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https://www.readbyqxmd.com/read/28890719/outer-membrane-vesicles-prime-and-activate-macrophage-inflammasomes-and-cytokine-secretion-in-vitro-and-in-vivo
#1
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, William Singleton, Alexis Perez-Gonzalez, Ashley Mansell, Eric C Reynolds
Outer membrane vesicles (OMVs) are proteoliposomes blebbed from the surface of Gram-negative bacteria. Chronic periodontitis is associated with an increase in subgingival plaque of Gram-negative bacteria, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. In this study, we investigated the immune-modulatory effects of P. gingivalis, T. denticola, and T. forsythia OMVs on monocytes and differentiated macrophages. All of the bacterial OMVs were phagocytosed by monocytes, M(naïve) and M(IFNγ) macrophages in a dose-dependent manner...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28858273/-microbiocenosis-of-subgingival-biofilm-and-intestinal-content-in-chronic-periodontal-disease-in-patients-with-metabolic-syndrome
#2
N B Petrukhina, O A Zorina, E V Shikh, E V Kartysheva
The aim of the study was to assess correlations of subgingival biofilm and intestinal microbiota in patients with chronic periodontal disease (CPD) and metabolic syndrome (MS). The study included 80 patients divided in 2 groups: 40 healthy individuals with no signs of periodontal disease and 40 patients with CPD and MS. Oral and intestinal microbial consortia compositions were revealed using deep sequencing libraries of 16S rDNA. The study showed than the qualitative composition of the intestinal microbiome in patients with CPD differ significantly from the microbiome of controls...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28854287/risk-of-superinfection-in-peri-implantitis-after-systemic-broad-spectrum-antibiotics
#3
Fernando Verdugo
Peri-implant disease has developed over the last few years as a complication that is often difficult to resolve. The disease process is mainly attributed to bacterial infection. Proposed combined therapies use broad-spectrum antibiotics to halt its progression. A major associated risk is the undetected development of superinfections that are difficult to eradicate. A group of healthy individuals with advanced peri-implantitis (PI) were referred for evaluation due to severe, rapidly progressive bone loss. Previous nonsurgical and empiric antibiotic therapy had been rendered...
August 30, 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28844191/microbiological-response-to-periodontal-therapy-and-multivariable-prediction-of-clinical-outcome
#4
Andrea Mombelli, Adnan Almaghlouth, Norbert Cionca, José Cancela, Delphine S Courvoisier, Catherine Giannopoulou
BACKGROUND: This study assessed the microbiological effects of a 2-phase antimicrobial periodontal therapy and tested microbiological, clinical, and biological markers as prognostic indicators for clinical success. METHODS: Eighty patients with chronic or aggressive periodontitis received periodontal treatment supplemented with 375 mg amoxicillin plus 500 mg metronidazole, 3/d for 7 days. In group A the antibiotics were given during the first, non-surgical (T1), in group B during the second, surgical, phase (T2)...
August 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28800622/microbial-profile-comparisons-of-saliva-pooled-and-site-specific-subgingival-samples-in-periodontitis-patients
#5
Daniel Belstrøm, Maria Lynn Sembler-Møller, Maria Anastasia Grande, Nikolai Kirkby, Sean Liam Cotton, Bruce J Paster, Palle Holmstrup
OBJECTIVES: The purpose of this study was to compare microbial profiles of saliva, pooled and site-specific subgingival samples in patients with periodontitis. We tested the hypotheses that saliva can be an alternative to pooled subgingival samples, when screening for presence of periopathogens. DESIGN: Site specific subgingival plaque samples (n = 54), pooled subgingival plaque samples (n = 18) and stimulated saliva samples (n = 18) were collected from 18 patients with generalized chronic periodontitis...
