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https://www.readbyqxmd.com/read/27914958/comparative-analysis-of-motility-and-other-properties-of-treponema-denticola-strains
#1
Keiji Nagano, Yoshiaki Hasegawa, Yasuo Yoshida, Fuminobu Yoshimura
The periodontitis-associated pathogen Treponema denticola is a spirochetal bacterium that swims by rotating its cell body like a corkscrew using periplasmic flagella. We compared physiologic and pathogenic properties, including motility, in four strains of T. denticola. Phase-contrast microscopy showed differential motility between the strains; ATCC 35404 showed the highest motility, followed by ATCC 33521, and the remaining two strains (ATCC 35405 and ATCC 33520) showed the lowest motility. Transmission electron microscopy showed that the low motility strains exhibited extracellular flagellar protrusions resulting from elongated flagella...
November 30, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27899684/high-risk-periodontal-pathogens-contribute-to-the-pathogenesis-of-atherosclerosis
#2
REVIEW
Bradley Field Bale, Amy Lynn Doneen, David John Vigerust
Periodontal disease (PD) is generated by microorganisms. These microbes can enter the general circulation causing a bacteraemia. The result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. Level A evidence supports that PD is independently associated with arterial disease. PD is a common chronic condition affecting the majority of Americans 30 years of age and older. Atherosclerosis remains the largest cause of death and disability. Studies indicate that the adverse cardiovascular effects from PD are due to a few putative or high-risk bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola or Fusobacterium nucleatum There are three accepted essential elements in the pathogenesis of atherosclerosis: lipoprotein serum concentration, endothelial permeability and binding of lipoproteins in the arterial intima...
November 29, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27888369/prevalence-of-periodontal-pathogens-as-predictor-of-the-evolution-of-periodontal-status
#3
Miriam Puig-Silla, José María Montiel-Company, Francisco Dasí-Fernández, José Manuel Almerich-Silla
The aim of this study was to determine the relationship between the prevalence of Porphyromonas gingivalis, its fimA genotypes, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Treponema denticola and the evolution of periodontal health. In a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. PCR was employed to determine the presence of the periodontopathogenic bacteria...
November 25, 2016: Odontology
https://www.readbyqxmd.com/read/27876716/-the-relationship-of-molecular-genetic-markers-with-clinical-signs-and-risk-factors-of-periodontitis
#4
O A Zorina, N K Aimadinova, A A Basova, D V Rebrikov
The study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P. intermedia and Tannerella forsythensis. Expression of IL8, TNF-α, MMP8 and MMP9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing IL8 as positive diagnostic marker...
2016: Stomatologii︠a︡
https://www.readbyqxmd.com/read/27864174/multilocus-sequence-analysis-of-phylogroup-1-and-2-oral-treponeme-strains
#5
Yong-Biao Huo, Yuki Chan, Donnabella C Lacap-Bugler, Sisu Mo, Patrick C Y Woo, W Keung Leung, Rory M Watt
: More than 75 'species-level' phylotypes of spirochete bacteria belonging to the genus Treponema reside within the human oral cavity. The majority of these oral treponeme phylotypes correspond to as-yet uncultivated taxa, or strains of uncertain standing in taxonomy. Here, we analyze phylogenetic and taxonomic relationships between oral treponeme strains using a multilocus sequence analysis (MLSA) scheme based on the highly-conserved 16S rRNA, pyrH, recA and flaA genes. We utilize this MLSA scheme to analyze genetic data from a curated collection of oral treponeme strains (n=71) of diverse geographical origins...
November 18, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27858553/cross-sectional-evaluation-of-periodontal-status-microbiological-and-rheumatoid-parameters-in-a-large-cohort-of-patients-with-rheumatoid-arthritis
#6
Jan Schmickler, Annegret Rupprecht, Susann Patschan, Daniel Patschan, Gerhard A Müller, Rainer Haak, Rainer F Mausberg, Gerhard Schmalz, Tanja Kottmann, Dirk Ziebolz
BACKGROUND: This study evaluates periodontal conditions and microbiological findings and their influence on rheumatological disease parameters in patients with rheumatoid arthritis (RA). METHODS: 168 RA-patients were included. A healthy control group (HC, n=168) was composed according to age, gender and smoking habits. Rheumatological data (duration of illness, DAS28, RF, aCCP, medications) were extracted from patients' records. Dental examination included: dental findings (DMF-T), gingival inflammation (PBI), periodontal status (probing depth [PD], attachment loss [AL])...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27786620/a-novel-rat-model-of-polymicrobial-peri-implantitis-a-preliminary-study
#7
Theofilos Koutouzis, Christie Eastman, Sasanka Chukkapalli, Hannu Larjava, Lakshmyya Kesavalu
BACKGROUND: Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. There are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known microbial biofilms observed in humans. The aim is to develop a novel peri-implant rat model using an established model of polymicrobial periodontitis. METHODS: Wistar rats were used for the study of experimental peri-implantitis...
