keyword
MENU ▼
Read by QxMD icon Read
search

fat cell

keyword
https://www.readbyqxmd.com/read/28239754/neprilysin-facilitates-adipogenesis-through-potentiation-of-the-phosphatidylinositol-3-kinase-pi3k-signaling-pathway
#1
Juwan Kim, Dasol Han, Sung-Hyun Byun, Mookwang Kwon, Sun-Jung Cho, Young Ho Koh, Keejung Yoon
Neprilysin (NEP) is a zinc metallopeptidase that cleaves a number of small peptides into inactive forms. Despite the recent evidence of a significant correlation between the levels of NEP in plasma and the severity of obesity in humans, a cause-and-effect relationship or a functional role of NEP in obesity has remained uncertain. In this study, we show that NEP has a positive regulatory effect on fat cell formation from precursor cells. NEP increases the accumulation of cytoplasmic triglycerides in 3T3-L1 preadipocytes or the C3H10T1/2 mesenchymal stem cell line in differentiation conditions...
February 27, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28239403/lipid-overload-during-gestation-and-lactation-can-independently-alter-lipid-homeostasis-in-offspring-and-promote-metabolic-impairment-after-new-challenge-to-high-fat-diet
#2
Laís Angélica de Paula Simino, Thaís de Fante, Marina Figueiredo Fontana, Fernanda Oliveira Borges, Márcio Alberto Torsoni, Marciane Milanski, Lício Augusto Velloso, Adriana Souza Torsoni
BACKGROUND: Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should be better understood. Here we evaluated whether maternal HFD consumption during gestation and lactation could differently affect liver miR-122 and miR-370 expression leading to metabolic damages observed in offspring. Moreover, we investigate whether early overnutrition program offspring to more harmful response to HFD in later life...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28239164/adipocyte-c1qtnf5-expression-is-bmi-dependently-related-to-early-adipose-tissue-dysfunction-and-systemic-ctrp5-serum-levels-in-obese-children
#3
J T Schwartze, K Landgraf, U Spielau, D Rockstroh, D Löffler, J Kratzsch, W Kiess, A Körner
BACKGROUND/OBJECTIVES: The recently identified adipocytokine C1QTNF5 (encodes for CTRP5) has been demonstrated to inhibit pro-metabolic insulin signaling in adipocytes. We hypothesized that adipocyte C1QTNF5 expression in subcutaneous (sc) adipose tissue (AT) would correlate with the degree of obesity, systemic CTRP5 serum levels, and early AT and metabolic dysfunction in children. SUBJECTS/METHODS: Sc AT samples were obtained from 33 healthy Caucasian lean children aged 10...
February 27, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28238909/apple-polysaccharide-inhibits-microbial-dysbiosis-and-chronic-inflammation-and-modulates-gut-permeability-in-hfd-fed-rats
#4
Sheng Wang, Qian Li, Yue Zang, Yang Zhao, Nan Liu, Yifei Wang, Xiaotao Xu, Li Liu, Qibing Mei
The saying "An apple a day keeps the doctor away" has been known for over 150 years, and numerous studies have shown that apple consumption is closely associated with reduced risks of chronic diseases. It has been well accepted that dysbiosis is the reflection of various chronic diseases. Therefore, this study investigates the effects of apple polysaccharides (AP) on gut dysbiosis. High-fat diet (HFD) fed rats were treated for 14 weeks with AP. The microbiota composition, microbiota-generated short chain fatty acids (SCFAs), gut permeability and chronic inflammation were analyzed...
February 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28238496/prevalence-of-polycystic-ovary-syndrome-in-chinese-obese-women-of-reproductive-age-with-or-without-metabolic-syndrome
#5
Peiwen Liang, Liuqing Xi, Juan Shi, Wanyu Li, Shaoqian Zhao, Yuying Deng, Rui Wang, Yingkai Sun, Bin Gu, Lihui Yuan, Yifei Zhang, Weiqiong Gu, Weiqing Wang, Jie Hong
OBJECTIVE: To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age. DESIGN: Cross-sectional clinical study. SETTING: Tertiary hospital. PATIENT(S): We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality...
