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https://www.readbyqxmd.com/read/28341446/pkr-induces-the-expression-of-nlrp3-by-regulating-the-nf-%C3%AE%C2%BAb-pathway-in-porphyromonas-gingivalis-infected-osteoblasts
#1
Kaya Yoshida, Hirohiko Okamura, Yuka Hiroshima, Kaori Abe, Jun-Ichi Kido, Yasuo Shinohara, Kazumi Ozaki
The double-stranded RNA-dependent kinase (PKR), which is activated by double stranded RNA, induces inflammation by regulating NF-κB signaling. The NLR family pyrin domain-containing 3 (NLRP3) inflammasome also modulates inflammation in response to infection. Porphyromonas gingivalis (P.gingivalis) is an oral bacterium which is implicated in the pathogenesis of periodontal diseases. We previously reported that PKR is a key modulator of bone metabolism and inflammation in the periodontal tissue. PKR was also reported to induce inflammation in response to microbes by regulating the NLRP3 inflammasome, suggesting that PKR could affect inflammation along with NLRP3 in periodontal diseases...
March 21, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28340249/orthodontic-strain-affects-the-hippo-pathway-effector-yap-concomitant-with-proliferation-in-human-periodontal-ligament-fibroblasts
#2
Diana Huelter-Hassler, Pascal Tomakidi, Thorsten Steinberg, Britta A Jung
Objectives: During orthodontic tooth movement (OTM), human periodontal ligament fibroblasts (hPDLFs) sense, and respond to mechanical forces. Since the molecular constituents involved in these processes are not fully elucidated, the objective of the present study was to identify further key molecules of the cellular strain response. Materials and Methods: Primary hPDLFs were strained with a static equiaxial strain of 2.5 per cent for 15 minutes, 1 hour, 6 hours, and 24 hours...
March 17, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28338390/biologic-remodeling-of-periodontal-dimensions-of-areas-treated-with-gingival-augmentation-procedure-gap-a-25-year-follow-up-observation
#3
Giancarlo Agudio, Leandro Chambrone, Giovanpaolo Pini Prato
BACKGROUND: The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for many years. This study assessed the long-term "biologic remodeling" of periodontal dimensions of teeth treated with free gingival grafts (FGG) compared to their adjacent/untreated teeth. METHODS: Seventy-four patients, with at least one site showing absence or a reduced amount of attached gingiva associated with gingival recession at baseline, were treated with FGG in a private practice...
March 24, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28338103/transreplantation-%C3%A2-an-alternative-for-periodontally-hopeless-teeth
#4
Önder Solakoglu, Andreas Filippi
The periodontal therapy of severely damaged teeth that have advanced bone loss, a significant degree of mobility, and often tooth migration and elongation, frequently exposes the dental clinician to difficult decisions regarding the appropriate therapy for the patient. Extensive rehabilitation, with the replacement of periodontally hopeless teeth, has biologic, prognostic, and financial limitations. A possible alternative in such cases is the transreplantation of periodontally hopeless teeth. Ankylosis of the tooth is induced by appropriate extraoral pretreatment and thus the mobility disappears and the alveolar bone is reformed...
