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https://www.readbyqxmd.com/read/29771309/identification-of-a-specific-domain-of-porphyromonas-gingivalis-hgp44-responsible-for-adhesion-to-treponema-denticola
#1
Kouki Yoshikawa, Yuichiro Kikuchi, Eitoyo Kokubu, Kentaro Imamura, Atsushi Saito, Kazuyuki Ishihara
Interaction between two periodontal pathogens, Porphyromonas gingivalis and Treponema denticola, contributes to plaque biofilm formation. P. gingivalis forms aggregates with T. denticola through its adhesion/hemagglutinin domain (Hgp44). In this study, we investigated the specific domain of P. gingivalis Hgp44 responsible for adhesion to T. denticola using expression vectors harboring P. gingivalis Hgp44 DNA sequences encoding amino acid residues 1-419. Six plasmids harboring fragments in this region were generated by PCR amplification and self-ligation, and recombinant proteins r-Hgp44 (residues 1-419), r-Hgp441 (residues 1-124), r-Hgp442 (1-199), r-Hgp443 (1-316), r-Hgp444 (199-419), r-Hgp445 (124-198), and r-Hgp446 (199-316) were produced, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting...
May 16, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29766330/laser-reduction-of-specific-microorganisms-in-the-periodontal-pocket-using-er-yag-and-nd-yag-lasers-a-randomized-controlled-clinical-study
#2
K Grzech-Leśniak, A Sculean, Boris Gašpirc
The objective of this study was to evaluate the microbiological and clinical outcomes following nonsurgical treatment by either scaling and root planing, combination of Nd:YAG and Er:YAG lasers, or by Er:YAG laser treatment alone. The study involved 60 patients with generalized chronic periodontitis, randomly assigned into one of three treatment groups of 20 patients. The first group received scaling and root planing by hand instruments (SRP group), the second group received Er:YAG laser treatment alone (Er group), and the third group received combined treatment with Nd:YAG and Er:YAG lasers (NdErNd group)...
May 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29753881/confocal-fluorescence-imaging-to-evaluate-the-effect-of-antimicrobial-photodynamic-therapy-depth-on-p-gingivalis-and-t-denticola-biofilms
#3
Stephen Rogers, Kiyonobu Honma, Thomas S Mang
BACKGROUND: Porphyromonas gingivalis and Treponema denticola are both principally implicated in the incidence of both periodontal disease and peri-implantitis. Recent studies have demonstrated that these bacteria exhibit symbiotic growth in vitro and a synergistic virulence in co-infection of animal models. Found at varying depths throughout the biofilm, these bacteria present a significant challenge to traditional antimicrobial treatment modalities. Antimicrobial photodynamic therapy ( aPDT ) has yielded high success against bacterial biofilms, namely those found in the oral cavity...
May 10, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29747237/treponema-denticola-chymotrypsin-like-proteinase-is-present-in-early-stage-mobile-tongue-squamous-cell-carcinoma-and-related-to-the-clinicopathological-features
#4
Dyah Listyarifah, Mikko T Nieminen, Laura K Mäkinen, Caj Haglund, Daniel Grenier, Valtteri Häyry, Dan Nordström, Marcela Hernandez, Tülay Yucel-Lindberg, Taina Tervahartiala, Mari Ainola, Timo Sorsa, Jaana Hagström
BACKGROUND: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics...
May 10, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29744199/putative-periodontopathic-bacteria-and-herpes-viruses-interactions-in-the-subgingival-plaque-of-patients-with-aggressive-periodontitis-and-healthy-controls
#5
Amal Elamin, Raouf Wahab Ali, Vidar Bakken
The microbial profile of aggressive periodontitis patients is considered to be complex with variations among populations in different geographical areas. The aim of this study was to assess the presences of 4 putative periodontopathic bacteria (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) and 2 periodontal herpes viruses (Epstein-Barr virus type 1 [EBV-1] and human cytomegalovirus [HMCV]) in subgingival plaque of Sudanese subjects with aggressive periodontitis and healthy controls...
