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https://www.readbyqxmd.com/read/28938197/a-collagen-membrane-containing-osteogenic-protein-1-facilitates-bone-regeneration-in-a-rat-mandibular-bone-defect
#1
Manami Ozaki, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Mayu Nagao, Natsuko Tanabe, Akira Nakajima, Naoto Suzuki, Masao Maeno, Seiichi Yamano, Shuichi Sato
OBJECTIVES: Osteogenic protein-1 (OP-1) has shown osteoinductive activities and is useful for clinical treatments, including bone regeneration. Regenerative procedures using a bioabsorbable collagen membrane (BCM) are well established in periodontal and implant dentistry. We evaluated the subsequent effects of the BCM in combination with OP-1 on bone regeneration in a rat mandibular circular critical-sized bone defect in vivo. DESIGN: We used 8 rats that received surgery in both sides of the mandible, and created the total 16 defects which were divided into 4 groups: Group 1; no treatment, as a control, Group 2; BCM alone, Group 3; BCM containing low dose 0...
September 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28937990/treatment-of-opg-deficient-mice-with-wp9qy-a-rankl-binding-peptide-recovers-alveolar-bone-loss-by-suppressing-osteoclastogenesis-and-enhancing-osteoblastogenesis
#2
Yuki Ozaki, Masanori Koide, Yuriko Furuya, Tadashi Ninomiya, Hisataka Yasuda, Midori Nakamura, Yasuhiro Kobayashi, Naoyuki Takahashi, Nobuo Yoshinari, Nobuyuki Udagawa
Osteoblasts express two key molecules for osteoclast differentiation, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG), a soluble decoy receptor for RANKL. RANKL induces osteoclastogenesis, while OPG inhibits it by blocking the binding of RANKL to RANK, a cellular receptor of RANKL. OPG-deficient (OPG-/-) mice exhibit severe alveolar bone loss with enhanced bone resorption. WP9QY (W9) peptide binds to RANKL and blocks RANKL-induced osteoclastogenesis. W9 is also reported to stimulate bone formation in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28937973/oral-and-dental-health-issues-in-people-with-mental-disorders
#3
Julio Torales, Iván Barrios, Israel González
Patients with mental disorders are subject to a greater number of risk factors for oral and dental disease than the general population. This is mostly caused by the side effects of the medications that they receive, lack of self-care, difficulty to access health services, a negative attitude towards healthcare providers, and patients’ lack of cooperation in dental treatments. The most common psychiatric disorders in our population are depression, anxiety disorders, schizophrenia, bipolar disorder, and dementia...
September 21, 2017: Medwave
https://www.readbyqxmd.com/read/28937904/periodontal-pathogen-colonization-in-young-children-by-pcr-quantification-a-longitudinal-survey
#4
Karine Takahashi, Robson Frederico Cunha, Elerson Gaetti Jardim Junior
INTRODUCTION: Periodontal diseases are among the leading causes of premature tooth loss in adults, but the microbiota associated with this problem is established over time in childhood. AIM: This longitudinal study aimed to verify the occurrence of periodontal pathogens in the oral cavity of children aged six, twelve, eighteen and twenty-four months through PCR quantification, correlating them with the oral microbiota of their mothers. STUDY DESIGN: Saliva and oral biofilm samples were collected from mothers and children by using sterilized paper points...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937901/pulp-calcification-in-traumatized-primary-teeth-classification-clinical-and-radiographic-aspects
#5
Anna Carolina Volpi Mello-Moura, Ana Maria Antunes Santos, Gabriela Azevedo Vasconcelos Cunha Bonini, Cristina Giovannetti Del Conte Zardetto, Cacio Moura-Netto, Marcia Turolla Wanderley
OBJECTIVE: The aim of this study was to standardize the nomenclature of pulp alteration to pulp calcification (PC) and to classify it according to type, quantity and location, as well as relate it to clinical and radiographic features. STUDY DESIGN: The dental records of 946 patients from the Research and Clinical Center for Dental Trauma in Primary Teeth were studied. Two hundred and fifty PC-traumatized upper deciduous incisors were detected. RESULTS: According to radiographic analysis of the records, 62...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937069/oral-health-in-diabetic-and-nondiabetic-patients-with-chronic-kidney-disease
#6
Lingam Amara Swapna, Pradeep Koppolu, Jyothi Prince
The objective of our study is to assess the subjective and objective oral manifestations and salivary pH in diabetic and nondiabetic uremic patients at a nephrology clinic. A total of 194 diabetic and nondiabetic patients with chronic kidney disease (CKD), who were divided into four groups, Group A, B, C, D, and who were attending a nephrology clinic were included in the study. Predialytic unstimulated whole salivary pH was recorded using pH- measuring strips. Subjective and objective findings were evaluated and recorded in the specially designed pro forma...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936913/evaluation-of-complete-blood-count-indices-nlr-plr-mpv-plt-and-plcri-in-healthy-dogs-dogs-with-periodontitis-and-dogs-with-oropharyngeal-tumors-as-potential-biomarkers-of-systemic-inflammatory-response
#7
Ana Rejec, Janos Butinar, Jerzy Gawor, Milan Petelin
