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https://www.readbyqxmd.com/read/29095027/the-two-sides-of-superior-mesenteric-artery-syndrome-treatment-conservative-or-surgical-management
#1
Elvia Johanna Osegueda de Rodríguez, Antonio Carlos Hernández-Villegas, Aurora Elizabeth Serralde-Zúñiga, Ana Luz Del Carmen Reyes-Ramírez
INTRODUCTION: Superior mesenteric artery syndrome (SMAS) is a rare condition characterized by vascular compression of the duodenum. There is controversy regarding the optimal treatment. CASE REPORT: In case 1, we describe the case of a 21-year-old woman (body mass index -BMI- 16.9 kg/m2) with high-level obstructive symptoms three months prior, with computed tomography scan (TC) showing a superior mesenteric artery aorta angle (SMAA) of 13º and compression of the third portion of the duodenum (D3), for this reason a nasojejunal tube was placed for enteral feeding...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28953124/laser-excisional-treatment-for-vaginal-intraepithelial-neoplasia-to-exclude-invasion-what-is-the-risk-of-complications
#2
Francesco Sopracordevole, Lorenzo Moriconi, Jacopo Di Giuseppe, Lara Alessandrini, Elvia Del Piero, Giorgio Giorda, Monica Buttignol, Giovanni De Piero, Vincenzo Canzonieri, Andrea Ciavattini
OBJECTIVE: We undertook a retrospective analysis of the incidence of complications of carbon dioxide (CO2) laser excision for high-grade vaginal intraepithelial neoplasia (HG-VaIN). MATERIALS AND METHODS: Retrospective large case series on 128 CO2 laser excisions for HG-VaIN in 106 women treated at the Department of Gynecologic Oncology, Oncologic Referral Center, Aviano, Italy. These procedures were performed under local anesthesia with a 20-W continuous laser beam focused to a 0...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28872919/a-safety-analysis-of-edaravone-mci-186-during-the-first-six-cycles-24-weeks-of-amyotrophic-lateral-sclerosis-als-therapy-from-the-double-blind-period-in-three-randomized-placebo-controlled-studies
#3
Alexander Kalin, Elvia Medina-Paraiso, Kaoru Ishizaki, Alex Kim, Yannong Zhang, Takanori Saita, Masahiko Wasaki
BACKGROUND: There continues to be a need for new therapies to treat ALS. OBJECTIVE: Provide an overview of safety for edaravone in ALS patients during the first six cycles of treatment. METHODS: Analysis was based on three randomised, placebo-controlled clinical trials. Endpoints included treatment-emergent adverse events (TEAEs), including AEs leading to discontinuation, serious adverse events (SAEs), and deaths. RESULTS: The analysis included a total of 368 patients (184 in the edaravone group and placebo group, respectively)...