October 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29736391/the-effects-of-antimicrobial-peptide-nal-p-113-on-inhibiting-periodontal-pathogens-and-improving-periodontal-status
#6
Hongyan Wang, Lisi Ai, Yu Zhang, Jyawei Cheng, Huiyuan Yu, Chen Li, Dongmei Zhang, Yaping Pan, Li Lin
Periodontal disease consists of chronic gingival inflammation characterized by both degradation of the periodontal connective tissue and alveolar bone loss. Drug therapy is used as an auxiliary treatment method in severe chronic periodontitis, aggressive periodontitis, and periodontitis-associated systemic disease. Nal-P-113, a modified antimicrobial peptide, specifically replaces the histidine residues of P-113 with the bulky amino acid β -naphthylalanine, and our previous studies have verified that this novel peptide is not toxic to the human body within a certain concentration range...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29728099/relationship-between-the-burden-of-major-periodontal-bacteria-and-serum-lipid-profile-in-a-cross-sectional-japanese-study
#7
Youn-Hee Choi, Takayuki Kosaka, Miki Ojima, Shinichi Sekine, Yoshihiro Kokubo, Makoto Watanabe, Yoshihiro Miyamoto, Takahiro Ono, Atsuo Amano
BACKGROUND: The association of periodontal bacteria with lipid profile alteration remains largely unknown, although it has been suggested that chronic periodontitis increases the atherosclerotic risk. This cross-sectional study investigated the relationship between the prevalence and total burden of periodontal bacteria and serum lipid profile. METHODS: Saliva from enrolled participants was collected to detect 4 major periodontal bacteria (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Prevotella intermedia) using Polymerase Chain Reaction method...
May 4, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29721223/periopathogenic-bacteria-in-dental-plaque-of-congolese-patients-with-periodontitis-a-pilot-study
#8
Em Kalala-Kazadi, Jean-Paul Sekele-Issouradi, Jaques Bolenge-Ileboso, Jérôme F Lasserre, Augustin Mantshumba-Milolo, Hubert Ntumba-Mulumba, Michel C Brecx
Background: Periopathogenic bacteria play an important role in the etiology of periodontal disease. At present, no study screening for periopathogens in the DR Congo was carried out. The aim of this pilot study was to investigate the prevalence of five periopathogens in Congolese patients with periodontitis and to determine the association between these bacteria. Material and Methods: Twelve patients (eight women and four men) with a mean age of 45 ± 19 years from those consulted in dental services of two medical centers of Kinshasa from April 2017 to October 2017 were included...
March 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29680846/association-of-time-under-immunosuppression-and-different-immunosuppressive-medication-on-periodontal-parameters-and-selected-bacteria-of-patients-after-solid-organ-transplantation
#9
G Schmalz, L Berisha, H Wendorff, F Widmer, A Marcinkowski, H Teschler, U Sommerwerck, R Haak, O Kollmar, D Ziebolz
BACKGROUND: Aim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT). MATERIAL AND METHODS: 169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and >10 years) and form of immunosuppression (Tacrolimus, Cyclosporine, Mycophenolate, Glucocorticoids, Sirolimus and monotherapy vs...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29593415/exercise-habituation-is-effective-for-improvement-of-periodontal-disease-status-a-prospective-intervention-study
#10
Shoei Omori, Fumihiko Uchida, Sechang Oh, Rina So, Takehiko Tsujimoto, Toru Yanagawa, Satoshi Sakai, Junichi Shoda, Kiyoji Tanaka, Hiroki Bukawa
Background and purpose: Periodontal disease is closely related to lifestyle-related diseases and obesity. It is widely known that moderate exercise habits lead to improvement in lifestyle-related diseases and obesity. However, little research has been undertaken into how exercise habits affect periodontal disease. The purpose of this study was to examine the effect of exercise habits on periodontal diseases and metabolic pathology. Methods: We conducted a prospective intervention research for 12 weeks...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29589156/effects-of-non-surgical-periodontal-therapy-on-periodontal-laboratory-and-clinical-data-as-well-as-on-disease-activity-in-patients-with-rheumatoid-arthritis
#11
Raluca Cosgarea, Roxana Tristiu, Raluca Bianca Dumitru, Nicole Birgit Arweiler, Simona Rednic, Cristina Ioana Sirbu, Liana Lascu, Anton Sculean, Sigrun Eick
OBJECTIVES: To compare the effect of non-surgical periodontal therapy on clinical and inflammatory parameters in patients with moderate to severe chronic periodontitis (CP) and rheumatoid arthritis (RA) (RA-CP) with that in CP patients without RA. MATERIAL AND METHODS: Eighteen patients with RA-CP and 18 systemically healthy patients with CP were treated with scaling and root planing (SRP) within 24 h. At baseline, and at 3 and 6 months after SRP, clinical periodontal parameters, inflammatory markers, and microorganisms in subgingival biofilm were assessed...
