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https://www.readbyqxmd.com/read/27913126/association-between-parkinson-s-disease-and-risk-of-colorectal-cancer
#1
Xin Xie, Xiaoguang Luo, Mingliang Xie
BACKGROUND: Growing evidence has reported that gut microbiota is involved in pathogenesis of Parkinson's disease (PD) and colorectal cancer (CRC), and the association between PD and CRC does not reach a consensus. In order to explore their correlation, herein we summarize the epidemiological evidence and included relevant studies to perform a meta-analysis. METHODS: A comprehensive literature search for relevant articles published was performed in Medline, Web of Science and Embase up to June 30, 2016...
November 22, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27911486/extended-mortality-results-for-prostate-cancer-screening-in-the-plco-trial-with-median-follow-up-of-15-years
#2
Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole
BACKGROUND: Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from the PLCO trial. METHODS: The PLCO trial randomized subjects from 1993 to 2001 to an intervention or control arm...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27910284/resting-heart-rate-is-an-independent-predictor-of-death-in-patients-with-colorectal-pancreatic-and-non-small-cell-lung-cancer-results-of-a-prospective-cardiovascular-long-term-study
#3
Markus S Anker, Nicole Ebner, Bert Hildebrandt, Jochen Springer, Marianne Sinn, Hanno Riess, Stefan D Anker, Ulf Landmesser, Wilhelm Haverkamp, Stephan von Haehling
AIMS: Patients with advanced cancer have been shown to suffer from abnormal cardiac function and impaired exercise capacity that may contribute to their impaired quality of life. As tachycardia is considered as a sign of potential early cardiac damage, we sought to determine whether resting heart rate and other ECG-derived variables have prognostic value. METHODS AND RESULTS: From 2005 to 2010, we enrolled 145 patients with histologically confirmed cancer (36 colorectal, 72 pancreatic, and 37 non-small cell lung cancer patients) and 59 healthy controls...
December 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27907852/the-relevance-of-primary-tumour-location-in-patients-with-metastatic-colorectal-cancer-a-meta-analysis-of-first-line-clinical-trials
#4
Julian Walter Holch, Ingrid Ricard, Sebastian Stintzing, Dominik Paul Modest, Volker Heinemann
BACKGROUND: Retrospective subgroup analyses suggest that primary tumour location (PTL) has a prognostic importance and relates to response to targeted therapy. METHODS: We conducted a meta-analysis of first-line clinical trials available up to October 2016, which assessed the relevance of PTL in patients with metastatic colorectal cancer (mCRC). Right- and left-sided colorectal cancers were differentiated (RC and LC). RESULTS: In 13 first-line randomised controlled trials and one prospective pharmacogenetic study, RC was associated with a significantly worse prognosis compared with LC (hazard ratio [HR] for overall survival: 1...
November 28, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27907203/tp53-polymorphisms-and-colorectal-cancer-risk-in-patients-with-lynch-syndrome-in-taiwan-a-retrospective-cohort-study
#5
Abram Bunya Kamiza, Ling-Ling Hsieh, Reiping Tang, Huei-Tzu Chien, Chih-Hsiung Lai, Li-Ling Chiu, Tsai-Ping Lo, Kuan-Yi Hung, Jeng-Fu You, Wen-Chang Wang, Chao A Hsiung, Chih-Ching Yeh
BACKGROUND AND AIM: TP53 encodes p53, which has a crucial role in modulating genes that regulate defense against cancer development. This study investigated whether TP53 polymorphisms are associated with colorectal cancer (CRC) in patients with Lynch syndrome and whether TP53 interacts with lifestyle factors to modify CRC risk. METHODS: We identified 260 MLH1 and MSH2 germline mutation carriers from the Taiwan Hereditary Nonpolyposis Colorectal Cancer Consortium...
