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https://www.readbyqxmd.com/read/28530186/synthesis-and-characterisation-of-neem-leaf-extract-2-3-dehydrosalanol-and-quercetin-dihydrate-mediated-silver-nano-particles-for-therapeutic-applications
#1
Bodaballa Avinash, Ravipati Venu, Tollamadugu N V K V Prasad, Mekapogu Alpha Raj, Kothapalli Srinivasa Rao, Chintamaneni Srilatha
The utility of green silver nanoparticles (AgNPs) in veterinary medicine is steadily increasing as they have many therapeutic applications against pathogens and arthropods of livestock. In this study, green AgNPs using neem (N-AgNPs), 2,3-dehydrosalanol (2,3-DHS-AgNPs) and quercetin dihydrate (QDH-AgNPs) were synthesised and characterised. Synthesised compounds were characterised by UV-Vis spectroscopy and the peak absorbance was recorded at 370 nm for neem extract. For N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs, the maximum absorbance peaks were at 430, 230 and 220 nm, respectively...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28515436/nimbolide-upregulates-reck-by-targeting-mir-21-and-hif-1%C3%AE-in-cell-lines-and-in-a-hamster-oral-carcinogenesis-model
#2
Jaganathan Kowshik, Rajakishore Mishra, Josephraj Sophia, Satabdi Rautray, Kumaraswamy Anbarasu, G Deepak Reddy, Madhulika Dixit, Sundarasamy Mahalingam, Siddavaram Nagini
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a potent inhibitor of matrix metalloproteinases (MMPs) is a common negative target of oncogenic signals and a potential therapeutic target for novel drug development. Here, we show that sequential RECKlessness stimulates angiogenesis and Notch signalling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model, a paradigm for oral oncogenesis and chemointervention. We also report the chemotherapeutic effect of nimbolide, a limonoid from the neem tree (Azadirachta indica) based on the upregulation of RECK as well as modulation of the expression of key molecules involved in invasion and angiogenesis...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28512541/anti-plaque-and-anti-gingivitis-effect-of-papain-bromelain-miswak-and-neem-containing-dentifrice-a-randomized-controlled-trial
#3
Abhinav Tadikonda, Kalyana-Chakravarthy Pentapati, Arun-Sreenivas Urala, Shashidhar Acharya
BACKGROUND: Patients undergoing fixed orthodontic therapy may have difficulty in maintaining a good oral hygiene due to the difficulty posed by the appliances in accessing such areas. This study aimed to compare anti-plaque and anti-gingivitis efficacy of dentifrice containing Papain, Bromelain, Miswak and Neem with a standard dentifrice among patient's undergoing fixed orthodontic treatment. MATERIAL AND METHODS: Single center, single blind, parallel arm, randomized controlled clinical trial with an allocation ratio of 1:1 was conducted...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28512455/non-edible-oil-cakes-as-a-novel-substrate-for-dpa-production-and-augmenting-biocontrol-activity-of-paecilomyces-variotii
#4
Kalpana Arora, Satyawati Sharma, Suresh B N Krishna, Jamila K Adam, Ashwani Kumar
The present study investigated the use of waste non-edible oil cakes (Jatropha, Karanja, Neem, and Mahua) as a substrate for the growth of Paecilomyces variotii and dipicolinic acid (DPA) production. Previous researches proved the efficacy of DPA in suppressing certain pathogens that are deleterious to the plants in the rhizosphere. DPA production was statistical optimized by amending non-edible oil cakes in growing media as nitrogen and sugars (Dextrose, Glucose, and Lactose) as carbon source. Plackett-Burman design (PBD), indicated that Jatropha cake, Karanja cake, and Dextrose were the most significant components (p < 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28497627/allergic-contact-stomatitis-caused-by-neem-leaves-azadirachta-indica
#5
Betsy Ambooken, Sarin Abdulsalam, Neelakandhan Asokan, Anita Abraham
No abstract text is available yet for this article.
