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https://www.readbyqxmd.com/read/28741455/pivotal-roles-of-interleukin-17-as-the-epicenter-of-bone-loss-diseases
#1
Chongshan Liao, Chengfei Zhang, Yanqi Yang
Bone remodelling is a strictly regulated dynamic process between bone resorption and bone formation. Many factors are involved in the process and affect the dynamic balance. Inflammation-mediated bone loss is a major feature of various bone diseases, including periodontitis, rheumatoid arthritis (RA) and spondyloarthritis (SpA). Interleukin-17 (IL-17) plays an important role in inflammatory bone disease and could be an attractive therapeutic target. This review focuses on the osteoclastic effects of IL-17 in different cell types and summarizes the current knowledge of IL-17 signalling pathways...
May 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28740974/wound-closure-and-wound-healing-suture-techniques-in-contemporary-periodontal-and-implant-surgery-interactions-requirements-and-practical-considerations
#2
Otto Zuhr, Dodji Lukas Akakpo, Markus Hürzeler
In contemporary reconstructive periodontal and implant surgery, attaining uncomplicated wound healing in the early postoperative healing phase is the key to achieving a successful treatment outcome and is of central interest, from the clinical as well as the scientific perspective. The realization of primary wound healing is the central challenge in most cases. Two of the evidence-based factors that affect postoperative wound healing can be influenced by the surgeon: the blood supply to the surgical site and postoperative wound stability...
July 20, 2017: Quintessence International
https://www.readbyqxmd.com/read/28738710/use-of-traditional-herbal-medicine-as-an-alternative-in-dental-treatment-in-mexican-dentistry-a-review
#3
Cindy Cruz Martínez, Martha Diaz Gómez, Myung Sook Oh
CONTEXT: Herbal therapies are used worldwide to treat health conditions. In Mexico, generations have used them to treat gingivitis, periodontitis, mouth infections, and discoloured teeth. However, few studies have collected scientific evidence on their effects. OBJECTIVE: This study aimed at searching and compiling scientific evidence of alternative oral and dental treatments using medicinal herbs from Mexico. METHODS: We collected various Mexican medicinal plants used in the dental treatment from the database of the Institute of Biology at the National Autonomous University of Mexico...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28738247/asiatic-acid-inhibits-lps-induced-inflammatory-response-in-human-gingival-fibroblasts
#4
Chunbo Hao, Buling Wu, Zhiming Hou, Qi Xie, Tianan Liao, Tao Wang, Dandan Ma
Asiatic acid, a triterpenoid component isolated from Centella asiatica (L.) Urban, possesses antioxidative and anti-inflammatory activities. In this study, we aimed to investigate the anti-inflammatory effects of asiatic acid both in vivo and in vitro. HGFs or RAW264.7 cells were treated with asiatic acid 1h before LPS treatment. Cell viability was measured by MTT assay. The levels of PGE2, NO, IL-6, and IL-8 were detected by ELISA. Protein expression levels were detected by western blot analysis. In vivo, asiatic acid significantly inhibited LPS-induced IL-6 and IL-8 expression levels in gingival tissues...
July 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28736819/evaluation-of-dna-methylation-of-inflammatory-genes-following-treatment-of-chronic-periodontitis-a-pilot-case-control-study
#5
Farah Asa'ad, Valentina Bollati, Giorgio Pagni, Rogerio M Castilho, Eleonora Rossi, Francesca Pomingi, Letizia Tarantini, Dario Consonni, William V Giannobile, Giulio Rasperini
OBJECTIVE: To evaluate the influence of periodontal therapy on DNA methylation in chronic periodontitis patients as compared to healthy individuals. MATERIALS & METHODS: Twenty patients were enrolled into two groups: 1) 10 diagnosed as clinically healthy; and 2) 10 diagnosed with chronic periodontitis. Clinical measures were recorded and gingival biopsies were harvested at baseline (both patient groups) and at 2 and 8 weeks post-baseline for diseased individuals...
