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https://www.readbyqxmd.com/read/28046776/su-f-j-207-non-small-cell-lung-cancer-patient-survival-prediction-with-quantitative-tumor-textures-analysis-in-baseline-ct
#1
Y Wu, J Zou, P Murillo, J Nosher, J Amorosa, M Bramwit, N Yue, S Jabbour, D Foran
PURPOSE: Chemo-radiation therapy (CRT) is widely used in treating patients with locally advanced non-small cell lung cancer (NSCLC). Determination of the likelihood of patient response to treatment and optimization of treatment regime is of clinical significance. Up to date, no imaging biomarker has reliably correlated to NSCLC patient survival rate. This pilot study is to extract CT texture information from tumor regions for patient survival prediction. METHODS: Thirteen patients with stage II-III NSCLC were treated using CRT with a median dose of 6210 cGy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029405/distributed-learning-developing-a-predictive-model-based-on-data-from-multiple-hospitals-without-data-leaving-the-hospital-a-real-life-proof-of-concept
#2
Arthur Jochems, Timo M Deist, Johan van Soest, Michael Eble, Paul Bulens, Philippe Coucke, Wim Dries, Philippe Lambin, Andre Dekker
PURPOSE: One of the major hurdles in enabling personalized medicine is obtaining sufficient patient data to feed into predictive models. Combining data originating from multiple hospitals is difficult because of ethical, legal, political, and administrative barriers associated with data sharing. In order to avoid these issues, a distributed learning approach can be used. Distributed learning is defined as learning from data without the data leaving the hospital. PATIENTS AND METHODS: Clinical data from 287 lung cancer patients, treated with curative intent with chemoradiation (CRT) or radiotherapy (RT) alone were collected from and stored in 5 different medical institutes (123 patients at MAASTRO (Netherlands, Dutch), 24 at Jessa (Belgium, Dutch), 34 at Liege (Belgium, Dutch and French), 48 at Aachen (Germany, German) and 58 at Eindhoven (Netherlands, Dutch))...
October 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27929499/development-and-evaluation-of-a-clinical-model-for-lung-cancer-patients-using-stereotactic-body-radiotherapy-sbrt-within-a-knowledge-based-algorithm-for-treatment-planning
#3
Karen Chin Snyder, Jinkoo Kim, Anne Reding, Corey Fraser, James Gordon, Munther Ajlouni, Benjamin Movsas, Indrin J Chetty
The purpose of this study was to describe the development of a clinical model for lung cancer patients treated with stereotactic body radiotherapy (SBRT) within a knowledge-based algorithm for treatment planning, and to evaluate the model performance and applicability to different planning techniques, tumor locations, and beam arrangements. 105 SBRT plans for lung cancer patients previously treated at our institution were included in the development of the knowledge-based model (KBM). The KBM was trained with a combination of IMRT, VMAT, and 3D CRT techniques...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27905909/development-of-a-measure-of-model-fidelity-for-mental-health-crisis-resolution-teams
#4
Brynmor Lloyd-Evans, Gary R Bond, Torleif Ruud, Ada Ivanecka, Richard Gray, David Osborn, Fiona Nolan, Claire Henderson, Oliver Mason, Nicky Goater, Kathleen Kelly, Gareth Ambler, Nicola Morant, Steve Onyett, Danielle Lamb, Sarah Fahmy, Ellie Brown, Beth Paterson, Angela Sweeney, David Hindle, Kate Fullarton, Johanna Frerichs, Sonia Johnson
BACKGROUND: Crisis Resolution Teams (CRTs) provide short-term intensive home treatment to people experiencing mental health crisis. Trial evidence suggests CRTs can be effective at reducing hospital admissions and increasing satisfaction with acute care. When scaled up to national level however, CRT implementation and outcomes have been variable. We aimed to develop and test a fidelity scale to assess adherence to a model of best practice for CRTs, based on best available evidence. METHODS: A concept mapping process was used to develop a CRT fidelity scale...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27893478/loads-and-movement-speeds-dictate-differences-in-power-output-during-circuit-training
#5
Kirk B Roberson, Sean Chowdhari, Morgan White, Joseph F Signorile