2017: Quintessence International
https://www.readbyqxmd.com/read/28338039/coronally-advanced-flap-combined-with-connective-tissue-graft-treatment-of-choice-for-root-coverage-following-recession
#5
Ed Madeley, Brett Duane
Data sourcesMedline, The Cochrane Database Trials Register, Embase, supplemented by handsearching of five prominent periodontal journals, references from reviewed papers and contact with experts in the field of mucogingival surgery.Study selectionRandomised controlled trials (RCTs) with or without a split-mouth design, on human patients. RCTs had to compare at least two different surgical interventions on clearly specified recession defects, be over six months in duration and have clearly specified clinical measurements regarding root coverage...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28338037/psychological-approaches-to-behaviour-for-improving-plaque-control
#6
Brett Duane
Data sourcesThe Cochrane Oral Health Groups Trial Register, Medline, Embase and PsycINFO.Study selectionRandomised controlled trials (RCTs), controlled clinical trials (CCTs), cohort studies or case-control studies were considered. Only studies in patients aged 18 or older with pre-existing periodontal disease and clearly stating a psychological model or theory had been used were included. Studies exploring smoking cessation were not included.Data extraction and synthesisAll data were collected by a single author using pre-decided parameters...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28338036/to-cord-or-not-to-cord-that-is-still-a-question
#7
Analia Veitz-Keenan, James R Keenan
Data sourcesA broad computerised search with similar key terms was performed in different databases that included: Ovid Medline, Thomson's ISI Web of Science, PubMed, Science Direct, EMBASE and the Cochrane Library. Grey literature, dissertations, abstracts and theses were searched too. Reference lists of the selected articles were hand-searched.Study selectionThe inclusion criteria included in vivo randomised clinical trials and quasi-randomised clinical trials using gingival retraction techniques with and without cord...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28338030/implant-outcomes-poorer-in-patients-with-history-of-periodontal-disease
#8
Analia Veitz-Keenan, James R Keenan
Data sourcesMedline and Embase databases and bibliographies of all included articles and relevant review articles were screened for possible inclusion.Study selectionLongitudinal studies were included reporting on implant survival, success, incidence of peri-implantitis, bone loss and periodontal status and on partially dentate patients with a history of treatment for periodontitis. There were no language restrictions for the included studies.Data extraction and synthesisAuthors independently and in duplicate assessed the studies for eligibility and data extraction...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28338023/implant-maintenance-treatment-and-peri-implant-health
#9
Mark-Steven Howe
Data sourcesMedline (PubMed), Embase, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases and a manual search of the Journal of Dental Research, Journal of Clinical Periodontology, Journal of Periodontology and the International Journal of Periodontics and Restorative Dentistry from January 2014 to February 2015.Study selectionProspective, retrospective, randomised or not, case-controlled or case series trials showing the incidence or recurrence of peri-implant disease plus or minus PIMT over more than six months...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28337902/helicobacter-pylori-in-periodontal-pockets-and-saliva-a-possible-role-in-gastric-infection-relapses
#10
L Azzi, F Carinci, S Gabaglio, F Cura, F Croveri, L Tettamanti, A Tagliabue, S Segato
It has been a long time since the scientific community started to speculate upon the presence of Helicobacter pylori (HP) in periodontal pockets as an extra-gastric reservoir responsible for gastric relapses after eradication therapy. The aim of this study is to evaluate the presence of oral HP in a group of patients who underwent examination for gastric infection. Sixty patients were enrolled in the current study, subdivided into two groups: 30 patients with a positive result for HP gastric infection with C-Breath Test Urea examination, and 30 patients with a negative result for HP gastric infection...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337876/the-efficacy-of-proanthocyanidins-and-secnidazole-in-the-treatment-of-chronic-periodontitis-after-scaling-and-root-planing-therapy
#11
M Li, R Li, Q Jin, J Pang, Z Xu
The aim of this study is to evaluate the clinical and microbiological effect of the systemic antibiotic therapy of proanthocyanidins and secnidazole on periodontitis. Seventy-five subjects with chronic periodontitis were randomly divided into two treatment groups (secnidazole or proanthocyanidins) and one placebo control group (25 cases each). Plaque index (PI), gingival index (GI), gingival bleeding index (BI), probing pocket depth (PPD), and clinical attachment level (CAL) were carried out at baseline, post-treatment and 3 months after treatment...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337422/the-combined-use-of-computer-guided-minimally-invasive-flapless-corticotomy-and-clear-aligners-as-a-novel-approach-to-moderate-crowding-a-case-report
#12
Michele Cassetta, Federica Altieri, Stefano Pandolfi, Matteo Giansanti
The aim of this case report was to describe an innovative orthodontic treatment method that combined surgical and orthodontic techniques. The novel method was used to achieve a positive result in a case of moderate crowding by employing a computer-guided piezocision procedure followed by the use of clear aligners. A 23-year-old woman had a malocclusion with moderate crowding. Her periodontal indices, oral health-related quality of life (OHRQoL), and treatment time were evaluated. The treatment included interproximal corticotomy cuts extending through the entire thickness of the cortical layer, without a full-thickness flap reflection...
