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https://www.readbyqxmd.com/read/28527357/functionalization-of-electrospun-polymeric-wound-dressings-with-antimicrobial-peptides
#1
REVIEW
Helena P Felgueiras, M Teresa P Amorim
Wound dressings have evolved considerably since ancient times. Modern dressings are now important systems that combine the physical and biochemical properties of natural and synthetic polymers with active compounds that are beneficial to wound healing. Antimicrobial peptides (AMPs) are the most recent addition to these systems. These aim to control the microbial proliferation and colonization of pathogens and to modulate the host's immune response. In the last decade, electrospun wound dressings have been extensively studied and the electrospinning technique recognized as an efficient approach for the production of nanoscale fibrous mats...
May 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28526303/the-use-of-biobrane-%C3%A2-for-wound-coverage-in-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#2
Alan D Rogers, Erin Blackport, Robert Cartotto
INTRODUCTION: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN. METHODS: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted...
May 16, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28523994/potential-biomolecules-and-current-treatment-technologies-for-diabetic-foot-ulcer-an-overview
#3
Zenith Khashim, Shila Samuel, Nallusamy Duraisamy, Kathiravan Krishnan
BACKGROUND: Diabetic foot ulceration remains a major challenge is one of the most expensive and a leading cause of major and minor among patients with a diabetic foot ulcer. Hence the purpose of this review emphases on potential molecular markers involved in diabetic ulcer physiology, the efficacy of different types of dressing materials, therapy and newer therapeutic approach like nanoparticles for the of diabetic foot ulcer. METHODS: We conducted a systematic literature reviews search by using Pubmed and other web search...
May 18, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28523889/collagenase-for-wound-debridement-in-the-neonatal-intensive-care-unit-a-retrospective-case-series
#4
Elizabeth Huett, Whitney Bartley, Darla Morris, Della Reasbeck, Beth McKitrick-Bandy, Charlotte Yates
BACKGROUND/OBJECTIVES: The use of collagenase for enzymatic wound debridement has been studied extensively and has been established as the standard of care for nonhealing and necrotic wounds in individuals for whom surgical intervention is not an option. Collagenase has been shown to be effective in adults but has been studied in a limited capacity in infants and neonates. The purpose of this study was to investigate the use of collagenase in the neonatal intensive care unit (NICU). METHODS: Retrospective chart review of infants and neonates admitted to the NICU at Arkansas Children's Hospital with nonhealing wounds for which collagenase was used for wound healing over a 1-year time period...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28523167/a-novel-facilitated-negative-pressure-wound-therapy-for-thoracic-incision-infection-after-esophagectomy
#5
Zhi-Tian Wang, Jin-Lin Cao, Ping Yuan, Lu-Ming Wang, Zhe-Hao He, Wang Lv, Jian Hu
BACKGROUND: Negative-pressure wound therapy (NPWT) is the therapeutic management of traumatic soft-tissue wounds and infections. The efficacy of NPWT in the treatment of thoracic incision infection is unclear. We assess the effectiveness and safety of a novel facilitated NPWT for thoracic incision infection after esophagectomy. METHODS: Between Jan. 2013 and Mar. 2016, 380 patients underwent open esophagectomy in our department. Forty-five patients with thoracic incision infection were retrospectively reviewed...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28522813/in-situ-assembly-of-ag-nanoparticles-agnps-on-porous-silkworm-cocoon-based-would-film-enhanced-antimicrobial-and-wound-healing-activity
#6
Kun Yu, Fei Lu, Qing Li, Honglei Chen, Bitao Lu, Jiawei Liu, Zhiquan Li, Fangying Dai, Dayang Wu, Guangqian Lan
Preventing wound infection and retaining an appropriate level of moisture around wounds represent the most critical issues in wound treatment. Towards these ends, special focus has been placed on Bombyx mori cocoons because the protective function of the silkworm cocoon resembles the manner in which the skin protects the human body. We have designed a facile technique to develop a novel silkworm cocoon-based wound film (SCWF) wound dressing utilizing a CaCl2-ethanol-H2O solution. To improve the anti-bacterial performance of SCWF, we have incorporated the ability of silk sericin to act as a reducing agent for the conversion of Ag(+) to Ag, yielding nanoparticles (AgNPs) linked together by peptide bonds of silkworm cocoon wound film (SCWF-AgNPs)...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28520604/in-vitro-evaluation-of-betafoam-a-new-polyurethane-foam-dressing
#7
Jae-A Jung, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong, Kang-Gyun Park, Woo-Kyung Kim
BACKGROUND: A new polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam; Genewell, Seoul, Korea) was recently developed based on the hypothesis that its physical properties, including improved moisture-retention capacity and antimicrobial activity, are at least as good as those achieved with the current foam dressings that contain silver, but also associated with reduced cost and cytotoxicity to host cells. The purpose of this in vitro study was to evaluate the efficacy of Betafoam by comparing its physical properties, antimicrobial activity, and cytotoxicity with those of 3 silver foam dressings (Allevyn-Ag [Smith & Nephew, Hull, United Kingdom]; Mepilex-Ag [Mölnlycke Health Care, Gothenburg, Sweden]; and PolyMem-Ag [Ferris MFG Corp, Burr Ridge, Illinois]) used worldwide...
