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Ion Alexandru Bobulescu, Yair Lotan, Jianning Zhang, Tara R Rosenthal, John T Rogers, Beverley Adams-Huet, Khashayar Sakhaee, Orson W Moe
Obesity is associated with increased risk for kidney disease and uric acid nephrolithiasis, but the pathophysiological mechanisms underpinning these associations are incompletely understood. Animal experiments have suggested that renal lipid accumulation and lipotoxicity may play a role, but whether lipid accumulation occurs in humans with increasing body mass index (BMI) is unknown. The association between obesity and abnormal triglyceride accumulation in non-adipose tissues (steatosis) has been described in the liver, heart, skeletal muscle and pancreas, but not in the human kidney...
2014: PloS One
Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu
Natural herbal medications may be one answer to the worldwide epidemic of obesity. This study examines the effects of Cassia seed ethanol extract (CSEE) upon lipid accumulation in white adipose tissue (WAT). CSEE exhibited a significant concentration-dependent decrease in the intracellular accumulation of trigycerides in 3T3-L1 adipocytes. After being fed a high-fat diet (HFD) for 2 weeks, rats were fed CSEE (100, 200 or 300 mg/kg) once daily for 8 weeks. CSEE caused dose-related reductions in body weight gain (as well as plasma lipid levels and epididymal WAT sizes in HFD-fed rats)...
January 15, 2013: Food Chemistry
Rita P S Middelberg, Andrew C Heath, Pamela A F Madden, Grant W Montgomery, Nicholas G Martin, John B Whitfield
A recent meta-analysis of genome-wide association (GWA) studies identified 95 loci that influence lipid traits in the adult population and found that collectively these explained about 25-30% of heritability for each trait. Little is known about how these loci affect lipid levels in early life, but there is evidence that genetic effects on HDL- and LDL-cholesterol (HDL-C, LDL-C) and triglycerides vary with age. We studied Australian adults (N = 10,151) and adolescents (N = 2,363) who participated in twin and family studies and for whom we have lipid phenotypes and genotype information for 91 of the 95 genetic variants...
2012: PloS One
Nilank C Shah, Jian-Ping Liu, Jahangir Iqbal, Mahmood Hussain, Xian-Cheng Jiang, Zhiqiang Li, Yan Li, Tao Zheng, Wenyan Li, Anthony C Sica, Jose Luis Perez-Albela, Bella T Altura, Burton M Altura
The present work tested the hypothesis that short-term (S-T) dietary deficiency of magnesium (Mg) (21 days) in rats would: 1) result in reduction in serum(s) sphingomyelin (SM) and changes in several blood lipids, HDL-cholesterol (HDL-C) and phosphatidylcholine (PC) concomitant with elevations in s cholesterol (chol), s LDL+VLDL and trigycerides (TG), as well as reduction in the PC/cholesterol ratio; 2) lead to oxidative stress, characterized by reductions in glutathione (glut) content in the various chambers of the heart and activation of e-NOS and n-NOS in the atria, ventricles and aortic smooth muscle (ASM); 3) produce early cardiac damage characterized by leakage of creatine kinase (CK) and lactic dehydrogenase (LDH); and 4) demonstrate that these pathophysiological changes are a result of profound reductions in s ionized Mg (Mg(2+)) and activation of the SM-ceramide pathway...
2011: International Journal of Clinical and Experimental Medicine
Daniela Matei, Al D Ciochină, C Corciova, Ana Stratone
UNLABELLED: Diabetes mellitus (DM), metabolic disease with chronic evolution, affects various organs through its macro- and micro-angiopathic complications which it causes, one of this target organs for diabetes being the lungs. OBJECTIVES: The aim of the study is to evaluate the relationship between type 2 diabetes mellitus and the pulmonary function. MATERIAL AND METHOD: 50 non-smoking patients diagnosed with type 2 DM, without respiratory problems were included in this study...
October 2009: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Andrew J Kerr, Andrew McLachlan, Sue Furness, Joanna Broad, Tania Riddell, Rod Jackson, Susan Wells
AIMS: To investigate the burden of modifiable cardiovascular disease (CVD) risk factors in patients admitted to coronary care by age, ethnicity, and socioeconomic status. DESIGN AND SETTING: Cross-sectional study of patients presenting to the Middlemore Hospital Coronary Care Unit with an acute CVD event from July 2004 to June 2006. METHODS: CVD risk factor data was electronically collected using Acute PREDICT. Socioeconomic status was estimated using the NZ Deprivation 2001 index (NZDep01)...
November 14, 2008: New Zealand Medical Journal
N Matikainen, S Mänttäri, A Schweizer, A Ulvestad, D Mills, B E Dunning, J E Foley, M-R Taskinen
AIMS/HYPOTHESIS: We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS: This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Patients received vildagliptin (50 mg twice daily, n=15) or placebo (n=16) for 4 weeks. Triglyceride, cholesterol, lipoprotein, glucose, insulin, glucagon and glucagon-like peptide-1 (GLP-1) responses to a fat-rich mixed meal were determined for 8 h postprandially before and after 4 weeks of treatment...
