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https://www.readbyqxmd.com/read/28101946/repeat-hepatectomy-is-independently-associated-with-favorable-long-term-outcome-in-patients-with-colorectal-liver-metastases
#1
Christopher P Neal, Gael R Nana, Michael Jones, Vaux Cairns, Wee Ngu, John Isherwood, Ashley R Dennison, Giuseppe Garcea
Up to three-quarters of patients undergoing liver resection for colorectal liver metastases (CRLM) develop intrahepatic recurrence. Repeat hepatic resection appears to provide the optimal chance of cure for these patients. The aim of this study was to analyze short- and long-term outcomes following index and repeat hepatectomy for CRLM. Clinicopathological data were obtained from a prospectively maintained database. Perioperative variables and outcomes were compared using the Chi-squared test. Variables associated with long-term survival following index and second hepatectomy were identified by Cox regression analyses...
January 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28101227/downregulation-of-mir-23b-in-plasma-is-associated-with-poor-prognosis-in-patients-with-colorectal-cancer
#2
Chang-Hua Kou, Tian Zhou, Xi-Lin Han, Hui-Jie Zhuang, Hai-Xin Qian
MicroRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs have potential as cancer biomarkers. The main objective of the present study was to assess the effect of miRNA-23b (miR-23b) expression in plasma on the diagnosis and prognosis of colorectal cancer (CRC). Reverse transcription-quantitative polymerase chain reaction (PCR) was used to measure miR-23b expression levels, and methylation-specific PCR was used to test the promoter methylation status...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28098895/microrna-133b-is-regulated-by-tap63-while-no-gene-mutation-is-present-in-colorectal-cancer
#3
Yifei Chen, Yi Zhang, Jianhuai He, Ying Fu, Changwei Lin, Xiaorong Li
Downregulation of miR-133b has been reported in multiple types of malignancies including colorectal cancer (CRC). We previously confirmed that TAp63 actively translates microRNA-133b (miR-133b) transcripts. While the presence of miRNA mutations have frequently been described in CRC, most CRCs do not show any variation in the miR‑133b coding sequence. Therefore, it is important to elucidate the relationship between TAp63 and miR-133b, and identify other mediators of miR-133b downregulation in CRC. The expression of TAp63 was detected by RT-qPCR, western blotting, immunohistochemistry (IHC) and densitometric analysis using Image-Pro Plus 6...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28097381/rotating-night-shift-work-sleep-and-colorectal-adenoma-in-women
#4
Elizabeth E Devore, Jennifer Massa, Kyriaki Papantoniou, Eva S Schernhammer, Kana Wu, Xuehong Zhang, Walter C Willett, Charles S Fuchs, Andrew T Chan, Shuji Ogino, Edward Giovannucci, Esther K Wei
PURPOSE: This study aims to investigate the associations of rotating night shift work history and sleep duration with risk of colorectal adenoma. METHODS: We evaluated 56,275 cancer-free participants of the Nurses' Health Study II, who had their first colonoscopy or sigmoidoscopy between 1991 and 2011; rotating night shift work and sleep duration were reported by mailed questionnaire. Multivariable-adjusted logistic regression was used to estimate relative risks (RR) of colorectal adenoma, with 95% confidence intervals (CI), across categories of rotating night shift work history (none, 1-4, 5-9, and ≥10 years) and sleep duration (≤5, 6, 7, 8, and ≥9 h/day)...
