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https://www.readbyqxmd.com/read/29352461/clinical-and-microbiological-evaluation-of-the-effect-of-lactobacillus-reuteri-in-the-treatment-of-mucositis-and-peri-implantitis-a-triple-blind-randomized-clinical-trial
#1
M Galofré, D Palao, M Vicario, J Nart, D Violant
BACKGROUND AND OBJECTIVE: Oral probiotics appear to improve the treatment of periodontal diseases but there is limited evidence on their efficacy in the treatment of peri-implant diseases. The objective of the present study was to evaluate, clinically and microbiologically, the effect of the oral probiotic, Lactobacillus reuteri Prodentis, as adjuvant to non-surgical mechanical therapy in implants with mucositis or peri-implantitis, placed in patients with a history of periodontal disease...
January 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29333776/-clinical-and-microbiologic-follow-up-evaluations-after-non-surgical-periodontal-treatment-with-nd-yag-laser-and-scaling-and-root-planning
#2
Yin Yanli, Xu Chunmei, Wu Yafei, Zhao Lei
OBJECTIVE: Our research aimed to detect the efficacy of non-surgical periodontal treatment with Nd: YAG laser and scaling and root planning (SRP) for chronic periodontitis. METHODS: We recruited chronic periodontitis patients who have more than four teeth with clinical pocket depth of 4-8 mm. These teeth were distributed in four different zones within the oral cavity. Moreover, the teeth were single root teeth and not adjacent to each other. The subordinated teeth were randomized into four groups, as follows: no treatment (C group), simple SRP (SRP group), Nd: YAG laser after SRP treatment (SRP+L group), and SRP after Nd: YAG laser treatment (L+SRP group)...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29327500/multiplex-polymerase-chain-reaction-detection-of-selected-bacterial-species-from-symptomatic-and-asymptomatic-non-vital-teeth-with-primary-endodontic-infections
#3
Smita Pattanshetty, Vijayalakshmi S Kotrashetti, Kishore Bhat, Ramakant S Nayak, Pradeep Somannavar, Madhu Pujar
AIM: The aim of the present study was to investigate the presence of selective anaerobic microorganisms in primary root canal infections of symptomatic and asymptomatic non-vital teeth with periapical pathosis using multiplex polymerase chain reaction. METHODS: A total of 100 root canal samples (50 from symptomatic and 50 from asymptomatic teeth) were obtained from patients with primary endodontic infections. DNA extracted from the samples was amplified by using specific primers for the 16S rRNA gene of each bacterium, and semiquantification was done to analyze the prevalence of microorganisms and their correlation to clinical features...
January 11, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29327449/clinical-microbiological-and-cytomorphometric-evaluation-of-low-level-laser-therapy-as-an-adjunct-to-periodontal-therapy-in-patients-with-chronic-periodontitis
#4
M S Petrović, I Y Kannosh, J M Milašin, D S Mihailović, R R Obradović, S R Bubanj, L G Kesić
OBJECTIVE: A clinical prospective study was designed to evaluate microbiological, cytomorphometric and clinical efficacy of low-level laser therapy (LLLT) as an adjunct to periodontal therapy in the treatment of chronic periodontitis. METHODS: Sixty subjects were included and randomly assigned into 2 groups: SRP (scaling root planning) group (n = 30) and LLLT + SRP group (n = 30). Clinical parameters were measured before intervention, after the fifth treatment, and after a month...
January 12, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29205773/treponema-denticola-increases-mmp-2-expression-and-activation-in-the-periodontium-via-reversible-dna-and-histone-modifications
#5
Islam M Ateia, Pimchanok Sutthiboonyapan, Pachiyappan Kamarajan, Taocong Jin, Valentina Godovikova, Yvonne L Kapila, J Christopher Fenno
Host-derived matrix metalloproteinases (MMPs) and bacterial proteases mediate destruction of extracellular matrices and supporting alveolar bone in periodontitis. The Treponema denticola dentilisin protease induces MMP-2 expression and activation in periodontal ligament (PDL) cells, and dentilisin-mediated activation of pro-MMP-2 is required for cellular fibronectin degradation. Here we report that T. denticola regulates MMP-2 expression through epigenetic modifications in the periodontium. PDL cells were treated with epigenetic enzyme inhibitors before or after T...
