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https://www.readbyqxmd.com/read/27933720/autogenous-bone-grafting-for-treatment-of-osseous-defect-after-impacted-mandibular-third-molar-extraction-a-randomized-controlled-trial
#1
Jing Ge, Chi Yang, Jiawei Zheng, Yingkai Hu
BACKGROUND: Extraction of impacted mandibular third molar (M3) has been cited as causing osseous defect at the distal aspect of the adjacent second molar (M2). PURPOSE: This randomized controlled trial was aimed to evaluate the effect of autogenous bone grafting in situ for regeneration of periodontal osseous defect distal to the M2 compared with non-grafting after impacted M3 removal. MATERIALS AND METHODS: A total of 60 sites in 51 adult patients were enrolled and randomly assigned to the control group or the test group...
December 8, 2016: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/27933671/causal-inference-in-obesity-research
#2
REVIEW
P W Franks, N Atabaki-Pasdar
Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle and surgical interventions. Thus, whilst obesity is widely considered the major modifiable risk factor for many chronic diseases, its causes and consequences are often difficult to determine...
December 8, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27933445/correlation-of-crevicular-fluid-and-serum-levels-of-retinol-binding-protein-4-and-leptin-in-chronic-periodontitis-and-obesity
#3
Dharmendra Kanoriya, A R Pradeep, A Mallika, Sandeep Singhal, Vibhuti Garg
OBJECTIVE: Retinol-binding protein 4 (RBP4) and leptin are both adipokines and involved in the pathophysiology of different vascular and inflammatory diseases and selectively elevated in patients with obesity. The aim of the present study was to determine and correlate the levels of RBP4 and leptin in gingival crevicular fluid (GCF) and serum in patients with chronic periodontitis (CP) and obesity. MATERIALS AND METHODS: A total of 70 patients with age group 25 to 45 years were divided into four groups based on gingival index (GI), probing depth (PD), clinical attachment level (CAL), body mass index (BMI) and radiographic evidence of bone loss...
December 8, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27933212/spontaneous-destructive-periodontitis-and-skeletal-bone-damage-in-transgenic-mice-carrying-a-human-shared-epitope-coding-hla-drb1-allele
#4
Prashasnika Gehlot, Sarah L Volk, Hector F Rios, Karl J Jepsen, Joseph Holoshitz
OBJECTIVE: Shared epitope (SE)-coding DRB1 alleles are associated with bone erosion in several diseases, including rheumatoid arthritis (RA) and periodontal disease (PD), but the underlying mechanism is unknown. We have recently identified the SE as an osteoclast-activating ligand. To better understand the biological effects of the SE in vivo, here we sought to determine whether it can facilitate spontaneous bone damage in naïve mice. METHODS: 3-month old naïve transgenic mice that carry the human SE-coding allele DRB1*04:01, or a SE-negative allele DRB1*04:02 were studied...
2016: RMD Open
https://www.readbyqxmd.com/read/27932844/what-factors-influence-patient-compliance-with-supportive-periodontal-therapy-in-a-general-practice-setting
#5
C Perrell-Jones, R S Ireland
Background The importance of supportive periodontal therapy following active treatment has been well documented but numerous studies have shown patient compliance to be poor. The aim of this study was to ascertain which factors affect patient compliance and whether this included routinely recorded periodontal indices.Methodology This was a five-year retrospective service evaluation study set within a private general dental practice. It utilised demographic and periodontal data from patients who attended the practice for chronic periodontal treatment in 2009 and ascertained whether there were links between this data and compliance with the supportive phase of periodontal treatment...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932832/should-implants-be-considered-for-patients-with-periodontal-disease
#6
E King, R Patel, A Patel, L Addy
Dental implants are seen as a good option for replacing missing teeth. The success and survival rates for implants are very high. Concerns are developing about the problem of peri-implantitis. The reports of its prevalence vary but it is noted that the presence of periodontal disease is a risk factor. The issue of peri-implantitis was raised in the House of Lords in 2014. Complaints relating to implants is on the rise with the General Dental Council. Placement of implants in patients with periodontal disease is not a treatment that should be done without a full periodontal assessment and stabilisation of periodontal disease first...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932811/a-pilot-study-of-the-gingival-response-when-smokers-switch-from-smoking-to-vaping
#7
R Wadia, V Booth, H F Yap, D L Moyes
Introduction Tobacco smoking is one of the most important risk factors for periodontitis as it alters the host response to plaque. Although the prevalence of tobacco smoking has declined in recent years, the use of electronic-cigarettes (vaping) has increased. The effect of vaping on the gingiva is unknown and an evidence-base needs to be established before providing dental advice about the use of these products.Objective To compare the gingival health of a group of established smokers before and after substituting vaping for smoking tobacco...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932408/early-responses-of-human-periodontal-ligament-fibroblasts-to-cyclic-and-static-mechanical-stretching
#8
Adamantia Papadopoulou, Anna Iliadi, Theodore Eliades, Dimitris Kletsas
OBJECTIVE: To compare the mechanotransduction caused by cyclic and static mechanical strains in human periodontal ligament fibroblasts (hPDLFs) cultured under identical conditions. MATERIALS AND METHODS: hPDLFs, originating from the same donors, were exposed either to cyclic or to static tensile strain using specially designed devices and under identical culture conditions. Activation of all members of mitogen-activated protein kinases (MAPKs) was monitored by western immunoblot analysis...