January 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28096201/serum-c-peptide-total-and-high-molecular-weight-adiponectin-and-pancreatic-cancer-do-associations-differ-by-smoking
#5
Leticia M Nogueira, Christina C Newton, Michael N Pollak, Debra T Silverman, Demetrius Albanes, Satu Männistö, Stephanie J Weinstein, Eric J Jacobs, Rachael Z Stolzenberg-Solomon
BACKGROUND: Studies examining associations between circulating concentrations of C-peptide and total adiponectin, two biomarkers related to obesity and insulin secretion and sensitivity and pancreatic ductal adenocarcinoma (PDA) risk have shown inconsistent results and included limited numbers of smokers. METHODS: We examined associations of these biomarkers and high molecular weight (HMW) adiponectin with PDA, overall, and by smoking status. We conducted a pooled nested case-control analysis in 3 cohorts (Prostate, Lung, Colorectal, and Ovarian Cancer Trial, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and Cancer Prevention Study-II), with 758 cases (435 current smokers) and 1052 controls (531 smokers) matched by cohort, age, sex, race, blood draw date and follow-up time...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28094538/the-obesity-paradox-in-colorectal-cancer-surgery-an-analysis-of-korean-healthcare-big-data-2012-2013
#6
Sanghun Lee
Although it is well known that obesity increases the risk of colorectal cancer, several studies have recently suggested that those who are overweight or class-one obese have better outcomes after surgery. However, the impact of obesity on the success of colorectal cancer surgery remains controversial. The medical records of patients diagnosed with colorectal cancer who were treated surgically from 2012 through 2013 were retrospectively analyzed. Data from a total of 36,740 patients were provided by the Healthcare Big Data Hub of the Korean Health Insurance Review & Assessment Service...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28093732/long-term-hormone-therapy-for-perimenopausal-and-postmenopausal-women
#7
REVIEW
Jane Marjoribanks, Cindy Farquhar, Helen Roberts, Anne Lethaby, Jasmine Lee
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment...
January 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28089385/tailored-telephone-counselling-to-increase-participation-of-underusers-in-a-population-based-colorectal-cancer-screening-programme-with-faecal-occult-blood-test-a-randomized-controlled-trial
#8
B Denis, G Broc, E A Sauleau, I Gendre, K Gana, P Perrin
BACKGROUND: Despite the involvement of general practitioners, the mailing of several recall letters and of the faecal occult blood test (FOBT) kit, the uptake remains insufficient in the French colorectal cancer-screening programme. Some studies have demonstrated a greater efficacy of tailored telephone counselling over usual care, untailored invitation mailing and FOBT kit mailing. We evaluated the feasibility and the effectiveness of telephone counselling on participation in the population-based FOBT colorectal cancer-screening programme implemented in Alsace (France)...
January 11, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28087510/effectiveness-of-flexible-sigmoidoscopy-screening-in-men-and-women-and-different-age-groups-pooled-analysis-of-randomised-trials
#9
Øyvind Holme, Robert E Schoen, Carlo Senore, Nereo Segnan, Geir Hoff, Magnus Løberg, Michael Bretthauer, Hans-Olov Adami, Mette Kalager
OBJECTIVE:  To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age. DESIGN:  Pooled analysis of randomised trials (the US Prostate, Lung, Colorectal and Ovarian cancer screening trial (PLCO), the Italian Screening for Colon and Rectum trial (SCORE), and the Norwegian Colorectal Cancer Prevention trial (NORCCAP)). DATA SOURCES:  Aggregated data were pooled from each randomised trial on incidence of colorectal cancer and mortality stratified by sex, age at screening, and colon subsite (distal v proximal)...