The aim of the study was to retrospectively assess complete blood count (CBC) indices of dogs with periodontitis (PD; n = 73) and dogs with oropharyngeal tumors (OT; n = 92) in comparison to CBC indices of healthy dogs (HD; n = 71). Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, mean platelet volume to platelet ratio, and platelet large cell ratio index (PLCRi) were evaluated as biomarkers of systemic inflammatory response provoked by PD and OT. Results of multivariable polytomous logistic regression analysis indicated no significant associations between CBC indices and PD...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28936289/socioeconomic-factors-and-severity-of-periodontal-disease-in-adults-35-44-years-a-cross-sectional-study
#8
José-Manuel Almerich-Silla, Pedro J Almiñana-Pastor, Montserrat Boronat-Catalá, Carlos Bellot-Arcís, José-María Montiel-Company
BACKGROUND: Periodontal disease or periodontitis is an inflammatory disease with a hight prevalence. According to the last oral health survey of the Spanish population, between 24% and 37% of Spaniards aged over 35 years have periodontitis and 6% to 10% of the adult population have deep periodontal pockets. The aim of this study was to determine the association between risk factors and the presence of periodontal pockets in the adult population. MATERIAL AND METHODS: A cross sectional or prevalence study of a representative sample of the adult population of the Valencia region was designed...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28935533/analysis-of-gene-expression-of-basic-fibroblast-growth-factor-bfgf-following-photodynamic-therapy-in-human-gingival-fibroblasts
#9
Roghayeh Mokhtari Asl, Pegah Ghoraeian, Abbas Monzavi, Abbas Bahador
BACKGROUND: Periodontal diseases are pathological inflammatory conditions of multifactorial etiology that develops in response to periodontopathic bacteria. Recently, photodynamic therapy (PDT) has begun to be incorporated as an adjuvant treatment for periodontal diseases. However, the effect of PDT on tissue regeneration is not yet completely clear. This study aimed to analyze the gene expression of basic fibroblast growth factor (bFGF) following PDT in human gingival fibroblasts (HuGu) cells in vitro...
September 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28934367/exploring-the-salivary-microbiome-of-children-stratified-by-the-oral-hygiene-index
#10
Izumi Mashima, Citra F Theodorea, Boonyanit Thaweboon, Sroisiri Thaweboon, Frank A Scannapieco, Futoshi Nakazawa
Poor oral hygiene often leads to chronic diseases such as periodontitis and dental caries resulting in substantial economic costs and diminished quality of life in not only adults but also in children. In this study, the salivary microbiome was characterized in a group of children stratified by the Simplified Oral Hygiene Index (OHI-S). Illumina MiSeq high-throughput sequencing based on the 16S rRNA was utilized to analyze 90 salivary samples (24 Good, 31 Moderate and 35 Poor oral hygiene) from a cohort of Thai children...
2017: PloS One
https://www.readbyqxmd.com/read/28934361/restriction-modification-mediated-barriers-to-exogenous-dna-uptake-and-incorporation-employed-by-prevotella-intermedia
#11
Christopher D Johnston, Chelsey A Skeete, Alexey Fomenkov, Richard J Roberts, Susan R Rittling
Prevotella intermedia, a major periodontal pathogen, is increasingly implicated in human respiratory tract and cystic fibrosis lung infections. Nevertheless, the specific mechanisms employed by this pathogen remain only partially characterized and poorly understood, largely due to its total lack of genetic accessibility. Here, using Single Molecule, Real-Time (SMRT) genome and methylome sequencing, bisulfite sequencing, in addition to cloning and restriction analysis, we define the specific genetic barriers to exogenous DNA present in two of the most widespread laboratory strains, P...
2017: PloS One
https://www.readbyqxmd.com/read/28934245/angiopoietin-like-protein-2-regulates-porphyromonas-gingivalis-lipopolysaccharide-induced-inflammatory-response-in-human-gingival-epithelial-cells
#12
Tasuku Ohno, Genta Yamamoto, Jun-Ichiro Hayashi, Eisaku Nishida, Hisashi Goto, Yasuyuki Sasaki, Takeshi Kikuchi, Mitsuo Fukuda, Yoshiaki Hasegawa, Makio Mogi, Akio Mitani
Angiopoietin-like protein 2 (ANGPTL2) maintains tissue homeostasis by inducing inflammation and angiogenesis. It is produced in infiltrating immune cells or resident cells, such as adipocytes, vascular endothelial cells, and tumor cells. We hypothesized that ANGPTL2 might play an important role as a unique mediator in both systemic and periodontal disease. We demonstrated an increased ANGPTL2 concentration in gingival crevicular fluid from chronic periodontitis patients. Porphyromonas gingivalis lipopolysaccharide (LPS) treatment strongly induced ANGPTL2 mRNA and protein levels in Ca9-22 human gingival epithelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28933370/a-case-of-systemic-infection-caused-by-streptococcus-pyogenes-oral-infection-in-an-edentulous-patient
#13
Yumi Inagaki, Masanobu Abe, Ryoko Inaki, Liang Zong, Hideyuki Suenaga, Takahiro Abe, Kazuto Hoshi
BACKGROUND: Infections in the oral and maxillofacial region can sometimes extend beyond the oral cavity, with serious consequences. Most oral infections are odontogenic, occurring through the root apex of the tooth or the periodontal pocket. It thus makes sense that edentulous patients have a much lower risk of oral bacterial infection. For this reason, while there are many reports on systemic infections caused by oral infections, few of these describe such infections in edentulous patients...