September 2006: Diabetologia
Visnja Katalinić, Sasa Radić, Darko Ropac, Rosanda Mulić, Ana Katalinić
AIM: The aim of this study was to determine the antioxidative activity of propolis from ecologically clean parts of Dalmatia. METHODS: Phenol concentration in ethanolic propolis extracts was determined by Folin-Ciocalteu reagent using gallic acid as the standard. Flavonoid phenolic compounds were analyzed after precipitation with formaldehyde. The residual non-flavonoid phenolics were also determined by Folin-Ciocalteu method. By determining the change of peroxide number (PN), of tiobarbiture acid reactive species (TBARS), and of DPPH-radical activity, antioxidative efficiency of propolis was tested and compared with well known and widely used synthetic antioxidants...
2004: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Kunihisa Miwa, Toshinori Makita, Katsuhisa Ishii, Nobuaki Okuda, Ataru Taniguchi
BACKGROUND: Dyslipidemia with increased oxidative stress but without elevation of low-density lipoprotein cholesterol has been recently implicated in the pathogenesis of coronary vasospasm. HYPOTHESIS: Disordered triglyceride-rich lipoprotein metabolism may be linked to the genesis of coronary artery spasm. METHODS: Both serum remnant lipoprotein (RLP) and alpha-tocopherol levels were determined in 18 patients with the active stage of variant angina (VA), in 16 patients with the inactive stage of variant angina (IVA), and in 19 control subjects (CONTROL)...
June 2004: Clinical Cardiology
F K Welty
Cardiovascular disease, primarily coronary heart disease (CHD), outnumbers the next 16 causes of death in women combined. However, the long-held belief that heart disease in women has a more benign prognosis than in men has resulted in less aggressive diagnosis and management patterns. Appreciation of the differences between men and women in CHD risk factors and presentation can assist in treatment decisions. Although estrogen replacement offers substantial beneficial effects on lipid levels in postmenopausal women, the first 2 randomized trials of estrogen alone and estrogen plus progestin, the Heart and Estrogen/Progestin Replacement Study and Estrogen Replacement and Atherosclerosis Study, observed no benefit in reducing risk of CHD death and nonfatal myocardial infarction and angiographic progression of CHD, respectively, in women with CHD...
February 26, 2001: Archives of Internal Medicine
C Lundberg, S J Jungles, R C Mulligan
The hormone leptin has been shown to be an afferent signal in a negative-feedback loop regulating body weight, and consequently, the administration of the gene product for the treatment of obesity has recently attracted considerable attention. Leptin is produced by adipocytes in response to increased trigyceride storage, and appears to affect body weight primarily through target cells in the hypothalamus. Although plasma levels of leptin correlate positively with adipose tissue mass in normal humans and animals, recent studies have shown that obese humans and animals appear to be relatively resistant to the increased plasma levels of leptin...
February 2001: Nature Biotechnology
M Ho, D Veale, C Eastmond, G Nuki, J Belch
OBJECTIVE: To determine if macrovascular disease is more prevalent in systemic sclerosis (SSc) compared with unaffected subjects. METHODS: 54 patients with SSc (both limited and diffuse disease) and 43 unaffected control subjects of similar age and sex were recruited. All subjects underwent a basic screen for conventional atherosclerotic disease risk factors. All had non-invasive vascular assessments-that is, carotid duplex scanning and measurement of ankle brachial blood pressure index-to identify the presence of asymptomatic peripheral vascular disease...
January 2000: Annals of the Rheumatic Diseases
Z Abbadia, E Vericél, P Mathevet, N Bertin, G Panaye, L Frappart
UNLABELLED: The mammary gland is an organ under complex hormonal and developmental regulation. Among the mediators involved in this process are polypeptides, steroid hormones and certain lipids and their metabolites. The fatty acid content of the breast adipocytes is investigated because of the importance of their role in the proliferation and differentiation of the breast epithelial cells. MATERIALS AND METHODS: To address the hypothesis that polyunsaturated acid might be a risk factor for breast cancer, we examined the association between arachidonic acid (20:4n-6) and menopausal status in the women using lipid extraction from isolated human adipocytes and CD36 detection on a FACS flow cytometer...
March 1997: Anticancer Research
E Blesbois, D Hermier
Qualitative and quantitative characterization of lipoproteins found in seminal plasma from domestic cocks was performed after isolation by density gradient ultracentrifugation. Trigyceride-rich lipoproteins (very low, intermediate- and low density lipoproteins) were not detectable in seminal plasma. High-density lipoproteins (HDL), identified on the basis of size, chemical composition and protein moiety, were present at a concentration of 66 micrograms/ml. A fraction possibly corresponding to VHDL (very high density lipoproteins, 77% protein, 23% lipid) was also detected but appeared contaminated by a protein-rich opalescent material...
November 1990: Journal of Reproduction and Fertility
T Christensson, K Einarsson
Eight males and 36 females with hypercalcaemia were operated upon for primary hyperparathyroidism and parathyroid adenomata were revealed in every case. The serum levels of cholesterol and triglycerides were determined before the operations and 6,12 and 18 months after them. Furthermore, the serum lipids of the patients were compared with those of a normacalcaemic sex- and age-matched control group. The serum cholesterol concentration in primary hyperparathyroidism was about 8-10% lower in both females and males compared with the correspondeing control cases and the levels of serum trigycerides were about 22% and 60% lower...
August 1, 1977: Clinica Chimica Acta; International Journal of Clinical Chemistry
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