Zhiwen Deng, Liangyu Zhao, Sha Li, Xiaoyang Chen, Xiaohan Ling, Jiajun Zheng, Kunkun Yu, Jing Xu, Chencheng Yao, Sha Han, Jiayi Liang, Huimin Feng, Lanlan Wu, Peng Li, Ruhui Tian, Tao Jing, Yuxin Tang, Yingbo Dai, Minbo Yan, Chenchen Wang, Zheng Li, Zhi Zhou
Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as late-onset hypogonadism (LOH), remain incompletely understood. Using single-cell RNA sequencing on human testes with LOH, we delineated Sertoli cells (SCs) as pivotal metabolic coordinators within the testicular microenvironment. In particular, lysosomal acidity probing revealed compromised degradative capacity in aged SCs, hindering autophagy and phagocytic flux...
April 22, 2024: Nature aging