February 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28238109/erythrocyte-fatty-acid-composition-of-nepal-breast-fed-infants
#6
Sigrun Henjum, Øyvind Lie, Manjeswori Ulak, Andrew L Thorne-Lyman, Ram K Chandyo, Prakash S Shrestha, Wafaie W Fawzi, Tor A Strand, Marian Kjellevold
PURPOSE: Essential fatty acids play a critical role in the growth and development of infants, but little is known about the fatty acid status of populations in low-income countries. The objective was to describe the fatty acid composition of red blood cells (RBC) in breastfeed Nepali infants and a subsample of their mothers and to identify the main sources of fatty acids in the mother's diet, as well as the fatty acid composition of breast milk. METHODS: RBC fatty acid composition was analyzed in a random sample of 303 infants and 72 mother, along with 68 breastmilk samples...
February 25, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28237848/il-17-axis-accelerates-the-inflammatory-progression-of-obese-in-mice-via-tbk1-and-ikbke-pathway
#7
Seung Hoon Lee, JooYeon Jhun, Jae-Kyung Byun, Eun-Kyung Kim, KyoungAh Jung, Ji Eun Lee, Jong Young Choi, Sung-Hwan Park, Mi-La Cho
Obesity mediates immune inflammatory response and induces IL-17 expression. Adipgenesis can be regulated by IL-17 and it causes TBK1 activation. The inhibition of TBK1 and the inhibition of I IKBKE reduces inflammatory response and improves obesity. It is hypothesized that IL-17 deficiency inhibits obesity progression and inflammation. 3T3-L1 preadipocytes were differentiated in vitro and treated with IL-17. RAW264.7 cells and differentiated 3T3-L1 were pretreated with TBK1 inhibitor and then stimulated with IL-17...
February 22, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28237819/the-complex-roles-of-mechanistic-target-of-rapamycin-in-adipocytes-and-beyond
#8
REVIEW
Peter L Lee, Su Myung Jung, David A Guertin
Having healthy adipose tissue is essential for metabolic fitness. This is clear from the obesity epidemic, which is unveiling a myriad of comorbidities associated with excess adipose tissue including type 2 diabetes, cardiovascular disease, and cancer. Lipodystrophy also causes insulin resistance, emphasizing the importance of having a balanced amount of fat. In cells, the mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1 and mTORC2, respectively) link nutrient and hormonal signaling with metabolism, and recent studies are shedding new light on their in vivo roles in adipocytes...
February 22, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28237595/effect-of-short-term-feed-restriction-on-temporal-changes-in-milk-components-and-mammary-lipogenic-gene-expression-in-mid-lactation-holstein-dairy-cows
#9
A M Abdelatty, M E Iwaniuk, M Garcia, K M Moyes, B B Teter, P Delmonte, A K G Kadegowda, M A Tony, F F Mohamad, R A Erdman
Investigations of the temporal changes in mammary gene expression that occur during sudden diet change have been limited by the use of mammary tissue as the source of RNA because of the invasive nature of mammary biopsy procedures. However, the cytosolic crescent, present in 1% of the largest milk fat globules, contains mammary epithelial cell RNA that has become trapped between the inner and outer milk fat globule membranes during final formation and secretion of milk fat into the lumen of the mammary alveoli...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237590/production-and-calving-traits-of-montbeliarde-%C3%A3-holstein-and-viking-red-%C3%A3-holstein-cows-compared-with-pure-holstein-cows-during-first-lactation-in-8-commercial-dairy-herds
#10
A R Hazel, B J Heins, L B Hansen
Montbeliarde (MO) × Holstein (HO) and Viking Red (VR) × HO crossbred cows were compared with pure HO cows in 8 large, high-performance dairy herds. All cows were either 2-breed crossbred or pure HO cows that calved for the first time from December 2010 to April 2014. Best Prediction was used to calculate 305-d milk, fat, and protein production, as well as somatic cell score, and 513 MO × HO, 540 VR × HO, and 978 HO cows were analyzed for production in first lactation. Calving difficulty was scored from 1 (no assistance) to 5 (extreme difficulty)...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237295/carbohydrate-quality-and-quantity-affects-the-composition-of-the-red-blood-cell-fatty-acid-membrane-in-overweight-and-obese-individuals
#11
Simona Giardina, Aleix Sala-Vila, Pablo Hernández-Alonso, Carlos Calvo, Jordi Salas-Salvadó, Mònica Bulló
BACKGROUND: Cell membrane fatty acid (FA) composition may play a role in human metabolic diseases. However, the modulatory effect of nutrients other than fat is poorly explored. OBJECTIVE: To investigate the effect of moderate-carbohydrate diets with different glycemic indices (GI) and a low-fat diet (LF) on red blood cell (RBC) FA membrane composition. DESIGN: The RBC FA profile was measured in 87 subjects from the GLYNDIET study. Participants were randomly assigned to one of the following energy-restricted diet for 6 months: moderate-carbohydrate/low-GI diet (LGI, n = 31), moderate-carbohydrate/high-GI diet (HGI, n = 30) or LF-diet (n = 26)...
