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Audrie A Medina-Colorado, Elvia Y Osorio, Omar A Saldarriaga, Bruno L Travi, Fanping Kong, Heidi Spratt, Lynn Soong, Peter C Melby
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in the spleen, liver and bone marrow. The disease is characterized by fever, splenomegaly, cachexia, and pancytopenia, and progresses to death if not treated. Control of Leishmania infection is mediated by Th1 (IFNγ-producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill intracellular parasites. However, despite expansion of CD4+ T cells and increased IFNγ expression in the spleen, humans with active VL do not control the infection...
2017: PloS One
Rodríguez-Fonseca Rolando Alberto, Sixto-López Yudibeth, Fragoso-Vázquez M Jonathan, Flores-Mejía Raúl, Cabrera-Pérez Laura Cristina, Vázquez-Moctezuma Ismael, Rosales-Hernández Martha Cecilia, Bello Martiniano, M Martínez-Archundia, Trujillo-Ferrara José Guadalupe, Becerra-Martínez Elvia, Correa-Basurto José
The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc. Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference. The target compounds were submitted to theoretical ADMET analyses and their binding properties on different HDAC6 conformers were evaluated through docking calculations...
January 2, 2017: Anti-cancer Agents in Medicinal Chemistry
Elvia A Chavez Panduro, Karine Assaker, Thomas Beuvier, Jean-Luc Blin, Marie-José Stébé, Oleg Konovalov, Alain Gibaud
Surfactant templated silica thin films were self-assembled on solid substrates by dip-coating using a partially fluorinated surfactant R8(F)(EO)9 as the liquid crystal template. The aim was 2-fold: first we checked which composition in the phase diagram was corresponding to a 2D rectangular highly ordered crystalline phase and second we exposed the films to sc-CO2 to foster the removal of the surfactant. The films were characterized by in situ X-ray reflectivity (XRR) and grazing incidence small angle X-ray scattering (GISAXS) under CO2 pressure from 0 to 100 bar at 34 °C...
January 11, 2017: ACS Applied Materials & Interfaces
Karen Blaha, Ryan J Burrus, Jorge L Orozco-Mora, Elvia Ruiz-Beltrán, Abu B Siddique, V D Hatamipour, Francesco Sorrentino
Coupled oscillators were believed to exclusively exist in a state of synchrony or disorder until Kuramoto theoretically proved that the two states could coexist, called a chimera state, when portions of the population had a spatial dependent coupling. Recent work has demonstrated the spontaneous emergence of chimera states in an experiment involving mechanical oscillators coupled through a two platform swing. We constructed an experimental apparatus with three platforms that each contains a population of mechanical oscillators in order investigate the effects of a network symmetry on naturally arising chimera states...
November 2016: Chaos
Alfredo R Ortega, Naytzé Ortiz-Pastrana, Leovigildo Quijano, Elvia Becerra-Martínez, José O Olmedo-Aguirre, Pedro Joseph-Nathan
The structure of the dimeric eudesmanolide hydroxy-bis-dihydrofarinosin (1) from Encelia farinosa followed after contrasting their (1) H and (13) C NMR spectra with those of encelin (6), hydroxy-bis-dihydroencelin (3), and farinosin (4). Structure 1 was verified by single-crystal X-ray diffraction analysis, which further provided the stereochemistry of the hydroxy group at C-4. Comparison of the experimental vibrational circular dichroism spectrum of its derived diacetate 2 with that calculated by density functional theory provided the absolute configuration, which resulted the same as that of its biogenetic precursor 4...
November 16, 2016: Magnetic Resonance in Chemistry: MRC
Liliana Carmona-Aparicio, Cecilia Zavala-Tecuapetla, María Eva González-Trujano, Aristides Iii Sampieri, Hortencia Montesinos-Correa, Leticia Granados-Rojas, Esaú Floriano-Sánchez, Elvia Coballase-Urrutía, Noemí Cárdenas-Rodríguez
The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identification of specific central targets, through which novel agents may act and be useful as SE therapies. Currently, studies have focused on the association between oxidative stress and SE, the most severe epileptic condition...