December 4, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29151456/characterization-of-specimens-obtained-by-different-sampling-methods-for-evaluation-of-periodontal-bacteria
#6
Ayako Okada, Kaoru Sogabe, Hiroaki Takeuchi, Masaaki Okamoto, Yoshiaki Nomura, Nobuhiro Hanada
Quantitative analysis of periodontal bacteria is considered useful for clinical diagnosis, evaluation and assessment of the risk of periodontal disease. The purpose of this study was to compare the effectiveness of sampling of saliva, supragingival and subgingival plaque for evaluation of periodontal bacteria. From each of 12 subjects, i) subgingival plaque was collected from the deepest pocket using a sterile paper point, ii) stimulated whole saliva was collected after chewing gum, and iii) supragingival plaque was collected using a tooth brush...
November 17, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29149107/treponema-denticola-chymotrypsin-like-proteinase-may-contribute-to-orodigestive-carcinogenesis-through-immunomodulation
#7
Mikko T Nieminen, Dyah Listyarifah, Jaana Hagström, Caj Haglund, Daniel Grenier, Dan Nordström, Veli-Jukka Uitto, Marcela Hernandez, Tülay Yucel-Lindberg, Taina Tervahartiala, Mari Ainola, Timo Sorsa
BACKGROUND: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown. Treponema denticola (Td) is associated with severe periodontitis, a chronic inflammatory disease leading to tooth loss. The anaerobic spirochete Td is an invasive bacteria due to its major virulence factor chymotrypsin-like proteinase. Here we aimed to investigate the presence of Td chymotrypsin-like proteinase (Td-CTLP) in major orodigestive tumours and to elucidate potential mechanisms for Td to contribute to carcinogenesis...
November 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29138754/the-relation-between-periodontopathogenic-bacterial-levels-and-resistin-in-the-saliva-of-obese-type-2-diabetic-patients
#8
Natheer Al-Rawi, Farah Al-Marzooq
This study aims to investigate the relation between resistin and periodontopathogenic bacterial levels in the saliva of obese adults compared to healthy control and to examine whether salivary resistin can serve as a biomarker of type 2 diabetes in obese patients. A total of 78 saliva samples were collected from patients attending to the University Dental Hospital, Sharjah, UAE. The patients were divided into three equal groups: obese diabetics, obese nondiabetics, and nonobese nondiabetic control. Salivary resistin was measured using ELISA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29110296/the-combined-and-individual-impact-of-diabetes-and-smoking-on-key-subgingival-periodontal-pathogens-in-patients-with-chronic-periodontitis
#9
C R Joaquim, T S Miranda, L M Marins, H D P Silva, M Feres, L C Figueiredo, P M Duarte
BACKGROUND AND OBJECTIVE: Comprehension of the similarities and differences in the composition of the subgingival microbiota of patients with diabetes mellitus (DM), smokers or smokers with DM is an important step in developing therapies specific for these groups at risk for periodontitis. Therefore, the aim of this study was to compare the combined and individual effects of DM and smoking on the levels and prevalence of key subgingival periodontal pathogens in patients with chronic periodontitis...
November 6, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29084027/antimicrobial-efficacy-of-materials-used-for-sealing-the-implant-abutment-screw-hole-an-in-vitro-evaluation
#10
Mohammed Alshehri, Hamad Albaqiah
AIM: The aim of this in vitro study was to assess the antimicrobial efficacy of materials (gutta percha [GP], polytetrafluoroethylene [PTFE] tape, and vinyl polysiloxane [VP]) used for sealing the implant abutment screw hole (IASH). METHODS: Sixty implants with a Morse cone connection were used. The implants were randomly divided into 3 groups (20 implants/group). In groups 1, 2, and 3, the IASH was sealed with GP, PTFE, and VP, respectively. Unstimulated whole saliva (UWS) was used as a contaminant medium for the incubation of the specimens...