February 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28237279/diagnosis-of-renal-angiomyolipomas-classic-fat-poor-and-epithelioid-types
#12
Masahiro Jinzaki, Stuart G Silverman, Hirotaka Akita, Shuji Mikami, Mototsugu Oya
With the increasing discovery of small renal masses with cross-sectional imaging, there has been the concomitant rise in their treatment. With the intent of early curative surgery for a presumed renal cell carcinoma, many renal masses are being resected at surgery without a confirmed diagnosis. Many of them are benign, and some are angiomyolipomas. The diagnosis of renal angiomyolipoma using imaging is, therefore, is as important as ever. Although most, if not all angiomyolipomas with abundant fat are diagnosed readily, some have too little fat to be detected with imaging...
February 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28236966/regulation-of-drosophila-development-by-the-golgi-kinase-four-jointed
#13
Yoko Keira, Moe Wada, Hiroyuki O Ishikawa
Despite intensive research on kinases and protein phosphorylation, most studies focus on kinases localized to the cytosol and nucleus. Studies in Drosophila discovered a novel signaling pathway that regulates growth and planar cell polarity. In this pathway, the atypical cadherin Fat acts as a receptor, and the cadherin Dachsous (Ds) serves as its ligand. Genetic studies in Drosophila identified the four-jointed gene as a regulator of the Fat pathway. Four-jointed (Fj) resides in the Golgi and phosphorylates the cadherin domains of Fat and Ds...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28236860/effect-of-equipotent-doses-of-bupivacaine-and-ropivacaine-in-high-fat-diet-fed-neonatal-rodent-model
#14
Ying-Dong Lian, Zong-Xiang Chen, Kang-Ru Zhu, Shu-Yin Sun, Li-Ping Zhu
OBJECTIVES: The increase in the prevalence of obesity presents a significant health and economic problem. Obesity has been reported to be a major contributor to variety of chronic diseases. Childhood obesity has been rising over the past decades leading to various complications in health. Millions of infants and children undergo surgery every year on various health grounds. The present investigation was undertaken to evaluate the effect of spinal anesthesia of equipotent doses of ropivacaine and bupivacaine on over-weight neonatal rats...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28236856/could-mucin-16-and-colony-stimulating-factor-2-receptor-beta-possible-graft-versus-host-disease-biomarkers-medical-hypotheses
#15
Milena Monteiro de Souza, Fabiana Martins de Paula, Ricardo Hsieh, Maria Cristina Martins Almeida Macedo, Marcelo Andreetta Corral, Thaís Borguezan Nunes, Fernanda De Paula, Silvia Vanessa Lourenço
Graft versus host disease (GVHD) occurs after bone marrow transplantation and is one of the most important causes of death worldwide. Reviews demonstrated GVHD patients with involvement of various tissues and organs, such as salivary glands. The diagnosis of acute GVHD has been the biopsies and the histopathologic evaluation of tissue from an involved organ. These procedures are invasive. Saliva proteins as possible biomarker for GVHD could facilitate the management and diagnosis accuracy. For support the proposed hypotheses, in this pilot study we collected whole saliva samples from patients with undergoing allogeneic hematopoietic cell transplantation (HCT) and from healthy subjects...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28236433/regulators-of-mitochondrial-quality-control-differ-in-subcutaneous-fat-of-metabolically-healthy-and-unhealthy-obese-monkeys
#16
Kylie Kavanagh, Ashley T Davis, Diane E Peters, Andre C LeGrand, Manish S Bharadwaj, Anthony J A Molina
OBJECTIVE: Obesity exists with and without accompanying cardiometabolic disease, termed metabolically unhealthy obesity (MUO) and healthy obesity (MHO), respectively. Underlying differences in the ability of subcutaneous (SQ) fat to respond to nutrient excess are emerging as a key pathway. This study aimed to document the first spontaneous animal model of MHO and MUO and differences in SQ adipose tissue. METHODS: Vervet monkeys (Chlorocebus aethiops; N = 171) were screened for metabolic syndrome...