2016: PloS One
https://www.readbyqxmd.com/read/27906680/chemopreventive-effects-of-5-aminosalicylic-acid-on-inflammatory-bowel-disease-associated-colorectal-cancer-and-dysplasia-a-systematic-review-with-meta-analysis
#6
Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang
BACKGROUND AND AIMS: The chemopreventive effect of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) has been widely studied; however, the results remain conflicting. The aim of this study was to systematically review the literature and update evidence concerning effects of 5-ASA on the risk of colorectal cancer (CRC) and dysplasia (Dys) in patients with ulcerative colitis (UC) or Crohn's disease (CD). RESULTS: 5-ASA showed a chemopreventive effect against CRC/Dys in IBD patients (OR = 0...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27906448/a-randomized-controlled-trial-of-a-multicomponent-targeted-low-literacy-educational-intervention-compared-with-a-nontargeted-intervention-to-boost-colorectal-cancer-screening-with-fecal-immunochemical-testing-in-community-clinics
#7
Stacy N Davis, Shannon M Christy, Enmanuel A Chavarria, Rania Abdulla, Steven K Sutton, Alyssa R Schmidt, Susan T Vadaparampil, Gwendolyn P Quinn, Vani N Simmons, Chukwudi B Ufondu, Chitra Ravindra, Ida Schultz, Richard G Roetzheim, David Shibata, Cathy D Meade, Clement K Gwede
BACKGROUND: The objective of the current study was to improve colorectal cancer (CRC) screening uptake with the fecal immunochemical test (FIT). The current study investigated the differential impact of a multicomponent, targeted, low-literacy educational intervention compared with a standard, nontargeted educational intervention. METHODS: Patients aged 50 to 75 years who were of average CRC risk and not up-to-date with CRC screening were recruited from either a federally qualified health center or a primary care community health clinic...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27901479/the-association-between-the-tp53-arg72pro-polymorphism-and-colorectal-cancer-an-updated-meta-analysis-based-on-32-studies
#8
Xin Tian, Shundong Dai, Jing Sun, Shenyi Jiang, Youhong Jiang
Several previous studies evaluated the association between the Arg72Pro (rs1042522) polymorphism in the TP53 tumor suppressor gene and colorectal cancer (CRC). However, the results are conflicting. This meta-analysis aimed to shed new light on the precise association between TP53 variants and CRC. We analyzed 32 published case-control studies involving 8,586 cases and 10,275 controls using crude odd ratios (ORs) with 95% confidence intervals (CIs). The meta-analysis was performed using a fixed-effect or random-effects model, as appropriate...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898658/reproductive-and-menstrual-factors-and-colorectal-cancer-incidence-in-the-women-s-health-initiative-observational-study
#9
Neil Murphy, Linzhi Xu, Alice Zervoudakis, Xiaonan Xue, Geoffrey Kabat, Thomas E Rohan, Sylvia Wassertheil-Smoller, Mary Jo O'Sullivan, Cynthia Thomson, Catherine Messina, Howard D Strickler, Marc J Gunter
BACKGROUND: Reproductive and menstrual factors have been evaluated as surrogates for long-term hormonal exposures in several prospective studies of colorectal cancer, yet findings have been conflicting. METHODS: The relation of reproductive and menstrual factors (self-reported via a reproductive history questionnaire) with incident colorectal cancer was investigated among women enrolled in the Women's Health Initiative Observational Study (WHI-OS), a longitudinal cohort of 93 676 postmenopausal women (aged 50-79 years at enrolment) in which 1149 incident cases of colorectal cancer occurred over a median follow-up of 11...
