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https://www.readbyqxmd.com/read/29341946/microemulgel-of-voriconazole-an-unfathomable-protection-to-counter-fungal-contagiousness
#1
Kalpesh C Ashara, Jalpa S Paun, Moinuddin M Soniwala, Jayant R Chavda
BACKGROUND: Fluconazole and ketoconazole both have poor minimum inhibitory concentration than voriconazole. Voriconazole had serious side effects in oral and intravenous doses. It has poor water solubility. The objective of the study was to prepare and optimize microemulgel of voriconazole for topical delivery. AIM: Formulation, development, and evaluation of voriconazole microemulgel for topical delivery. METHODS: Oil and emulsifi ers selected were on the basis of equilibrium solubility study and emulsification property respectively...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29322079/fibroblast-and-keratinocyte-gene-expression-following-exposure-to-extracts-of-neem-plant-azadirachta-indica
#2
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R G S Wijesekara
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name "Kohomba" in Sri Lanka, harvested in Sri Lanka. For fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (HAS1), hyaluronan synthase 2 (HAS2), hyaluronidase-1 (HYAL1), hyaluronidase-2 (HYAL2), versican, aggrecan, CD44, collagen, type I, alpha 1 (COL1A1), collagen, type III, alpha 1 (COL3A1), collagen, type VII, alpha 1 (COL7A1), matrix metalloproteinase 1 (MMP1), acid ceramidase, basic fibroblast growth factor (bFGF), fibroblast growth factor-7 (FGF7), vascular endothelial growth factor (VEGF), interleukin-1 alpha (IL-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (TGF-β), and aquaporin 3 (AQP3)...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29287176/removal-of-pb-ii-from-water-using-a-bio-composite-adsorbent-a-systematic-approach-of-optimizing-synthesis-and-process-parameters-by-response-surface-methodology
#3
Jayabrata Maity, Samit Kumar Ray
The synthesis parameters for preparing a novel bio-composite adsorbent by integrating a copolymer of 2-hydroxyethyl methacrylate (HEMA), acrylamide (AM) and crosslinker N, N'-methylene bis acrylamide (MBA), polyethylene glycol (PEG) and Azadirachta Indica or Neem leaf (NL) and the process parameters for its subsequent use for adsorption of Pb(II) ion from water were optimized with central composite design (CCD) of response surface methodology (RSM). The structure of the bio-composite was characterized by FTIR, XRD, TGA, DMA, FESEM-EDX and PZC analysis...
December 26, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29281183/development-of-an-attract-and-kill-co-formulation-containing-saccharomyces-cerevisiae-and-neem-extract-attractive-towards-wireworms
#4
Pascal Humbert, Marina Vemmer, Frauke Mävers, Mario Schumann, Stefan Vidal, Anant V Patel
BACKGROUND: Wireworms (Coleoptera: Elateridae) are major insect pests of world-wide relevance. Due to the progressive phasing-out of chemical insecticides, there is a great demand for innovative control options. This study reports on the development of an attract-and-kill co-formulation based on Ca-alginate beads, which release CO2 and contain neem extract as a bioinsecticidal compound. Our objectives were to figure out, (i) whether neem extract can be efficiently immobilized, (ii) whether CO2 -releasing Saccharomyces cerevisiae and neem extract are suitable for co-encapsulation, and (iii) whether co-encapsulated neem extract affects the attractiveness of CO2 -releasing beads towards wireworms...