March 27, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29537663/effect-of-compliance-during-periodontal-maintenance-therapy-on-levels-of-bacteria-associated-with-periodontitis-a-6-year-prospective-study
#12
Fernando Oliveira Costa, Thaís Riberal Vieira, Sheila Cavalca Cortelli, Luís Otávio Miranda Cota, José Eustáquio Costa, Maria Cássia Ferreira Aguiar, José Roberto Cortelli
BACKGROUND: It is well established that regular compliance during periodontal maintenance therapy (PMT) maintains the stability of periodontal clinical parameters obtained after active periodontal therapy (APT). However, compliance during PMT has not yet been related to subgingival bacterial levels. Thus, this study followed individuals in PMT over 6 years and longitudinally evaluated the effects of compliance on periodontitis-associated bacterial levels and its relation to periodontal status...
March 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29534128/the-efficacy-of-an-anatase-coated-collar-surface-in-inhibiting-the-bacterial-colonization-of-oral-implants-a-pilot-prospective-study-in-humans
#13
Alessandro Cucchi, Federica Molè, Lucia Rinaldi, Claudio Marchetti, Giuseppe Corinaldesi
PURPOSE: The primary prevention of peri-implantitis onset is a key factor in long-term implant success, and the evaluation of the antibacterial efficacy of different implant surfaces is fundamental in this way. The aim of this study was to assess if implants with collars coated with anatase were less subjected to bacterial colonization than implants with noncoated collars, and to investigate how implant bacterial colonization varies over time. MATERIALS AND METHODS: Eighteen patients in need of implant-supported rehabilitation were selected to have two adjacent implants placed, one with an anatase-coated collar and one with the collar uncoated...
March 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29525436/inhibition-of-methionine-gamma-lyase-deaminase-and-the-growth-of-porphyromonas-gingivalis-a-therapeutic-target-for-halitosis-periodontitis
#14
U Kandalam, N Ledra, H Laubach, K V Venkatachalam
BACKGROUND AND OBJECTIVES: Pathogenic infections caused by Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia can result in the production of volatile sulfur compounds (VSC's) and other toxic compounds from methionine catabolism that can lead to halitosis and periodontitis. Our aim is to block the activity of methionine gammalyase-deaminase (Mgld) of methionine catabolism to prevent halitosis/periodontitis. DESIGNS: Cloned, expressed, Mgld protein was tested for purity by SDS-PAGE and western blotting...
March 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29520798/influence-of-periodontal-treatment-on-subgingival-and-salivary-microbiotas
#15
Daniel Belstrøm, Maria Anastasia Grande, Maria Lynn Sembler-Møller, Nikolai Kirkby, Sean L Cotton, Bruce J Paster, Palle Holmstrup
BACKGROUND: The purpose of this study was to characterize and compare subgingival and salivary microbiotas before and after periodontal treatment to learn if any changes of the subgingival microbiota were reflected in saliva. We tested the hypothesis that salivary levels of specific periopathogens correlate with corresponding subgingival levels before and after periodontal treatment. METHODS: Twenty-five patients with generalized chronic periodontitis completed the study...
