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Prevention of sudden cardiac death with implantable defibrillator in hypertrophic cardiomyopathy

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https://www.readbyqxmd.com/read/29735354/prediction-of-sudden-death-risk-in-obstructive-hypertrophic-cardiomyopathy-potential-for-refinement-of-current-criteria
#1
Milind Y Desai, Nicholas G Smedira, Ashwat Dhillon, Ahmad Masri, Oussama Wazni, Mohamad Kanj, Kimi Sato, Maran Thamilarasan, Zoran B Popovic, Harry M Lever
BACKGROUND: In patients with hypertrophic cardiomyopathy (HCM), the use of an implantable cardioverter defibrillator (ICD) can prevent sudden cardiac death (SCD). In patients with obstructive HCM, we sought to determine the prognostic utility of European Society of Cardiology (ESC) SCD risk score and to evaluate whether additional factors modulate SCD risk. METHODS: We studied 1809 consecutive patients with obstructive HCM (mean age, 50 ± 14 years; 63% males; mean maximal outflow tract gradient, 93 ± 40 mm Hg)...
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29696341/risk-stratification-in-hypertrophic-cardiomyopathy
#2
REVIEW
S Marrakchi, I Kammoun, E Bennour, L Laroussi, S Kachboura
Sudden cardiac death (SCD) is the most devastating complication of hypertrophic cardiomyopathy (HCM). The greatest challenge in the management of HCM is identifying those at increased risk, since an implantable cardioverter-defibrillator (ICD) is a potentially life-saving therapy. We sought to summarize the available data on SCD in HCM and provide a clinical perspective on the current differing and somewhat conflicting data on risk stratification, with balanced guidance regarding rational clinical decision-making...
April 25, 2018: Herz
https://www.readbyqxmd.com/read/29407088/programmed-ventricular-stimulation-predicts-arrhythmic-events-and-survival-in-hypertrophic-cardiomyopathy
#3
Konstantinos A Gatzoulis, Stavros Georgopoulos, Christos-Konstantinos Antoniou, Aris Anastasakis, Polychronis Dilaveris, Petros Arsenos, Skevos Sideris, Dimitris Tsiachris, Stefanos Archontakis, Elias Sotiropoulos, Artemisia Theopistou, Ioannis Skiadas, Ioannis Kallikazaros, Christodoulos Stefanadis, Dimitrios Tousoulis
BACKGROUND: Sudden cardiac death (SCD) risk stratification in hypertrophic cardiomyopathy (HCM) in the context of primary prevention remains suboptimal. The purpose of this study was to examine the additional contribution of programmed ventricular stimulation (PVS) on established risk assessment. METHODS: Two-hundred-and-three consecutive patients with diagnosed HCM and ≥1 noninvasive risk factors were prospectively enrolled over 19years. Patients were risk stratified, submitted to PVS and received an implantable cardioverter-defibrillator (ICD) according to then-current American Heart Association (AHA) guidelines and inducibility...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29237655/evaluation-using-cardiac-insertable-devices-and-telephone-in-hypertrophic-cardiomyopathy-elucidate-hcm-rationale-and-design-a-prospective-observational-study-on-incidence-of-arrhythmias-in-sweden
#4
Peter Magnusson, Stellan Mörner
INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease associated with sudden cardiac death (SCD) mainly due to ventricular tachycardia (VT) or fibrillation even though life-threatening bradycardia occurs. Risk stratification takes several variables into consideration including non-sustained VT (NSVT). An implantable cardioverter defibrillator effectively prevents SCD.Atrial fibrillation (AF) is common among patients with HCM and warrants anticoagulation even without conventional risk factors according to European guidelines...