June 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28520509/recent-advances-in-electrospun-nanofibers-for-wound-healing
#8
Shixuan Chen, Bing Liu, Mark A Carlson, Adrian F Gombart, Debra A Reilly, Jingwei Xie
Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full-thickness skin regeneration...
May 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28511700/a-new-easy-to-make-pectin-honey-hydrogel-enhances-wound-healing-in-rats
#9
Gessica Giusto, Cristina Vercelli, Francesco Comino, Vittorio Caramello, Massimiliano Tursi, Marco Gandini
BACKGROUND: Honey, alone or in combination, has been used for wound healing since ancient times and has reemerged as a topic of interest in the last decade. Pectin has recently been investigated for its use in various biomedical applications such as drug delivery, skin protection, and scaffolding for cells. The aim of the present study was to develop and evaluate a pectin-honey hydrogel (PHH) as a wound healing membrane and to compare this dressing to liquid honey. METHODS: Thirty-six adult male Sprague-Dawley rats were anesthetized and a 2 × 2 cm excisional wound was created on the dorsum...
May 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28509885/the-role-of-phytochemicals-in-the-inflammatory-phase-of-wound-healing
#10
REVIEW
Ahmed Shah, Saeid Amini-Nik
Historically, plant-based products have been the basis of medicine since before the advent of modern Western medicine. Wound dressings made of honey, curcumin and other phytochemical-rich compounds have been traditionally used. Recently, the mechanisms behind many of these traditional therapies have come to light. In this review, we show that in the context of wound healing, there is a global theme of anti-inflammatory and antioxidant phytochemicals in traditional medicine. Although promising, we discuss the limitations of using some of these phytochemicals in order to warrant more research, ideally in randomized clinical trial settings...
May 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28508548/a-prospective-evaluation-of-methylene-blue-and-gentian-violet-dressing-for-management-of-chronic-wounds-with-local-infection
#11
Kevin Y Woo, Jolene Heil
The objective of this prospective, non-randomised study was to evaluate the performance of an antibacterial foam dressing containing methylene blue and gentian violet (Hydrofera Blue Classic dressing(®) ) for the management of chronic wounds with local infection. Patients in this study were ≥18 years of age (n = 29), and each had at least one chronic wound ≥1 cm(2) in size that showed signs of localised infection or critical colonisation but with good potential for healing based on clinical assessment...
May 16, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28508517/on-demand-antimicrobial-treatment-with-antibiotic-loaded-porous-silicon-capped-with-a-ph-responsive-dual-plasma-polymer-barrier
#12
Roshan Bharath Vasani, Endre J Szili, Gayathri Rajeev, Nicolas Hans Voelcker
Chronic wounds are a major socio-economic problem. Bacterial infections in such wounds are a major contributor to lack of wound healing. An early indicator of wound infection is an increase in pH of the wound fluid. Herein, we describe the development of a pH-responsive drug delivery device that can potentially be used for wound decontamination in situ and on-demand in response to an increase in the pH of the wound environment. The device is based on a porous silicon film that provides a reservoir for encapsulation of an antibiotic within the pores...
May 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28507787/the-feasibility-of-a-handheld-electrospinning-device-for-the-application-of-nanofibrous-wound-dressings
#13
Josef Haik, Rachel Kornhaber, Biader Blal, Moti Harats
Objectives: The aim of this study was to determine the feasibility of a portable electrospinning device for the application of wound dressings. Approach: Four polymer nanofibers dressings were applied on superficial partial thickness wounds to a porcine model and compared with a traditional paraffin tulle gras dressing. The polymer nanofibrous dressings were applied using a handheld portable electrospinning device activated at a short distance from the wound. The partial thickness donor sites were evaluated on day 2, 7, and 14 when dressings were removed and tissue samples were taken for histological examination...