February 19, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29505065/ageing-with-hiv-a-periodontal-perspective
#16
Boško Toljić, Alexander M Trbovich, Sanja Matić Petrović, Ibrahim Yousif Kannosh, Gordana Dragović, Djordje Jevtović, Silvio R De Luka, Jasna L Ristić-Djurović, Jelena Milašin
The importance of oral microflora composition in HIV-infected patients is well recognized. However, no studies so far have dealt with age-related changes in periodontal pathogens occurrence in HIV+ individuals. The aim of the present study was to assess and compare temporal changes of bacteria frequency in younger (≤35 years) and older (≥50 years) HIV-infected and non-infected individuals. Bacterial DNA was isolated from buccal swabs of 30 younger and 30 older subjects in both HIV+ and HIV- groups. By means of PCR the following microorganisms were detected: Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Peptostreptococcus micros, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola...
January 2018: New Microbiologica
https://www.readbyqxmd.com/read/29498487/plasminogen-binding-and-degradation-by-treponema-denticola-identification-of-the-plasminogen-binding-interface-on-the-fhbb-protein
#17
B K Tegels, L D Oliver, D P Miller, R T Marconi
Treponema denticola is a proteolytic-anaerobic spirochete whose abundance in the subgingival crevice correlates with periodontal disease severity. Treponema denticola evades serum-mediated killing through the binding of factor H (FH), a negative regulator of the complement system. The T. denticolaFH receptor has been identified as FhbB, an 11.4kDa immunodominant lipoprotein. Three distinct subfamilies of FhbB proteins have been delineated and designated as FhbB1, FhbB2 and FhbB3. In this study we demonstrate that all FhbB variants bind human plasminogen (Plg)...
June 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29480639/response-of-epithelial-cells-infected-by-treponema-denticola
#18
E Kokubu, T Inoue, K Ishihara
OBJECTIVE: In the gingival crevice, the interaction between epithelial cells and periodontopathic bacteria is important for the development of periodontitis. Treponema denticola is a major pathogen of chronic periodontitis and possesses several virulence factors, such as major surface protein (Msp) and prolyl-phenylalanine-specific protease (dentilisin). Here, we investigated the behaviours of epithelial cells infected with T. denticola by measuring the expression of interleukin (IL)-1β, IL-6, β defensin 2 (BD-2) and heat-shock protein 70 (HSP70)...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29468598/microbiological-analysis-and-the-outcomes-of-periodontal-treatment-with-or-without-adjunctive-systemic-antibiotics-a-retrospective-study
#19
Sigrun Eick, Jasmin Nydegger, Walter Bürgin, Giovanni E Salvi, Anton Sculean, Christoph Ramseier
OBJECTIVES: The purpose of this retrospective study was to assess the impact of microbiological diagnostics on the outcomes of periodontal treatment with or without adjunctive use of systemic antibiotics. MATERIALS AND METHODS: Patient files were screened for microbiological analysis before (T1) and after non-surgical periodontal therapy (T2). Medical history, diagnosis, clinical data, and results of the microbiological analysis were extracted from the patient's file...
February 21, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29467738/worlds-apart-transcriptome-profiles-of-key-oral-microbes-in-the-periodontal-pocket-compared-to-single-laboratory-culture-reflect-synergistic-interactions
#20
Zhi-Luo Deng, Helena Sztajer, Michael Jarek, Sabin Bhuju, Irene Wagner-Döbler
Periodontitis is a worldwide prevalent oral disease which results from dysbiosis of the periodontal microbiome. Some of the most active microbial players, e.g., Porphyromonas gingivalis, Treponema denticola , and Fusobacterium nucleatum , have extensively been studied in the laboratory, but it is unclear to which extend these findings can be transferred to in vivo conditions. Here we show that the transcriptional profiles of P. gingivalis, T. denticola , and F. nucleatum in the periodontal niche are distinct from those in single laboratory culture and exhibit functional similarities...
2018: Frontiers in Microbiology
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