the functional relevance of mTOR enzymatic activity in β-cell development and in glucose homeostasis, we generated mice overexpressing either one or two copies of a kinase-dead mTOR mutant (KD-mTOR) transgene exclusively in β-cells. We examined glucose homeostasis and β-cell function of these mice in control chow and in high-fat diet (HFD)...
May 25, 2017: Diabetes
https://www.readbyqxmd.com/read/28545881/high-fat-diet-and-saturated-fatty-acid-palmitate-inhibits-igf-1-function-in-chondrocytes
#12
Sumaiya A Nazli, Richard F Loeser, Susan Chubinskaya, Jeffrey S Willey, Raghunatha R Yammani
INTRODUCTION: Insulin-like growth factor-1 (IGF-1) promotes matrix synthesis and cell survival in cartilage. Chondrocytes from aged and osteoarthritic cartilage have a reduced response to IGF-1. The purpose of this study was to determine the effect of free fatty acids present in a high-fat diet on IGF-1 function in cartilage and the role of ER stress. METHODS: C57BL/6 male mice were maintained on either a high-fat (60% kcal from fat) or a low-fat (10% kcal from fat) diet for 4 months...
May 22, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28544542/conditional-macrophage-depletion-increases-inflammation-and-does-not-inhibit-the-development-of-osteoarthritis-in-obese-mafia-mice
#13
Chia-Lung Wu, Jenna McNeill, Kelsey Goon, Dianne Little, Kelly Kimmerling, Janet Huebner, Virginia Kraus, Farshid Guilak
OBJECTIVE: Macrophages are believed to play a critical role in the inflammation associated with the development of osteoarthritis (OA) in obesity. The objective of the study was to investigate whether short-term, systemic depletion of macrophages would mitigate OA following injury in obese mice. METHODS: CSF-1R-GFP(+) Macrophage Fas-Induced Apoptosis (MaFIA) transgenic mice that allow conditional depletion of macrophages were placed on a high-fat diet and underwent surgery to induce knee OA...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28543963/ageing-is-associated-with-brown-adipose-tissue-remodelling-and-loss-of-white-fat-browning-in-female-c57bl-6-mice
#14
Leidyanne Ferreira Gonçalves, Thaissa Queiroz Machado, Camila Castro-Pinheiro, Nathalia Guimaraes de Souza, Karen Jesus Oliveira, Caroline Fernandes-Santos
Fat storage changes throughout life and affects body metabolism. Ageing impact on brown (BAT) and white adipose tissue (WAT) deserves attention, especially in females, because they are less prone to age-induced weight gain. While in male mice the impact of ageing on adipose tissue remodelling is well characterized, the effects in female mice remain largely unclear. Thus, we investigated BAT and WAT remodelling during ageing in female C57BL/6 mice. At 3 months, body weight was 24 ± 0.3 g (mean±SD), and it increased from 6 to 9 months of age (+20%, P < 0...
May 24, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28543181/loss-of-l-selectin-guided-cd8-but-not-cd4-cells-protects-against-ischemia-reperfusion-injury-in-a-steatotic-liver
#15
Vasantha L Kolachala, Sirish Palle, Ming Shen, Alayna Feng, Dmitry Shayakhmetov, Nitika A Gupta
BACKGROUND & AIMS: Steatotic liver responds with increased hepatocellular injury when exposed to an ischemic-reperfusion insult. Increasing evidence supports the role of immune cells as key mediators of this injury in a normal (lean) state, but data about their role in a steatotic liver are practically non-existent. The objective of the current study was to delineate contribution of specific phenotypes of T cells and adhesion molecules in exacerbated cell death in steatotic liver injury...
