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Arshad Mehmood, Lei Zhao, Chengtao Wang, Muhammad Nadeem, Ali Raza, Nawazish Ali, Amjad Abbas Shah
Hyperuricemia, a condition due to high serum uric acid level and is notorious to health. It is considered to be a potent risk factor for gout and dramatically associated in the development of many chronic diseases such as malignant tumor, cardiovascular disorders and renal failure. Modern innovative medicinal and therapeutic interventions are underlying these days to combat hyperuricemia. Previously reported studies revealed the significant impact of dietary polyphenols (e.g. anthocyanins, phenolic acids, flavonoids etc...
December 26, 2017: Critical Reviews in Food Science and Nutrition
Zi-Nan Wang, Ping Li, Ran-Hua Jiang, Ling Li, Xue Li, Liang Li, Cong Liu, Cong-Liang Tian
PURPOSE: Data about the association between serum uric acid and metabolic syndrome in healthy adolescents are sparse. This study examined this association and determined the optimal cutoffs for serum uric acid to predict metabolic syndrome among healthy adolescents. METHODS: During 2010-2011, we conducted a cross-sectional study of 927 adolescents (53.0% boys) aged 11-16 years from junior and senior high schools in northeast China. All participants received a physical examination and gave venous blood samples...
2015: International Journal of Clinical and Experimental Medicine
L A A Orellano, S A Almeida, P P Campos, S P Andrade
Recent data has indicated that, besides its classical therapeutic indication in hyperurecemia and gout, xanthine oxidase inhibitors can be used to various forms of ischemia and other types of tissue and vascular injuries. We tested the hypothesis that allopurinol, an inhibitor of xanthine oxidase (XO), might modulate acute and/or chronic inflammatory angiogenesis induced by subcutaneous implantation of synthetic matrix in mice. C57/BL6 male mice (6-7 weeks) were implanted with polyether-polyurethane sponge discs...
September 2015: Microvascular Research
Hirohide Yokokawa, Hiroshi Fukuda, Akihito Suzuki, Kazutoshi Fujibayashi, Toshio Naito, Yuki Uehara, Akiyoshi Nakayama, Hirotaka Matsuo, Hironobu Sanada, Pedro A Jose, Yuichi Miwa, Teruhiko Hisaoka, Hiroshi Isonuma
This cross-sectional study from January 2012 to December 2012 aimed to examine the sex-specific association between serum uric acid (SUA) levels/hyperuricemia and hypertension among Japanese patients. SUA level, medical histories, and lifestyle-related items were collected from 85,286 of 136,770 participants. Among those with hyperuricemia, the median age was 46 years and 97% were men, which was significantly different than those without hyperurecemia (44 years and 56%, respectively; P<.01). Hyperuricemia was 1...
January 2016: Journal of Clinical Hypertension
L Khondker, S I Khan
Psoriatic arthritis is a condition that causes inflammation of the joints of psoriatic patients. Psoriatic arthritis also affects tissues surrounding the joints including tendon and ligaments. Psoriatic arthritis (PsA), recognized for over 100 years, is the second most frequent diagnostic category after Rhematoid Arthritis (RA) and occurring up to 10% of patients with skin psoriasis. Although PsA is a sero-negative arthritis and the absence of rheumatoid factor is a characteristic laboratory finding, it may be present in 3% of psoriatic arthritis (PsA) patients...
July 2014: Mymensingh Medical Journal: MMJ
Chandra Shekhar Pundir, Rooma Devi
Xanthine (3,7-dihydro-purine-2,6-dione) is generated from guanine by guanine deaminase and hypoxanthine by xanthine oxidase (XOD). The determination of xanthine in meat indicates its freshness, while its level in serum/urine provides valuable information about diagnosis and medical management of certain metabolic disorders such as xanthinuria, hyperurecemia, gout and renal failure. Although chromatographic methods such a HPLC, capillary electrophoresis and mass spectrometry are available for quantification of xanthine in biological materials, these suffer from certain limitations such as complexity, time consuming sample preparation and requirement of expensive apparatus and trained persons to operate...
April 10, 2014: Enzyme and Microbial Technology
Anjana G Vij, Ruma Dutta, Narinder K Satija
Hypoxia-mediated oxidative stress has been implicated in the pathophysiology of high altitude maladaptations. To explore whether prolonged exposure to high altitude can trigger an adaptive response to oxidative stress and restore redox homeostasis in the body, the study was conducted to evaluate biochemical variables related to oxidative stress and antioxidant status in humans at sea level (190 m) and following 3- and 13- month sojourns at altitude (4,500 m). After 3 months at altitude, whole-blood thiobarbituric acid reactive substances (TBARS) were significantly higher (65...
2005: High Altitude Medicine & Biology
Gloria Lena Vega
Atherogenic dyslipidemia is prevalent in various conditions associated with central obesity, hypertension, hyperurecemia, and impaired beta-cell function (ie, the metabolic syndrome). Because of clinical trial evidence, most high-risk patients with atherogenic dyslipidemia require statin therapy. Coadministration of drugs targeted to reduction of low-density lipoprotein precursors, however,is likely to improve the metabolic profile of all non-high-density lipoproteins and produce a significant rise in high-density lipoprotein cholesterol...
September 2004: Endocrinology and Metabolism Clinics of North America
K Reinhardt, M Wagner
A practically complete destruction of both femoral heads including the femoral necks and acetabula was encountered in a 69-year-old patient with diabetes, which varied in intensity. This destruction, documented by radiographs which had been taken 8 years prior, had started as the typical picture of "idiopathic femoral head necrosis". In addition to diabetes, hyperuricemia and hyperlipoproteinemia were present at the time when the femoral head necrosis was first evidenced. One episode of gout was recorded. In recent years, following therapy, the hyperurecemia and hyperlipoproteinemia had normalized...
1980: Archives of Orthopaedic and Traumatic Surgery. Archiv Für Orthopädische und Unfall-Chirurgie
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