October 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28838971/a-loss-of-function-splice-acceptor-variant-in-igf2-is-protective-for-type-2-diabetes
#4
Josep M Mercader, Rachel G Liao, Avery D Bell, Zachary Dymek, Karol Estrada, Taru Tukiainen, Alicia Huerta-Chagoya, Hortensia Moreno-Macías, Kathleen A Jablonski, Robert L Hanson, Geoffrey A Walford, Ignasi Moran, Ling Chen, Vineeta Agarwala, María Luisa Ordoñez-Sánchez, Rosario Rodríguez-Guillen, Maribel Rodríguez-Torres, Yayoi Segura-Kato, Humberto García-Ortiz, Federico Centeno-Cruz, Francisco Barajas-Olmos, Lizz Caulkins, Sobha Puppala, Pierre Fontanillas, Amy L Williams, Sílvia Bonàs-Guarch, Chris Hartl, Stephan Ripke, Katherine Tooley, Jacqueline Lane, Carlos Zerrweck, Angélica Martínez-Hernández, Emilio J Córdova, Elvia Mendoza-Caamal, Cecilia Contreras-Cubas, María E González-Villalpando, Ivette Cruz-Bautista, Liliana Muñoz-Hernández, Donaji Gómez-Velasco, Ulises Alvirde, Brian E Henderson, Lynne R Wilkens, Loic Le Marchand, Olimpia Arellano-Campos, Laura Riba, Maegan Harden, Stacey Gabriel, Hanna E Abboud, Maria L Cortes, Cristina Revilla-Monsalve, Sergio Islas-Andrade, Xavier Soberon, Joanne E Curran, Christopher P Jenkinson, Ralph A DeFronzo, Donna M Lehman, Craig L Hanis, Graeme I Bell, Michael Boehnke, John Blangero, Ravindranath Duggirala, Richa Saxena, Daniel MacArthur, Jorge Ferrer, Steven A McCarroll, David Torrents, William C Knowler, Leslie J Baier, Noel Burtt, Clicerio González-Villalpando, Christopher A Haiman, Carlos A Aguilar-Salinas, Teresa Tusié-Luna, Jason Flannick, Suzanne B R Jacobs, Lorena Orozco, David Altshuler, Jose C Florez
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2D and 12,966 individuals without T2D of Latino descent. We identified a novel genetic variant in the IGF2 gene associated with ∼20% reduced risk for T2D. This variant, which has an allele frequency of 17% in the Mexican population but is rare in Europe, prevents splicing between IGF2 exons 1 and 2...
November 2017: Diabetes
https://www.readbyqxmd.com/read/28833480/aromatic-regions-govern-the-recognition-of-nadph-oxidase-inhibitors-as-diapocynin-and-its-analogues
#5
Martha E Macías Pérez, Maricarmen Hernández Rodríguez, Laura C Cabrera Pérez, M Jonathan Fragoso-Vázquez, José Correa-Basurto, Itzia I Padilla-Martínez, David Méndez Luna, Elvia Mera Jiménez, César Flores Sandoval, Feliciano Tamay Cach, Martha C Rosales-Hernández
Oxidative stress is related to the pathogenesis and progress of several human diseases. NADPH oxidase (NOX), and mainly the NOX2 isoform, produces superoxide anions (O2(•)(-) ). To date, it is known that NOX2 can be inhibited by preventing the assembly of its subunits, p47phox and p22phox. In this work, we analyzed the binding to NOX2 of the apocynin dimer, diapocynin (C1), a known NOX2 inhibitor, and of 18 designed compounds (C2-C19) which have chemical relationships to C1, by in silico methods employing a p47phox structure from the Protein Data Bank (PDB code: 1WLP)...
October 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28783911/wind-induced-changes-in-the-dynamics-of-fluorescent-organic-matter-in-the-coastal-nw-mediterranean
#6
Fran L Aparicio, Mar Nieto-Cid, Eva Calvo, Carles Pelejero, Àngel López-Sanz, Josep Pascual, Jordi Salat, Elvia D Sánchez-Pérez, Patricia De La Fuente, Josep M Gasol, Cèlia Marrasé
Marine biogeochemistry dynamics in coastal marine areas is strongly influenced by episodic events such as rain, intense winds, river discharges and anthropogenic activities. We evaluated in this study the importance of these forcing events on modulating seasonal changes in the marine biogeochemistry of the northwestern coast of the Mediterranean Sea, based on data gathered from a fixed coastal sampling station in the area. A 4-year (2011-2014) monthly sampling at four depths (0.5m, 20m, 50m and 80m) was performed to examine the time variability of several oceanographic variables: seawater temperature, salinity, inorganic nutrient concentrations (NO3(-), PO4(3-) and SiO2), chlorophyll a (Chl a), dissolved organic carbon (DOC) and fluorescent dissolved organic matter (FDOM)...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28755902/low-triiodothyronine-is-associated-with-elevation-of-n-terminal-pro-brain-natriuretic-peptide-nt-probnp-and-mortality-in-dialysis-patients
#7
María Del Carmen Prado-Uribe, María-de-Jesús Ventura, Marcela Ávila-Díaz, Carmen J Mora, Antonio Méndez-Durán, Diana Villanueva-Noches, Alejandra Cisneros, Begoña Ilabaca, Alfonso Cueto-Manzano, Fernando García-Contreras, Bengt Lindholm, Elvia García-López, Ramón Paniagua
BACKGROUND: Low thyroid hormone (TH) levels and myocardial damage are common in dialysis patients and are associated with mortality. However, little is known about the role of THs on myocardial damage as has been described in primary thyroid diseases. The aim of this study was to explore the potential relationship between low total triiodothyronine (total T3) and biomarkers of myocardial damage and the effect of their interaction on mortality, to ascertain if cardiovascular damage is the link between low THs and the risk of death in dialysis patients with CKD...
