Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Alejandro Rubiales-Martínez, Joel Martínez, Elvia Mera-Jiménez, Javier Pérez-Flores, Guillermo Téllez-Isaías, René Miranda Ruvalcaba, Maricarmen Hernández-Rodríguez, Teresa Mancilla Percino, Martha Edith Macías Pérez, María Inés Nicolás-Vázquez
Poly-ADP-Ribose Polymerase (PARP-1) is an overexpressed enzyme in several carcinomas; consequently, the design of PARP-1 inhibitors has acquired special attention. Hence, in the present study, three compounds ( 8 - 10 ) were produced through a Michael addition protocol, using phenylmethanethiol, 5-fluoro-2-mercaptobenzyl alcohol, and 4-mercaptophenylacetic acid, respectively, as nucleophiles and perezone as the substrate, expecting them to be convenient candidates that inhibit PARP-1. It is convenient to note that in the first stage of the whole study, the molecular dynamics (MD) simulations and the quantum chemistry studies of four secondary metabolites, i...
January 10, 2024: International Journal of Molecular Sciences
#22
JOURNAL ARTICLE
Saul A Beltran-Ontiveros, Jose A Contreras-Gutierrez, Erik Lizarraga-Verdugo, Erick P Gutierrez-Grijalva, Kenia Lopez-Lopez, Emilio H Lora-Fierro, Miguel A Trujillo-Rojas, Jose M Moreno-Ortiz, Diana L Cardoso-Angulo, Emir Leal-Leon, Jose R Zatarain-Lopez, Hector M Cuen-Diaz, Marisol Montoya-Moreno, Brisceyda Arce-Bojorquez, Juan L Rochin-Teran, Daniel E Cuen-Lazcano, Victor A Contreras-Rodriguez, Ricardo Lascurain, Liliana Carmona-Aparicio, Elvia Coballase-Urrutia, Francisco Gallardo-Vera, Daniel Diaz
The global burden of cancer is on the rise, with varying national patterns. To gain a better understanding and control of cancer, it is essential to provide national estimates. Therefore, we present a comparative description of cancer incidence and mortality rates in Mexico from 1990 to 2019, by age and sex for 29 different cancer groups. Based on public data from the Global Burden of Disease Study 2019, we evaluated the national burden of cancer by analyzing counts and crude and age-standardized rates per 100,000 people with 95% uncertainty intervals for 2019 and trends using the annual percentage change from 1990 to 2019...
December 28, 2023: Cancers
#23
JOURNAL ARTICLE
Elvia Rivera-Figueroa, Md Abu Yusuf M Ansari, Emily Turner Mallory, Padma Garg, Ali Mirza Onder
OBJECTIVE: This single-centre, retrospective cohort study was conducted to investigate the predictors of early peritoneal dialysis initiation in newborns and young infants undergoing cardiac surgery. METHODS: There were fifty-seven newborns and young infants. All subjects received peritoneal dialysis catheter after completion of the cardiopulmonary bypass. Worsening post-operative (post-op) positive fluid balance and oliguria (<1 ml/kg/hour) despite furosemide were the clinical indications to start early peritoneal dialysis (peritoneal dialysis +)...
January 2, 2024: Cardiology in the Young
#24
Matthan Moy, Anh Truonghuynh, Elvia Villarreal, Derek Neal
The peripartum period, which can be further delineated into postpartum and antepartum periods, poses a heightened risk for psychiatric symptoms. While much is known about the risk of psychiatric symptoms in the postpartum period, antepartum psychosis remains exceedingly rare and poorly understood. This report presents a unique case of a 34-year-old pregnant woman with a past psychiatric history significant for recurrent major depressive disorder, generalized anxiety disorder, and substance use disorder of alcohol and marijuana, who developed preeclampsia with severe features and acute psychosis during the antepartum period...
November 2023: Curēus
#25
JOURNAL ARTICLE
Elvia E Silva, Steven J Moioffer, Mariah Hassert, Roger R Berton, Matthew G Smith, Stephanie van de Wall, David K Meyerholz, Thomas S Griffith, John T Harty, Vladimir P Badovinac
Patients infected with SARS-CoV-2 experience variable disease susceptibility, and patients with comorbidities such as sepsis are often hospitalized for COVID-19 complications. However, the extent to which initial infectious inoculum dose determines disease outcomes and whether this can be used for immunological priming in a genetically susceptible host has not been completely defined. We used an established SARS-like murine model in which responses to primary and/or secondary challenges with murine hepatitis virus type 1 (MHV-1) were analyzed...