June 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28493718/tamarixetin-3-o-%C3%AE-d-glucopyranoside-from-azadirachta-indica-leaves-gastroprotective-role-through-inhibition-of-matrix-metalloproteinase-9-activity-in-mice
#6
Dharmendra K Yadav, Yogesh P Bharitkar, Abhijit Hazra, Uttam Pal, Sugreev Verma, Sayantan Jana, Umesh P Singh, Nakul C Maiti, Nirup B Mondal, Snehasikta Swarnakar
Neem (Azadirachta indica) is a well-known medicinal and insecticidal plant. Although previous studies have reported the antiulcer activity of neem leaf extract, the lead compound is still unidentified. The present study reports tamarixetin 3-O-β-d-glucopyranoside (1) from a methanol extract of neem leaves and its gastroprotective activity in an animal model. Compound 1 showed significant protection against indomethacin-induced gastric ulceration in mice in a dose-dependent manner. Moreover, ex vivo and circular dichroism studies confirmed that 1 inhibited the enzyme matrix metalloproteinase-9 (MMP-9) activity with an IC50 value of ca...
May 11, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28488042/randomized-investigator-blinded-controlled-clinical-study-with-lice-shampoo-licener%C3%A2-versus-dimethicone-jacutin%C3%A2-pedicul-fluid-for-the-treatment-of-infestations-with-head-lice
#7
Margit Semmler, Fathy Abdel-Ghaffar, Falk Gestmann, Mohammed Abdel-Aty, Ibrahim Rizk, Saleh Al-Quraishy, Walter Lehmacher, Norman-Philipp Hoff
The present clinical trial was conducted to obtain additional data for the safety and efficacy of a head lice shampoo that is free of silicone compared with an anti-head lice product containing dimethicone. Both products act by a physical mode of action. This randomized, investigator-blinded, controlled clinical study was conducted between July and November 2016 in households of two villages (Abou Rawash and Shandalat) in Egypt. Children older than 2 years with an active head lice infestation were treated with either a shampoo-based head lice treatment containing neem extract (Licener®) or dimethicone (Jacutin® Pedicul Fluid) on day 1 and additionally on day 9...
May 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28476978/study-of-bio-fabrication-of-iron-nanoparticles-and-their-fungicidal-property-against-phytopathogens-of-apple-orchards
#8
Hilal Ahmad, Kalyanaraman Rajagopal, Ashiq Hussain Shah, Arif Hussain Bhat, Kalyanaraman Venugopal
Current research trends on iron nanoparticles (FeNPs) are extensively focused because of their unique magnetic and electrical properties mostly applicable in essential medical devices. However, their fungicidal property against plant pathogens is very less known until date. Present study demonstrates a green technique for blending of FeNPs by utilising aqueous extract of neem leaf (Azadirachta indica A. Juss.) as reducing agent. Various characterisation techniques such as ultraviolet (UV)-visible spectroscopy, Fourier transform infrared spectroscopy transmission electron microscopy, scanning electron microscopy and X-ray diffraction were performed for FeNPs...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28423430/bioactivity-of-novel-botanical-insecticide-from-gnidia-kaussiana-thymeleaceae-against-callosobruchus-maculatus-coleoptera-chrysomelidae-in-stored-vigna-subterranea-fabaceae-grains
#9
D Kosini, E N Nukenine
Hexane, acetone, and methanol extracts from Gnidia kaussiana Meisn (Thymeleaceae), each at two dosages (0.2 and 1 ml/50 g grains corresponding, respectively to 1 and 5g/kg), and neem seed oil (NSO), used as standard insecticide were evaluated for repellence, toxicity to Callosobruchus maculatus (F.) (Coleoptera: Chrysomelidae) adults, F1 progeny inhibition, persistence and as grain protectant during storage. Experiments were laid out at complete randomized design with five replications for repellence test and four for others...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28419927/synthesis-and-evaluation-of-anti-plasmodial-and-cytotoxic-activities-of-epoxyazadiradione-derivatives
#10
P Ashok Yadav, Ch Pavan Kumar, Bandi Siva, K Suresh Babu, Aparna Devi Allanki, Puran Singh Sijwali, Nishant Jain, A Veerabhadra Rao
Epoxyazadiradione (1), a major compound derived from Neem oil, showed modest anti-plasmodial activity against CQ-resistant and CQ-sensitive strains of the most virulent human malaria parasite P. falciparum. A series of analogues were synthesized by modification of the key structural moieties of this high yield natural product. Out of the library of all compounds tested, compounds 3c and 3g have showed modest anti-plasmodial activity against CQ-sensitive (IC50 2.8 ± 0.29 μM and 1.5 ± 0.01 μM) and CQ-resistant strains (IC50 1...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28414726/neem-leaf-glycoprotein-prevents-post-surgical-sarcoma-recurrence-in-swiss-mice-by-differentially-regulating-cytotoxic-t-and-myeloid-derived-suppressor-cells
#11
Madhurima Sarkar, Sarbari Ghosh, Avishek Bhuniya, Tithi Ghosh, Ipsita Guha, Subhasis Barik, Jaydip Biswas, Anamika Bose, Rathindranath Baral
Post-surgical tumor recurrence is a common problem in cancer treatment. In the present study, the role of neem leaf glycoprotein (NLGP), a novel immunomodulator, in prevention of post-surgical recurrence of solid sarcoma was examined. Data suggest that NLGP prevents tumor recurrence after surgical removal of sarcoma in Swiss mice and increases their tumor-free survival time. In NLGP-treated tumor-free mice, increased cytotoxic CD8+ T cells and a decreased population of suppressor cells, especially myeloid-derived suppressor cells (MDSCs) was observed...