November 29, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27895793/evaluation-of-recurrent-disease-in-the-re-staging-of-colorectal-cancer-by-18-f-fdg-pet-ct-use-of-cea-and-ca-19-9-in-patient-selection
#10
Agostino Chiaravalloti, Alessandro Fiorentini, Erika Palombo, Davide Rinino, Annamaria Lacanfora, Roberta Danieli, Carmen Di Russo, Daniele Di Biagio, Ettore Squillaci, Orazio Schillaci
The aim of the present retrospective study was to evaluate the sensitivity and specificity of fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing the recurrence of colorectal cancer (CRC) with regard to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). (18)F-FDG PET/CT was performed in 100 patients for the re-staging of CRC. Therapy was discontinued prior to the examination. The mean (± standard deviation) CEA value (measured ~30 days prior to PET/CT examination) was 23...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895498/meta-analysis-of-outcomes-of-patients-with-stage-iv-colorectal-cancer-managed-with-chemotherapy-radiochemotherapy-with-and-without-primary-tumor-resection
#11
Ko-Chao Lee, Yu-Che Ou, Wan-Hsiang Hu, Chia-Cheng Liu, Hong-Hwa Chen
BACKGROUND: Colorectal cancer is the third leading cause of death worldwide. Currently, novel chemotherapeutic agents are first-line therapy for unresectable stage IV colorectal cancer, while benefits of noncurative primary tumor resection in advanced disease remain debatable. OBJECTIVE: This meta-analysis evaluated outcomes of patients with unresectable stage IV colorectal cancer receiving systemic chemotherapy with or without primary tumor resection. MATERIALS AND METHODS: A database search of PubMed and Cochrane Library databases identified 167 studies that were screened for relevance...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27893653/adjuvant-radiotherapy-for-the-treatment-of-stage-iv-rectal-cancer-after-curative-resection-a-propensity-score-matched-analysis-and-meta-analysis
#12
Min Jung Kim, Sang Jin Kim, Sung-Chan Park, Dae Yong Kim, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Heung Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Jung Nam Joo, Jae Hwan Oh
The role of pelvic radiotherapy (RT) in stage IV rectal cancer with total mesorectal excision (TME) has not been defined. We evaluated the impact of RT on oncologic outcomes among patients with stage IV rectal cancer who underwent TME and performed a meta-analysis of published studies.The records of stage IV rectal cancer patients who underwent TME between August 2001 and December 2011 were reviewed. Patients who received pelvic RT (RT group) and those who did not (non-RT group) were matched using a propensity score...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27892965/diabetes-mellitus-and-risk-of-colorectal-cancer-mortality-in-japan-the-japan-collaborative-cohort-study
#13
Ce Tan, Mitsuru Mori, Yasushi Adachi, Kenji Wakai, Sadao Suzuki, Koji Suzuki, Shuji Hashimoto, Yoshiyuki Watanabe, Akiko Tamakoshi
Objective: Our aim was to estimate whether diabetes mellitus (DM) may be associated with an increased risk of colorectal cancer (CRC) mortality in Japan. Methods: The Japan Collaborative Cohort (JACC) Study is a nationwide prospective study, initiated in 1988, which involves 110,585 subjects (age range: from 40 to 79 years; 46,395 males and 64,190 females). Our present analysis population comprised 96,081 (40,510 men and 55,571 women) who provided details on DM history. The questionnaire also included age, sex, weight, height, family history of CRC, smoking, drinking and exercise habits, and education...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27890853/chromoendoscopy-for-surveillance-in-ulcerative-colitis-and-crohn-s-disease-a-systematic-review-of-randomized-trials
#14
REVIEW
Andrea Iannone, Marinella Ruospo, Germaine Wong, Mariabeatrice Principi, Michele Barone, Giovanni Fm Strippoli, Alfredo Di Leo
BACKGROUND & AIMS: Key international guideline agencies recommend dysplasia surveillance in inflammatory bowel diseases with chromoendoscopy. We performed a systematic review of randomized trials comparing chromoendoscopy versus other endoscopic techniques for dysplasia surveillance in inflammatory bowel diseases. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials for relevant studies published through September 2016. We estimated risk ratios (RR) for dichotomous outcomes (all-cause/colorectal cancer-related mortality, time to interval cancer, patients with dysplasia, total/subtypes of dysplastic lesions, dysplasia detected by targeted biopsies, adverse events), mean differences (MD) for continuous outcomes (procedural time, costs, total/targeted biopsies) and their 95% confidence intervals (CI) using a random-effects model...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27889548/impact-of-physician-adherence-to-colonoscopy-surveillance-guidelines-on-interval-colon-cancer
#15
Jennifer Nayor, John R Saltzman, Emily J Campbell, Molly L Perencevich, Kunal Jajoo, James M Richter