December 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29191938/international-external-validation-study-of-the-2014-european-society-of-cardiology-guidelines-on-sudden-cardiac-death-prevention-in-hypertrophic-cardiomyopathy-evidence-hcm
#5
Constantinos O'Mahony, Fatima Jichi, Steve R Ommen, Imke Christiaans, Eloisa Arbustini, Pablo Garcia-Pavia, Franco Cecchi, Iacopo Olivotto, Hiroaki Kitaoka, Israel Gotsman, Gerald Carr-White, Jens Mogensen, Loizos Antoniades, Saidi A Mohiddin, Mathew S Maurer, Hak Chiaw Tang, Jeffrey B Geske, Konstantinos C Siontis, Karim D Mahmoud, Alexa Vermeer, Arthur Wilde, Valentina Favalli, Oliver P Guttmann, Maria Gallego-Delgado, Fernando Dominguez, Ilaria Tanini, Toru Kubo, Andre Keren, Teofila Bueser, Sarah Waters, Issa F Issa, James Malcolmson, Tom Burns, Neha Sekhri, Christopher W Hoeger, Rumana Z Omar, Perry M Elliott
BACKGROUND: Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk of sudden cardiac death (SCD) and require a prophylactic implantable cardioverter defibrillator is challenging. In 2014, the European Society of Cardiology proposed a new risk stratification method based on a risk prediction model (HCM Risk-SCD) that estimates the 5-year risk of SCD. The aim was to externally validate the 2014 European Society of Cardiology recommendations in a geographically diverse cohort of patients recruited from the United States, Europe, the Middle East, and Asia...
March 6, 2018: Circulation
https://www.readbyqxmd.com/read/29154461/patient-understanding-of-disease-and-the-use-and-outcome-of-implantable-cardioverter-defibrillators-in-hypertrophic-cardiomyopathy
#6
Shankar Baskar, John L Jefferies, Lisa Salberg, Philip R Khoury, David S Spar, Timothy K Knilans, Richard J Czosek
Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden cardiac death (SCD) in young individuals. Implantable cardioverter defibrillators (ICD) are the primary therapy for sudden death prevention; however, are associated with both physical and psychological complications. We sought to determine factors associated with ICD understanding and patient satisfaction. This was a cross-sectional study, using patient/parent answered questionnaires distributed to patients enrolled in the Hypertrophic Cardiomyopathy Association...
January 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29042423/low-prevalence-of-inappropriate-shocks-in-patients-with-inherited-arrhythmia-syndromes-with-the-subcutaneous-implantable-defibrillator-single-center-experience-and-long-term-follow-up
#7
Boris Rudic, Erol Tülümen, Veronika Berlin, Susanne Röger, Ksenija Stach, Volker Liebe, Ibrahim El-Battrawy, Christina Dösch, Theano Papavassiliu, Ibrahim Akin, Martin Borggrefe, Jürgen Kuschyk
BACKGROUND: Up to 40% of patients with transvenous implantable cardioverter-defibrillator (ICD) experience lead-associated complications and may suffer from high complication rates when lead extraction is indicated. Subcutaneous ICD may represent a feasible alternative; however, the efficacy of the subcutaneous ICD in the detection and treatment of ventricular arrhythmias in patients with hereditary arrhythmia syndromes has not been fully evaluated. METHODS AND RESULTS: Patients with primary hereditary arrhythmia syndromes who fulfilled indication for defibrillator placement were eligible for enrollment...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28944170/implantable-cardioverter-defibrillator-therapy-in-hypertrophic-cardiomyopathy-an-updated-systematic-review-and-meta-analysis-of-outcomes-and-complications
#8
REVIEW
Nelson Wang, Ashleigh Xie, Richard Tjahjono, David H Tian, Steven Phan, Tristan D Yan, Pietro Bajona, Kevin Phan
BACKGROUND: Since the introduction of the implantable cardioverter-defibrillator (ICD) in patients with hypertrophic cardiomyopathy (HCM), the incidence of sudden cardiac death (SCD) has been significantly reduced. Given its widespread use, it is important to identify the outcomes associated with ICD use in patients with HCM. The present paper is a systematic review and meta-analysis of the rates of appropriate and inappropriate interventions, mortality, and device complications in HCM patients with an ICD...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28936893/severe-hypertrophic-cardiomyopathy-in-a-patient-with-atypical-anderson-fabry-disease
#9
Daniele Masarone, Giovanni Duro, Santo Dellegrottaglie, Paolo Colomba, Marta Rubino, Annapaola Cirillo, Antonio Pisani, Martina Caiazza, Perry Mark Elliott, Paolo Calabrò, Giuseppe Pacileo, Giuseppe Limongelli
AIM: Anderson-Fabry disease (AFD) is a hereditary disorder caused by a deficiency in the lysosomal enzyme α-galactosidase A which causes dysfunctions in multiple organ systems. Cardiac manifestation includes left ventricular hypertrophy, thickening of the valves, conduction disturbances and in the late phase, extensive areas of myocardial fibrosis with increased risk of sudden cardiac death. Case example: A case of AFD with exclusive cardiac involvement is described. During follow-up, due to the high risk of life-threatening arrhythmic events, implantation of an implantable cardioverter defibrillator is performed...