July 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28706454/participation-of-cox-1-and-cox-2-in-the-contractile-effect-of-phenylephrine-in-prepubescent-and-old-rats
#8
Gustavo Guevara-Balcazar, Israel Ramirez-Sanchez, Elvia Mera-Jimenez, Ivan Rubio-Gayosso, Maria Eugenia Aguilar-Najera, Maria C Castillo-Hernandez
Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial pressure and inflammatory processes)...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28701043/in-situ-x-ray-tomography-study-of-cement-exposed-to-co2-saturated-brine
#9
E A Chavez Panduro, M Torsæter, K Gawel, R Bjørge, A Gibaud, Y Yang, S Bruns, Y Zheng, H O Sørensen, D W Breiby
For successful CO2 storage in underground reservoirs, the potential problem of CO2 leakage needs to be addressed. A profoundly improved understanding of the behavior of fractured cement under realistic subsurface conditions including elevated temperature, high pressure and the presence of CO2 saturated brine is required. Here, we report in situ X-ray micro computed tomography (μ-CT) studies visualizing the microstructural changes upon exposure of cured Portland cement with an artificially engineered leakage path (cavity) to CO2 saturated brine at high pressure...
August 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28535821/seven-fractions-to-deliver-partial-breast-irradiation-the-toxicity-is-low
#10
Marco Trovo, Michele Avanzo, Lorenzo Vinante, Carlo Furlan, Francesco Fiorica, Tiziana Perin, Loredana Militello, Simon Spazzapan, Massimiliano Berretta, Rajesh Jena, Joseph Stancanello, Erica Piccoli, Mario Mileto, Elvia Micheli, Mario Roncadin, Samuele Massarut
PURPOSE: To assess toxicity and clinical outcome, in breast cancer patients treated with external beam partial breast irradiation (PBI) consisting of 35 Gy in 7 daily fractions (5 Gy/fraction). MATERIALS AND METHODS: Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old or over and treated with breast conservative surgery for early stage invasive carcinoma. RESULTS: Seventy-three patients were analyzed...
May 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28493309/effect-of-nanoemulsified-and-microencapsulated-mexican-oregano-lippia-graveolens-kunth-essential-oil-coatings-on-quality-of-fresh-pork-meat
#11
Elvia Hernández-Hernández, César Y Lira-Moreno, Isabel Guerrero-Legarreta, Graciela Wild-Padua, Prospero Di Pierro, Blanca E García-Almendárez, Carlos Regalado-González
Fresh meat is a highly perishable food. This work aimed to evaluate the influence of Mexican oregano (Lippia graveolens Kunth) incorporated into active coatings (ACs) spread on fresh pork meat as free (FEO), nanoemulsified (NEO), and microencapsulated (MEO) essential oil (EO), on its microbiological, physicochemical and sensory properties during 15 d at 4 ± 1 °C. Thymol and γ-terpinene were identified in the EO. In vitro effect of 2.85 mg EO/cm(2) was tested against Brochothrix thermosphacta, Micrococcus luteus, Lactobacillus plantarum, Pseudomonas fragi, and Salmonella Infantis...