2017: PloS One
https://www.readbyqxmd.com/read/28384103/emulsion-of-chloramphenicol-an-overwhelming-approach-for-ocular-delivery
#12
Kalpesh C Ashara, Ketan V Shah
BACKGROUND: Ophthalmic formulations of chloramphenicol have poor bioavailability of chloramphenicol in the ocular cavity. AIM: The present study aimed at exploring the impact of different oil mixtures in the form of emulsion on the permeability of chloramphenicol after ocular application. MATERIALS AND METHODS: Selection of oil mixture and ratio of the components was made by an equilibrium solubility method. An emulsifier was chosen according to its emulsification properties...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28370810/the-effects-of-neem-oil-azadirachta-indica-a-juss-enriched-with-different-concentrations-of-azadirachtin-on-the-integument-of-semi-engorged-rhipicephalus-sanguineus-sensu-lato-acari-ixodidae-females
#13
José Ribamar Lima de Souza, Rafael Neodini Remedio, André Arnosti, Rusleyd Maria Magalhães de Abreu, Maria Izabel Camargo-Mathias
Several studies searching for methods to control Rhipicephalus sanguineus s.l., (dog tick) infestations have been developed aiming to minimize the damages caused by these ectoparasites to the hosts and the environment, which is harmed by the indiscriminate use of toxic acaricide products. In this scenario, neem oil has been used as a natural alternative against ticks, once this chemical has repellent properties and interferes in the growth regulation of these ectoparasites, inhibiting ecdysis. The present study evaluated the effects of azadirachtin-enriched neem oil on the integument of semi-engorged R...
March 29, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28361965/transcriptomics-and-proteomic-studies-reveal-acaricidal-mechanism-of-octadecanoic-acid-3-4-tetrahydrofuran-diester-against-sarcoptes-scabiei-var-cuniculi
#14
Xu Song, Zhenzhen Chen, Renyong Jia, Mei Cao, Yuanfeng Zou, Lixia Li, Xiaoxia Liang, Lizi Yin, Changliang He, Guizhou Yue, Zhongqiong Yin
In our previous study, a new compound, octadecanoic acid-3, 4-tetrahydrofuran diester, possessing potent acaricidal activity was obtained from neem oil. This study performed RNA-seq transcriptomics and iTRAQ proteomics to uncover the acaricidal mechanism of the compound against Sarcoptes scabiei var. cuniculi. The results of transcriptomics indicated that after treatment with octadecanoic acid-3, 4-tetrahydrofuran diester, genes related to "Energy metabolism" were significantly up-/down-regulated, including citrate cycle, oxidative phosphorylation pathway and fatty acid metabolism...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28347172/ultrastructural-changes-in-raillietina-platyhelminthes-cestoda-exposed-to-sulfonoquinovosyldiacylglyceride-sqdg-isolated-from-neem-azadirachta-indica
#15
Anirban Ash, Yogesh P Bharitkar, Sanatan Murmu, Abhijit Hazra, V Ravichandiran, Pradip Kumar Kar, Nirup Bikash Mondal
Neem (Azadirachta indica), has been known to be a curative for various ailments and diseases in the traditional Indian medicinal system from times immemorial. A glycolipid sulfonoquinovosyldiacylglyceride (SQDG) isolated from the leaves of neem has been found to be a proactive antibacterial and antiviral agent in previous studies. The current communication pertains to the anthelmintic activity of SQDG in vitro against a model cestode Raillietina spp. The results of efficacy tests showed a paralysis time of 1...