Power training has become a common exercise intervention for improving muscle strength, power, and physical function, while reducing injury risk. Few studies, however, have evaluated acute load changes on power output during traditional resistance-training protocols. Therefore, the aim of this study was to quantify the effects of different loading patterns on power output during a single session of circuit resistance training (CRT). Nine males (age=19.4±0.9 y) and eleven females (age=20.6±1.6 y) completed three CRT protocols during separate testing sessions using seven pneumatic exercises...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27875131/non-invasive-personalisation-of-a-cardiac-electrophysiology-model-from-body-surface-potential-mapping
#6
Sophie Giffard-Roisin, Thomas Jackson, Lauren Fovargue, Jack Lee, Herve Delingette, Reza Razavi, Nicholas Ayache, Maxime Sermesant
Modelling cardiac electrophysiology (EP) can help understand pathologies and predict the response to therapies. Moreover, estimating patient-specific parameters of the EP model is crucial to obtain personalised information. The novelty of this paper is to use non-invasive data (body surface potential mapping, BSPM) in order to personalise the main parameters of a cardiac EP model for predicting different pacing conditions. First, an efficient forward model is proposed, coupling the Mitchell- Schaeffer transmembrane potential model with a current dipole formulation...
November 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27748469/imaging-predictive-factors-and-exercise-training-in-crt-patients
#7
Ana Abreu, Helena Santa Clara
Cardiac resynchronization therapy (CRT) is an established treatment for patients with moderate-to-severe chronic heart failure (CHF) and intraventricular conduction delay, which is identified by a QRS interval of 120msec or more on a 12-lead electrocardiogram (ECG). CRT improved functional capacity, reduced hospitalizations for worsening CHF and increased survival. However, about 30-40% of patients who underwent CRT were non-responders with no clinical or echocardiographic improvement. Imaging parameters for prediction of CRT response have been reviewed...
October 14, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27748467/cardiac-rehabilitation-in-patients-with-pacemakers-and-implantable-cardioverter-defibrillators
#8
Marie Christine Iliou, Jean Christophe Blanchard, Aurélia Lamar-Tanguy, Pascal Cristofini, François Ledru
Large subsets of patients admitted in cardiac rehabilitation centers are having a pacemaker, cardiac resynchronization (CRT) or implantable cardiac defibrillator (ICD). Cardiac rehabilitation for patients, mostly with heart failure, with implanted electronic devices as pacemakers or ICD is a unique opportunity not only to optimize the medical treatment, to increase their exercise capacity and improves their clinical condition but also to supervise the correct functioning of the device. CRT reduces clinical symptoms and increases slightly the exercise capacity...
October 14, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27672428/delaying-surgery-after-neoadjuvant-chemoradiotherapy-improves-prognosis-of-rectal-cancer
#9
Mehmet Mihmanlı, Esin Kabul Gürbulak, İsmail Ethem Akgün, Mustafa Fevzi Celayir, Pınar Yazıcı, Deniz Tunçel, Tuba Tülin Bek, Ayhan Öz, Sinan Ömeroğlu
AIM: To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy (CRT) and surgery in locally advanced rectal cancer. METHODS: We evaluated 87 patients with locally advanced mid- or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at Şişli Hamidiye Etfal Training and Research Hospital, Istanbul between January 2009 and January 2014. Patients were divided into two groups according to the interval before surgery: < 8 wk (group I) and ≥ 8 wk (group II)...
September 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27632546/fostering-self-awareness-in-collaborative-reflective-training-commentary-response
#10
Barbara Couden Hernandez, Lana Kim, Adrian Lavery, T Kent Denmark
Replies to comments by DeCaporale-Ryan, Dadiz, and Peyre (see record 2016-27364-002) on the original article by Kim, Hernandez, Lavery, and Denmark (see record 2016-18380-001). The current authors thank DeCaporale-Ryan, Dadiz, and Peyre for presenting a rich theoretical counterpoint to their article and respond to issues they raised regarding their collaborative reflecting team (CRT) model.