December 27, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29244971/developing-antimicrobial-calcium-alginate-fibres-from-neem-and-papaya-leaves-extract
#5
F Hussain, M F Khurshid, R Masood, W Ibrahim
OBJECTIVE: The aim of this study was to evaluate an alternative approach to developing antimicrobial alginate fibres using plant extracts, such as those from neem and papaya leaves. METHOD: Aqueous leaves extract from neem, papaya and their hybrid combinations were used as solvent to develop sodium alginate fibres. Sodium alginate polymer containing these extracts was extruded in a calcium chloride (CaCl2) bath to develop neem (NE), papaya (PE) and their hybrid combinations-based calcium alginate fibres (H-1 to H-5)...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29211914/stinging-nettle-and-neem-enhance-antibody-response-to-local-killed-and-imported-live-infectious-bursal-disease-vaccines-in-indigenous-chicken-in-kenya
#6
M O Bwana, L W Njagi, P N Nyaga, P G Mbuthia, L C Bebora, M W Wahome, W U Mutinda, P M Kitala
Immune responses are critical for protection of chickens from infectious bursal disease (IBD). In this study, the antibody response-enhancing effect of drinking water supplementation of 1% stinging nettle and neem on different IBD vaccines and vaccination regimes was evaluated, using 36 (n = 36) specific antibody negative indigenous chicks. The birds were allocated into 3 groups as follows: 1A-C, 2A-C, and 3A-B, while group 3C acted as the unvaccinated non-supplemented control. A local inactivated K1 and imported live attenuated D78 IBD vaccines were given to groups 1A-C and 3A-B at 14 and 28 d of age, respectively...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29208784/impact-of-mouthwashes-on-antibacterial-activity-of-subjects-with-fixed-orthodontic-appliances-a-randomized-clinical-trial
#7
A Nishad, N S Sreesan, Joseph Joy, Lakshmi Lakshmanan, Joyce Thomas, V A Anjali
AIM: The study aimed to assess the impact of mouthwashes on antibacterial activity of individuals with fixed orthodontic appliances. MATERIALS AND METHODS: A total of 60 individuals were considered in the study. Sixty (20 each group) nonextraction class I individuals were randomly divided into experimental and control groups. Group I: Experimental group [chlorhexidine (CHX) mouthwash], group II: Experimental group (neem mouthwash), group III: Control group (distilled water)...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29193806/inhibition-of-larval-growth-and-adult-fecundity-in-asian-long-horned-beetle-anoplophora-glabripennis-exposed-to-azadirachtins-under-quarantine-laboratory-conditions
#8
Dean G Thompson, Amanda Tonon, Eduardo Beltran, Felix Hernandez
BACKGROUND: The Asian Long-horned Beetle (ALB; Anoplophora glabripennis (Motschulsky)), is an invasive, wood-boring insect posing significant economic and ecological threats to the deciduous forests of North America. An efficacious and environmentally acceptable chemical control technique is a requirement of a comprehensive, integrated response strategy. RESULTS: Results of this study demonstrate statistically significant, concentration-dependent effects of azadirachtins, a family of natural compounds derived from the neem tree, on both ALB larval and adult life-stages...
November 28, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29192402/comparative-studies-on-the-performance-and-emissions-of-a-direct-injection-diesel-engine-fueled-with-neem-oil-and-pumpkin-seed-oil-biodiesel-with-and-without-fuel-preheater
#9
Muneeswaran Ramakrishnan, Thansekhar Maruthu Rathinam, Karthickeyan Viswanathan
In the present experimental analysis, two non-edible oils namely neem oil and pumpkin seed oil were considered. They are converted into respective biodiesels namely neem oil methyl ester (B1) and pumpkin seed oil methyl ester (B2) through transesterification process and their physical and chemical properties were examined using ASTM standards. Diesel was used as a baseline fuel in Kirloskar TV1 model direct injection four stroke diesel engine. A fuel preheater was designed and fabricated to operate at various temperatures (60, 70, and 80 °C)...
December 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29191878/the-target-landscape-of-clinical-kinase-drugs
#10
Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne-Kathrin Garz, Bjoern-Oliver Gohlke, Daniel Paul Zolg, Gian Kayser, Tonu Vooder, Robert Preissner, Hannes Hahne, Neeme Tõnisson, Karl Kramer, Katharina Götze, Florian Bassermann, Judith Schlegl, Hans-Christian Ehrlich, Stephan Aiche, Axel Walch, Philipp A Greif, Sabine Schneider, Eduard Rudolf Felder, Juergen Ruland, Guillaume Médard, Irmela Jeremias, Karsten Spiekermann, Bernhard Kuster
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the "druggable" kinome, highlighted (non)kinase off-targets, and suggested potential therapeutic applications. Integration of phosphoproteomic data refined drug-affected pathways, identified response markers, and strengthened rationale for combination treatments...