December 27, 2023: Journal of Immunology
#26
JOURNAL ARTICLE
Gloricel Serena-Romero, Anaís Ignot-Gutiérrez, Osvaldo Conde-Rivas, Marlenne Y Lima-Silva, Armando J Martínez, Daniel Guajardo-Flores, Elvia Cruz-Huerta
This study evaluated the impact of in vitro gastrointestinal digestion on the digestibility, amino acid release, and antioxidant activity of proteins from amaranth ( Amarantus cruentus L.) and cañihua ( Chenopodium pallidicaule Aellen). Antioxidant activity was assessed using ORAC, ABTS, DPPH, and cellular antioxidant activity (CAA) assays in human intestinal Caco-2 and hepatic Hep-G2 cell lines. The results showed that amaranth had higher protein digestibility (79.19%) than cañihua (71.22%). In addition, intestinal digestion promoted the release of essential amino acids, such as leucine, lysine, and phenylalanine, in both protein concentrates...
December 5, 2023: Antioxidants (Basel, Switzerland)
#27
JOURNAL ARTICLE
Evan L Barrios, Monty B Mazer, Patrick W McGonagill, Christian B Bergmann, Michael D Goodman, Robert W Gould, Mahil Rao, Valerie E Polcz, Ruth Davis, Drew Del Toro, Marvin Dirain, Alexandra Dram, Lucas Hale, Mohammad Heidarian, Caleb Y Kim, Tamara A Kucaba, Jennifer P Lanz, Ashley McCray, Alexandra Meszaros, Sydney M Miles, Candace Nelson, Ivanna Rocha, Elvia E Silva, Ricardo Ungaro, Andrew Walton, Julie Xu, Leilani Zeumer-Spataro, Anne M Drewry, Muxuan Liang, Letita E Bible, Tyler J Loftus, Isaiah R Turnbull, Philip A Efron, Kenneth E Remy, Scott C Brakenridge, Vladimir P Badovinac, Thomas S Griffith, Lyle L Moldawer, Richard S Hotchkiss, Charles C Caldwell
BACKGROUND: Sepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical outcomes and immunological endotyping of septic patients has generally relied on using blood protein or mRNA biomarkers, or static cell phenotyping. Here, we sought to determine whether functional immune responsiveness would yield improved precision. METHODS: An ex vivo whole blood enzyme-linked immunosorbent (ELISpot) assay for cellular production of interferon-γ (IFN-γ) was evaluated in 107 septic and 68 non-septic patients from five academic health centers using blood samples collected on days 1, 4 and 7 following ICU admission...
December 15, 2023: JCI Insight
#28
JOURNAL ARTICLE
Oscar Alonso-Luna, Gabriela E Mercado-Celis, Jorge Melendez-Zajgla, Rodrigo Barquera, Marta Zapata-Tarres, Luis Enrique Juárez-Villegas, Elvia Cristina Mendoza-Caamal, Elianeth Rey-Helo, Socorro Aida Borges-Yañez
BACKGROUND: Childhood cancer is one of the primary causes of disease-related death in 5- to 14-year-old children and currently no prevention strategies exist to reduce the incidence of this disease. Childhood cancer has a larger hereditary component compared with cancer in adults. Few genetic studies have been conducted on children with cancer. Additionally, Latin American populations are underrepresented in genomic studies compared with other populations. Therefore, the aim of this study is to analyze germline mutations in a group of mixed-ancestry Mexican pediatric patients with solid and hematological cancers...
December 13, 2023: Molecular Genetics & Genomic Medicine
#29
JOURNAL ARTICLE
Celia Hubert López, Leticia Suárez-López, Elvia De la Vara-Salazar, Aremis Villalobos
OBJETIVO: Caracterizar la situación de la salud sexual y reproductiva (SSR) en población adolescente (10-19) y adulta (20-49). Material y métodos. Utilizando la Encuesta Nacional de Salud y Nutrición 2022, se estimaron prevalencias e intervalos de confianza al 95% para indicadores de SSR. RESULTADOS: En adolescentes, 73.2% ha escuchado hablar de anticonceptivos, 88.1% saben que el condón se usa una sola vez y 60.4% que previene embarazos e infecciones de transmisión sexual; 22...
