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https://www.readbyqxmd.com/read/28636235/stem-cell-based-tooth-and-periodontal-regeneration
#1
Lei Hu, Yi Liu, Songlin Wang
Currently regeneration of tooth and periodontal damage still remains great challenge. Stem cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem cells for tooth and periodontal regeneration include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from the dental apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), dental epithelial stem cells (DESCs), bone marrow mesenchymal stem cells (BMMSCs), adipose-derived stem cells (ADSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
June 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28635358/disability-and-the-impact-of-need-for-periodontal-care-on-quality-of-life-a-cross-sectional-study
#2
Maha El Tantawi, Adel AlAgl
Objective The need for periodontal care may negatively impact daily life. We compared the need for periodontal care and its impact on daily life between disabled and healthy adults in the Eastern Province, Saudi Arabia. Methods In this cross-sectional study of 819 adults, a questionnaire was used to assess personal background factors; the impact of periodontitis on pain, avoiding foods, embarrassment, sleeplessness, work absence, and discontinuing daily activities; and risk factors (smoking, diabetes, toothbrushing, insurance, professional tooth cleaning, and dental visits)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28633943/diet-borne-systemic-inflammation-is-associated-with-prevalent-tooth%C3%A2-loss
#3
Georgios A Kotsakis, Vanessa Chrepa, Nitin Shivappa, Michael Wirth, James Hébert, Ai Koyanagi, Stefanos Tyrovolas
BACKGROUND & AIMS: The deleterious effect of cariogenic dietary patterns on tooth loss is well characterized, but the contribution of diet-borne systemic inflammation to loss of teeth remains uncharted. Recent efforts have unveiled a protective role of single nutrients to periodontal health. However, the assessment of overall diet as a modifiable risk factor for oral health remains elusive. Thus, the aim of this study was to assess the association between diet-borne systemic inflammation and tooth loss in a representative sample of the US adult non-institutionalized population...
June 9, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28633647/meeting-the-oral-health-needs-of-12-year-olds-in-china-human-resources-for-oral-health
#4
Xiangyu Sun, Eduardo Bernabé, Xuenan Liu, Shuguo Zheng, Jennifer E Gallagher
BACKGROUND: An appropriate level of human resources for oral health [HROH] is required to meet the oral health needs of population, and enable maximum improvement in health outcomes. The aim of this study was to estimate the required HROH to meet the oral health needs of the World Health Organization [WHO] reference group of 12-year-olds in China and consider the implications for education, practice, policy and HROH nationally. METHODS: We estimated the need of HROH to meet the needs of 12-year-olds based on secondary analysis of the epidemiological and questionnaire data from the 3rd Chinese National Oral Health Survey, including caries experience and periodontal factors (calculus), dentally-related behaviour (frequency of toothbrushing and sugar intake), and social factors (parental education)...
June 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28633639/fusobacterial-liver-abscess-a-case-report-and-review-of-the-literature
#5
Dilip Jayasimhan, Linus Wu, Paul Huggan
BACKGROUND: Fusobacteriae are facultative anaerobic gram-negative bacilli which cause a range of invasive infections, amongst which pyogenic liver abscesses are rare. We describe a case of Fusobacterium nucleatum liver abscess and review the relevant literature. CASE PRESENTATION: A 51-year-old lady presented with a 4-day history of abdominal pain, diarrhoea, fever, rigors, and lethargy. Imaging revealed an abscess which was drained. Cultures of the blood and abscess aspirate grew Fusobacterium nucleatum and Prevotella pleuritidis respectively...
June 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28633586/porphyromonas-gingivalis-and-its-lps-differentially-regulate-the-expression-of-peptidyl-arginine-deiminases-in-human-chondrocytes
#6
René Elkaim, Isaac Maximiliano Bugueno-Valdebenito, Nadia Benkirane-Jessel, Henri Tenenbaum
Periodontitis, an inflammatory disease initiated by Gram-negative bacteria such as Porphyromonas gingivalis ( Pg), is considered as a risk factor for rheumatoid arthritis (RA). Our study aimed to determine the effect of Pg and its LPS on the expression of peptidyl arginine deiminase isotypes (PADs) in human primary chondrocytes (HC). HCs were infected with Pg and activated by its LPS (LPS- Pg). The mRNA expression levels of human PADs (1, 2, 3, 4 and 6) and bacterial enzyme (PADPg) were quantified by RT-qPCR...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28632755/potassium-is-a-key-signal-in-host-microbiome-dysbiosis-in-periodontitis
#7
Susan Yost, Ana E Duran-Pinedo, Keerthana Krishnan, Jorge Frias-Lopez
Dysbiosis, or the imbalance in the structural and/or functional properties of the microbiome, is at the origin of important infectious inflammatory diseases such as inflammatory bowel disease (IBD) and periodontal disease. Periodontitis is a polymicrobial inflammatory disease that affects a large proportion of the world's population and has been associated with a wide variety of systemic health conditions, such as diabetes, cardiovascular and respiratory diseases. Dysbiosis has been identified as a key element in the development of the disease...