2017: PloS One
https://www.readbyqxmd.com/read/28766745/exploring-the-microbiome-of-healthy-and-diseased-peri-implant-sites-using-illumina-sequencing
#6
I Sanz-Martin, J Doolittle-Hall, R P Teles, M Patel, G N Belibasakis, C H Hämmerle, R E Jung, F R F Teles
AIM: To compare the microbiome of healthy (H) and diseased (P) peri-implant sites and determine the core peri-implant microbiome. MATERIALS AND METHODS: Submucosal biofilms from 32 H and 35 P sites were analyzed using 16S rRNA sequencing (MiSeq, Illumina), QIIME and HOMINGS. Differences between groups were determined using Principal Coordinate Analysis (PCoA), t-tests and Wilcoxon rank sum test and FDR-adjusted. The peri-implant core microbiome was determined. RESULTS: PCoA showed partitioning between H and P at all taxonomic levels...
August 2, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28764300/effect-of-pranayama-on-ppar-%C3%AE-nf-%C3%AE%C2%BAb-expressions-and-red-complex-microorganisms-in-patients-with-chronic-periodontitis-a-clinical-trial
#7
Jaideep Mahendra, Little Mahendra, R Ananthalakshmi, Prathahini S Parthiban, Sandhya Cherukuri, Mohammed Junaid
INTRODUCTION: Sudarshankriya pranayama is the control of breathing movements to regulate the energy flow throughout the body, which has shown to positively affect immune function, autonomic nervous system and psychologic-neuro pathways. The practice of pranayama has been proven to show several benefits such as reduction in stress levels, relieves anxiety and depression, increase in antioxidant levels, reduces insulin resistance and improves respiratory function. AIM: The objective of the study was to evaluate the levels of Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ), Nuclear Factor-Kappa B (NF-κB) and the presence of Red Complex Microorganisms (RCM) such as Treponema denticola, Porphyromonas gingivalis and Tannerella forsythia in the subgingivalpl aque samples of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to Scaling and Root Planing (SRP)...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28757933/prevalence-of-periodontal-pathogens-among-italian-patients-with-chronic-periodontitis-a-retrospective-study-on-2992-patients
#8
L Tettamanti, R M Gaudio, F Cura, D Mucchi, N Illuzzi, A Tagliabue
PURPOSE: The aim of the present study was to evaluate the prevalence of some periodontal pathogens in Italian adults with chronic periodontitis. MATERIALS AND METHODS: The sample consisted of 2992 patients with a clinical diagnosis of chronic periodontitis, based on the criteria of the American Academy of Periodontology, sampled in the period 2013-2016: 2108 patients were from Northern, 690 from Central and 194 from Southern Italy. Porphyromonas gengivalis, Treponema denticola, and Tannerella forsythia were investigated in all patients of the present study, while Campylobacter rectus, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans only in 2514 (84%) patients...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28748041/effect-of-azithromycin-on-a-red-complex-polymicrobial-biofilm
#9
Hwei Sze Ong, Orit Oettinger-Barak, Stuart G Dashper, Ivan B Darby, Kheng H Tan, Eric C Reynolds
Azithromycin has recently gained popularity for the treatment of periodontal disease, despite sparse literature supporting efficiency in treating periodontal bacterial biofilms. The aim of this study was to evaluate the effect of azithromycin on biofilms comprised of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in comparison to an amoxicillin and metronidazole combination. P. gingivalis W50, T. denticola ATCC35405, and T. forsythia ATCC43037 grown under anaerobic conditions at 37°C were aliquoted into 96-well flat-bottom plates in different combinations with addition of azithromycin or amoxicillin + metronidazole at various concentrations...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28691459/periodontal-microbioma-and-rheumatoid-arthritis-the-role-of-porhyromonas-gingivalis
#10
L Azzi, S Rania, R Vinci, F Spadari, F Croveri, C Scognamiglio, D Farronato, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
Rheumatoid Arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. The current study aims at evaluating the correlation between Rhematoid Arthritis (RA) and Periodontal Disease (PD), with special attention to the microbioma detected in the gums. Thirty-four patients with RD were recruited into the current study. Among rheumatic parameters, Rheumatoid Factor (RF), anti-citrullinated protein antibody (CCP), HLA-BDR1 and DAS28 were collected...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28686335/infection-and-apoptosis-associated-with-inflammation-in-periodontitis-an-immunohistologic-study
#11
D Listyarifah, A Al-Samadi, A Salem, A Syaify, T Salo, T Tervahartiala, D Grenier, D C Nordström, T Sorsa, M Ainola
OBJECTIVE: Evidence of increased apoptosis is observed in periodontitis and may be associated with destruction of the periodontal tissue caused by the increased cell death, with the release of danger signals and subsequent stimulation of the proinflammatory processes. However, the exact mechanisms associated with these processes remain unclear. This study aimed to investigate the presence of the periodontal pathogen Treponema denticola, apoptosis, high mobility group box 1 as a damage-associated molecular pattern, and several inflammatory markers in periodontitis and gingivitis subjects...