January 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28078116/pretreatment-tumor-volume-as-a-prognostic-factor-in-metastatic-colorectal-cancer-treated-with-selective-internal-radiation-to-the-liver-using-yttrium-90-resin-microspheres
#10
Neha Bhooshan, Navesh K Sharma, Shahed Badiyan, Adeel Kaiser, Fred M Moeslein, Young Kwok, Pradip P Amin, Svetlana Kudryasheva, Michael D Chuong
BACKGROUND: Yttrium-90 ((90)Y)-resin microspheres can prolong intrahepatic disease control and improve overall survival (OS) in patients with metastatic colorectal cancer (CRC). Prognostic factors for improved outcomes in patients undergoing selective internal radiation therapy (SIRT) have been studied, but the relationship between pre-SIRT liver tumor volume and outcomes has not well described. METHODS: We retrospectively reviewed the records of patients with metastatic CRC who were treated at our institution with (90)Y-resin microspheres...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28078114/colorectal-cancer-anatomic-distribution-patterns-remain-the-same-after-sessile-serrated-adenoma-polyp-considered-cancer-precursor-a-9-year-comparison-study-from-community-based-endoscopy-centers
#11
Juliana F Yang, Amy E Noffsinger, Deepak Agrawal, Qing-Hua Yang
BACKGROUND: The overall incidence of colorectal cancer (CRC) in the United States has steadily decreased. However, the incidence of right-sided CRC remains unchanged for the past two decades. The serrated neoplastic pathway (sessile serrated adenoma/polyp, SSA/P) has been considered an important pathway of colorectal carcinogenesis, especially in the right-sided CRC. The aim of this study was to compare CRC anatomic distribution patterns in a 9-year interval in the general population before and after SSA/P was recognized and treated as a CRC precursor...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28077427/serum-trimethylamine-n-oxide-carnitine-choline-and-betaine-in-relation-to-colorectal-cancer-risk-in-the-alpha-tocopherol-and-beta-carotene-study
#12
Kristin A Guertin, Xinmin S Li, Barry I Graubard, Demetrius Albanes, Stephanie J Weinstein, James J Goedert, Zeneng Wang, Stanley L Hazen, Rashmi Sinha
BACKGROUND: TMAO, a choline-derived metabolite produced by gut microbiota, and its biomarker precursors have not been adequately evaluated in relation to colorectal cancer risk. METHODS: We investigated the relationship between serum concentrations of TMAO and its biomarker precursors (choline, carnitine and betaine) and incident colorectal cancer risk in a nested case-control study of male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study...
January 11, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28076249/fecal-immunochemical-test-fit-for-colon-cancer-screening-variable-performance-with-ambient-temperature
#13
Chyke A Doubeni, Christopher D Jensen, Stacey A Fedewa, Virginia P Quinn, Ann G Zauber, Joanne E Schottinger, Douglas A Corley, Theodore R Levin
INTRODUCTION: Fecal immunochemical tests (FITs) are widely used in colorectal cancer (CRC) screening, but hemoglobin degradation, due to exposure of the collected sample to high temperatures, could reduce test sensitivity. We examined the relation of ambient temperature exposure with FIT positivity rate and sensitivity. METHODS: This was a retrospective cohort study of patients 50 to 75 years in Kaiser Permanente Northern California's CRC screening program, which began mailing FIT kits annually to screen-eligible members in 2007...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28073517/predictive-factors-of-long-term-colorectal-cancer-survival-after-ultrasound-controlled-metastatic-hepatic-ablation
#14
Carmen Rosa Hernández-Socorro, Pedro Saavedra, José Ramírez Felipe, Uriel Bohn Sarmiento, Sergio Ruiz-Santana
BACKGROUND AND OBJECTIVE: The risk factors associated to long-term survival were assessed in patients with liver metastases of colorectal carcinoma undergoing ablative therapies. PATIENTS AND METHODS: Single-centre cohort study, retrospectively analysed and prospectively collected consecutive patients with unresectable metastatic liver disease of colorectal carcinoma treated with ablative therapies between 1996 and 2013. Factors associated with survival time were identified using Cox's proportional hazard model with time-dependent covariates...