December 8, 2016: European Journal of Orthodontics
https://www.readbyqxmd.com/read/27932407/torque-differences-according-to-tooth-morphology-and-bracket-placement-a-finite-element-study
#9
Spyridon N Papageorgiou, Iosif Sifakakis, Ludger Keilig, Raphael Patcas, Stefan Affolter, Theodore Eliades, Christoph Bourauel
INTRODUCTION: Torque of the maxillary incisors is essential in esthetics and proper occlusion, while torque expression is influenced by many factors. The aim of this finite element study was to assess the relative effect of tooth morphology, bracket prescription, and bracket positioning on tooth displacement and developed stresses/strains after torque application. METHODS: A three-dimensional upper right central incisor with its periodontal ligament (PDL) and alveolus was modelled...
December 8, 2016: European Journal of Orthodontics
https://www.readbyqxmd.com/read/27931484/treatment-of-plaque-induced-gingivitis-chronic-periodontitis-and-other-clinical-conditions
#10
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27931483/guideline-for-periodontal-therapy
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27931482/periodontal-diseases-of-children-and-adolescents
#12
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27930933/calcitonin-induces-collagen-synthesis-and-osteoblastic-differentiation-in-human-periodontal-ligament-fibroblasts
#13
Yibo Wei, Qing Ye, Zhen Tang, Gang Tian, Qiang Zhu, Haocheng Gao, Dalin Wang, Zhizhong Cao
BACKGROUND: Extracellular matrix (ECM) secretion and osteogenic differentiation in periodontal ligament fibroblasts (PDLF) facilitate the neogenesis of alveolar bone, which is the cellular basis for alveolar bone repair. Calcitonin (CT) has been reported to play an important role in promoting ECM expression and inducing osteogenic differentiation in osteoblast, but its effects on PDLFs remain obscure. METHODS: The expression of CT, transforming growth factor-beta 1(TGF-β1) and bone morphogenetic protein (BMP) in gingival crevicular fluid (GCF) was measured by ELISA...
November 28, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27930932/production-of-endogenous-hydrogen-sulfide-in-human-gingival-tissue
#14
Jiang Chun-Mei, Chen Wu, Meng Guo-Liang, Gu Yue, Chen Ning, Yong Ji
OBJECTIVE: Endogenous hydrogen sulfide (H2S) has recently been shown to play an important role in inflammation, but the role of endogenous H2S in the human gingival tissue is unknown. The aim of this study was to investigate whether gingiva had enzymes for H2S synthesis, and whether the effect of these enzymes for H2S production changed with periodontal inflammation. DESIGN: Gingival tissues were collected from patients undergoing periodontal operation including gingivitis, moderate chronic periodontitis, severe chronic periodontitis and normal controls...
November 28, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27930822/estimating-effects-of-craniofacial-morphology-on-gingival-recession-and-clinical-attachment-loss
#15
Loutfi Salti, Birte Holtfreter, Christiane Pink, Mohamad Habes, Reiner Biffar, Stavros Kiliaridis, Karl-Friedrich Krey, Robin Bülow, Henry Völzke, Thomas Kocher, Amro Daboul
OBJECTIVES: Evidence on possible associations between facial morphology, attachment loss and gingival recession is lacking. We analyzed whether the facial type, which can be described by the ratio of facial width and length (facial index), is related to periodontal loss of attachment, hypothesizing that a broad face might be associated with less gingival recession (GR) and less clinical attachment loss (CAL) than a long face. MATERIALS AND METHODS: Data from the 11-years follow-up of the population-based Study of Health in Pomerania were used...