July 24, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28736293/zirconia-based-versus-metal-based-single-crowns-veneered-with-overpressing-ceramic-for-restoration-of-posterior-endodontically-treated-teeth-5-year-results-of-a-randomized-controlled-clinical-study
#6
Carlo Monaco, Altin Llukacej, Paolo Baldissara, Antonio Arena, Roberto Scotti
OBJECTIVES: The aim of this 5-year randomized controlled trial was to compare the longevity and clinical behavior of single posterior crowns made with pressable ceramic on zirconia and on metal frameworks, and if failures occur, to delineate the contributing factors. METHODS: 72 patients, who needed the covering of at least a molar and/or premolar, were included in the study. All teeth were endodontically treated, with absence of periapical lesion or active periodontitis...
July 20, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28736072/antibacterial-activities-of-natural-lichen-compounds-against-streptococcus-gordonii-and-porphyromonas-gingivalis
#7
Alaa Sweidan, Marylene Chollet-Krugler, Aurelie Sauvager, Pierre van de Weghe, Ali Chokr, Martine Bonnaure-Mallet, Sophie Tomasi, Latifa Bousarghin
The oral bacteria not only infect the mouth and reside there, but also travel through the blood and reach distant body organs. If left untreated, the dental biofilm that can cause destructive inflammation in the oral cavity may result in serious medical complications. In dental biofilm, Streptococcus gordonii, a primary oral colonizer, constitutes the platform on which late pathogenic colonizers like Porphyromonas gingivalis, the causative agent of periodontal diseases, will bind. The aim of this study was to determine the antibacterial activity of eleven natural lichen compounds belonging to different chemical families and spanning from linear into cyclic and aromatic structures to uncover new antibiotics which can fight against the oral bacteria...
July 20, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28735759/associations-between-tooth-loss-and-prognostic-biomarkers-and-the-risk-for-cardiovascular-events-in-patients-with-stable-coronary-heart-disease
#8
Ola Vedin, Emil Hagström, Ollie Östlund, Alvaro Avezum, Andrzej Budaj, Marcus D Flather, Robert A Harrington, Wolfgang Koenig, Joseph Soffer, Agneta Siegbahn, Philippe Gabriel Steg, Ralph A H Stewart, Lars Wallentin, Harvey D White, Claes Held
BACKGROUND: Underlying mechanisms behind the hypothesized relationship between periodontal disease (PD) and coronary heart disease (CHD) have been insufficiently explored. We evaluated associations between self-reported tooth loss- a marker of PD- and prognostic biomarkers in 15,456 (97%) patients with stable CHD in the global STABILITY trial. METHODS AND RESULTS: Baseline blood samples were obtained and patients reported their number of teeth according to the following tooth loss levels: "26-32 (All)" [lowest level], "20-25", "15-19", "1-14", and "No Teeth" [highest level]...
July 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28735626/differentiation-of-hmsc-and-hpdlsc-induced-by-pge2-or-bmp-7-in-3d-models
#9
Christina Ern, Tamara Berger, Iris Frasheri, Richard Heym, Reinhard Hickel, Matthias Folwaczny
Regenerative therapies of pathogenic tissue defects are gaining increasing importance in periodontology. Among others, the osteogenic effect of BMP-7 seems to play a major role in the development of teeth and alveolar bone. Human periodontal ligament stem cells (hPDLSC), as well as human mesenchymal stem cells (hMSC), show the ability to differentiate into various types of tissues. Regarding prostaglandin E2, many studies have confirmed that it is involved in the inflammation associated to periodontitis stimulating osteoclasts, which ultimately leads to resorption of tooth supporting bone...
July 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28735521/myd88-erk-nfkb%C3%A2-pathways-and-pro-inflammatory-cytokines-release-in-periodontal-ligament-stem-cells-stimulated-by-porphyromonas%C3%A2-gingivalis
#10
Francesca Diomede, Maria Zingariello, Marcos F X B Cavalcanti, Ilaria Merciaro, Jacopo Pizzicannella, Natalia De Isla, Sergio Caputi, Patrizia Ballerini, Oriana Trubiani
The present study was aimed at investigating whether human Periodontal Ligament Stem Cells (hPDLSCs) were capable of sensing and reacting to lipopolysaccharide from Porphyromonas gingivalis (LPS-G) which is widely recognized as a major pathogen in the development and progression of periodontitis. At this purpose hPDLCs were stimulated with 5 μg/mL LPS-G various times and the expression of toll-like receptor 4 (TLR4) was evaluated. Toll-like receptors (TLRs) play an essential role in innate immune signaling in response to microbial infections, and in particular TLR4, type-I transmembrane proteins, has been shown recognizing LPS-G...