October 2016: Experimental and Therapeutic Medicine
Cecilia Contreras-Cubas, Beatríz E Sánchez-Hernández, Humberto García-Ortiz, Angélica Martínez-Hernández, Francisco Barajas-Olmos, Miguel Cid, Elvia C Mendoza-Caamal, Federico Centeno-Cruz, Gabriela Ortiz-Cruz, José Concepción Jiménez-López, Emilio J Córdova, Eva Gabriela Salas-Bautista, Yolanda Saldaña-Alvarez, Juan Carlos Fernández-López, Osvaldo M Mutchinick, Lorena Orozco
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have been studied worldwide, particularly the C677T and A1298C. We genotyped the C677T and A1298C MTHFR polymorphisms in Mexican Amerindians (MAs), from the largest sample included in a genetic study (n = 2026, from 62 ethnic groups), and in a geographically-matched Mexican Mestizo population (MEZ, n = 638)...
2016: PloS One
Elvia Michelli, Adriana Millán, Hectorina Rodulfo, Mirian Michelli, Jesús Luiggi, Numirin Carreño, Marcos De Donato
INTRODUCTION: Diarrheagenic Escherichia coli is an important causative agent of acute diarrheic syndrome.  OBJECTIVE: To identify clonal groups of enteropathogenic E. coli (EPEC), in 485 children with acute diarrhea aged 0 to 10 years attending health care centers in Arismendi, Benítez and Sucre municipalities, Sucre state, Venezuela, from March to December, 2011.  MATERIALS AND METHODS: After obtaining the informed consent, stool samples were collected...
March 28, 2016: Biomédica: Revista del Instituto Nacional de Salud
Adán Pérez-Arredondo, Eduardo Cázares-Ramírez, Paul Carrillo-Mora, Marina Martínez-Vargas, Noemí Cárdenas-Rodríguez, Elvia Coballase-Urrutia, Radamés Alemón-Medina, Aristides Sampieri, Luz Navarro, Liliana Carmona-Aparicio
Traumatic brain injury (TBI) is an alteration in brain function, caused by an external force, which may be a hit on the skull, rapid acceleration or deceleration, penetration of an object, or shock waves from an explosion. Traumatic brain injury is a major cause of morbidity and mortality worldwide, with a high prevalence rate in pediatric patients, in which treatment options are still limited, not available at present neuroprotective drugs. Although the therapeutic management of these patients is varied and dependent on the severity of the injury, general techniques of drug types are handled, as well as physical and surgical...
November 2016: Clinical Neuropharmacology
Nilesh Patil, Eirik Torbjørn Bakken Skjønsfjell, Niko Van den Brande, Elvia Anabela Chavez Panduro, Raf Claessens, Manuel Guizar-Sicairos, Bruno Van Mele, Dag Werner Breiby
Optimizing the morphology of bulk heterojunctions is known to significantly improve the photovoltaic performance of organic solar cells, but available quantitative imaging techniques are few and have severe limitations. We demonstrate X-ray ptychographic coherent diffractive imaging applied to all-organic blends. Specifically, the phase-separated morphology in bulk heterojunction photoactive layers for organic solar cells, prepared from a 50:50 blend of poly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM) and thermally treated for different annealing times is imaged to high resolution...
