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Chrysin AND Testosterone

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https://www.readbyqxmd.com/read/24932515/chrysin-alleviates-testicular-dysfunction-in-adjuvant-arthritic-rats-via-suppression-of-inflammation-and-apoptosis-comparison-with-celecoxib
#1
COMPARATIVE STUDY
Hebatallah A Darwish, Hany H Arab, Rania M Abdelsalam
Long standing rheumatoid arthritis (RA) is associated with testicular dysfunction and subfertility. Few studies have addressed the pathogenesis of testicular injury in RA and its modulation by effective agents. Thus, the current study aimed at evaluating the effects of two testosterone boosting agents; chrysin, a natural flavone and celecoxib, a selective COX-2 inhibitor, in testicular impairment in rats with adjuvant arthritis, an experimental model of RA. Chrysin (25 and 50mg/kg) and celecoxib (5mg/kg) were orally administered to Wistar rats once daily for 21days starting 1h before arthritis induction...
September 1, 2014: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/22852850/evaluation-of-the-mutagenic-activity-of-chrysin-a-flavonoid-inhibitor-of-the-aromatization-process
#2
G A R Oliveira, E R A Ferraz, A O Souza, R A Lourenço, D P Oliveira, D J Dorta
Chrysin is one of the natural flavonoids present in plants, and large amounts are present in honey and propolis. In addition to anticancer, antioxidation, and anti-inflammatory activities, chrysin has also been reported to be an inhibitor of aromatase, an enzyme converting testosterone into estrogen. The present study evaluated the mutagenicity of this flavonoid using micronucleus (MN) with HepG2 cells and Salmonella. Cell survival after exposure to different concentrations of chrysin was also determined using sulforhodamine B (SRB) colorimetric assay in HepG2 cells and the influence of this flavonoid on growth of cells in relation to the cell cycle and apoptosis...
2012: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/21486424/beneficial-effects-of-chrysin-on-the-reproductive-system-of-adult-male-rats
#3
O Ciftci, I Ozdemir, M Aydin, A Beytur
In this study, the beneficial effect of chrysin, a natural flavonoid currently under investigation due to its important biological activities, on reproductive system of rats was investigated. Rats (n = 16) were divided randomly into two equal groups. Rats in control group were given corn oil as carrier. Chrysin was orally administered at the dose of 50 mg kg(-1) per day by gavages, and it was dissolved in corn oil for 60 days. Tissue thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, antioxidant enzyme activity (CAT, SOD and GSH-Px), sperm parameters (motility, concentration and abnormal sperm rate), reproductive organ weight (testes, epididymis, vesicula seminalis, prostate) and serum testosterone levels were determined in the rats...
June 2012: Andrologia
https://www.readbyqxmd.com/read/19766177/cyp1a1-and-cyp3a4-modulation-by-dietary-flavonoids-in-human-intestinal-caco-2-cells
#4
Thérèse Sergent, Isabelle Dupont, Edwige Van der Heiden, Marie-Louise Scippo, Luc Pussemier, Yvan Larondelle, Yves-Jacques Schneider
Flavonoids have been proposed to exert beneficial effects in a multitude of disease states. However, evidence of potential toxic actions has also emerged. Since large doses of flavonoids can be encountered in the intestine simultaneously with ingested drugs and pollutants, this study aimed at investigating nine individual flavonoid compounds and their interactions with the major intestinal isoforms of cytochrome P450, i.e. CYPs 1A1 and 3A4, using human intestinal Caco-2 cells cultivated in a serum-free medium...
December 15, 2009: Toxicology Letters
https://www.readbyqxmd.com/read/18586291/testosterone-and-dihydrotestosterone-inhibit-gallbladder-motility-through-multiple-signalling-pathways
#5
Loren W Kline, Edward Karpinski
Testosterone (T) has been shown to cause vasodilation in rabbit coronary arteries through a nongenomic pathway. Part of this T-induced relaxation was shown to be mediated by opening voltage dependent K(+) channels. T infusion also reduces peripheral resistance in human males with heart failure. The effects of T or its active metabolite 5-alpha dihydrotestosterone (DHT) are not well studied. This study investigates the effect of T and DHT on contraction in guinea pig gallbladder strips. T or DHT induced a concentration-dependent relaxation of cholecystokinin octapeptide (CCK)-induced tension...
October 2008: Steroids
https://www.readbyqxmd.com/read/18434361/chrysin-a-natural-flavonoid-enhances-steroidogenesis-and-steroidogenic-acute-regulatory-protein-gene-expression-in-mouse-leydig-cells
#6
Kuladip Jana, Xiangling Yin, Randolph B Schiffer, Jau-Jiin Chen, Akhilesh K Pandey, Douglas M Stocco, Paula Grammas, Xingjia Wang
During the aging process of males, testosterone biosynthesis declines in testicular Leydig cells resulting in decreases in various physiological functions. To explore the possibility of delaying the decline using food supplements, we have studied steroidogenic effects of a natural flavonoid, chrysin, in mouse Leydig cells. Chrysin dramatically increased cyclic AMP (cAMP)-induced steroidogenesis in MA-10 mouse Leydig tumor cells. This result was confirmed using Leydig cells isolated from mouse testes. The steroidogenic effect of chrysin is not associated with an increase in expression of the P450 side-chain cleavage enzyme, required for the conversion of cholesterol to pregnenolone...