July 7, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28674708/the-association-of-periodontopathic-bacteria-levels-%C3%A2-in-saliva-and-tongue-coating-with-oral-malodor-in-periodontitis-patients
#12
Hironobu Takeuchi, Miho Machigashira, Naoshi Takeuchi, Toshiaki Nakamura, Kazuyuki Noguchi
PURPOSE: To elucidate the association oral malodor with the levels of periodontopathic bacteria in saliva and tongue coating of periodontitis patients with oral malodor. MATERIALS AND METHODS: In 25 periodontitis patients, the organoleptic test (OLT) was performed, the levels of volatile sulfur compounds (VSCs) were measured, tongue coating (TC) score was determined, and periodontal parameters and the proportions of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia and Prevotella intermedia in the saliva and the tongue coating were evaluated...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28671506/chronic-periodontal-disease-periodontal-pathogen-colonization-and-an-increased-risk-of-precancerous-gastric-lesions
#13
Jinghua Sun, Min Zhou, Christian R Salazar, Rosemary Hays, Sukhleen Bedi, Yu Chen, Yihong Li
BACKGROUND: The present study assessed the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (PLGC) in a clinical setting. METHODS: The present study included 35 newly diagnosed patients with PLGC and 70 age-matched individuals without PLGC. A full-mouth intra-oral examination was performed to assess the periodontal conditions. Stimulated whole saliva and pooled plaque samples were collected to evaluate colonization by Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia and Actinobacillus actinomycetemcomitans and to characterize the oral microbial diversity in the saliva and dental plaque...
July 3, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28667678/effects-of-photodynamic-therapy-in-periodontal-treatment-a-randomized-controlled-clinical-trial
#14
Marta Segarra-Vidal, Sol Guerra-Ojeda, Lilian Soraya Vallés, Andrés López-Roldán, María Dolores Mauricio, Martín Aldasoro, Francisco Alpiste-Illueca, Jose María Vila
AIM: To evaluate the effects of photodynamic therapy (PDT) in the nonsurgical treatment of chronic periodontitis. MATERIALS AND METHODS: A randomized, single-blind, controlled, parallel-group clinical trial was performed. Sixty patients were enrolled: 20 healthy controls and 40 patients with periodontitis. The 40 patients were randomized for scaling and root planing (SRP) or SRP + PDT. Periodontal (plaque index, probing depth, clinical recession, clinical attachment level, bleeding on probing and gingival crevicular fluid volume, corresponding to 381 versus 428 critical sites), microbiological (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia and Campylobacter rectus presence, 18 versus 19 samples) and biochemical (interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α, receptor activator of nuclear factor-kappaB ligand (RANK-L) and osteoprotegerin (OPG) levels, 18 versus 19 samples) parameters were recorded...