June 9, 2023: Salud Pública de México
#30
JOURNAL ARTICLE
Leticia Suárez-López, Celia Hubert, Elvia De la Vara-Salazar, Aremis Villalobos
OBJETIVO: Analizar la utilización de servicios preventivos de salud sexual y reproductiva (SPSSR) en mujeres y hombres adultos antes y durante la pandemia Covid-19 y características sociodemográficas asociadas. Material y métodos. Usando la Encuesta Nacional de Salud y Nutrición 2018-19, 2021 y 2022 se analizó información sobre las pruebas realizadas de Papanicolaou y VPH, exploración clínica de mamas, mastografía, antígeno prostático y tacto rectal...
November 13, 2023: Salud Pública de México
#31
JOURNAL ARTICLE
Elvia De la Vara-Salazar, Aremis Villalobos, Celia Hubert, Leticia Suárez-López
OBJETIVO: Analizar factores asociados con el inicio sexual temprano (IST) en mujeres y hombres de 15 a 19 años. Material y métodos. Utilizando información de adolescentes de la Encuesta Nacional de Salud y Nutrición 2022, se examina el IST (<15 años). Mediante un enfoque ecológico se ajustaron modelos probit multivariados por sexo para explorar factores sociodemográficos, psicosociales y de comportamiento sexual asociados con IST. RESULTADOS: Mujeres residentes en la región Pacífico-Centro y Pacífico-Sur, así como aquellas con pareja sexual de mayor edad por cinco años o más y hombres con estrato socioeconómico medio, tienen mayor probabilidad de IST que sus contrapartes de la región Pacífico-Norte, diferencia de edad con la pareja menor a cinco años y estrato bajo, respectivamente...
November 13, 2023: Salud Pública de México
#32
JOURNAL ARTICLE
Elvia Battaglia, Paolo Banfi, Elena Compalati, Antonello Nicolini, Teresa Diaz DE Teran, Monica Gonzales, Paolo Solidoro
Sleep-disordered breathing has a relatively high prevalence, which varies from 3-7% in males and from 2-5% in females in the adult population. Studies published in the literature have shown that sleep apnea is closely related to an increased risk of developing various pathologies, among which arterial hypertension stands out. The prevalence of hypertension in patients suffering from obstructive sleep apnea (OSA) ranges from 35-80% and appears to be related to OSA severity. Approximately 40-50% of patients affected by hypertension are also affected by OSA and this association seems to be stronger in young and middle-aged adults (<50 years of age)...
November 10, 2023: Minerva Medica
#33
JOURNAL ARTICLE
Patricio Dabdoub-González, Edgar Abel Márquez-García, Juan Gerardo Reyes-García, Jorge Arturo Cabrera-Escamilla, David Fernando Servín-Carmona, Víctor Hugo Tejerina-Gorena, Cristóbal Herrera-Palacios, Elvia Janike Rodríguez-Córdoba
BACKGROUND: Central Cord Syndrome is the most common incomplete spinal cord injury, and it represents 9% of all spinal injuries of the adult. OBJECTIVE: to determine the risk factors associated with lethality or/and mechanical ventilation (MV) in patients with Central Cord Syndrome (CCS). MATERIAL AND METHODS: upon a retrospective cohort with patients with posttraumatic CCS we evaluated at the time of emergency admission and until the hospital discharge...
October 2, 2023: Revista Médica del Instituto Mexicano del Seguro Social
#34
JOURNAL ARTICLE
Sai Krishna Katla, Wan Zhou, Hamed Tavakoli, Elvia Lilia Padilla Méndez, Xiujun Li
A low-cost microfluidic platform integrated with a flexible heater was developed for in situ temperature-dependent spectroscopic measurement at the point of care. After verifying the system by comparing on-chip spectroscopic measurement of methylene blue with the conventional spectroscopy, we demonstrated its applications in temperature-dependent absorption spectroscopy of a model biomolecule, curcumin. The system is portable, battery-powered and requires ultra-low volumes of analytes, which is highly suitable for point-of-care characterization...
April 2023: View (Beijing)
#35
JOURNAL ARTICLE
Ricardo Ballinas-Indilí, María Inés Nicolás-Vázquez, Joel Martínez, María Teresa Ramírez-Apan, Cecilio Álvarez-Toledano, Alfredo Toscano, Maricarmen Hernández-Rodríguez, Elvia Mera Jiménez, René Miranda Ruvalcaba
To aid the possible prevention of multidrug resistance in tumors and cause lower toxicity, a set of sixteen novel dihydropyridine carboxylic acids derivatives 3a-p were produced; thus, the activation of various ynones with triflic anhydride was performed, involving a nucleophilic addition of several bis (trimethylsilyl) ketene acetals, achieving good yields requiring easy workup. The target molecules were unequivocally characterized by common spectroscopic methods. In addition, two of the tested compounds ( 3a , and 3b ) were selected to perform in silico studies due to the highest cytotoxic activity towards the HCT-15 cell line (7...