August 18, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28932156/possible-interaction-between-visfatin-periodontal-infection-and-other-systemic-diseases-a-brief-review-of-literature
#14
REVIEW
Mojtaba Bayani, Mohammad Pourali, Mohammad Keivan
Gingivitis and periodontitis are common bacterial infections caused by a variety of microorganisms. Despite the microorganisms' roles as etiologic agents, inflammation-induced substances also have crucial parts in the loss of connective tissue and the supporting alveolar bone. Visfatin is a pleiotropic mediator, which acts as growth factor, cytokine, and pre-B-cell colony-enhancing factor. A positive correlation was detected between the serum/plasma levels of visfatin and inflammatory disorders such as diabetes mellitus and cardiovascular disease...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28932154/malpositioned-canine-treatment-with-autotransplantation-and-laser
#15
Serap Keskin Tunc, Mehmet Savas Kayasan, Esma Ozeroglu, Cennet Neslihan Eroglu
Children and young adults often have tooth loss due to congenital tooth deficiency, trauma, or caries. Autotransplantation has many benefits. The transplanted tooth can be moved orthodontically, maintains alveolar bone growth potential during eruption, and functional periodontal ligament function also permits tooth eruption, allows the defected areas to be filled with the bones; gingival contour is much more successful than the one obtained with prosthesis. In this paper, treatment steps and follow-up results of autotransplantation case supported with biostimulation are mentioned...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28932143/tooth-extraction-pattern-and-etiology-from-extreme-northwestern-nigeria
#16
Abdurrazaq Olanrewaju Taiwo, Adebayo Aremu Ibikunle, Ramat Oyebunmi Braimah, Omotayo Amidu Sulaiman, Olalekan Micah Gbotolorun
OBJECTIVE: Tooth extraction is a commonly performed procedure in dental clinics. It has been shown that the reasons for and pattern of tooth extraction vary across geographical regions. Few reports on the pattern of extraction among a semi-urban populace exist. To the best of our knowledge, there is no study on the pattern and reasons for tooth mortality from Sokoto, Northwestern Nigeria, which is a semi-urban region. MATERIALS AND METHODS: A review of the records of patients that had tooth extraction at our center between January 2009 and January 2016, was done...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28932137/role-of-herpesviruses-in-chronic-periodontitis-and-their-association-with-clinical-parameters-and-in-increasing-severity-of-the-disease
#17
Mohammad Mukhit Abdul Gaffar Kazi, Renu Bharadwaj
OBJECTIVE: This study aims to assess the role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity. MATERIALS AND METHODS: This was a prospective case-control study. Ethical approval and prior consent were taken. A subgingival plaque sample was collected from a total of 300 patients and 300 controls and processed for DNA extraction and multiplex polymerase chain reaction for detection of herpesviruses...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28932049/evaluation-of-two-flap-designs-on-the-mandibular-second-molar-after-third-molar-extractions
#18
Nabeeh A Alqahtani, S Khaleelahmed, Farheen Desai
BACKGROUND: The extraction of third molars is associated with some clinical outcomes and periodontal problems. It is imperative to note that the type of incision used in the surgery for the removal of the impacted third molar is critical. The design of the flap influences the healing of the surgically created defect and damage to the distal periodontal area of the adjacent second molar. However, till date, there have been conflicting reports on the influence of different flap designs used for the surgical removal of impacted third molars...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28932043/gingival-mesenchymal-stem-cells
#19
Deepak Venkatesh, K P Mohan Kumar, Jyoti B Alur
The human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone. In the last year's gingival mesenchymal stem/progenitor cells (GMSCs), with promising regenerative and immunomodulatory properties, have been isolated and characterized from the gingival lamina propria. These cells, in contrast to other mesenchymal stem/progenitor cell (MSC) sources, are abundant, readily accessible and easily obtainable through minimally invasive cell isolation techniques...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28932033/glandular-odontogenic-cyst-series-of-five-cases
#20
Aadithya B Urs, Priya Kumar, Jeyaseelan Augustine, Rewa Malhotra
INTRODUCTION: Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour. MATERIALS AND METHODS: Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
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