June 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28469926/primary-hypertrophic-osteoarthropathy-due-to-a-novel-slco2a1-mutation-masquerading-as-acromegaly
#12
Ruth Mangupli, Adrian F Daly, Elvia Cuauro, Paul Camperos, Jaime Krivoy, Albert Beckers
SUMMARY: A 20-year-old man with an 8-year history of progressive enlargement of his hands and feet, coarsening facial features, painful joints and thickened, oily skin was referred for investigation of acromegaly. On examination, the subject was of normal height and weight. He had markedly increased skin thickness around the forehead, eyelids and scalp with redundant skin folds. Bilateral painful knee swelling was accompanied by enlargement of the extremities, and his fingers were markedly clubbed...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28344485/biochemical-and-molecular-modulation-of-ccl4-induced-peripheral-and-central-damage-by-tilia-americana-var-mexicanaextracts
#13
Elvia Coballase-Urrutia, Noemí Cárdenas-Rodríguez, María Carolina González-García, Eithan Núñez-Ramírez, Esaú Floriano-Sánchez, María Eva González-Trujano, Berenice Fernández-Rojas, José Pedraza-Chaverrí, Hortencia Montesinos-Correa, Liliana Rivera-Espinosa, Aristides Iii Sampieri, Liliana Carmona-Aparicio
Around the world, species from the genus Tilia are commonly used because of their peripheral and central medicinal effects; they are prepared as teas and used as tranquilizing, anticonvulsant, and analgesic agents. In this study, we provide evidence of the protective effects of organic and aqueous extracts (100 mg/kg, i.p.) obtained from the leaves of Tilia americana var. mexicana on CCl4-induced liver and brain damage in the rat. Protection was observed in the liver and brain (cerebellum, cortex and cerebral hemispheres) by measuring the activity of antioxidant enzymes and levels of malondialdehyde (MDA) using spectrophotometric methods...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28103263/splenic-cd4-t-cells-in-progressive-visceral-leishmaniasis-show-a-mixed-effector-regulatory-phenotype-and-impair-macrophage-effector-function-through-inhibitory-receptor-expression
#14
Audrie A Medina-Colorado, Elvia Y Osorio, Omar A Saldarriaga, Bruno L Travi, Fanping Kong, Heidi Spratt, Lynn Soong, Peter C Melby
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in the spleen, liver and bone marrow. The disease is characterized by fever, splenomegaly, cachexia, and pancytopenia, and progresses to death if not treated. Control of Leishmania infection is mediated by Th1 (IFNγ-producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill intracellular parasites. However, despite expansion of CD4+ T cells and increased IFNγ expression in the spleen, humans with active VL do not control the infection...
2017: PloS One
https://www.readbyqxmd.com/read/28044941/design-synthesis-and-biological-evaluation-of-a-phenyl-butyric-acid-derivative-n-4-chlorophenyl-4-phenylbutanamide-a-hdac6-inhibitor-with-anti-proliferative-activity-on-cervix-cancer-and-leukemia-cells
#15
Rodriguez-Fonseca Rolando Alberto, Sixto-Lopez Yudibeth, Fragoso-Vazquez M Jonathan, Flores-Mejia Raul, Cabrera-Perez Laura Cristina, Vazquez-Moctezuma Ismael, Rosales-Hernandez Martha Cecilia, Bello Martiniano, Martinez-Archundia M, Trujillo-Ferrara Jose Guadalupe, Becerra-Martinez Elvia, Correa-Basurto Jose
BACKGROUND: The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc. OBJECTIVE: Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference. METHOD: The target compounds were submitted to theoretical ADMET analyses and their binding properties on different HDAC6 conformers were evaluated through docking calculations...