2016: PloS One
Vivian L Vignoles, Ellinor Owe, Maja Becker, Peter B Smith, Matthew J Easterbrook, Rupert Brown, Roberto González, Nicolas Didier, Diego Carrasco, Maria Paz Cadena, Siugmin Lay, Seth J Schwartz, Sabrina E Des Rosiers, Juan A Villamar, Alin Gavreliuc, Martina Zinkeng, Robert Kreuzbauer, Peter Baguma, Mariana Martin, Alexander Tatarko, Ginette Herman, Isabelle de Sauvage, Marie Courtois, Ragna B Garðarsdóttir, Charles Harb, Inge Schweiger Gallo, Paula Prieto Gil, Raquel Lorente Clemares, Gabriella Campara, George Nizharadze, Ma Elizabeth J Macapagal, Baland Jalal, David Bourguignon, Jianxin Zhang, Shaobo Lv, Aneta Chybicka, Masaki Yuki, Xiao Zhang, Agustín Espinosa, Aune Valk, Sami Abuhamdeh, Benjamin Amponsah, Emre Özgen, E Ülkü Güner, Nil Yamakoğlu, Phatthanakit Chobthamkit, Tom Pyszczynski, Pelin Kesebir, Elvia Vargas Trujillo, Paola Balanta, Boris Cendales Ayala, Silvia H Koller, Jas Laile Jaafar, Nicolay Gausel, Ronald Fischer, Taciano L Milfont, Ersin Kusdil, Selinay Çağlar, Said Aldhafri, M Cristina Ferreira, Kassahun Habtamu Mekonnen, Qian Wang, Márta Fülöp, Ana Torres, Leoncio Camino, Flávia Cristina Silveira Lemos, Immo Fritsche, Bettina Möller, Camillo Regalia, Claudia Manzi, Maria Brambilla, Michael Harris Bond
Markus and Kitayama's (1991) theory of independent and interdependent self-construals had a major influence on social, personality, and developmental psychology by highlighting the role of culture in psychological processes. However, research has relied excessively on contrasts between North American and East Asian samples, and commonly used self-report measures of independence and interdependence frequently fail to show predicted cultural differences. We revisited the conceptualization and measurement of independent and interdependent self-construals in 2 large-scale multinational surveys, using improved methods for cross-cultural research...
August 2016: Journal of Experimental Psychology. General
Ruth Mangupli, Liliya Rostomyan, Emilie Castermans, Jean-Hubert Caberg, Paul Camperos, Jaime Krivoy, Elvia Cuauro, Vincent Bours, Adrian F Daly, Albert Beckers
INTRODUCTION: Pituitary gigantism is a rare condition caused by growth hormone secreting hypersecretion, usually by a pituitary tumor. Acromegaly and gigantism cases that have a genetic cause are challenging to treat, due to large tumor size and poor responses to some medical therapies (e.g. AIP mutation affected cases and those with X-linked acrogigantism syndrome). MATERIALS AND METHODS: We performed a retrospective study to identify gigantism cases among 160 somatotropinoma patients treated between 1985 and 2015 at the University Hospital of Caracas, Venezuela...
October 2016: Pituitary
Jose Luis Acosta, Alma Cristal Hernández-Mondragón, Laura Carolina Correa-Acosta, Sandra Nathaly Cazañas-Padilla, Berenice Chávez-Florencio, Elvia Yamilet Ramírez-Vega, Tulia Monge-Cázares, Carlos A Aguilar-Salinas, Teresa Tusié-Luna, Laura Del Bosque-Plata
BACKGROUND: Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico. Here, we sequenced and analyzed the variation of the TCF7L2 gene in three Amerindian populations and compared the results with whole-exon-sequencing of Mestizo populations from Sigma and the 1000 Genomes Project to assess the roles of selection and recombination in diversity...
2016: BMC Genetics
Aditi Singh, Bidhan Chandra Koner, Prakash Chandra Ray, Sudha Prasad, Elvia Jamatia, Mirza Masroor, Vijay Kumar Singh
BACKGROUND: Psychological factor alters fertility hormones and contributes to male infertility. Anxiety and depression are common manifestations of psychological distress. Cytochrome P-4501A1 (CYP1A1) metabolizes xenobiotics and fertility hormones that influence male fertility. The effect of CYP1A1 polymorphism on male fertility has remained controversial. The present study was designed to assess the effect of psychological distress and CYP1A1 polymorphisms and their interactions on parameters of seminal analysis...