December 2017: Implant Dentistry
https://www.readbyqxmd.com/read/29077095/caspase-4-activation-by-a-bacterial-surface-protein-is-mediated-by-cathepsin-g-in-human-gingival-fibroblasts
#11
Hye-Kyoung Jun, Young-Jung Jung, Suk Ji, Sun-Jin An, Bong-Kyu Choi
Caspase-4 is an inflammatory caspase; however, its mechanism of activation is poorly understood. In this study, we demonstrate that Td92, a surface protein of the periodontal pathogen Treponema denticola and a homolog of the Treponema pallidum surface protein Tp92, activates caspase-4 and induces pyroptosis in primary cultured human gingival fibroblasts (HGFs) via cathepsin G activation. Cathepsin G inhibition or siRNA knockdown of cathepsin G inhibited Td92-induced caspase-4 activation and cell death. Td92-induced cell death was significantly inhibited by siRNA knockdown of gasdermin D...
October 27, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29063339/metagenomic-analysis-of-gingival-sulcus-microbiota-and-pathogenesis-of-periodontitis-associated-with-type-2-diabetes-mellitus
#12
E A Babaev, I P Balmasova, A M Mkrtumyan, S N Kostryukova, E S Vakhitova, E N Il'ina, V N Tsarev, A G Gabibov, S D Arutyunov
Biofilm of the gingival sulcus from 22 patients with type 2 diabetes mellitus and periodontitis, 30 patients with periodontitis not complicated by diabetes mellitus (reference group), and 22 healthy volunteers without signs of gingival disease (control group) was studied by quantitative PCR. Quantitative analysis for the content of P. gingivalis, T. forsythia, A. ctinomycetemcomitans, T. denticola, P. intermedia, F. nucleatum/periodonticum, and P. endodontalis in the dental plaque was performed with a Dentoscreen kit...
October 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29038532/the-major-outer-sheath-protein-forms-distinct-conformers-and-multimeric-complexes-in-the-outer-membrane-and-periplasm-of-treponema-denticola
#13
Robbins Puthenveetil, Sanjiv Kumar, Melissa J Caimano, Abhishek Dey, Arvind Anand, Olga Vinogradova, Justin D Radolf
The major outer sheath protein (MOSP) is a prominent constituent of the cell envelope of Treponema denticola (TDE) and one of its principal virulence determinants. Bioinformatics predicts that MOSP consists of N- and C-terminal domains, MOSP(N) and MOSP(C). Biophysical analysis of constructs refolded in vitro demonstrated that MOSP(C), previously shown to possess porin activity, forms amphiphilic trimers, while MOSP(N) forms an extended hydrophilic monomer. In TDE and E. coli expressing MOSP with a PelB signal sequence (PelB-MOSP), MOSP(C) is OM-embedded and surface-exposed, while MOSP(N) resides in the periplasm...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29031240/colonization-of-oropharynx-and-lower-respiratory-tract-in-critical-patients-risk-of-ventilator-associated-pneumonia
#14
Ivany Machado de Carvalho Baptista, Frederico Canato Martinho, Gustavo Giacomelli Nascimento, Carlos Eduardo da Rocha Santos, Renata Falchete do Prado, Marcia Carneiro Valera
OBJECTIVE: To investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (BAL), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard DNA-DNA hybridisation. Also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship between VAP (ventilator-associated pneumonia) and bacterial species studied...
October 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29031238/the-effect-of-supragingival-biofilm-re-development-on-the-subgingival-microbiota-in-chronic-periodontitis
#15
Fátima Aparecida Rocha Resende Hartenbach, Carina Maciel Silva-Boghossian, Ana Paula Vieira Colombo
OBJECTIVE: In this study, we hypothesized that in the absence of oral hygiene, re-growth of the climax microbial communities of supra and subgingival biofilm happens in a faster and more intense fashion in individuals with chronic periodontitis (CP) compared to periodontally healthy controls (PH). DESIGN: Thirty patients (PH=15 and CP=15) received professional supragingival prophylaxis, and were asked to refrain from oral hygiene for 7days. Supra and subgingival biofilm samples and GCF were collected from randomly selected quadrants at baseline (before prophylaxis), immediately after prophylaxis, 2h, 6h, 24h, and 7days after prophylaxis...