March 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28337048/validity-of-a-new-kit-measuring-salivary-lactate-dehydrogenase-level-for-screening-gingivitis
#13
Daisuke Ekuni, Mayu Yamane-Takeuchi, Kota Kataoka, Aya Yokoi, Ayano Taniguchi-Tabata, Hirofumi Mizuno, Hisataka Miyai, Yoko Uchida, Daiki Fukuhara, Yoshio Sugiura, Takaaki Tomofuji, Manabu Morita
Aim. The aim of this study was to determine the usefulness of a new kit that can evaluate salivary lactate dehydrogenase (LD) level in real time for screening gingivitis. Materials and Methods. The study included 70 systemic healthy volunteers [29 males and 41 females; mean age ± SD: 24.1 ± 2.6 years]. Resting saliva was collected from each participant and LD level was evaluated in real time using the kit (a color-changing sheet with an integer scale ranging from 1 to 10). A dentist measured probing pocket depth, clinical attachment level, and the proportion of sites with bleeding on probing (% BOP) at six sites on all teeth...
2017: Disease Markers
https://www.readbyqxmd.com/read/28337007/cost-effectiveness-of-regular-versus-irregular-supportive-periodontal-therapy-or-tooth-removal
#14
(no author information available yet)
Regular SPT (supportive periodontal treatment) retains teeth longer than irregular SPT but this regimen is not necessarily cheaper; extraction and replacement of teeth was usually the most expensive.
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28336998/characteristics-and-treatment-of-invasive-cervical-resorption-in-vital-teeth-a-narrative-review-and-a-report-of-two-cases
#15
P Tsaousoglou, E Markou, N Efthimiades, I Vouros
Invasive cervical resorption (ICR) is a significant defect of the root surface where the hard dental tissues are undermined and become translucent due to the resorptive granulomatous tissue. It is mainly detected on radiographs. The radiographic appearance of ICR is asymmetrical radiolucency with irregular margins and an unchanged root canal. The purpose of this study is to present a comprehensive review together with the characteristics and the treatment of ICR through two cases which were followed-up for 36 months...
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28336586/draft-genome-sequence-of-tannerella-forsythia-clinical-isolate-9610
#16
Sesha Hanson-Drury, Thao T To, Quanhui Liu, Anh T Vo, Michelle Kim, Michael Watling, Roger S Bumgarner, Jeffrey S McLean
We present here the draft genome sequence of Tannerella forsythia 9610, a clinical isolate obtained from a periodontitis patient. The genome is composed of 79 scaffolds with 82 contigs, for a length of 3,201,941 bp and a G+C of 47.3%.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28336292/structural-elucidation-and-physiologic-functions-of-specialized-pro-resolving-mediators-and-their-receptors
#17
REVIEW
Nan Chiang, Charles N Serhan
The acute inflammatory response is host protective to contain foreign invaders. Many of today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious unwanted side effects such as immune suppression. Uncontrolled inflammation is now considered a pathophysiologic basis associated with, many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity and asthma, as well as the classic inflammatory diseases, e.g. arthritis, periodontal diseases...
March 20, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28335262/nanomaterials-for-tissue-engineering-in-dentistry
#18
REVIEW
Manila Chieruzzi, Stefano Pagano, Silvia Moretti, Roberto Pinna, Egle Milia, Luigi Torre, Stefano Eramo
The tissue engineering (TE) of dental oral tissue is facing significant changes in clinical treatments in dentistry. TE is based on a stem cell, signaling molecule, and scaffold triad that must be known and calibrated with attention to specific sectors in dentistry. This review article shows a summary of micro- and nanomorphological characteristics of dental tissues, of stem cells available in the oral region, of signaling molecules usable in TE, and of scaffolds available to guide partial or total reconstruction of hard, soft, periodontal, and bone tissues...
July 21, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#19
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334934/a-pseudaminic-acid-or-a-legionaminic-acid-derivative-transferase-is-strain-specifically-implicated-in-the-general-protein-o-glycosylation-system-of-the-periodontal-pathogen-tannerella-forsythia
#20
Markus B Tomek, Bettina Janesch, Daniel Maresch, Markus Windwarder, Friedrich Altmann, Paul Messner, Christina Schäffer
The occurrence of nonulosonic acids in bacteria is wide-spread and linked to pathogenicity. However, the knowledge of cognate nonulosonic acid transferases is scarce. In the periodontopathogen Tannerella forsythia, several proposed virulence factors carry strain-specifically either a pseudaminic or a legionaminic acid derivative as terminal sugar on an otherwise structurally identical, protein-bound oligosaccharide. This study aims to shed light on the transfer of either nonulosonic acid derivative on a proximal N-acetylmannosaminuronic acid residue within the O-glycan structure, exemplified with the bacterium's abundant S-layer glycoproteins...
March 16, 2017: Glycobiology
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