May 24, 2016: Reproductive Health
Philip E Stuart, Rajan P Nair, Lam C Tsoi, Trilokraj Tejasvi, Sayantan Das, Hyun Min Kang, Eva Ellinghaus, Vinod Chandran, Kristina Callis-Duffin, Robert Ike, Yanming Li, Xiaoquan Wen, Charlotta Enerbäck, Johann E Gudjonsson, Sulev Kõks, Külli Kingo, Tõnu Esko, Ulrich Mrowietz, Andre Reis, H Erich Wichmann, Christian Gieger, Per Hoffmann, Markus M Nöthen, Juliane Winkelmann, Manfred Kunz, Elvia G Moreta, Philip J Mease, Christopher T Ritchlin, Anne M Bowcock, Gerald G Krueger, Henry W Lim, Stephan Weidinger, Michael Weichenthal, John J Voorhees, Proton Rahman, Peter K Gregersen, Andre Franke, Dafna D Gladman, Gonçalo R Abecasis, James T Elder
Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory musculoskeletal condition. To discern differences in genetic risk factors for PsA and cutaneous-only psoriasis (PsC), we carried out a genome-wide association study (GWAS) of 1,430 PsA case subjects and 1,417 unaffected control subjects. Meta-analysis of this study with three other GWASs and two targeted genotyping studies, encompassing a total of 9,293 PsV case subjects, 3,061 PsA case subjects, 3,110 PsC case subjects, and 13,670 unaffected control subjects of European descent, detected 10 regions associated with PsA and 11 with PsC at genome-wide (GW) significance...
December 3, 2015: American Journal of Human Genetics
Elvia R Krajewski-Jaime, Markus Whitehead, Jennifer Kellman-Fritz
This article presents findings of a study conducted to identify stressors that may contribute to mental health issues of military female veterans. Female members in the U.S. Armed Forces currently occupy more non-traditional roles; therefore deployment to combat zones, commonly reserved for males, is being taken on by females. While at the present time females serving in the military are not allowed to serve in combat occupations, the reality is that many are being placed in combat roles or environments. Consequently, many are now confronted with stressors related to combat and multiple deployments...
2013: International Journal of Health, Wellness & Society
Luz Elvia Vera-Becerra, Martha L Lopez, Lucia L Kaiser
The purpose of this study was to examine relative validity of a food frequency questionnaire (FFQ) to measure food acculturation in young Mexican-origin children. In 2006, Spanish-speaking staff interviewed mothers in a community-based sample of households from Ventura, California (US) (n = 95) and Guanajuato, Mexico (MX) (n = 200). Data included two 24-h dietary recalls (24-DR); a 30-item FFQ; and anthropometry of the children. To measure construct, convergent, and discriminant validity, data analyses included factor analysis, Spearman correlations, t-test, respectively...
February 1, 2016: Appetite
Elvia Cruz-Huerta, Daniel Martínez Maqueda, Lucia de la Hoz, Vera S Nunes da Silva, Maria Teresa Bertoldo Pacheco, Lourdes Amigo, Isidra Recio
Peptides with iron-binding capacity obtained by hydrolysis of whey protein with Alcalase (Novozymes, Araucaria, PR, Brazil), pancreatin, and Flavourzyme (Novozymes) were identified. Hydrolysates were subjected to iron (III)-immobilized metal ion affinity chromatography, and the bound peptides were sequenced by mass spectrometry. Regardless of the enzyme used, the domains f(42-59) and f(125-137) from β-lactoglobulin enclosed most of identified peptides. This trend was less pronounced in the case of peptides derived from α-lactalbumin, with sequences deriving from diverse regions...
January 2016: Journal of Dairy Science
Luis Téllez, Elvia Michelli, José Andrés Mendoza, Silvana Vielma, María-Eugenia Noguera, Diana Callejas, María Cavazza, María Correnti
Cervical lesions have been associated with infection by high-risk human papilloma virus (high-risk HPV). In 409 women aged >15 years high-risk HPV lesions were identified. In a cohort of this population persistent infection was compared with cytological, colposcopic, and histological lesions. Cervical scrapes were taken and DNA was isolated. HPV was detected by PCR in the E6/E7 region. Genotyping was performed by PCR nested multiple E6/E7. HPV was detected in a 37.40% (153/409), high-risk HPV in 86% (153/178), HPV18 46...
2015: Ecancermedicalscience
Sandra Elvia Hernández Valencia, Lucía Méndez Sánchez, Patricia Clark, Laura Moreno Altamirano, Juan Manuel Mejía Aranguré
BACKGROUND: after a traumatic injury or post surgical orthopedic, the loss of skeletal muscle strength is common. In addition to strength training schemes and/or resistance to treatment, it has been proposed as an additional treatment, the use of some amino acids such as glutamine (Gln) in isolation or combination with other nutrients. However, the information on the effectiveness of oral Gln supplementation during exercise strength schemes and / or endurance in adults with strength deficit is inconsistent...
October 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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