July 1, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28631313/salivary-gingival-crevicular-fluid-and-serum-levels-of-ghrelin-and-chemerin-in-patients-with-periodontitis-and-overweight
#15
H F R Jentsch, N Arnold, V Richter, J Deschner, T Kantyka, S Eick
BACKGROUND AND OBJECTIVE: Nutrition and body weight are modifying factors for periodontitis. The purpose of this study was to quantify two molecules (ghrelin and chemerin), released in association with food intake and obesity, in periodontally healthy and diseased individuals with respect to different body mass categories. MATERIAL AND METHODS: The two main groups (patients with chronic periodontitis and periodontally healthy/gingivitis volunteers) were subdivided into groups of subjects with normal weight [body mass index (BMI) <25] and groups of overweight/obese subjects (BMI ≥25)...
June 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28611978/periodontal-pathogens-in-the-etiology-of-pancreatic-cancer
#16
REVIEW
Mesut Öğrendik
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. Chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, collectively called the Red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28548883/simultaneous-detection-of-oral-pathogens-in-subgingival-plaque-and-prostatic-fluid-of-men-with-periodontal-and-prostatic-diseases
#17
John Estemalik, Catherine Demko, Nabil F Bissada, Nishant Joshi, Donald Bodner, Eswar Shankar, Sanjay Gupta
BACKGROUND: Chronic prostatitis (CP) and benign prostatic hyperplasia (BPH) are complex inflammatory conditions for which the etiological determinants are still poorly defined. Periodontitis is caused by subgingival colonizing bacteria in the oral cavity. The causal effect of periodontal disease on prostatic inflammation has not been established. The purpose of this study is to isolate oral pathogens from expressed prostatic secretions of patients with periodontal disease and chronic prostatitis or benign prostatic hyperplasia...
May 26, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28499236/putative-periodontal-pathogens-in-the-subgingival-plaque-of-sudanese-subjects-with-aggressive-periodontitis
#18
N T Hashim, G J Linden, L Winning, M E Ibrahim, B G Gismalla, F T Lundy, I A El Karim
BACKGROUND AND OBJECTIVES: There has been limited study of the bacterial species associated with aggressive periodontitis (AgP) in high-risk populations in Africa. The aim of this study was to investigate and quantify the presence of four putative periodontal pathogens in the subgingival plaque of Sudanese subjects with AgP. A secondary aim was to investigate the effect of varying the detection threshold on the reported prevalence of the bacterial species investigated. MATERIALS AND METHODS: Subgingival plaque samples were collected from AgP cases (n=73) and healthy controls (n=71)...
April 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28498507/effect-of-surgical-periodontal-treatment-associated-to-antimicrobial-photodynamic-therapy-on-chronic-periodontitis-a-randomized-controlled-clinical-trial
#19
Sérgio H L Martins, Arthur B Novaes, Mario Taba, Daniela B Palioto, Michel R Messora, Danilo M Reino, Sérgio L S Souza
AIM: This randomized controlled clinical trial evaluated the effects of an adjunctive single application of antimicrobial photodynamic therapy (aPDT) in Surgical Periodontal Treatment (ST) in patients with severe chronic periodontitis (SCP). MATERIAL AND METHODS: In a split-mouth design, 20 patients with SCP were treated with aPDT+ST (Test Group, TG) or ST only (Control Group, CG). aPDT was applied in a single episode, using a diode laser and a phenothiazine photosensitizer...
May 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28492362/microbiota-analysis-of-biofilms-on-experimental-abutments-mimicking-dental-implants-an-in-vivo-model
#20
Berta Cortés-Acha, Rui Figueiredo, Ramón Seminago, Francisco J Roig, Carlos Llorens, Eduard Valmaseda-Castellón
BACKGROUND: The microbiota colonizing dental implants has been said to be similar to the microbiome surrounding teeth. In the absence of inflammation, a biofilm with pathological bacteria can cover implant surfaces exposed to the oral cavity, due for example, to a remodeling process. The aim of the present study was to identify the microbiota surrounding exposed dental implants in patients with and without a history of periodontitis through a deep-sequencing approach. METHODS: An experimental abutment with the same surface and structure as a commercially available dental implant was used...
May 11, 2017: Journal of Periodontology
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