May 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28507338/impact-of-trace-minerals-on-wound-healing-of-footpad-dermatitis-in-broilers
#14
Juxing Chen, Guillermo Tellez, Jeffery Escobar, Mercedes Vazquez-Anon
Footpad dermatitis (FPD) is used in the poultry industry as an animal welfare criterion to determine stocking density. Trace minerals (TM) play a role in skin integrity and wound healing. This study evaluated the impact of TM on FPD and consisted of 3 treatments supplemented with 0 (NTM), low (LTM) and high (HTM) TM levels in the same basal diet. On d21, 71% birds in all treatments developed mild FPD and pens were top-dressed with dry litter to promote FPD healing. Compared to NTM, LTM reduced area under the curve (AUC) of FPD lesion scores during d21-42, HTM reduced the AUC of FPD lesion scores during d7-21 and d21-42...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28505080/first-insights-into-human-fingertip-regeneration-by-echo-doppler-imaging-and-wound-microenvironment-assessment
#15
Paris Jafari, Camillo Muller, Anthony Grognuz, Lee Ann Applegate, Wassim Raffoul, Pietro G di Summa, Sébastien Durand
Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the response to tissue loss from a wound repair process towards regeneration. When analyzing by Immunoassay the wound exudate from occlusive dressings, the concentrations of brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were higher in fingertip exudates than in burn wounds (used as controls for wound repair versus regeneration)...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28504810/using-a-structured-checklist-to-improve-the-orthopedic-ward-round-a-prospective-cohort-study
#16
Adrian J Talia, James Drummond, Cameron Muirhead, Phong Tran
Comprehensive and timely documentation on orthopedic ward rounds continues to be problematic, leading to delayed or inappropriate patient care and miscommunication between health care providers. The authors introduced a simple checklist to improve the documentation on orthopedic ward rounds in their institution. A prospective cohort study was performed. Standard care was provided for cohort A. During a 2-week period, the documentation of patient care by physicians following a ward round was assessed in terms of venous thromboembolism prophylaxis, fasting status, wound or dressing plan, weight-bearing status, and important surgical details...
May 15, 2017: Orthopedics
https://www.readbyqxmd.com/read/28503896/antibacterial-efficacy-of-poly-vinyl-alcohol-composite-nanofibers-embedded-with-silver-anchored-silica-nanoparticles
#17
Abdul Wahab Jatoi, Yun Kee Jo, Hoik Lee, Seong-Geun Oh, Dong Soo Hwang, Zeeshan Khatri, Hyung Joon Cha, Ick Soo Kim
Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Immobilization of silver is an effective approach to reduce silver release. Herein, we present poly(vinyl alcohol) (PVA) composite nanofibers embedded with silver-anchored silica nanoparticles (SSNs) as a novel antibacterial material...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28503756/biofilms-and-delayed-healing%C3%A2-%C3%A2-an-in-vitro-evaluation-of-silver-and-iodine-containing-dressings-and-their-effect-on-bacterial-and-human-cells
#18
Katie A Bourdillon, Craig P Delury, Breda M Cullen
This study investigated whether there are differences in the ability of wound dressings to modulate certain factors known to affect wound healing. A selection of antimicrobial dressings (AQUACEL(®) Ag Extra(™) , AQUACEL(®) Ag+ Extra(™) , IODOFLEX(™) , ACTICOAT(™) 7 and PROMOGRAN PRISMA(™) matrix) were tested for their effect on both bacterial bioburden and human dermal fibroblasts. Some dressings underwent further evaluation for activity against Pseudomonas aeruginosa biofilms using a colony-drip flow reactor model...
May 14, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28497248/-aseptic-loosening-of-total-ankle-replacement-one-stage-revision-ankle-arthroplasty
#19
G Pagenstert, M D Wimmer, M Jacxsens, C L Saltzman, A Barg
OBJECTIVE: To revise one or both loosened prosthesis components, to achieve postoperative pain relief, and preserve ankle range of motion. INDICATIONS: Aseptic loosening of the tibial and/or talar ankle prosthesis components without substantial bone defect of the tibial or talar bone stock. CONTRAINDICATIONS: General surgical or anesthesiological risks, infections, critical soft tissue conditions, nonmanageable hindfoot instability, neurovascular impairment of the lower extremity, neuroarthropathy (e...
May 11, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28497218/to-evaluate-the-efficacy-of-an-acellular-flowable-matrix-in-comparison-with-a-wet-dressing-for-the-treatment-of-patients-with-diabetic-foot-ulcers-a-randomized-clinical-trial
#20
F Campitiello, M Mancone, A Della Corte, R Guerniero, S Canonico
The authors aimed to evaluate the efficacy of an advanced wound matrix (Integra Flowable Wound Matrix, Integra LifeScience Corp, Plainsboro, NJ, USA) for treating wounds with irregular geometries versus a wet dressing in patients with diabetic foot ulcers. Sixty patients with diabetic foot ulcers (Grades 3 Wagner) were included in this randomized clinical trial. The study was conducted in the General Surgery Unit and Geriatric of the Second University of Naples, Italy, in the last 12 months. Forty-six cases of diabetic foot ulcers were equally and randomly divided into control and test groups...
May 11, 2017: Updates in Surgery
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