May 24, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28734651/chromographic-analysis-and-cytotoxic-effects-of-chlorhexidine-and-sodium-hypochlorite-reaction-mixtures
#11
Giuseppina Nocca, Hany Mohamed Aly Ahmed, Giuseppe Ettore Martorana, Cinzia Callà, Gianluca Gambarini, Sandro Rengo, Gianrico Spagnuolo
INTRODUCTION: The literature reveals controversies regarding the formation of para-chloroaniline (PCA) when chlorhexidine (CHX) is mixed with sodium hypochlorite (NaOCl). This study aimed to investigate the stability of PCA in the presence of NaOCl and to examine the in vitro cytotoxic effects of CHX/NaOCl reaction mixtures. METHODS: Different volumes of NaOCl were added to CHX (mix 1) or PCA (mix 2). Upon centrifugation, the supernatant and precipitate fractions collected from samples were analyzed using high-performance liquid chromatography...
July 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28733997/natural-history-of-periodontitis-disease-progression-and-tooth-loss-over-40-years
#12
C A Ramseier, Å Ånerud, M Dulac, M Lulic, M P Cullinan, G J Seymour, M J Faddy, W Büergin, M Schätzle, N P Lang
OBJECTIVES: To assess long-term attachment and periodontitis-related tooth loss (PTL) in untreated periodontal disease over 40 years. MATERIAL AND METHODS: Data originated from the natural history of periodontitis study in Sri Lankan tea labourers first examined in 1970. In 2010, 75 subjects (15.6%) of the original cohort were re-examined. RESULTS: PTL over 40 years varied between 0 and 28 teeth (mean 13.1). Four subjects presented with no PTL while 12 were edentulous...
July 22, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28733984/implant-treatment-in-pharmacologically-immunosuppressed-liver-transplant-patients-a-prospective-controlled-study
#13
Víctor Paredes, Rosa María López-Pintor, Jesús Torres, Juan Carlos de Vicente, Mariano Sanz, Gonzalo Hernández
OBJECTIVES: The main objective of this prospective study was to evaluate the long-term outcome of implant therapy in liver transplant patients (LTP). The secondary goal was to assess several implant- and patient-dependent variables, such as peri-implantitis (PI), peri-implant mucositis (PIM), bone loss (BL), and immediate postoperative complications. MATERIAL AND METHODS: Two groups, including 16 pharmacologically immunosuppressed LTP and 16 matched controls, received 52 and 54 implants, respectively, between 1999 and 2008...
July 21, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28732738/association-of-microrna-125a-and-microrna-499a-polymorphisms-in-chronic-periodontitis-in-a-sample-south-indian-population-a-hospital-based-genetic-association-study
#14
Priyanka Venugopal, Vamsi Lavu, Suresh Ranga Rao, Vettriselvi Venkatesan
Periodontitis is a chronic inflammatory disease, caused by interaction between periodontopathic bacteria and the host immune response. MicroRNAs are small, single-stranded molecules, which play a key role in the regulation of diverse biological processes. Dysregulation of microRNAs function can lead to several diseases such as autoimmune and chronic inflammatory diseases. The objective of the study was to determine the association between selected single nucleotide polymorphisms in miR-125a, miR-499 and LIN28 homology A with chronic periodontitis susceptibility in a sample population from south India...
July 18, 2017: Gene
https://www.readbyqxmd.com/read/28732584/boric-acid-probably-increases-clinical-attachment-level-and-reduces-probing-depth-and-intrabony-defect-depth-when-used-as-an-adjunct-to-scaling-and-root-planing-in-patients-with-chronic-periodontitis
#15
Romina Brignardello-Petersen
No abstract text is available yet for this article.