October 27, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27786617/comparison-of-two-different-sampling-methods-for-subgingival-plaque-subgingival-paper-points-or-mouthrinse-sample
#8
Katrin Nickles, Susanne Scharf, Lasse Röllke, Bettina Dannewitz, Peter Eickholz
OBJECTIVE: The collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. The collection of saliva, however, is simple and contains pathogens of all intraoral surfaces. The aim of this study is to investigate whether sampling with a mouthrinse (mouthrinse sample/MSP; test) leads to comparable results as the standard sampling method (multiple site test from the deepest pocket of each quadrant/MT4; control). METHODS: In 50 patients with periodontitis, subgingival plaque was sampled from the deepest pocket of each quadrant by using paper points and by gaining saliva with a saline mouthrinse...
October 27, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27745799/bacteria-in-the-apical-root-canals-of-teeth-with-apical-periodontitis
#9
Li-Wan Lee, Ya-Ling Lee, Sheng-Huang Hsiao, Hung-Pin Lin
BACKGROUND/PURPOSE: Bacteria in the tooth root canal may cause apical periodontitis. This study examined the bacterial species present in the apical root canal of teeth with apical periodontitis. Antibiotic sensitivity tests were performed to evaluate whether these identified bacterial species were susceptible to specific kinds of antibiotics. METHODS: Selective media plating and biochemical tests were used first to detect the bacterial species in samples taken from the apical portion of root canals of 62 teeth with apical periodontitis...
October 10, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27727287/salivary-periodontopathic-bacteria-in-children-and-adolescents-with-down-syndrome
#10
Camila Faria Carrada, Flávia Almeida Ribeiro Scalioni, Dionéia Evangelista Cesar, Karina Lopes Devito, Luiz Cláudio Ribeiro, Rosangela Almeida Ribeiro
OBJECTIVE: To assess and compare salivary periodontopathic bacteria between groups of Down syndrome and non-Down syndrome children and adolescents. MATERIALS AND METHODS: This study included a sample of 30 Down syndrome children and adolescents (G-DS) and 30 age- and sex-matched non-Down syndrome subjects (G-ND). Clinical examination determined the gingival bleeding index (GBI) and plaque index. Unstimulated whole saliva samples were collected from all participants...
2016: PloS One
https://www.readbyqxmd.com/read/27727278/associations-of-toll-like-receptor-and-%C3%AE-defensin-polymorphisms-with-measures-of-periodontal-disease-pd-in-hiv-north-american-adults-an-exploratory-study
#11
Rajeev K Mehlotra, Noemi B Hall, Barne Willie, Catherine M Stein, Aaron Weinberg, Peter A Zimmerman, Lance T Vernon
Polymorphisms in toll-like receptor (TLR) and β-defensin (DEFB) genes have been recognized as potential genetic factors that can influence susceptibility to and severity of periodontal diseases (PD). However, data regarding associations between these polymorphisms and PD are still scarce in North American populations, and are not available in HIV+ North American populations. In this exploratory study, we analyzed samples from HIV+ adults (n = 115), who received primary HIV care at 3 local outpatient HIV clinics and were monitored for PD status...
2016: PloS One
https://www.readbyqxmd.com/read/27697692/treponema-denticola-porphyromonas-gingivalis-and-tannerella-forsythia-induce-cell-death-and-release-of-endogenous-danger-signals
#12
Hye-Kyoung Jun, Young-Jung Jung, Bong-Kyu Choi
OBJECTIVE: The aim of this study was to analyze whether periodontopathogens induced inflammatory cell death and the release of diverse endogenous danger molecules in THP-1-derived macrophages. METHODS: The macrophages were treated with Treponema denticola, Porphyromonas gingivalis, and Tannerella forsythia. Activation of caspase-1 and caspase-4 was detected by Western blotting. Cell death of bacteria-stimulated macrophages was examined using a lactate dehydrogenase (LDH) assay and propidium iodide (PI)/annexin V (AV) staining...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27696564/a-novel-glycan-modifies-the-flagellar-filament-proteins-of-the-oral-bacterium-treponema-denticola
#13
Kurni Kurniyati, John F Kelly, Evgeny Vinogradov, Anna Robotham, Youbing Tu, Juyu Wang, Jun Liu, Susan M Logan, Chunhao Li
While protein glycosylation has been reported in several spirochetes including the syphilis bacterium Treponema pallidum and Lyme disease pathogen Borrelia burgdorferi, the pertinent glycan structures and their roles remain uncharacterized. Herein, a novel glycan with an unusual chemical composition and structure in the oral spirochete Treponema denticola, a keystone pathogen of periodontitis was reported. The identified glycan of mass 450.2 Da is composed of a monoacetylated nonulosonic acid (Non) with a novel extended N7 acyl modification, a 2-methoxy-4,5,6-trihydroxy-hexanoyl residue in which the Non has a pseudaminic acid configuration (L-glycero-L-manno) and is β-linked to serine or threonine residues...