June 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28632668/low-intensity-pulsed-ultrasound-lipus-promotes-bmp9-induced-osteogenesis-and-suppresses-inflammatory-responses-in-human-periodontal-ligament-derived-stem-cells
#8
Joji Kusuyama, Toshiaki Nakamura, Tomokazu Ohnishi, Nahoko Eiraku, Kazuyuki Noguchi, Tetsuya Matsuguchi
OBJECTIVE: We previously reported that low intensity pulsed ultrasound (LIPUS) promotes marrow stromal cell (MSC) osteogenesis and suppresses the LPS-induced inflammatory response in osteoblasts. Here, we examined the effects of LIPUS on human periodontal ligament-derived stem cells (hPDLSCs) in chronic inflammatory bone disease, such as periodontitis. MATERIALS AND METHODS: hPDLSCs were collected from 3 healthy third molars. hPDLSCs were induced to differentiate by either recombinant BMP2 or BMP9 with or without daily LIPUS treatment (20 min/d)...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28632321/is-aggregatibacter-actinomycetemcomitans-the-missing-link-between-periodontitis-and-rheumatoid-arthritis
#9
David Polak
The impact of chronic conditions on the modern population is even more evident in view of a prolonged human life span. In addition, most individuals will probably simultaneously suffer from more than one chronic condition. As such, unveiling the pathogenesis of chronic diseases, as well as the causal factors that crosstalk between different conditions, is one of the greatest challenges faced by modern medicine. Two such conditions are periodontitis and rheumatoid arthritis (RA). This article is protected by copyright...
June 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28631896/boric-acid-gel-as-local-drug-delivery-in-the-treatment-of-class-ii-furcation-defects-in-chronic-periodontitis-a-randomized-controlled-clinical-trial
#10
Sandeep Singhal, Avani Raju Pradeep, Dharmendra Kanoriya, Shruti Garg, Vibhuti Garg
AIM: Boric acid (BA) exhibits antibacterial, anti-inflammatory, as well as osteoblastic, activity. The aim of the present study was to explore the efficacy of 0.75% BA gel as a local drug-delivery system in adjunct to scaling and root planing (SRP) for the treatment of class II furcation defects in comparison with placebo gel. METHODS: A total of 48 mandibular class II furcation defects were randomized and treated with either 0.75% BA gel or placebo gel. Clinical parameters were recorded at baseline, 3 months, and 6 months, while radiographic parameters were recorded at baseline and 6 months...
June 20, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28631541/semilunar-coronally-advanced-periodontal-flap-to-increase-soft-tissue-coverage-of-a-maxillary-fourth-premolar-in-a-dog
#11
Allen Skinner, Brook Niemiec
A 7-year-old, 31.3 kg spayed female Golden Retriever dog was presented for the treatment of Miller Class I gingival recession at the right maxillary fourth premolar (108). A semilunar coronally advanced periodontal flap was performed at this tooth and created an increase of approximately 3 mm of soft tissue coverage of the tooth. This method may have benefits over traditional periodontal advancement flaps in that there is no need for suturing, can be done more quickly, maintains lateral blood supply to the flap, and likely has decreased risk of surgical site dehiscence...
June 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28631388/the-efficacy-of-commercial-tooth-storage-media-for-maintaining-the-viability-of-human-periodontal-ligament-fibroblasts
#12
W Lee, S Stover, M Rasoulianboroujeni, K Sherman, F Fahimipour, E Dashtimoghadam, C Zito, H Jazayeri, L Tayebi
AIM: To evaluate Save-A-Tooth (SAT), EMT Toothsaver (EMT), and Hank's Balanced Salt Solution (HBSS) for their influence on the viability and proliferative capacity of human periodontal ligament fibroblast (HPDLF). METHODOLOGY: Primary HPDLFs were seeded on 96-well cell culture plates and exposed to SAT, EMT, HBSS and water (negative control) for 0.5, 1, 3, 6, 12 and 24 hours at room temperature (22°C). After each exposure time, cell viability was measured by quantifying adenosine triphosphate (ATP) using a luminescent dye...
June 20, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28631313/salivary-gingival-crevicular-fluid-and-serum-levels-of-ghrelin-and-chemerin-in-patients-with-periodontitis-and-overweight
#13
H F R Jentsch, N Arnold, V Richter, J Deschner, T Kantyka, S Eick
BACKGROUND AND OBJECTIVE: Nutrition and body weight are modifying factors for periodontitis. The purpose of this study was to quantify two molecules (ghrelin and chemerin), released in association with food intake and obesity, in periodontally healthy and diseased individuals with respect to different body mass categories. MATERIAL AND METHODS: The two main groups (patients with chronic periodontitis and periodontally healthy/gingivitis volunteers) were subdivided into groups of subjects with normal weight [body mass index (BMI) <25] and groups of overweight/obese subjects (BMI ≥25)...