November 2017: Future Cardiology
https://www.readbyqxmd.com/read/28670752/sudden-cardiac-death-in-nonischemic-cardiomyopathy-refining-risk-assessment
#10
REVIEW
Matthew M Zipse, Wendy S Tzou
Sudden cardiac death (SCD) risk assessment among patients with nonischemic cardiomyopathy (NICM) has been has been less straightforward than for patients with ischemic cardiomyopathy. The common surrogate that has been associated with highest SCD risk for all cardiomyopathies, and which has been universally used to guide implantation of primary-prevention implantable cardioverter-defibrillators (ICDs), is left ventricular ejection fraction (LVEF) ≤35%. However, this practice has been called into question, especially in light of recent trials suggesting that ICD treatment may not be of additional survival benefit among those with NICM treated with optimal medical therapy...
November 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28625400/successful-treatment-of-ventricular-fibrillation-storm-triggered-by-short-long-short-sequence-time-to-avoid-managed-ventricular-pacing
#11
Hilmi Alnsasra, Yuval Konstantino, Sergiy Bereza, Moti Haim
Sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) is caused by ventricular tachyarrhythmia that can be effectively treated by implantable cardioverter defibrillator (ICD) therapy. We report of a 28-year-old man with HCM and a dual chamber ICD, originally implanted for primary prevention of SCD, (programmed to AAI(R)-DDD(R); managed ventricular pacing (MVP) mode, Medtronic Inc. St Paul, MN USA). He presented with recurrent ICD shocks due to ventricular fibrillation (VF) despite antiarrhythmic therapy...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28005231/life-long-tailoring-of-management-for-patients-with-hypertrophic-cardiomyopathy-awareness-and-decision-making-in-changing-scenarios
#12
M Michels, I Olivotto, F W Asselbergs, J van der Velden
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, characterised by complex pathophysiology and extensive genetic and clinical heterogeneity. In most patients, HCM is caused by mutations in cardiac sarcomere protein genes and inherited as an autosomal dominant trait. The clinical phenotype ranges from severe presentations at a young age to lack of left ventricular hypertrophy in genotype-positive individuals. No preventative treatment is available as the sequence and causality of the pathomechanisms that initiate and exacerbate HCM are unknown...
March 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27749559/cardiac-device-implantation-in-fabry-disease-a-retrospective-monocentric-study
#13
Thomas Sené, Olivier Lidove, Joel Sebbah, Jean-Marc Darondel, Hervé Picard, Laurent Aaron, Olivier Fain, Thierry Zenone, Dominique Joly, Philippe Charron, Jean-Marc Ziza
The incidence and predictive factors of arrhythmias and/or conduction abnormalities (ACAs) requiring cardiac device (CD) implantation are poorly characterized in Fabry disease (FD). The aim of our retrospective study was to determine the prevalence, incidence, and factors associated with ACA requiring CD implantation in a monocentric cohort of patients with confirmed FD who were followed up in a department of internal medicine and reference center for FD.Forty-nine patients (20M, 29F) were included. Nine patients (4M, 5F; 18%) had at least one episode of ACA leading to device therapy...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27645989/a-novel-method-for-epicardial-defibrillator-lead-placement-in-young-children-coil-between-the-great-arteries
#14
Raghav Murthy, Matthew R Williams, James C Perry, Suzanne Shepard, Daniel DiBardino
The primary and secondary prevention of sudden cardiac death resulting from malignant arrhythmia, channelopathy, and hypertrophic cardiomyopathy often requires the implantation of automatic internal cardiac defibrillators (AICDs) in the pediatric population. In young patients, the small size of the systemic veins, complex anatomy of congenital heart disease, and body habitus often preclude safe and durable transvenous placement of the AICD coil, requiring innovative methods to circumvent this problem. This report describes the technique used at Rady Children's Hospital San Diego/UCSD for the epicardial placement of an ICD system with a transvenous ICD coil placed between the aorta and pulmonary artery, thereby producing a stable location and excellent coil-to-can vector for successful defibrillation...