March 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28330106/enhanced-production-of-pectinase-by-aspergillus-terreus-ncft-4269-10-using-banana-peels-as-substrate
#16
Bijay Kumar Sethi, Prativa Kumari Nanda, Santilata Sahoo
Aspergillus terreus NCFT4269.10 was implemented in solid-state (SSF) and liquid static surface fermentation (LSSF) for biosynthesis of pectinase. Amongst various substrates, like, mustard oil cake, neem oil cake, groundnut oil cake, black gram peels, green gram peels, chickling vetch peels/grass pea peels wheat bran, pearl millet residues, finger millet waste, broken rice, banana peels (BP), apple pomace (AP) and orange peels, banana peel (Musa paradisiaca L.; Family: Musaceae) was most suitable for pectinase biosynthesis (LSSF: 400 ± 21...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28319870/topical-application-of-neem-leaves-prevents-wrinkles-formation-in-uvb-exposed-hairless-mice
#17
Hien T T Ngo, Eunson Hwang, Seul-A Seo, Bom Park, Zheng-Wang Sun, Mengyang Zhang, Yu-Kyong Shin, Tae-Hoo Yi
No abstract text is available yet for this article.
March 14, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28296187/lethal-and-sublethal-effects-of-pesticides-in-the-management-of-polyphagotarsonemus-latus-banks-acari-tarsonemidae-on-capsicum-annuum-l
#18
Mariana O Breda, José V Oliveira, Alberto B Esteves Filho, Douglas Rs Barbosa, Andrezo A Santos
BACKGROUND: The evaluation of lethal and sublethal effects is of great importance for a complete assessment of the total impact of chemical compounds upon pest populations and the development of management strategies. In this study, we evaluated the lethal and sublethal effects of different synthetic and botanical products on the broad mite Polyphagotarsonemus latus (Banks), a major pest of Capsicum annuum L. and other crops. RESULTS: Abamectin had the highest lethal effect on P...
March 15, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28278641/a-new-azadirachta-from-the-crude-extracts-of-neem-azadirachta-indica-a-juss-seeds
#19
Quan Gao, Jia Sun, Hang Xun, Xi Yao, Jin Wang, Feng Tang
One new compound, 2H, 3H-cyclopent[b] furo [2',3':4,5] naphtho [2,4-d] heptlactone-[3,7] furan-6aceticacid, 3-(acetyloxy)-8-(3-furyl)-2a, 4a, 4b, 4c,5,5a, 6, 6a, 8, 9,9a, 10a,10b-13 hydrogen-2a,5a,6a,5-tetramethyl-3-[[(2E)-2-methyl-1-oxo-2-butenyl]oxy]-methyl ester, named azadirachta R (1), along with 10 known ones, Azadirachta A, AZ-B, AZ-D, AZ-H, AZ-I, nimbin, deacetylnimbin, salannin, deacetylsalannin and azadiradione were isolated from the crude extracts of neem (Azadirachta indica A. Juss) seeds, which were determined by UV, IR, HR-ESI-MS and NMR data analyses...
February 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28246003/in-vitro-evaluation-of-acaricidal-activity-of-novel-green-silver-nanoparticles-against-deltamethrin-resistance-rhipicephalus-boophilus-microplus
#20
B Avinash, R Venu, M Alpha Raj, K Srinivasa Rao, Ch Srilatha, T N V K V Prasad
An investigation was undertaken to study, for the first time, in vitro acaricidal activity of green silver nanoparticles on deltamethrin resistance Rhipicephalus (Boophilus) microplus. The compounds tested were neem coated silver nanoparticles (N-Ag NPs), deltamethrin neem coated silver nanoparticles (DN-Ag NPs), 2, 3 dehydrosalannol (2,3 DHS), 2, 3 DHS coated silver nanoparticles (2, 3-DHS-Ag NPs), Quercetin dihydrate (QDH) and QDH coated silver nanoparticles (QDH-Ag NPs). Also included in this study, for the purpose of comparison, were neem leaf extract (NLE), silver nitrate (AgNO3) and deltamethrin (D)...
February 21, 2017: Veterinary Parasitology
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