February 25, 2017: Obesity
https://www.readbyqxmd.com/read/28235412/the-herbal-formula-kh-204-is-protective-against-erectile-dysfunction-by-minimizing-oxidative-stress-and-improving-lipid-profiles-in-a-rat-model-of-erectile-dysfunction-induced-by-hypercholesterolaemia
#17
Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang, Sae Woong Kim
BACKGROUND: Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidative stress damage in the vascular endothelium and erectile tissue. KH-204 is an herbal formula with a strong antioxidant effect. We evaluated the effects of KH-204 on erectile function in a rat model of HC-induced ED. METHODS: Male Sprague-Dawley rats (6 weeks old) were divided into normal control, high-fat and cholesterol diet (HFC), and HFC with KH-204 treatment (HFC + KH) groups (n = 12 each)...
February 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28231275/suppression-of-tgf-%C3%AE-pathway-by-pirfenidone-decreases-extracellular-matrix-deposition-in-ocular-fibroblasts-in-vitro
#18
Thomas Stahnke, Bhavani S Kowtharapu, Oliver Stachs, Klaus-Peter Schmitz, Johannes Wurm, Andreas Wree, Rudolf Friedrich Guthoff, Marina Hovakimyan
In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pathway plays a key role in fibroblast function, differentiation and proliferation. The aim of this study was the characterization of the fibrotic potential of two subtypes of primary human ocular fibroblasts and the attempt to inhibit fibrotic processes specifically, without impairing cell viability. For fibrosis inhibition we focused on the small molecule pirfenidone, which has been shown to prevent pulmonary fibrosis by the decrease of the expression of TGF-β1, TGF-β2 and TGF-β3 cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28231175/mushroom-polysaccharides-chemistry-and-antiobesity-antidiabetes-anticancer-and-antibiotic-properties-in-cells-rodents-and-humans
#19
REVIEW
Mendel Friedman
More than 2000 species of edible and/or medicinal mushrooms have been identified to date, many of which are widely consumed, stimulating much research on their health-promoting properties. These properties are associated with bioactive compounds produced by the mushrooms, including polysaccharides. Although β-glucans (homopolysaccharides) are believed to be the major bioactive polysaccharides of mushrooms, other types of mushroom polysaccharides (heteropolysaccharides) also possess biological properties. Here we survey the chemistry of such health-promoting polysaccharides and their reported antiobesity and antidiabetic properties as well as selected anticarcinogenic, antimicrobial, and antiviral effects that demonstrate their multiple health-promoting potential...
November 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231095/optimization-of-fat-reduced-puff-pastry-using-response-surface-methodology
#20
Christoph Silow, Emanuele Zannini, Claudia Axel, Markus C E Belz, Elke K Arendt
Puff pastry is a high-fat bakery product with fat playing a key role, both during the production process and in the final pastry. In this study, response surface methodology (RSM) was successfully used to evaluate puff pastry quality for the development of a fat-reduced version. The technological parameters modified included the level of roll-in fat, the number of fat layers (50-200) and the final thickness (1.0-3.5 mm) of the laminated dough. Quality characteristics of puff pastry were measured using the Texture Analyzer with an attached Extended Craft Knife (ECK) and Multiple Puncture Probe (MPP), the VolScan and the C-Cell imaging system...
February 22, 2017: Foods (Basel, Switzerland)
keyword
keyword
113237
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"