2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28030765/nonionic-fluorinated-surfactant-removal-from-mesoporous-film-using-sc-co2
#16
Elvia A Chavez Panduro, Karine Assaker, Thomas Beuvier, Jean-Luc Blin, Marie-José Stébé, Oleg Konovalov, Alain Gibaud
Surfactant templated silica thin films were self-assembled on solid substrates by dip-coating using a partially fluorinated surfactant R8(F)(EO)9 as the liquid crystal template. The aim was 2-fold: first we checked which composition in the phase diagram was corresponding to a 2D rectangular highly ordered crystalline phase and second we exposed the films to sc-CO2 to foster the removal of the surfactant. The films were characterized by in situ X-ray reflectivity (XRR) and grazing incidence small angle X-ray scattering (GISAXS) under CO2 pressure from 0 to 100 bar at 34 °C...
January 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27908014/symmetry-effects-on-naturally-arising-chimera-states-in-mechanical-oscillator-networks
#17
Karen Blaha, Ryan J Burrus, Jorge L Orozco-Mora, Elvia Ruiz-Beltrán, Abu B Siddique, V D Hatamipour, Francesco Sorrentino
Coupled oscillators were believed to exclusively exist in a state of synchrony or disorder until Kuramoto theoretically proved that the two states could coexist, called a chimera state, when portions of the population had a spatial dependent coupling. Recent work has demonstrated the spontaneous emergence of chimera states in an experiment involving mechanical oscillators coupled through a two platform swing. We constructed an experimental apparatus with three platforms that each contains a population of mechanical oscillators in order investigate the effects of a network symmetry on naturally arising chimera states...
November 2016: Chaos
https://www.readbyqxmd.com/read/27859567/structure-and-absolute-configuration-of-hydroxy-bis-dihydrofarinosin-from-encelia-farinosa
#18
Alfredo R Ortega, Naytzé Ortiz-Pastrana, Leovigildo Quijano, Elvia Becerra-Martínez, José O Olmedo-Aguirre, Pedro Joseph-Nathan
The structure of the dimeric eudesmanolide hydroxy-bis-dihydrofarinosin (1) from Encelia farinosa followed after contrasting their (1) H and (13) C NMR spectra with those of encelin (6), hydroxy-bis-dihydroencelin (3), and farinosin (4). Structure 1 was verified by single-crystal X-ray diffraction analysis, which further provided the stereochemistry of the hydroxy group at C-4. Comparison of the experimental vibrational circular dichroism spectrum of its derived diacetate 2 with that calculated by density functional theory provided the absolute configuration, which resulted the same as that of its biogenetic precursor 4...
November 16, 2016: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/27698680/status-epilepticus-using-antioxidant-agents-as-alternative-therapies
#19
Liliana Carmona-Aparicio, Cecilia Zavala-Tecuapetla, María Eva González-Trujano, Aristides Iii Sampieri, Hortencia Montesinos-Correa, Leticia Granados-Rojas, Esaú Floriano-Sánchez, Elvia Coballase-Urrutía, Noemí Cárdenas-Rodríguez
The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identification of specific central targets, through which novel agents may act and be useful as SE therapies. Currently, studies have focused on the association between oxidative stress and SE, the most severe epileptic condition...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27649570/heterogenous-distribution-of-mthfr-gene-variants-among-mestizos-and-diverse-amerindian-groups-from-mexico
#20
Cecilia Contreras-Cubas, Beatríz E Sánchez-Hernández, Humberto García-Ortiz, Angélica Martínez-Hernández, Francisco Barajas-Olmos, Miguel Cid, Elvia C Mendoza-Caamal, Federico Centeno-Cruz, Gabriela Ortiz-Cruz, José Concepción Jiménez-López, Emilio J Córdova, Eva Gabriela Salas-Bautista, Yolanda Saldaña-Alvarez, Juan Carlos Fernández-López, Osvaldo M Mutchinick, Lorena Orozco
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have been studied worldwide, particularly the C677T and A1298C. We genotyped the C677T and A1298C MTHFR polymorphisms in Mexican Amerindians (MAs), from the largest sample included in a genetic study (n = 2026, from 62 ethnic groups), and in a geographically-matched Mexican Mestizo population (MEZ, n = 638)...
2016: PloS One
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