May 2008: Journal of Endocrinology
https://www.readbyqxmd.com/read/17482226/-anti-estrogenic-effects-of-phytochemicals-on-human-primary-mammary-fibroblasts-mcf-7-cells-and-their-co-culture
#7
COMPARATIVE STUDY
J A van Meeuwen, N Korthagen, P C de Jong, A H Piersma, M van den Berg
In the public opinion, phytochemicals (PCs) present in the human diet are often considered beneficial (e.g. by preventing breast cancer). Two possible mechanisms that could modulate tumor growth are via interaction with the estrogen receptor (ER) and inhibition of aromatase (CYP19). Multiple in vitro studies confirmed that these compounds act estrogenic, thus potentially induce tumor growth, as well as aromatase inhibitory, thus potentially reduce tumor growth. It is thought that in the in vivo situation breast epithelial (tumor) cells communicate with surrounding connective tissue by means of cytokines, prostaglandins and estradiol forming a complex feedback mechanism...
June 15, 2007: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/15771232/comparative-effects-of-fibrates-on-drug-metabolizing-enzymes-in-human-hepatocytes
#8
COMPARATIVE STUDY
Thomayant Prueksaritanont, Karen M Richards, Yue Qiu, Kristine Strong-Basalyga, Alisha Miller, Chunze Li, Roy Eisenhandler, Edward J Carlini
PURPOSE: The induction potential of different fibric acid derivatives on human drug metabolizing enzymes was evaluated to help assess the role of enzyme induction on pharmacokinetic drug interactions. METHODS: Effects of gemfibrozil, fenofibric acid, and clofibric acid on expression levels of cytochromes P450 (CYPs) 3A4 and 2C8 and UDP-glucuronyltransferase (UGT) 1A1 were evaluated in primary human hepatocyte cultures. The potential for these fibrates to activate human pregnane X receptor (PXR) also was studied in a cell-based PXR reporter gene assay...
January 2005: Pharmaceutical Research
https://www.readbyqxmd.com/read/14977449/effects-of-chrysin-on-urinary-testosterone-levels-in-human-males
#9
Cristiana Gambelunghe, Ruggero Rossi, Marco Sommavilla, Chiara Ferranti, Riccardo Rossi, Chiara Ciculi, Stefania Gizzi, Alessandra Micheletti, Stefano Rufini
The equilibrium of sexual hormones in both sexes is controlled in vertebrates by the enzyme aromatase, a member of the cytochrome P450 superfamily, which catalyzes the conversion of androstenedione and testosterone into estrone and estradiol, respectively. Flavonoids are diphenolic compounds present in whole grains, legumes, fruits, and vegetables that are strongly implicated as protective in coronary heart disease, stroke, and cancer. One flavonoid, chrysin, found in high concentrations in honey and propolis, has been shown to be an inhibitor of aromatase enzyme activity...
2003: Journal of Medicinal Food
https://www.readbyqxmd.com/read/14690874/drug-substance-reversal-effects-of-a-novel-tri-substituted-benzoflavone-moiety-bzf-isolated-from-passiflora-incarnata-linn-a-brief-perspective
#10
REVIEW
Kamaldeep Dhawan
The present work is a mini-review of the author's original work on the plant Passiflora incarnata Linn., which is used in several parts of the world as a traditional medicine for the management of anxiety, insomnia, epilepsy and morphine addiction. A tri-substituted benzoflavone moiety (BZF) has been isolated from the bioactive methanol extract of this plant, which has been proposed in the author's earlier work to be responsible for the biological activities of this plant. The BZF moiety has exhibited significantly encouraging results in the reversal of tolerance and dependence of several addiction-prone psychotropic drugs, including morphine, nicotine, ethanol, diazepam and delta-9-tetrahydrocannabinol, during earlier pharmacological studies conducted by the author...
December 2003: Addiction Biology
https://www.readbyqxmd.com/read/14559928/ingestion-of-a-dietary-supplement-containing-dehydroepiandrosterone-dhea-and-androstenedione-has-minimal-effect-on-immune-function-in-middle-aged-men
#11
RANDOMIZED CONTROLLED TRIAL
Marian L Kohut, James R Thompson, Jeff Campbell, Greg A Brown, Matthew D Vukovich, Dave A Jackson, Doug S King
OBJECTIVE: This study investigated the effects of four weeks of intake of a supplement containing dehydroepiandrosterone (DHEA), androstenedione and herbal extracts on immune function in middle-aged men. DESIGN: Subjects consumed either an oral placebo or an oral supplement for four weeks. The supplement contained a total daily dose of 150 mg DHEA, 300 mg androstenedione, 750 mg Tribulus terrestris, 625 mg chrysin, 300 mg indole-3-carbinol and 540 mg saw palmetto...