BACKGROUND AND AIMS: Interval colorectal cancer (iCRC) incidence is the criterion standard benchmark for measuring the effectiveness of colonoscopy. Colonoscopy surveillance guidelines are designed to minimize iCRC cases. Our aims were to (1) describe characteristics of iCRC patients; and (2) assess if development of iCRC is related to colonoscopy surveillance guideline intervals. METHODS: We performed a retrospective cohort study of post-colonoscopy iCRC cases in a large healthcare system...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27888868/novel-findings-in-colorectal-polyp-surveillance
#16
Sabela Carballal
Colorectal adenomas and serrated polyps are the best characterised premalignant lesions involved in the development of colorectal cancer (CRC). Therefore, the identification and removal of these lesions, as well as post-polypectomy surveillance of affected patients, are key goals in the field of CRC prevention. Current post-polypectomy surveillance strategies differ among the various scientific societies and have several limitations that hamper their application in clinical practice. First, current surveillance intervals are based only on polyp characteristics, excluding other potential clinical conditions, such as diabetes or metabolic syndrome...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27888867/colorectal-cancer-screening
#17
Xavier Bessa Caserras
In the latest meeting of the American Gastroenterological Association, several clinical studies were presented that aimed to evaluate the various colorectal cancer screening strategies, although most assessed the various aspects of faecal immunochemical testing (FIT) and colonoscopy. Data were presented from consecutive FIT-based screening rounds, confirming the importance of adherence to consecutive screening rounds, achieving a similar or superior diagnostic yield to endoscopic studies. There was confirmation of the importance of not delaying endoscopic study after a positive result...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27885879/a-high-preoperative-carbohydrate-antigen-19-9-level-is-a-risk-factor-for-recurrence-in-stage-ii-colorectal-cancer
#18
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Kazuhito Sasaki, Koji Murono, Toshiaki Watanabe
BACKGROUND: Many risk factors for recurrence in stage II colorectal cancer (CRC) have been proposed, and the efficacy of adjuvant chemotherapy is still controversial. This study aimed to identify risk factors for tumor recurrence and assess whether they are related to the benefits of adjuvant chemotherapy in stage II CRC. MATERIAL AND METHODS: Patients with stage II CRC that was curatively operated on in a tertiary hospital between 2005 and 2014 were analyzed. Cox's proportional hazards models were applied to identify risk factors for recurrence and overall mortality...
November 25, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27885555/meat-intake-cooking-methods-and-doneness-and-risk-of-colorectal-tumours-in-the-spanish-multicase-control-study-mcc-spain
#19
Jordi de Batlle, Esther Gracia-Lavedan, Dora Romaguera, Michelle Mendez, Gemma Castaño-Vinyals, Vicente Martín, Núria Aragonés, Inés Gómez-Acebo, Rocío Olmedo-Requena, José Juan Jimenez-Moleon, Marcela Guevara, Mikel Azpiri, Cristóbal Llorens-Ivorra, Guillermo Fernandez-Tardon, Jose Andrés Lorca, José María Huerta, Victor Moreno, Elena Boldo, Beatriz Pérez-Gómez, Jesús Castilla, Tania Fernández-Villa, Juan Pablo Barrio, Montserrat Andreu, Antoni Castells, Trinidad Dierssen, Jone M Altzibar, Manolis Kogevinas, Marina Pollán, Pilar Amiano
PURPOSE: Although there is convincing evidence that red and processed meat intake increases the risk of colorectal cancer (CRC), the potential role of meat cooking practices has not been established yet and could partly explain the current heterogeneity of results among studies. Therefore, we aimed to investigate the association between meat consumption and cooking practices and the risk of CRC in a population-based case-control study. METHODS: A total of 1671 CRC cases and 3095 controls recruited in Spain between September 2008 and December 2013 completing a food frequency questionnaire with a meat-specific module were included in the analyses...
November 24, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27884041/follow-up-strategies-for-patients-treated-for-non-metastatic-colorectal-cancer
#20
REVIEW
Mark Jeffery, Brigid E Hickey, Phil N Hider, Adrienne M See
BACKGROUND: It is common clinical practice to follow patients with colorectal cancer (CRC) for several years following their curative surgery or adjuvant therapy, or both. Despite this widespread practice, there is considerable controversy about how often patients should be seen, what tests should be performed, and whether these varying strategies have any significant impact on patient outcomes. This is the second update of a Cochrane Review first published in 2002 and first updated in 2007...
November 24, 2016: Cochrane Database of Systematic Reviews
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