July 17, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28732580/mechanical-and-antibiotic-periodontal-therapies-may-be-no-different-in-terms-of-tooth-loss-in-patients-with-chronic-periodontitis
#16
Tahira Devji
No abstract text is available yet for this article.
July 17, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28732226/intermittent-administration-of-parathyroid-hormone-ameliorated-alveolar-bone-loss-in-experimental-periodontitis-in-streptozotocin-induced-diabetic-rats
#17
Helin Chen, Taozi Fu, Yuanyuan Ma, Xiangnan Wu, Xianxian Li, Xinyi Li, Jiefei Shen, Hang Wang
OBJECTIVE: Intermittent administration of parathyroid hormone (PTH) has been demonstrated to have anabolic effects on bone metabolism and is approved for use in the treatment of osteoporosis. This study evaluates the role of intermittent PTH administration on alveolar bone loss in streptozotocin (STZ)-induced diabetic rats. DESIGN: Fifty male Sprague Dawley rats were randomly divided into the following five groups: (1) a control group (saline placebo without ligature and STZ injection), (2) a PTH group (PTH administration without ligature and STZ injection), (3) an L group (saline placebo with ligature), (4) an L+STZ group (saline placebo with ligature and STZ injection), and (5) an L+STZ+PTH group (PTH administration with ligature and STZ injection)...
July 5, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28732187/do-genetic-markers-of-inflammation-modify-the-relationship-between-periodontitis-and-nonalcoholic-fatty-liver-disease-findings-from-the-ship-study
#18
A A Akinkugbe, C L Avery, A S Barritt, S R Cole, M Lerch, J Mayerle, S Offenbacher, A Petersmann, M Nauck, H Völzke, G D Slade, G Heiss, T Kocher, B Holtfreter
An association between periodontitis and nonalcoholic fatty liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies. This study investigated whether circulating levels of serum C-reactive protein (CRP) and a weighted genetic CRP score representing markers of inflammatory burden modify the association between periodontitis and NAFLD. Data came from 2,481 participants of the Study of Health in Pomerania who attended baseline examination that occurred between 1997 and 2001. Periodontitis was defined as the percentage of sites (0%, <30%, ≥30%) with probing pocket depth (PD) ≥4 mm, and NAFLD status was determined using liver ultrasound assessment...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28731780/evaluation-of-turmeric-chip-compared-with-chlorhexidine-chip-as-a-local-drug-delivery-agent-in-the-treatment-of-chronic-periodontitis-a-split-mouth-randomized-controlled-clinical-trial
#19
Abhilasha Singh, Raja Sridhar, Ravi Shrihatti, Akash Mandloy
AIMS AND OBJECTIVE: The aim of this study was to evaluate and compare the effect of chlorhexidine (CHX) chip and turmeric chip as a local drug delivery (LDD) agent in the treatment of patients with chronic periodontitis. MATERIALS AND METHODS: A total of 120 sites with pocket depths 5-8 mm were chosen as a split mouth design at 3 sites in the same patient. Selected sites were randomly divided into three groups to receive CHX chip in addition to scaling and root planing (SRP) in group A, turmeric chip in addition to SRP in group B, and SRP only in group C...
July 21, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28731373/efficacy-of-1-metformin-gel-in-moderate-and-severe-chronic-periodontitis-subjects-a-randomized-controlled-clinical-trial
#20
A R Pradeep, Kaushik Patnaik, Kanika Nagpal, Shruti Karvekar, C N Guruprasad, K M Kumaraswamy
BACKGROUND: To investigate efficacy of MF 1 % gel as, as an adjunct to scaling and root planing (SRP) in treatment of moderate and severe chronic periodontitis subjects. METHODS: Seventy subjects were categorized into two treatment groups: SRP plus 1% MF and SRP plus placebo. Clinical parameters were recorded at baseline, 3, 6 and 9 months; they included plaque index (PI), modified sulcus bleeding index (mSBI), pocket depth (PD), and clinical attachment level (CAL)...
July 21, 2017: Journal of Periodontology
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