December 8, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27930577/crosstalk-between-oral-and-general-health-status-in-e-smokers
#16
Marco Tatullo, Stefano Gentile, Francesco Paduano, Luigi Santacroce, Massimo Marrelli
Electronic cigarette (e-cigarette) simulates the act of tobacco smoking by vaporizing a mixture of propylene glycol, nicotine, and flavoring agents. e-cigarette has been proposed as a product able to aid to stop smoking. The aim of the study is to verify the clinical variations of periodontal health induced by e-cigarettes use and, moreover, to investigate about the awareness of the e-smokers about their health variations and about their hypothetical need to turn back to smoke combustible cigarettes.This clinical observational pilot study involved 110 out of 350 smokers, who switched to e-cigarette...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928641/dental-health-status-and-patient-reported-outcomes-at-baseline-in-patients-participating-in-the-osteonecrosis-of-the-jaw-registry-study-swog-s0702
#17
Catherine H Van Poznak, Amy Darke, Carol M Moinpour, Robert A Bagramian, Mark M Schubert, Julie R Gralow, James L Wade, Joseph M Unger
PURPOSE: SWOG S0702 was a cohort study of patients with cancer with bone metastases due to any cancer. Using baseline data from S0702, this report characterizes the oral health and oral health-related quality of life (OHRQoL) of patients with advanced cancer. METHODS: S0702 case report forms captured dental assessment and patient-reported outcome (PRO) data. This analysis compares PRO dental discomfort with selected clinical assessments of dental health. This analysis focuses on the 2294 patients who underwent baseline dental examination prior to study registration, but also reports on the 1235 patients for whom only OHRQol data are available...
December 7, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27927890/massively-increased-caries-susceptibility-in-an-irf6-cleft-lip-palate-model
#18
B Tamasas, T C Cox
Patients with cleft lip/palate (CLP) have been reported, in some studies, to exhibit an increased prevalence of caries, although the underlying cause for this increase is unknown. In genetically defined mouse models, studies of postnatal sequelae associated with CLP have been hampered by neonatal lethality. Using a conditional targeting approach, we ablated the major CLP gene Irf6 only in the late embryonic oral epithelium (Irf6 cKO), bypassing the role of the gene in lip and palate morphogenesis and thus ensuring survival to adulthood...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27926431/the-oral-microbiome-in-health-and-its-implication-in-oral-and-systemic-diseases
#19
B Sampaio-Maia, I M Caldas, M L Pereira, D Pérez-Mongiovi, R Araujo
The oral microbiome can alter the balance between health and disease, locally and systemically. Within the oral cavity, bacteria, archaea, fungi, protozoa, and viruses may all be found, each having a particular role, but strongly interacting with each other and with the host, in sickness or in health. A description on how colonization occurs and how the oral microbiome dynamically evolves throughout the host's life is given. In this chapter the authors also address oral and nonoral conditions in which oral microorganisms may play a role in the etiology and progression, presenting the up-to-date knowledge on oral dysbiosis as well as the known underlying pathophysiologic mechanisms involving oral microorganisms in each condition...
2016: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/27925695/integrated-biomarker-profiling-of-smokers-with-periodontitis
#20
Radhakrishnan Nagarajan, Mohanad Al-Sabbagh, Dolph Dawson, Jeffrey Ebersole
: In the context of precision medicine, understanding patient-specific variation is an important step in developing targeted and patient-tailored treatment regimens for periodontitis. While several studies have successfully demonstrated the usefulness of molecular expression profiling in conjunction with single classifier systems in discerning distinct disease groups, the majority of these studies do not provide sufficient insights into potential variations within the disease groups. AIM: The goal of the present study is to discern biological response profiles of periodontitis and non-periodontitis smoking subjects using an informed panel of biomarkers across multiple scales (salivary, oral microbiome, pathogens and other markers)...
December 7, 2016: Journal of Clinical Periodontology
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