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27371714/prevention-of-sudden-death-in-hypertrophic-cardiomyopathy-bridging-the-gaps-in-knowledge
#15
REVIEW
Adaya Weissler-Snir, Arnon Adler, Lynne Williams, Christiane Gruner, Harry Rakowski
Sudden cardiac death (SCD) is the most devastating complication of hypertrophic cardiomyopathy (HCM). Although the annual rate of SCD in the general HCM population is <1% per year according to contemporary series, there is still a small subset of patients who are at increased risk of SCD. The greatest challenge in the management of HCM is identifying those at increased risk as an implantable cardioverter defibrillator is a potentially life-saving therapy. In this review, we sought to summarize the available data on SCD in HCM and provide a clinical perspective on the current differing and somewhat conflicting European and American recommendations on risk stratification, with balanced guidance with regards to rational clinical decision making...
June 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/27138377/appropriate-implantable-defibrillator-therapy-in-adults-with-hypertrophic-cardiomyopathy
#16
Amalie C Thavikulwat, Todd T Tomson, Bradley P Knight, Robert O Bonow, Lubna Choudhury
INTRODUCTION: Implantable cardioverter-defibrillators (ICDs) are effective at terminating the ventricular arrhythmias that cause sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). However, identifying patients at risk for SCD remains an ongoing challenge. METHODS AND RESULTS: We retrospectively studied all adult patients with HCM treated with ICDs at our referral center from 2000 to 2013 to determine the risk factor profile, rates of appropriate ICD therapy, and complications associated with ICD implantation and discharge...
August 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27119790/implantable-cardioverter-defibrillator-outcomes-in-pediatric-and-congenital-heart-disease-time-to-system-revision
#17
Brynn E Dechert, David J Bradley, Gerald A Serwer, Macdonald Dick Ii, Martin J Lapage
BACKGROUND: Implantable cardioverter defibrillators (ICDs) are intended to prevent sudden cardiac death yet also impose a risk of morbidity. This study describes the outcomes of ICDs in a pediatric and congenital heart disease (CHD) population from a single center. METHODS: Retrospective cohort study of all patients with an ICD followed at the University of Michigan Congenital Heart Center from 2005-2013. The primary outcome was ICD system revision for any reason excluding routine generator change for battery depletion...
July 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27064795/cardiovascular-magnetic-resonance-imaging-in-hypertrophic-cardiomyopathy-current-state-of-the-art
#18
REVIEW
Muhammad Umar Kamal, Irbaz Bin Riaz, Rajesh Janardhanan
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with a prevalence of 1:500 (0.2%) in the general population. Sudden cardiac death (SCD) is the most feared presentation of HCM. Therefore, it is essential to identify individuals at high risk in order to prevent SCD. The absence of conventional risk factors does not nullify the risk of HCM related SCD. Although echocardiography is currently the most widely used imaging modality, cardiac magnetic resonance (CMR) allows detailed characterization of the HCM phenotype, which makes it possible to differentiate HCM from other causes of left ventricular hypertrophy...
2016: Cardiology Journal
https://www.readbyqxmd.com/read/26927864/exercise-and-inherited-arrhythmias
#19
REVIEW
Christopher C Cheung, Zachary W M Laksman, Gregory Mellor, Shubhayan Sanatani, Andrew D Krahn
Sudden cardiac death (SCD) in an apparently healthy individual is a tragedy that prompts a series of investigations to identify the cause of death and to prevent SCD in potentially at-risk family members. Several inherited channelopathies and cardiomyopathies, including long QT syndrome (LQTS), catecholaminergic polymorphic ventricular cardiomyopathy (CPVT), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC) are associated with exercise-related SCD. Exercise restriction has been a historical mainstay of therapy for these conditions...
April 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26897076/exercise-restrictions-for-patients-with-inherited-cardiac-conditions-current-guidelines-challenges-and-limitations
#20
REVIEW
Matthew Hammond-Haley, Riyaz S Patel, Rui Providência, Pier D Lambiase
Inherited primary arrhythmia syndromes are a clinically heterogeneous group of relatively uncommon but important inherited cardiac conditions that are associated with an increased risk of sudden cardiac death (SCD) in the setting of a structurally normal heart. These include long-QT syndrome (LQTS), Short-QT syndrome (SQTS), Brugada syndrome (BrS) and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). The cardiomyopathies represent the other major group of inherited cardiac conditions associated with SCD, of which hypertrophic cardiomyopathy (HCM) is the most common...
April 15, 2016: International Journal of Cardiology
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