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https://www.readbyqxmd.com/read/28104616/sequential-colonization-of-periodontal-pathogens-in-induction-of-periodontal-disease-and-atherosclerosis-in-ldlrnull-mice
#1
Sasanka S Chukkapalli, Meena Easwaran, Mercedes F Rivera-Kweh, Irina M Velsko, Sriram Ambadapadi, Jiayin Dai, Hannu Larjava, Alexandra R Lucas, Lakshmyya Kesavalu
Periodontal disease (PD) and atherosclerotic vascular disease (ASVD) are both chronic inflammatory diseases with a polymicrobial etiology and have been epidemiologically associated. The purpose is to examine whether periodontal bacteria that infect the periodontium, can also infect vascular tissues and enhance pre-existing early aortic atherosclerotic lesions in LDLR(null) mice. Mice were orally infected with intermediate bacterial colonizer Fusobacterium nucleatum for the first 12 weeks followed by late bacterial colonizers (Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia) for the remaining 12 weeks mimicking the human oral microbiota ecological colonization...
January 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28099577/effects-of-periodontal-treatment-on-primary-sj%C3%A8-gren-s-syndrome-symptoms
#2
Lucas Macedo Batitucci Ambrósio, Emanuel da Silva Rovai, Bruno Nunes de França, Danilo Andrés Balzarini, Ieda Santos Abreu, Sheyla Batista Bologna Lopes, Thaís Borguezan Nunes, Silvia Vanessa Lourenço, Sandra Gofinet Pasoto, Luciana Saraiva, Marinella Holzhausen
The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively)...
January 16, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28089378/butyrate-production-under-aerobic-growth-conditions-by-engineered-escherichia-coli
#3
Naoya Kataoka, Alisa S Vangnai, Thunyarat Pongtharangkul, Toshiharu Yakushi, Kazunobu Matsushita
Butyrate is an important industrial platform chemical. Although several groups have reported butyrate production under oxygen-limited conditions by a native producer, Clostridium tyrobutylicum, and by a metabolically engineered Escherichia coli, efforts to produce butyrate under aerobic growth conditions have met limited success. Here, we constructed a novel butyrate synthetic pathway that functions under aerobic growth conditions in E. coli, by modifying the 1-butanol synthetic pathway reported previously...
January 11, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28068479/secretable-small-rnas-via-outer-membrane-vesicles-in-periodontal-pathogens
#4
J-W Choi, S-C Kim, S-H Hong, H-J Lee
MicroRNAs (miRNAs) have been shown to be major regulators of eukaryotic gene expression. However, bacterial RNAs comparable in size to eukaryotic miRNAs (18-22 nucleotides) have received little attention. Recently, a novel class of small RNAs similar in size to miRNAs (miRNA-size, small RNAs or msRNAs) have also been found in several bacteria. Like miRNAs, msRNAs are approximately 15 to 25 nucleotides in length, and their precursors are predicted to form a hairpin loop secondary structure. Here, we identified msRNAs in the periodontal pathogens Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Treponema denticola...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28050984/evaluation-of-bacteriological-profile-in-the-apical-root-segment-of-the-patients-with-primary-apical-periodontitis
#5
Aravind Tatikonda, N Sudheep, Krishna P Biswas, K Gowtham, Sudarshan Pujari, Padam Singh
INTRODUCTION: Apical periodontitis usually results from bacterial accumulation and contamination occurring in the root-canal system, and extending beyond the apical foramen to involve the periapical tissues. Literature has a paucity of the studies that stress on the division and analysis of the pulp canal segments. The reason for this disparity might be the technique used for collecting the samples from the pulp canals. Hence, we carried out the present study to evaluate the microbial flora in the apical part of the roots with necrotic pulp canals...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28018496/an-experimental-model-of-peripheral-vascular-disease-involving-the-intravenous-injection-of-oral-bacteria
#6
Kimihiro Igari, Yoshinori Inoue, Takehisa Iwai
Objective: The purpose of this study was to observe the direct effects of oral bacteria, such as Porphyromonas gingivalis (Pg) and Treponema denticola (Td), on the peripheral vasculature. Materials and Methods: Beagles were directly injected (at various doses) with Pg or Td. Each leg vein was exposed, ligated at proximal and distal sites, and then injected with bacteria diluted with sterile saline. The collected vascular tissue was examined microscopically, and samples of the vascular tissue and blood were cultured and then subjected to the polymerase chain reaction (PCR) in order to detect the bacterial deoxyribonucleic acid (DNA)...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/28009086/1-2-diacylglycerol-choline-phosphotransferase-catalyzes-the-final-step-in-the-unique-treponema-denticola-phosphatidylcholine-biosynthesis-pathway
#7
Miguel Ángel Vences-Guzmán, M Paula Goetting-Minesky, Ziqiang Guan, Santiago Castillo-Ramirez, Luz América Córdoba-Castro, Isabel M López-Lara, Otto Geiger, Christian Sohlenkamp, J Christopher Fenno
Treponema denticola synthesizes phosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Treponema. However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear. We report here characterization of TDE0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step of the highly conserved Kennedy pathway for phosphatidylcholine synthesis in eukaryotes...