January 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28072719/association-between-dietary-fat-intake-and-colorectal-adenoma-in-korean-adults-a-cross-sectional-study
#15
Jeehyun Kim, Seung-Won Oh, Young-Sun Kim, Hyuktae Kwon, Hee-Kyung Joh, Ji-Eun Lee, Danbee Park, Jae-Hong Park, Ah-Ryoung Ko, Ye-Ji Kim
The incidence of colorectal cancer is rapidly increasing in South Korea. It is important to clarify the association between colorectal cancer and diet, being one of the main modifiable risk factors, as such studies in the Korean population are lacking.A cross-sectional study was performed using data from participants who had undergone a screening colonoscopy and a nutritional assessment during a routine health check-up from January 2008 to December 2011. Dietary intake data were derived from 1-day food records; colorectal adenoma was histopathologically confirmed by biopsy during colonoscopy...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070726/prognostic-and-oncologic-significance-of-perineural-invasion-in-sporadic-colorectal-cancer
#16
Abdulrahman Muaod Alotaibi, Jong Lyul Lee, Jihun Kim, Seok-Byung Lim, Chang Sik Yu, Tae Won Kim, Jong Hoon Kim, Jin Cheon Kim
BACKGROUND: The presence of perineural invasion (PNI) in colorectal cancer (CRC) indicates a more aggressive phenotype, resulting in a poor prognosis. The aims of this study were to evaluate the oncologic outcome of PNI+ tumors and to investigate whether PNI status affects patient survival. METHODS: The study retrospectively enrolled 3807 patients from a single institution who underwent surgery for colorectal adenocarcinoma between January 2006 and December 2010...
January 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28070476/evaluating-screening-colonoscopy-quality-in-an-uninsured-urban-population-following-patient-navigation
#17
Keith Naylor, Cassandra Fritz, Blase Polite, Karen Kim
Patient navigation (PN) increases screening colonoscopy completion in minority and uninsured populations. However, colonoscopy quality is under-reported in the setting of PN and quality indicators have often failed to meet benchmark standards. This study investigated screening colonoscopy quality indicators after year-one of a PN initiative targeting the medically uninsured. This was a retrospective analysis of 296 outpatient screening colonoscopies. Patients were 45 to 75 years of age with no history of bowel cancer, inflammatory bowel disease, or colorectal surgery...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28070019/smad7-polymorphisms-and-colorectal-cancer-risk-a-meta-analysis-of-case-control-studies
#18
Yongsheng Huang, Wenting Wu, Meng Nie, Chuang Li, Lin Wang
Mothers against decapentaplegic homolog 7 (SMAD7) inhibits the transforming growth factor-β (TGF-β) signaling pathway, which regulates carcinogenesis and cancer progression. A number of studies have reported that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) are associated with colorectal cancer (CRC) risk, but the results from these studies remain conflicting. To determine a more precise estimation of the relationship between SMAD7 and CRC, we undertook a large-scale meta-analysis of 63 studies, which included a total of 187,181 subjects (86,585 cases and 100,596 controls)...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/28066666/ct-guided-percutaneous-microwave-ablation-of-pulmonary-malignant-tumors
#19
Wei-Chun Ko, Yee-Fan Lee, Yi-Chang Chen, Ning Chien, Yu-Sen Huang, Yao-Hui Tseng, Jang-Ming Lee, Hsao-Hsun Hsu, Jin-Shing Chen, Yeun-Chung Chang
BACKGROUND: Microwave ablation (MWA) of lung tumors is a new approach for local tumor control. The purpose of this retrospective study was to evaluate the preliminary results of safety and efficacy of MWA with a dynamic frequency range (902-928 MHz) and power (10-32 W) for local tumor control of thoracic malignancies. METHODS: From December 1, 2013 to February 1, 2016, there were total 32 lung tumors among 15 patients (7 men, 8 women, age range 43-82 years, mean 57...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065664/racial-differences-in-stage-iv-colorectal-cancer-survival-in-younger-and-older-patients
#20
Kristin Wallace, Allan DeToma, David N Lewin, Shaoli Sun, Don Rockey, Carolyn D Britten, Jennifer D Wu, Aissatou Ba, Anthony J Alberg, Elizabeth G Hill
INTRODUCTION: African Americans (AAs) compared with European Americans (EAs) have poorer stage-specific survival from colorectal cancer (CRC). Recent reports have indicated that the racial difference in survival has worsened over time, especially among younger patients. To better characterize this association, we used population-based Surveillance, Epidemiology, and End Results registry data to evaluate the effect of race on stage IV CRC survival in patients aged < 50 and ≥ 50 years...
December 7, 2016: Clinical Colorectal Cancer
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