May 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28542922/study-of-retinal-neurodegeneration-and-maculopathy-in-diabetic-meriones-shawi-a-particular-animal-model-with-human-like-macula
#16
Imane Hammoum, Maha Benlarbi, Ahmed Dellaa, Klaudia Szabó, Bulcsú Dékány, Dávid Csaba, Zsuzsanna Almási, Rozina I Hajdú, Rached Azaiz, Ridha Charefeddine, Ákos Lukáts, Rafika Benchouacha-Chekir
The purpose of this work was to evaluate a potentially useful animal model, Meriones shawi (M.sh) - developing metabolic X syndrome, diabetes and possessing a visual streak similar to human macula - in the study of diabetic retinopathy and diabetic macular edema (DME). Type 2 diabetes (T2D) was induced by high fat diet administration in M.sh. Body weights, blood glucose levels were monitored throughout the study. Diabetic retinal histopathology was evaluated 3 and 7 months after diabetes induction. Retinal thickness was measured, retinal cell types were labeled by immunohistochemistry and the number of stained elements were quantified...
May 20, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28542568/nesfatin-1-like-peptide-is-a-novel-metabolic-factor-that-suppresses-feeding-and-regulates-whole-body-energy-homeostasis-in-male-wistar-rats
#17
Kavishankar Gawli, Naresh Ramesh, Suraj Unniappan
Nucleobindin-1 has high sequence similarity to nucleobindin-2, which encodes the anorectic and metabolic peptide, nesfatin-1. We previously reported a nesfatin-1-like peptide (NLP), anorectic in fish and insulinotropic in mice islet beta-like cells. The main objective of this research was to determine whether NLP is a metabolic regulator in male Wistar rats. A single intraperitoneal (IP) injection of NLP (100 μg/kg BW) decreased food intake and increased ambulatory movement, without causing any change in total activity or energy expenditure when compared to saline-treated rats...
2017: PloS One
https://www.readbyqxmd.com/read/28542499/lipidomic-and-metabolic-changes-in-the-p4-type-atpase-atp10d-deficient-c57bl-6j-wild-type-mice-upon-rescue-of-atp10d-function
#18
Alexander Sigruener, Christian Wolfrum, Alfred Boettcher, Thomas Kopf, Gerhard Liebisch, Evelyn Orsó, Gerd Schmitz
BACKGROUND: Sequence variants near the human gene for P4-type ATPase, class V, type 10D (ATP10D) were shown to significantly associate with circulating hexosylceramide d18:1/16:0 and d18:1/24:1 levels, obesity, insulin resistance, plasma high density lipoprotein (HDL), coronary stenotic index and intracranial atherosclerotic index. In mice Atp10d is associated with HDL modulation and C57BL/6 mice expressing a truncated, non-functional form of ATP10D easily develop obesity and insulin resistance on high-fat diet...
2017: PloS One
https://www.readbyqxmd.com/read/28542204/similar-regulatory-mechanisms-of-caveolins-and-cavins-by-myocardin-family-coactivators-in-arterial-and-bladder-smooth-muscle
#19
Baoyi Zhu, Catarina Rippe, Tran Thi Hien, Jianwen Zeng, Sebastian Albinsson, Karin G Stenkula, Bengt Uvelius, Karl Swärd
Caveolae are membrane invaginations present at high densities in muscle and fat. Recent work has demonstrated that myocardin family coactivators (MYOCD, MKL1), which are important for contractile differentiation and cell motility, increase caveolin (CAV1, CAV2, CAV3) and cavin (CAVIN1, CAVIN2, CAVIN3) transcription, but several aspects of this control mechanism remain to be investigated. Here, using promoter reporter assays we found that both MKL1/MRTF-A and MKL2/MRTF-B control caveolins and cavins via their proximal promoter sequences...
2017: PloS One
https://www.readbyqxmd.com/read/28542073/breast-cancer-recurrence-is-not-increased-with-lipofilling-reconstruction-a-case-controlled-study
#20
Claudio Silva-Vergara, Joan Fontdevila, Omar Weshahy, Marta Yuste, Jordi Descarrega, Luis Grande
BACKGROUND: Lipofilling use has become a revolutionary technique for the correction of breast defect including breast cancer sequelae. The potential risk that progenitor cells included in fat graft tissue may contribute to disease progression by stimulation of residuary breast cancer cells in a tumor bed has set alarms regarding its safety. The aim of this study was to identify lipofilling interference over breast recurrence in patients with cancer history. METHODS: We reviewed 205 patients with fat grafting reconstruction after breast cancer surgery performed in our institution between the years 2007 and 2015...
May 25, 2017: Annals of Plastic Surgery
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