October 1, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27670115/spirochaete-flagella-hook-proteins-self-catalyse-a-lysinoalanine-covalent-crosslink-for-motility
#14
Michael R Miller, Kelly A Miller, Jiang Bian, Milinda E James, Sheng Zhang, Michael J Lynch, Patrick S Callery, Justin M Hettick, Andrew Cockburn, Jun Liu, Chunhao Li, Brian R Crane, Nyles W Charon
Spirochaetes are bacteria responsible for several serious diseases, including Lyme disease (Borrelia burgdorferi), syphilis (Treponema pallidum) and leptospirosis (Leptospira interrogans), and contribute to periodontal diseases (Treponema denticola)(1). These spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space(2-11). The universal joint or hook that links the rotary motor to the filament is composed of ∼120-130 FlgE proteins, which in spirochaetes form an unusually stable, high-molecular-weight complex(9,12-17)...
August 8, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27632268/a-double-blind-randomized-trial-comparing-implants-with-laser-microtextured-and-machined-collar-surfaces-microbiologic-and-clinical-results
#15
Renzo Guarnieri, Giorgio Rappelli, Matteo Piemontese, Maurizio Procaccini, Alessandro Quaranta
PURPOSE: The purpose of this study was to compare the clinical outcome of and determine the differences in periodonto-pathogenic microbiota around two types of implant collar surfaces: laser-microtextured (test) vs machined (control). MATERIALS AND METHODS: Seventeen patients (11 periodontally healthy, and 6 periodontally compromised) were selected to receive the two different implants, placed randomly, in two edentulous sites. Six months following the surgical placement of the dental implants, subgingival plaque samples were collected using paper points from the peri-implant sulcus and from the sulcus of an adjacent tooth...
September 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27627556/the-distribution-of-porphyromonas-gingivalis-tannerella-forsythia-treponema-denticola-and-aggregatibacter-actinomycetemcomitans-in-patients-with-alcoholic-disease-a-pilot-study
#16
Aleksandra Sender-Janeczek, Marek Ziętek
BACKGROUND: Both drinking and periodontal disease are serious health and social problems. Findings on the effect of alcohol consumption on periodontal disease are inconclusive. OBJECTIVES: The aim of this study was to evaluate, in patients with alcoholic disease, the composition of the main periopathogens: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and Aggregatibacter actinomycetemcomitans. MATERIAL AND METHODS: The study was conducted on 25 alcoholics from the Department of Alcohol Addiction Closed Treatment and 25 non-alcoholic patients from the Department of Periodontology, Wroclaw Medical University...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27620215/herpesviral-bacterial-co-infection-in-mandibular-third-molar-pericoronitis
#17
Aleksandar Jakovljevic, Miroslav Andric, Aleksandra Knezevic, Biljana Milicic, Katarina Beljic-Ivanovic, Neda Perunovic, Nadja Nikolic, Jelena Milasin
OBJECTIVE: The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. MATERIALS AND METHODS: Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia...
September 12, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27602578/effect-of-helicobacter-pylori-infection-on-chronic-periodontitis-by-the-change-of-microecology-and-inflammation
#18
Zhekai Hu, Yu Zhang, Zhiyu Li, Yuedi Yu, Wenyan Kang, Yingnan Han, Xiwen Geng, Shaohua Ge, Yundong Sun
Helicobacter pylori (H. pylori), a pathogen inducing peptic disease, is recently found to be binding to the progress of periodontitis. Most previous studies are case-controlled, and they investigate the risk of H. pylori infection in disease the development of while few studies evaluate the correlation between H. pylori and periodontal pathogens. Therefore, we investigated the correlation between H. pylori infection with periodontal parameters, periodontal pathogens and inflammation. The results indicated that patients with H...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27591633/rapid-identification-and-quantitation-for-oral-bacteria-based-on-short-end-capillary-electrophoresis
#19
Jin Chen, Yi Ni, Chenchen Liu, Yoshinori Yamaguchi, Qinmiao Chen, Shinichi Sekine, Xifang Zhu, Xiaoming Dou
High-speed capillary electrophoresis (HSCE) is a promising technology applied in ultra-rapid and high-performance analysis of biomolecules (such as nucleic acids, protein). In present study, the short-end capillary electrophoresis coupled with one novel space domain internal standard method (SDIS) was employed for the rapid and simultaneous analysis of specific genes from three oral bacteria (Porphyromonas gingivalis (P.g), Treponema denticola (T.d) and Tannerela forsythia (T.f)). The reliability, reproducibility and accuracy properties of above mentioned SDIS method were investigated in detail...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27565999/periodontitis-contributes-to-adipose-tissue-inflammation-through-the-nf-kappa-b-jnk-and-erk-pathways-to-promote-insulin-resistance-in-a-rat-model
#20
Yanli Huang, Jin Zeng, Guoqing Chen, Xudong Xie, Weihua Guo, Weidong Tian
This study aimed to investigate the mechanism by which periodontitis affects the inflammatory response and systemic insulin resistance in the white adipose and liver tissues in an obese rat model. The obese model was generated by feeding rats a high fat diet. The periodontitis model was induced by ligatures and injection of "red complex", which consisted of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, for two weeks. When compared with rats without periodontitis, fasting glucose levels and homeostasis model assessment index were significantly increased in rats with periodontitis, suggesting that periodontitis promotes the development of insulin resistance in obese rats...
August 23, 2016: Microbes and Infection
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