October 21, 2023: International Journal of Molecular Sciences
#36
JOURNAL ARTICLE
Elvia Villarreal, Steven E Wolf, George Golovko, Shelby Bagby, Kendall Wermine, Sunny Gotewal, Ann Obi, Kassandra Corona, Lyndon Huang, Phillip Keys, Juquan Song, Amina El Ayadi
BACKGROUND: Opioids remain crucial in the management of burn pain. A comprehensive analysis of opioid use in burns and their complications has not been investigated. METHODS: Data were collected from TriNetX, a large multicenter database with de-identified patient information. The population included patients prescribed opioids on or following burn injury from January 1st, 1990, to December 31st, 2019. Opioid prescription use was analyzed after cohort stratification by decades: 1990-1999, 2000-2009, and 2010-2019...
September 28, 2023: Burns
#37
JOURNAL ARTICLE
Morgan E Braxton, Eucharia Nwabichie, Monica Diaz, Elvia Lish, Stephanie L Ayers, Allison N Willia, Mayra Tornel, Paul McKim, Jared Treichel, William C Knowler, Micah L Olson, Gabriel Q Shaibi
BACKGROUND: Latino families are disproportionately affected by type 2 diabetes (T2D) and lifestyle intervention is the first-line approach for preventing T2D. The purpose of this study is to test the efficacy of a culturally-grounded lifestyle intervention that prioritizes health promotion and diabetes prevention for Latino families. The intervention is guided by a novel Family Diabetes Prevention Model, leveraging the family processes of engagement, empowerment, resilience, and cohesion to orient the family system towards health...
October 16, 2023: Contemporary Clinical Trials
#38
JOURNAL ARTICLE
Edgar D Páez-Pérez, Araceli Hernández-Sánchez, Elvia Alfaro-Saldaña, J Viridiana García-Meza
There are few biophysical studies or structural characterizations of the type IV pilin system of extremophile bacteria, such as the acidophilic Acidithiobacillus thiooxidans. We set out to analyze their pili-comprising proteins, pilins, because these extracellular proteins are in constant interaction with protons of the acidic medium in which At. thiooxidans grows. We used the web server Operon Mapper to analyze and identify the cluster codified by the minor pilin of At. thiooxidans. In addition, we carried an in-silico characterization of such pilins using the VL-XT algorithm of PONDR® server...
October 17, 2023: Extremophiles: Life Under Extreme Conditions
#39
Rahel Tekeste, Elvia Villarreal, Matthan Moy, Bernard Karnath
Primary sclerosing cholangitis (PSC) is a rare type of autoimmune hepatic disease with unknown pathophysiology, often a sequela of ulcerative colitis (UC). Liver transplant, though curative, is inaccessible to many patients due to stringent organ availability and barriers to sufficient insurance coverage. Low health literacy and low socioeconomic class can significantly limit healthcare access and thus worsen overall healthcare outcomes. Here, we present the case of an uninsured 49-year-old man with untreated UC who was diagnosed with PSC and subsequently became lost to follow-up...
September 2023: Curēus
#40
Philip J Landrigan, Hervé Raps, Maureen Cropper, Caroline Bald, Manuel Brunner, Elvia Maya Canonizado, Dominic Charles, Thomas C Chiles, Mary J Donohue, Judith Enck, Patrick Fenichel, Lora E Fleming, Christine Ferrier-Pages, Richard Fordham, Aleksandra Gozt, Carly Griffin, Mark E Hahn, Budi Haryanto, Richard Hixson, Hannah Ianelli, Bryan D James, Pushpam Kumar, Amalia Laborde, Kara Lavender Law, Keith Martin, Jenna Mu, Yannick Mulders, Adetoun Mustapha, Jia Niu, Sabine Pahl, Yongjoon Park, Maria-Luiza Pedrotti, Jordan Avery Pitt, Mathuros Ruchirawat, Bhedita Jaya Seewoo, Margaret Spring, John J Stegeman, William Suk, Christos Symeonides, Hideshige Takada, Richard C Thompson, Andrea Vicini, Zhanyun Wang, Ella Whitman, David Wirth, Megan Wolff, Aroub K Yousuf, Sarah Dunlop
[This corrects the article DOI: 10.5334/aogh.4056.].
2023: Annals of Global Health
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