December 1, 2017: Science
https://www.readbyqxmd.com/read/29183617/azadirachtin-impact-on-mate-choice-female-sexual-receptivity-and-male-activity-in-drosophila-melanogaster-diptera-drosophilidae
#11
N Aribi, M C Oulhaci, S Kilani-Morakchi, J C Sandoz, L Kaiser, B Denis, D Joly
Azadirachtin, a neem compound (Azadirachta indica) with medical and anti-insect properties, is one the most successful botanical pesticides in agricultural use. However, its controversial impact on non-targeted species and its mechanism of action need to be clarified. In addition, Azadirachtin impact on pre- and post-mating traits remains largely undocumented. The current study examined the effects of Azadirachtin on Drosophila melanogaster as a non-target and model species. Azadirachtin was applied topically at its LD50 (0...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29183582/azadirachtin-induced-larval-avoidance-and-antifeeding-by-disruption-of-food-intake-and-digestive-enzymes-in-drosophila-melanogaster-diptera-drosophilidae
#12
Radia Bezzar-Bendjazia, Samira Kilani-Morakchi, Ferdenache Maroua, Nadia Aribi
Botanical insecticides are a promising alternative to reduce the harmful effects of synthetic chemicals. Among the botanical biopesticides, azadirachtin obtained from the Indian neem tree Azadirachta indica A. Juss. (Meliaceae) is probably the biorational insecticide with greatest agriculture use nowadays due to its broad insecticide activity. The current study, evaluated the lethal and sublethal effects of azadirachtin on larval avoidance, food intake and digestive enzymes of Drosophila melanogaster larvae as biological model...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29177786/nematicidal-potential-and-specific-enzyme-activity-enhancement-potential-of-neem-azadirachta-indica-a-juss-aerial-parts
#13
Arti Shivraj Nile, Shivraj Hariram Nile, Young Soo Keum, Doo Hwan Kim, Baskar Venkidasamy, Sathishkumar Ramalingam
Nematodes are considered as major plant parasites damaging most of the crops, and neem plant exhibits potential nematicidal and insecticidal properties. This study aimed to check nemato-toxic potential of neem (Azadirachta indica) plant using in vitro and in-planta trials against Meloidogyne incognita. The findings suggested that the neem extracts were lethal to second-stage juvenile (J2) and egg hatching with simultaneous enhancement in treated tomato plant growth. The egg numbers of M. incognita found less sensitive to the aqueous and alcoholic extracts than those of J2 as per LC50 values...
November 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29175783/total-antioxidant-capacity-of-commonly-used-fruits-vegetables-herbs-and-spices-of-pakistan
#14
Mobasher Ali Abid, Muhammad Ashfaq, Muhammad Junaid Hassan Sharif, Khalid Rauf, Wajahat Mahmood, Ikarmullah Khan, Ghulam Abbas
The current study was aimed at investigating the total antioxidant activity (TAC) of various fruits, vegetables, herbs and spices habitat in Pakistan. The ferric reducing ability of plasma (FRAP) assay was used to measure the TAC of various extracts (aqueous, ethanolic and aqueous-ethanolic). Following is the potency order for fruits (guava >strawberry >Pomegranate >apple >kinnow >melon >lemon >banana), vegetables (spinach >Cabbage (Purple) >Jalapeno >Radish >Brinjal >Bell Pepper >Lettuce >Carrot >Cabbage (White) >Onion >Potato >Tomato >Cucumber) and herbs/spices (clove >Rosemary >Thyme >Oregano >Cinnamon >Cumin >Kalonji >Paprika >Neem (Flower) >Fennel >Black Cardamom >Turmeric >Coriander >Ginger >Garlic)...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29116538/environmentally-benign-nanometric-neem-laced-urea-emulsion-for-controlling-mosquito-population-in-environment
#15
Prabhakar Mishra, Merlyn Keziah Samuel, Ruchishya Reddy, Brij Kishore Tyagi, Amitava Mukherjee, Natarajan Chandrasekaran