September 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27619658/theta-burst-stimulation-over-premotor-cortex-in-parkinson-s-disease-an-explorative-study-on-manual-dexterity
#11
Tim Vanbellingen, Manuela Wapp, Katharina Stegmayer, Manuel Bertschi, Eugenio Abela, Stefanie Kübel, Thomas Nyffeler, René Müri, Sebastian Walther, Tobias Nef, Mark Hallett, Stephan Bohlhalter
Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson's disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with one train of TBS in three experimental sessions: sham stimulation over vertex, continuous TBS (cTBS) over PMd and intermittent TBS (iTBS) over PMd, respectively...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27591218/exercise-training-improves-neurovascular-control-and-calcium-cycling-gene-expression-in-heart-failure-patients-with-cardiac-resynchronization-therapy
#12
Thais S Nobre, Ligia M Antunes-Correa, Raphaela V Groehs, Maria-Janieire N N Alves, Adriana O Sarmento, Aline Villa Nova Bacurau, Ursula Urias, Guilherme Barreto Alves, Maria Urbana P B Rondon, Patricia C Brum, Martino Martinelli, Holly R Middlekauff, Carlos E Negrao
Heart failure(HF) is characterized by decreased exercise capacity, attributable to neurocirculatory and skeletal muscle factors. Cardiac resynchronization therapy(CRT) and exercise training have each been shown to decrease muscle sympathetic nerve activity(MSNA) and increase exercise capacity in patients with HF. We hypothesized that exercise training in the setting of CRT would further reduce MSNA and vasoconstriction and would increase Ca(2+) handling gene expression in skeletal muscle in chronic systolic HF patients...
September 2, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27572313/circulating-serum-microrna-345-correlates-with-unfavorable-pathological-response-to-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#13
Jing Yu, Ning Li, Xin Wang, Hua Ren, Weihu Wang, Shulian Wang, Yongwen Song, Yueping Liu, Yexiong Li, Xuantong Zhou, Aiping Luo, Zhihua Liu, Jing Jin
Preoperative chemoradiotherapy (pre-CRT) has been represented as the standard treatment for locally advanced rectal cancer (LARC), but large variations of tumor radiation response to CRT have been reported in the clinic. To explore the function of microRNAs as potential therapeutic predictors of pre-CRT pathological response in LARC, we analyzed global miRNA expression in CRT-sensitive and CRT-resistant groups before treatment. MiR-345 was significantly elevated in the CRT-resistant group. Therefore, miR-345 was selected as a candidate for further analysis...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27572179/validation-of-an-automatic-diagnosis-of-strict-left-bundle-branch-block-criteria-using-12-lead-electrocardiograms
#14
Xiaojuan Xia, Anne-Christine Ruwald, Martin H Ruwald, Nene Ugoeke, Barbara Szepietowska, Valentina Kutyifa, Mehmet K Aktas, Poul Erik B Thomsen, Wojciech Zareba, Arthur J Moss, Jean-Philippe Couderc
AIMS: Strict left bundle branch block (LBBB) criteria were recently proposed to identify LBBB patients to benefit most from cardiac resynchronization therapy (CRT). The aim of our study was to automate identification of strict LBBB in order to facilitate its broader application. METHODS: We developed a series of algorithms to automatically detect and measure parameters required for strict LBBB criteria and proposed a definition of QRS notch detection. The algorithms were developed using training (n = 20) and validation (n = 592) sets consisting of signal-averaged 12-lead ECGs (1,000 Hz sampling) recorded from 612 LBBB patients from Multicenter Automatic Defibrillator Implantation Trial-CRT...
August 30, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27516906/does-the-beck-cognitive-insight-scale-predict-response-to-cognitive-remediation-in-schizophrenia
#15
Audrey Benoit, Philippe-Olivier Harvey, Louis Bherer, Martin Lepage
Cognitive remediation therapy (CRT) has emerged as a viable treatment option for people diagnosed with schizophrenia presenting disabling cognitive deficits. However, it is important to determine which variables can influence response to CRT in order to provide cost-effective treatment. This study's aim was to explore cognitive insight as a potential predictor of cognitive improvement after CRT. Twenty patients with schizophrenia completed a 24-session CRT program involving 18 hours of computer exercises and 6 hours of group discussion to encourage generalization of cognitive training to everyday activities...