October 10, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29030100/antimicrobial-susceptibility-profiles-of-oral-treponema-species
#16
Kazuko Okamoto-Shibayama, Jin Sekino, Kouki Yoshikawa, Atsushi Saito, Kazuyuki Ishihara
Treponemes occur in the microflora of the dental plaque. Certain Treponema species that are frequently isolated from chronic periodontitis lesions are involved in its initiation and progression. In addition to mechanical instrumentation, antimicrobial agents are used as an adjunctive treatment modality for periodontitis. Despite its importance for successful antimicrobial treatment, information about susceptibility is limited for Treponema species. The aim of this study was to assess the susceptibility of Treponema denticola strains, Treponema socranskii, and Treponema vincentii to eleven antimicrobial agents...
October 13, 2017: Anaerobe
https://www.readbyqxmd.com/read/29026924/gene-regulation-two-component-regulatory-systems-and-adaptive-responses-in-treponema-denticola
#17
Richard T Marconi
The oral microbiome consists of a remarkably diverse group of 500-700 bacterial species. The microbial etiology of periodontal disease is similarly complex. Of the ~400 bacterial species identified in subgingival plaque, at least 50 belong to the genus Treponema. As periodontal disease develops and progresses, T. denticola transitions from a low to high abundance species in the subgingival crevice. Changes in the overall composition of the bacterial population trigger significant changes in the local physical, immunological and physiochemical conditions...
October 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28987726/inhibition-of-malodorous-gas-formation-by-oral-bacteria-with-cetylpyridinium-and-zinc-chloride
#18
Jeong Hyun Kang, Dae Jeong Kim, Bong Kyu Choi, Ji Woon Park
OBJECTIVE: The antimicrobial efficacy of zinc- (ZnCl2) and cetylpyridinium-chloride (CPC) and their inhibition capacity on volatile sulfur compound (VSC) production by oral bacterial strains were investigated. DESIGN: Minimum inhibitory concentrations (MIC) and growth curves were determined for ZnCl2, CPC, and CPC with ZnCl2 solutions against eight oral microorganisms (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, Tannerella forsythia, Staphylococcus aureus and Streptococcus mutans) known to be involved in the pathophysiology of both halitosis and periodontal disease...
September 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28969941/ccr5%C3%AE-32-rs333-polymorphism-is-associated-with-decreased-risk-of-chronic-and-aggressive-periodontitis-a-case-control-analysis-based-in-disease-resistance-and-susceptibility-phenotypes
#19
Franco Cavalla, Claudia C Biguetti, Thiago J Dionisio, Michelle C S Azevedo, Walter Martins, Carlos F Santos, Ana Paula F Trombone, Renato M Silva, Ariadne Letra, Gustavo P Garlet
Chronic and aggressive periodontitis are infectious diseases characterized by the irreversible destruction of periodontal tissues, which is mediated by the host inflammatory immune response triggered by periodontal infection. The chemokine receptor CCR5 play an important role in disease pathogenesis, contributing to pro-inflammatory response and osteoclastogenesis. CCR5Δ32 (rs333) is a loss-of-function mutation in the CCR5 gene, which can potentially modulate the host response and, consequently periodontitis outcome...
September 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28890719/outer-membrane-vesicles-prime-and-activate-macrophage-inflammasomes-and-cytokine-secretion-in-vitro-and-in-vivo
#20
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, William Singleton, Alexis Perez-Gonzalez, Ashley Mansell, Eric C Reynolds
Outer membrane vesicles (OMVs) are proteoliposomes blebbed from the surface of Gram-negative bacteria. Chronic periodontitis is associated with an increase in subgingival plaque of Gram-negative bacteria, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. In this study, we investigated the immune-modulatory effects of P. gingivalis, T. denticola, and T. forsythia OMVs on monocytes and differentiated macrophages. All of the bacterial OMVs were phagocytosed by monocytes, M(naïve) and M(IFNγ) macrophages in a dose-dependent manner...
2017: Frontiers in Immunology
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