June 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28631261/distinct-post-translational-features-of-type-i-collagen-are-conserved-in-mouse-and-human-periodontal-ligament
#14
D M Hudson, M Garibov, D R Dixon, T Popowics, D R Eyre
BACKGROUND AND OBJECTIVE: Specifics of the biochemical pathways that modulate collagen cross-links in the periodontal ligament (PDL) are not fully defined. Better knowledge of the collagen post-translational modifications that give PDL its distinct tissue properties is needed to understand the pathogenic mechanisms of human PDL destruction in periodontal disease. In this study, the post-translational phenotypes of human and mouse PDL type I collagen were surveyed using mass spectrometry...
June 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28631250/lactobacillus-salivarius-nk02-a-potent-probiotic-for-clinical-application-in-mouthwash
#15
Neda Sajedinejad, Mojgan Paknejad, Behzad Houshmand, Hakimeh Sharafi, Reza Jelodar, Hossein Shahbani Zahiri, Kambiz Akbari Noghabi
A specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16S rRNA gene sequencing. The phylogenetic affiliation of the isolate confirmed that the NK02 strain had close association with the Lactobacillus salivarius. An effective mouthwash was developed for treatment of periodontitis and suppression of the indicator bacterium Aggregatibacter actinomycetemcomitans which is an obvious pathogen of periodontal disease. The mouthwash containing L...
June 19, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28631047/periodontal-disease-in-chinese-patients-with-systemic-lupus-erythematosus
#16
Qiuxiang Zhang, Xiaoli Zhang, Guijaun Feng, Ting Fu, Rulan Yin, Lijuan Zhang, Xingmei Feng, Liren Li, Zhifeng Gu
Disease of systemic lupus erythematosus (SLE) and periodontal disease (PD) shares the common multiple characteristics. The aims of the present study were to evaluate the prevalence and severity of periodontal disease in Chinese SLE patients and to determine the association between SLE features and periodontal parameters. A cross-sectional study of 108 SLE patients together with 108 age- and sex-matched healthy controls was made. Periodontal status was conducted by two dentists independently. Sociodemographic characteristics, lifestyle factors, medication use, and clinical parameters were also assessed...
June 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28630069/degradation-of-incretins-and-modulation-of-blood-glucose-levels-by-periodontopathic-bacterial-dipeptidyl-peptidase-4
#17
Yuko Ohara-Nemoto, Manami Nakasato, Yu Shimoyama, Tomomi T Baba, Takeshi Kobayakawa, Toshio Ono, Takashi Yaegashi, Shigenobu Kimura, Takayuki K Nemoto
Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is involved in regulation of blood glucose levels by cleaving incretins in humans. We examined the enzymatic characteristics of DPP4 from P. gingivalis as well as two other periodontopathic bacteria, Tannerella forsythia and Prevotella intermedia, and determined whether it is capable of regulating blood glucose levels...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28630066/porphyromonas-gulae-activates-unprimed-and-ifn%C3%AE-primed-macrophages-via-the-pattern-recognition-receptors-tlr-2-tlr-4-and-nod2
#18
James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca K H Orth, Ashley Mansell, Eric C Reynolds
Porphyromonas gulae is an anaerobic, Gram-negative coccobacillus that has been associated with periodontal disease in companion animals. The aims of this study were to analyse the ligation of pattern recognition receptors by P. gulae and the subsequent activation of macrophages. Exposure of HEK cells transfected with Toll-like receptors or NOD-like receptors to P. gulae resulted in the ligation of TLR2, TLR4 and NOD2. The effect of this engagement of receptors was investigated by measuring the synthesis of nitric oxide, CD86 expression and inflammatory cytokine production using wild type, TLR2-/- and TLR4-/- macrophages...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28629781/position-paper-for-the-evaluation-and-management-of-oral-status-in-patients-with-valvular-disease-groupe-de-travail-valvulopathies-de-la-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-cardiologie-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-chirurgie-orale-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-parodontologie-et-d-implantologie
#19
REVIEW
Sarah Millot, Philippe Lesclous, Marie-Laure Colombier, Loredana Radoi, Clément Messeca, Mathieu Ballanger, Jean-Luc Charrier, Philippe Tramba, Stéphane Simon, Alain Berrebi, Fabien Doguet, Emmanuel Lansac, Christophe Tribouilloy, Gilbert Habib, Xavier Duval, Bernard Iung
Oral health is of particular importance in patients with heart valve diseases because of the risk of infective endocarditis. Recommendations for antibiotic prophylaxis before dental procedures have been restricted, but the modalities of oral evaluation and dental care are not detailed in guidelines. Therefore, a multidisciplinary working group reviewed the literature to propose detailed approaches for the evaluation and management of buccodental status in patients with valvular disease. Simple questions asked by a non-dental specialist may draw attention to buccodental diseases...
June 16, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28628802/metabolic-control-and-periodontal-treatment-decreases-elevated-oxidative-stress-in-the-early-phases-of-type-1-diabetes-onset
#20
Cüneyt A Aral, Özlem Nalbantoğlu, Bilge G Nur, Mustafa Altunsoy, Kübra Aral
OBJECTIVE: Recently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment...
June 12, 2017: Archives of Oral Biology
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