2016: Schizophrenia Research and Treatment
https://www.readbyqxmd.com/read/27498280/new-automatic-tools-to-identify-responders-to%C3%A2-cardiac-resynchronization-therapy
#16
Razvan O Mada, Peter Lysyansky, Jürgen Duchenne, Ruxandra Beyer, Cristina Mada, Lucian Muresan, Horia Rosianu, Adela Serban, Stefan Winter, Wolfgang Fehske, Ivan Stankovic, Jens-Uwe Voigt
BACKGROUND: New echocardiographic parameters (apical rocking [AR], septal flash [SF]) are intended to detect patterns specific to responders to cardiac resynchronization therapy (CRT). The patterns are visually recognized and qualitatively described, requiring experience and training. Speckle-tracking echocardiography can reflect SF and AR by using newly developed, dedicated parameters, such as start systolic index (SSI) and peak longitudinal displacement (PLD). The aim of this study was to investigate whether SSI and PLD can identify potential CRT responders...
October 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27489356/a-scoring-system-basing-pathological-parameters-to-predict-regional-lymph-node-metastasis-after-preoperative-chemoradiotherapy-for-locally-advanced-rectal-cancer-implication-for-local-excision
#17
Xiao-Jie Wang, Pan Chi, Hui-Ming Lin, Xing-Rong Lu, Ying Huang, Zong-Bin Xu, Sheng-Hui Huang, Yan-Wu Sun, Dao-Xiong Ye, Qian Yu
Local excision is an alternative to radical surgery that is indicated in patients with locally advanced rectal cancer (LARC) who have a good response to chemoradiotherapy (CRT). Regional lymph node status is a major uncertainty during local excision of LARC following CRT. We retrospectively reviewed clinicopathologic variables for 244 patients with LARC who were treated at our institute between December 2000 and December 2013 in order to identify independent predictors of regional lymph node metastasis. Multivariate analysis of the training sample demonstrated that histopathologic type, tumor size, and the presence of lymphovascular invasion were significant predictors of regional nodal metastasis...
July 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27385544/circuit-resistance-training-in-women-with-normal-weight-obesity-syndrome-body-composition-cardiometabolic-and-echocardiographic-parameters-and-cardiovascular-and-skeletal-muscle-fitness
#18
Fabiano C Ferreira, Danilo R Bertucci, Marina R Barbosa, Joao E Nunes, Joao P Botero, Maria F Rodrigues, Gilberto E Shiguemoto, Valdir Santoro, Ana C Verzola, Rodrigo O Nonaka, Roberto M Verzola, Vilmar Baldissera, Sergio Perez
BACKGROUND: Normal weight obesity (NWO) syndrome has been characterised in subjects with normal BMI and high body fat mass percentage (BF% >30 for women) being a risk factor for cardiometabolic dysregulation and cardiovascular mortality. This study evaluated whether circuit resistance training (CRT) improves body composition, heart size and function, cardiometabolic parameters, and cardiorespiratory, cardiovascular and skeletal muscle fitness in women with NWO. METHODS: Data are means [95% Confidence Interval]...
July 6, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27341368/effectiveness-of-animal-assisted-therapy-after-brain-injury-a-bridge-to-improved-outcomes-in-crt
#19
Mary Stapleton
BACKGROUND: Animal Assisted Therapy (AAT) has been widely used as a complementary therapy in mental health treatment especially to remediate social skill deficits. The goal of AAT is to improve social, emotional, and cognitive functioning. OBJECTIVE: The purpose of this article is to draw upon the literature on AAT and explore specific applications to cognitive rehabilitation therapy (CRT) and social skills training. METHODS: This study provides a systematic review of most of the available literature on ATT and assesses that potential uses of ATT for brain injury rehabilitation...
June 18, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27198577/effects-of-high-definition-and-conventional-tdcs-on-response-inhibition
#20
J Hogeveen, J Grafman, M Aboseria, A David, M Bikson, K K Hauner
BACKGROUND: Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes...
September 2016: Brain Stimulation
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