December 23, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27994415/detection-of-porphyromonas-gingivalis-and-treponema-denticola-in-chronic-and-aggressive-periodontitis-patients-a-comparative-polymerase-chain-reaction-study
#8
Ramniwas M Kumawat, Sindhu M Ganvir, Vinay K Hazarey, Asifa Qureshi, Hemant J Purohit
BACKGROUND: The detection frequency of Porphyromonas gingivalis and Treponema denticola in chronic periodontitis (CP) and aggressive periodontitis (AgP) is not explored well in Indian population. AIM: The study was undertaken to detect P. gingivalis and T. denticola in CP as well as in AgP patients using polymerase chain reaction (PCR), and to determine the relationship between the frequency of these two microorganisms and the severity of clinical periodontal parameters...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27966504/evaluation-of-efficacy-of-photodynamic-therapy-as-an-adjunct-to-nonsurgical-periodontal-therapy-in-treatment-of-chronic-periodontitis-patients-a-clinico-microbiological-study
#9
K Ravi Raj, Svvs Musalaiah, M Nagasri, P Aravind Kumar, P Indeevar Reddy, M Greeshma
BACKGROUND AND OBJECTIVES: Photodynamic therapy (PDT) is a local noninvasive treatment modality without side effects caused by antibiotics. The aim of this study was to evaluate the efficacy of adjunctive use of PDT with scaling and root planing as compared with SRP alone in the treatment of chronic periodontitis. SUBJECTS AND METHODS: Twenty participants with chronic periodontitis having probing pocket depths (PDs) of ≥5 mm were selected for the study. Patients were randomly divided into control group and test group with ten patients in each group...
September 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27914958/comparative-analysis-of-motility-and-other-properties-of-treponema-denticola-strains
#10
Keiji Nagano, Yoshiaki Hasegawa, Yasuo Yoshida, Fuminobu Yoshimura
The periodontitis-associated pathogen Treponema denticola is a spirochetal bacterium that swims by rotating its cell body like a corkscrew using periplasmic flagella. We compared physiologic and pathogenic properties, including motility, in four strains of T. denticola. Phase-contrast microscopy showed differential motility between the strains; ATCC 35404 showed the highest motility, followed by ATCC 33521, and the remaining two strains (ATCC 35405 and ATCC 33520) showed the lowest motility. Transmission electron microscopy showed that the low motility strains exhibited extracellular flagellar protrusions resulting from elongated flagella...
January 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27899684/high-risk-periodontal-pathogens-contribute-to-the-pathogenesis-of-atherosclerosis
#11
REVIEW
Bradley Field Bale, Amy Lynn Doneen, David John Vigerust
Periodontal disease (PD) is generated by microorganisms. These microbes can enter the general circulation causing a bacteraemia. The result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. Level A evidence supports that PD is independently associated with arterial disease. PD is a common chronic condition affecting the majority of Americans 30 years of age and older. Atherosclerosis remains the largest cause of death and disability. Studies indicate that the adverse cardiovascular effects from PD are due to a few putative or high-risk bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola or Fusobacterium nucleatum There are three accepted essential elements in the pathogenesis of atherosclerosis: lipoprotein serum concentration, endothelial permeability and binding of lipoproteins in the arterial intima...
November 29, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27888369/prevalence-of-periodontal-pathogens-as-predictor-of-the-evolution-of-periodontal-status
#12
Miriam Puig-Silla, José María Montiel-Company, Francisco Dasí-Fernández, José Manuel Almerich-Silla
The aim of this study was to determine the relationship between the prevalence of Porphyromonas gingivalis, its fimA genotypes, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Treponema denticola and the evolution of periodontal health. In a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. PCR was employed to determine the presence of the periodontopathogenic bacteria...
November 25, 2016: Odontology
https://www.readbyqxmd.com/read/27876716/-the-relationship-of-molecular-genetic-markers-with-clinical-signs-and-risk-factors-of-periodontitis
#13
O A Zorina, N K Aimadinova, A A Basova, D V Rebrikov
The study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P. intermedia and Tannerella forsythensis. Expression of IL8, TNF-α, MMP8 and MMP9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing IL8 as positive diagnostic marker...
2016: Stomatologii︠a︡
https://www.readbyqxmd.com/read/27864174/multilocus-sequence-analysis-of-phylogroup-1-and-2-oral-treponeme-strains
#14
Yong-Biao Huo, Yuki Chan, Donnabella C Lacap-Bugler, Sisu Mo, Patrick C Y Woo, W Keung Leung, Rory M Watt
: More than 75 "species-level" phylotypes of spirochete bacteria belonging to the genus Treponema reside within the human oral cavity. The majority of these oral treponeme phylotypes correspond to as-yet-uncultivated taxa or strains of uncertain standing in taxonomy. Here, we analyze phylogenetic and taxonomic relationships between oral treponeme strains using a multilocus sequence analysis (MLSA) scheme based on the highly conserved 16S rRNA, pyrH, recA, and flaA genes. We utilized this MLSA scheme to analyze genetic data from a curated collection of oral treponeme strains (n = 71) of diverse geographical origins...