The increasing risk of vector-borne diseases and the environmental pollution in the day-to-day life due to the usage of the conventional pesticides makes the role of nanotechnology to come into the action. The current study deals with one of the applications of nanotechnology through the formulation of neem urea nanoemulsion (NUNE). NUNE was formulated using neem oil, Tween 20, and urea using the microfluidization method. Prior to the development of nanoemulsion, the ratio of oil/surfactant/urea was optimized using the response surface modeling method...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29104390/an-in-vitro-comparative-evaluation-of-efficacy-of-disinfecting-ability-of-garlic-oil-neem-oil-clove-oil-and-tulsi-oil-with-autoclaving-on-endodontic-k-files-tested-against-enterococcus-faecalis
#16
Shivayogi Hugar, Punit M Patel, Jyoti Nagmoti, Chaitanya Uppin, Laresh Mistry, Neha Dhariwal
Aim: To comparatively evaluate the efficacy of disinfecting ability of garlic oil, neem oil, clove oil, and tulsi oil with autoclaving on endodontic K files tested against Enterococcus faecalis. Materials and methods: Fifty endodontic K files were exposed to the test micro-organism and checked for its disinfecting ability using three different methods. Result: Garlic oil, clove oil, tulsi oil and autoclave showed considerable effectiveness against E...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29074140/airborne-allergic-contact-dermatitis-caused-by-neem-oil
#17
A Sánchez-Gilo, A Nuño González, M Gutiérrez Pascual, F J Vicente Martín
No abstract text is available yet for this article.
October 23, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29059091/contact-allergy-to-neem-oil
#18
Anton de Groot, Berend A Jagtman, Marjolijn Woutersen
A case of allergic contact dermatitis from neem oil is presented. Neem oil (synonyms: Melia azadirachta seed oil [INCI name], nim oil, margosa oil) is a vegetable (fixed) oil obtained from the seed of the neem tree Azadirachta indica by cold pressing. Contact allergy to neem oil has been described previously in only 3 patients. The allergen(s) is/are unknown.
November 2017: Dermatitis
https://www.readbyqxmd.com/read/29044755/epoxyazadiradione-purified-from-the-azadirachta-indica-seed-induced-mitochondrial-apoptosis-and-inhibition-of-nf%C3%AE%C2%BAb-nuclear-translocation-in-human-cervical-cancer-cells
#19
G Shilpa, J Renjitha, R Saranga, Francis K Sajin, Mangalam S Nair, Beena Joy, B S Sasidhar, S Priya
Epoxyazadiradione (EAD) is an important limonoid present in Neem (Azadirachta indica) plant. In the present study, we have purified EAD from Neem seed and studied its anticancer potential in human cervical cancer (HeLa) cells. Cell proliferation inhibition studies indicated that the GI50 value of EAD is 7.5 ± 0.0092 μM in HeLa cells, whereas up to 50 μM concentrations EAD did not affect the growth of normal H9C2 cells. The control drug cisplatin inhibited the growth of both HeLa and H9C2 cells with a GI50 value of 2...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29039495/protective-effects-of-neem-azadirachta-indica-a-juss-leaf-extract-against-cigarette-smoke-and-lipopolysaccharide-induced-pulmonary-inflammation
#20
Jae-Won Lee, Hyung Won Ryu, So-Yeon Park, Hyun Ah Park, Ok-Kyoung Kwon, Heung Joo Yuk, Krishna K Shrestha, Minwoo Park, Jung Hee Kim, Sangwoo Lee, Sei-Ryang Oh, Kyung-Seop Ahn
Neem (Azadirachta indica A. Juss.) leaf has been reported to exert anti-inflammatory, antibacterial and antioxidant effects. The purpose of this study was to investigate the protective effects of neem leaf extract (NLE) against cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with NLE significantly attenuated the infiltration of inflammatory cells, such as neutrophils and macrophages in bronchoalveolar lavage fluid (BALF). NLE also reduced the production of reactive oxygen species and the activity of neutrophil elastase in BALF...
October 10, 2017: International Journal of Molecular Medicine
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