October 2003: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/11725694/effects-of-androstenedione-herbal-supplementation-on-serum-sex-hormone-concentrations-in-30-to-59-year-old-men
#12
RANDOMIZED CONTROLLED TRIAL
G A Brown, M D Vukovich, E R Martini, M L Kohut, W D Franke, D A Jackson, D S King
The effectiveness of a nutritional supplement designed to enhance serum testosterone concentrations and prevent the formation of dihydrotestosterone and estrogens from the ingested androgens was investigated in healthy 30- to 59-year old men. Subjects were randomly assigned to consume DION (300 mg androstenedione, 150 mg dehydroepiandrosterone, 540 mg saw palmetto, 300 mg indole-3-carbinol, 625 mg chrysin, and 750 mg Tribulus terrestris per day; n = 28) or placebo (n = 27) for 28 days. Serum free testosterone, total testosterone, androstenedione, dihydrotestosterone, estradiol, prostate-specific antigen (PSA), and lipid concentrations were measured before and throughout the 4-week supplementation period...
September 2001: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/11601567/endocrine-and-lipid-responses-to-chronic-androstenediol-herbal-supplementation-in-30-to-58-year-old-men
#13
RANDOMIZED CONTROLLED TRIAL
G A Brown, M D Vukovich, E R Martini, M L Kohut, W D Franke, D A Jackson, D S King
OBJECTIVE: The effectiveness of an androgenic nutritional supplement designed to enhance serum testosterone concentrations and prevent the formation of dihydrotestosterone and estrogen was investigated in healthy 3 to 58 year old men. DESIGN: Subjects were randomly assigned to consume a nutritional supplement (AND-HB) containing 300-mg androstenediol, 480-mg saw palmetto, 450-mg indole-3-carbinol, 300-mg chrysin, 1,500 mg gamma-linolenic acid and 1.350-mg Tribulus terrestris per day (n = 28), or placebo (n = 27) for 28 days...
October 2001: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/11482939/different-catalytic-properties-and-inhibitor-responses-of-the-goldfish-brain-and-ovary-aromatase-isozymes
#14
COMPARATIVE STUDY
J Zhao, P Mak, A Tchoudakova, G Callard, S Chen
The brain and ovarian aromatase isozymes of goldfish (Carassius auratus) are encoded by different CYP19 genes. This study measured aromatase activity in the goldfish brain tissues. For a direct comparison of the properties of the two aromatase isozymes, Chinese hamster ovary cells were stably transfected with brain- and ovary-derived cDNAs (respectively, p450 arom B and -A) and the properties of the expressed isozymes were compared. The kinetic parameters of the two isozymes were determined using androstenedione and testosterone as substrates and compared to those of human aromatase...
August 2001: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/10997957/effects-of-anabolic-precursors-on-serum-testosterone-concentrations-and-adaptations-to-resistance-training-in-young-men
#15
RANDOMIZED CONTROLLED TRIAL
G A Brown, M D Vukovich, T A Reifenrath, N L Uhl, K A Parsons, R L Sharp, D S King
The effects of androgen precursors, combined with herbal extracts designed to enhance testosterone formation and reduce conversion of androgens to estrogens was studied in young men. Subjects performed 3 days of resistance training per week for 8 weeks. Each day during Weeks 1, 2, 4, 5, 7, and 8, subjects consumed either placebo (PL; n = 10) or a supplement (ANDRO-6; n = 10), which contained daily doses of 300 mg androstenedione, 150 mg DHEA, 750 mg Tribulus terrestris, 625 mg Chrysin, 300 mg Indole-3-carbinol, and 540 mg Saw palmetto...
September 2000: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/10544151/a-yeast-screen-system-for-aromatase-inhibitors-and-ligands-for-androgen-receptor-yeast-cells-transformed-with-aromatase-and-androgen-receptor
#16
P Mak, F D Cruz, S Chen
Endocrine disruptors are hormone mimics that modify hormonal action in humans and animals. It is thought that some endocrine disruptors modify estrogen and androgen action in humans and animals by suppressing aromatase activity. Aromatase cytochrome P450 is the key enzyme that converts C19 androgens to aromatic C18 estrogenic steroids. We have developed a novel aromatase inhibitor screening method that allows us to identify antiaromatase activity of various environmental chemicals. The screen was developed by coexpressing the human aromatase and the mouse androgen receptor in yeast cells, which carry the androgen-responsive ss-galactosidase reporter plasmid...
November 1999: Environmental Health Perspectives
https://www.readbyqxmd.com/read/6474163/inhibition-of-human-estrogen-synthetase-aromatase-by-flavones
#17
J T Kellis, L E Vickery
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement...
September 7, 1984: Science
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