February 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27858553/cross-sectional-evaluation-of-periodontal-status-microbiological-and-rheumatoid-parameters-in-a-large-cohort-of-patients-with-rheumatoid-arthritis
#15
Jan Schmickler, Annegret Rupprecht, Susann Patschan, Daniel Patschan, Gerhard A Müller, Rainer Haak, Rainer F Mausberg, Gerhard Schmalz, Tanja Kottmann, Dirk Ziebolz
BACKGROUND: This study evaluates periodontal conditions and microbiological findings and their influence on rheumatological disease parameters in patients with rheumatoid arthritis (RA). METHODS: 168 RA-patients were included. A healthy control group (HC, n=168) was composed according to age, gender and smoking habits. Rheumatological data (duration of illness, DAS28, RF, aCCP, medications) were extracted from patients' records. Dental examination included: dental findings (DMF-T), gingival inflammation (PBI), periodontal status (probing depth [PD], attachment loss [AL])...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27786620/a-novel-rat-model-of-polymicrobial-peri-implantitis-a-preliminary-study
#16
Theofilos Koutouzis, Christie Eastman, Sasanka Chukkapalli, Hannu Larjava, Lakshmyya Kesavalu
BACKGROUND: Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. There are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known microbial biofilms observed in humans. The aim is to develop a novel peri-implant rat model using an established model of polymicrobial periodontitis. METHODS: Wistar rats were used for the study of experimental peri-implantitis...
October 27, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27786617/comparison-of-two-different-sampling-methods-for-subgingival-plaque-subgingival-paper-points-or-mouthrinse-sample
#17
Katrin Nickles, Susanne Scharf, Lasse Röllke, Bettina Dannewitz, Peter Eickholz
OBJECTIVE: The collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. The collection of saliva, however, is simple and contains pathogens of all intraoral surfaces. The aim of this study is to investigate whether sampling with a mouthrinse (mouthrinse sample/MSP; test) leads to comparable results as the standard sampling method (multiple site test from the deepest pocket of each quadrant/MT4; control). METHODS: In 50 patients with periodontitis, subgingival plaque was sampled from the deepest pocket of each quadrant by using paper points and by gaining saliva with a saline mouthrinse...
October 27, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27745799/bacteria-in-the-apical-root-canals-of-teeth-with-apical-periodontitis
#18
Li-Wan Lee, Ya-Ling Lee, Sheng-Huang Hsiao, Hung-Pin Lin
BACKGROUND/PURPOSE: Bacteria in the tooth root canal may cause apical periodontitis. This study examined the bacterial species present in the apical root canal of teeth with apical periodontitis. Antibiotic sensitivity tests were performed to evaluate whether these identified bacterial species were susceptible to specific kinds of antibiotics. METHODS: Selective media plating and biochemical tests were used first to detect the bacterial species in samples taken from the apical portion of root canals of 62 teeth with apical periodontitis...
October 10, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27727287/salivary-periodontopathic-bacteria-in-children-and-adolescents-with-down-syndrome
#19
Camila Faria Carrada, Flávia Almeida Ribeiro Scalioni, Dionéia Evangelista Cesar, Karina Lopes Devito, Luiz Cláudio Ribeiro, Rosangela Almeida Ribeiro
OBJECTIVE: To assess and compare salivary periodontopathic bacteria between groups of Down syndrome and non-Down syndrome children and adolescents. MATERIALS AND METHODS: This study included a sample of 30 Down syndrome children and adolescents (G-DS) and 30 age- and sex-matched non-Down syndrome subjects (G-ND). Clinical examination determined the gingival bleeding index (GBI) and plaque index. Unstimulated whole saliva samples were collected from all participants...
2016: PloS One
https://www.readbyqxmd.com/read/27727278/associations-of-toll-like-receptor-and-%C3%AE-defensin-polymorphisms-with-measures-of-periodontal-disease-pd-in-hiv-north-american-adults-an-exploratory-study
#20
Rajeev K Mehlotra, Noemi B Hall, Barne Willie, Catherine M Stein, Aaron Weinberg, Peter A Zimmerman, Lance T Vernon
Polymorphisms in toll-like receptor (TLR) and β-defensin (DEFB) genes have been recognized as potential genetic factors that can influence susceptibility to and severity of periodontal diseases (PD). However, data regarding associations between these polymorphisms and PD are still scarce in North American populations, and are not available in HIV+ North American populations. In this exploratory study, we analyzed samples from HIV+ adults (n = 115), who received primary HIV care at 3 local outpatient HIV clinics and were monitored for PD status...
2016: PloS One
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